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Thyroid Gland Mucinous Carcinoma

MedGen UID:
1661824
•Concept ID:
C4744698
•
Neoplastic Process

Definition

A rare primary carcinoma of the thyroid gland characterized by the presence of clusters of malignant epithelial cells associated with abundant extracellular mucin deposition. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid Gland Mucinous Carcinoma

Recent clinical studies

Etiology

Clinicopathological observation of mature teratoma with malignant transformation, a single center retrospective study.
Yuan Y, Li H, Yang H
Indian J Pathol Microbiol 2022 Apr-Jun;65(2):369-373. doi: 10.4103/IJPM.IJPM_828_20. PMID: 35435373
Triple synchronous primary cancers of rectum, thyroid, and uterine cervix detected during the workup for hematochezia.
Lee JS, Moon W, Park SJ, Park MI, Kim KJ, Jang LL, Park MJ, Chun BK
Intern Med 2010;49(16):1745-7. Epub 2010 Aug 13 doi: 10.2169/internalmedicine.49.3549. PMID: 20720352
Thyroglossal duct cyst: a cytopathologic study of 26 cases.
Shahin A, Burroughs FH, Kirby JP, Ali SZ
Diagn Cytopathol 2005 Dec;33(6):365-9. doi: 10.1002/dc.20346. PMID: 16299737
New and unusual aspects of ovarian germ cell tumors.
Young RH
Am J Surg Pathol 1993 Dec;17(12):1210-24. doi: 10.1097/00000478-199312000-00002. PMID: 7694512

Diagnosis

SOX17: A Highly Sensitive and Specific Immunomarker for Ovarian and Endometrial Carcinomas.
Zhang X, Yao J, Niu N, Li X, Liu Y, Huo L, Euscher ED, Wang H, Bell D, Sood AK, Wang G, Lawson BC, Ramalingam P, Malpica A, Sahin AA, Ding Q, Liu J
Mod Pathol 2023 Feb;36(2):100001. Epub 2023 Jan 9 doi: 10.1016/j.modpat.2022.100001. PMID: 36853778
Identifying SOX17 as a Sensitive and Specific Marker for Ovarian and Endometrial Carcinomas.
Shaker N, Chen W, Sinclair W, Parwani AV, Li Z
Mod Pathol 2023 Jan;36(1):100038. doi: 10.1016/j.modpat.2022.100038. PMID: 36788073
Primary lesions that may imitate metastatic tumors histologically: A selective review.
Wick MR
Semin Diagn Pathol 2018 Mar;35(2):123-142. Epub 2017 Nov 17 doi: 10.1053/j.semdp.2017.11.010. PMID: 29174934
Mucinous Variant of Follicular Carcinoma of the Thyroid Gland: Case Report and Review of the Literature.
Squillaci S, Pitino A, Spairani C, Ferrari M, Carlon E, Cosimi MF
Int J Surg Pathol 2016 Apr;24(2):170-6. Epub 2015 Nov 18 doi: 10.1177/1066896915617026. PMID: 26582770
Primary mucinous carcinoma of the thyroid gland: case report with review of the literature.
Mnif H, Chakroun A, Charfi S, Ellouze S, Ghorbel M, Sallemi-Boudawara T
Pathologica 2013 Aug;105(4):128-31. PMID: 24466763

Therapy

Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: safety, feasibility and biological activity.
Nemunaitis J, Cunningham C, Buchanan A, Blackburn A, Edelman G, Maples P, Netto G, Tong A, Randlev B, Olson S, Kirn D
Gene Ther 2001 May;8(10):746-59. doi: 10.1038/sj.gt.3301424. PMID: 11420638
Current therapy of thyroid nodules.
Wright HK, Burrow GN, Spaulding S, Sheahan DG
Surg Clin North Am 1974 Apr;54(2):277-88. doi: 10.1016/s0039-6109(16)40279-3. PMID: 4361604

Prognosis

DOG1 expression is common in human tumors: A tissue microarray study on more than 15,000 tissue samples.
Jansen K, Farahi N, Büscheck F, Lennartz M, Luebke AM, Burandt E, Menz A, Kluth M, Hube-Magg C, Hinsch A, Höflmayer D, Weidemann S, Fraune C, Möller K, Lebok P, Sauter G, Simon R, Uhlig R, Wilczak W, Jacobsen F, Minner S, Krech R, Clauditz T, Bernreuther C, Dum D, Krech T, Marx A, Steurer S
Pathol Res Pract 2021 Dec;228:153663. Epub 2021 Oct 21 doi: 10.1016/j.prp.2021.153663. PMID: 34717148
Mucinous breast carcinoma metastatic to thyroid gland: Report of a case diagnosed by fine-needle aspiration cytology.
Wang M, Liu X, Wei B, Liu N, Li Q, Su X
Diagn Cytopathol 2020 May;48(5):475-478. Epub 2020 Feb 17 doi: 10.1002/dc.24396. PMID: 32065477
Nonthyroidal metastatic lesion in thyroid: A missed diagnosis and a lesson learnt.
Prameela CG, Ravind R, Sruthi K
J Cancer Res Ther 2019 Jul-Sep;15(3):665-668. doi: 10.4103/jcrt.JCRT_1043_16. PMID: 31169237
Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia: a clinicopathologic and molecular analysis of a distinct entity.
Shah AA, La Fortune K, Miller C, Mills SE, Baloch Z, LiVolsi V, Dacic S, Mahaffey AL, Nikiforova M, Nikiforov YE, Seethala RR
Mod Pathol 2017 Mar;30(3):329-339. Epub 2016 Dec 2 doi: 10.1038/modpathol.2016.180. PMID: 27910944Free PMC Article
Primary mucinous carcinoma with rhabdoid cells of the thyroid gland: a case report.
Matsuo M, Tuneyoshi M, Mine M
Diagn Pathol 2016 Jun 10;11(1):48. doi: 10.1186/s13000-016-0500-8. PMID: 27282149Free PMC Article

Clinical prediction guides

Medullary carcinoma of the ampulla has distinct clinicopathologic characteristics including common association with microsatellite instability and PD-L1 expression.
Xue Y, Balci S, Pehlivanoglu B, Muraki T, Memis B, Saka B, Kim G, Bandyopadhyay S, Knight J, El-Rayes B, Kooby D, Maithel SK, Sarmiento J, Basturk O, Reid MD, Adsay V
Hum Pathol 2023 Jan;131:38-46. Epub 2022 Dec 9 doi: 10.1016/j.humpath.2022.12.004. PMID: 36502926
Clinicopathological observation of mature teratoma with malignant transformation, a single center retrospective study.
Yuan Y, Li H, Yang H
Indian J Pathol Microbiol 2022 Apr-Jun;65(2):369-373. doi: 10.4103/IJPM.IJPM_828_20. PMID: 35435373
Primary lesions that may imitate metastatic tumors histologically: A selective review.
Wick MR
Semin Diagn Pathol 2018 Mar;35(2):123-142. Epub 2017 Nov 17 doi: 10.1053/j.semdp.2017.11.010. PMID: 29174934
Expression of pax8 as a useful marker in distinguishing ovarian carcinomas from mammary carcinomas.
Nonaka D, Chiriboga L, Soslow RA
Am J Surg Pathol 2008 Oct;32(10):1566-71. doi: 10.1097/PAS.0b013e31816d71ad. PMID: 18724243
Thyroglossal duct cyst: a cytopathologic study of 26 cases.
Shahin A, Burroughs FH, Kirby JP, Ali SZ
Diagn Cytopathol 2005 Dec;33(6):365-9. doi: 10.1002/dc.20346. PMID: 16299737

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