U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Unresectable Pleural Malignant Mesothelioma

MedGen UID:
1661826
•Concept ID:
C4743579
•
Neoplastic Process

Definition

Malignant mesothelioma of the pleura that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Pleural Malignant Mesothelioma

Professional guidelines

PubMed

True Benefits of Immune Checkpoint Inhibitors in the Treatment of Malignant Pleural Mesothelioma in Japan.
Kuribayashi K, Hirano J
Anticancer Res 2024 Oct;44(10):4135-4145. doi: 10.21873/anticanres.17244. PMID: 39348972
Nivolumab for the treatment of unresectable pleural mesothelioma.
Hotta K, Fujimoto N, Kozuki T, Aoe K, Kiura K
Expert Opin Biol Ther 2020 Feb;20(2):109-114. Epub 2019 Dec 16 doi: 10.1080/14712598.2020.1703945. PMID: 31825692
Systemic chemotherapy in the management of malignant peritoneal mesothelioma.
Garcia-Carbonero R, Paz-Ares L
Eur J Surg Oncol 2006 Aug;32(6):676-81. Epub 2006 Apr 17 doi: 10.1016/j.ejso.2006.03.009. PMID: 16616827

Recent clinical studies

Etiology

First-line nivolumab plus ipilimumab versus chemotherapy in patients with unresectable malignant pleural mesothelioma: 3-year outcomes from CheckMate 743.
Peters S, Scherpereel A, Cornelissen R, Oulkhouir Y, Greillier L, Kaplan MA, Talbot T, Monnet I, Hiret S, Baas P, Nowak AK, Fujimoto N, Tsao AS, Mansfield AS, Popat S, Zhang X, Hu N, Balli D, Spires T, Zalcman G
Ann Oncol 2022 May;33(5):488-499. Epub 2022 Feb 3 doi: 10.1016/j.annonc.2022.01.074. PMID: 35124183
First-line nivolumab plus ipilimumab in unresectable malignant pleural mesothelioma (CheckMate 743): a multicentre, randomised, open-label, phase 3 trial.
Baas P, Scherpereel A, Nowak AK, Fujimoto N, Peters S, Tsao AS, Mansfield AS, Popat S, Jahan T, Antonia S, Oulkhouir Y, Bautista Y, Cornelissen R, Greillier L, Grossi F, Kowalski D, Rodríguez-Cid J, Aanur P, Oukessou A, Baudelet C, Zalcman G
Lancet 2021 Jan 30;397(10272):375-386. Epub 2021 Jan 21 doi: 10.1016/S0140-6736(20)32714-8. PMID: 33485464
Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label, phase 3 trial.
Zalcman G, Mazieres J, Margery J, Greillier L, Audigier-Valette C, Moro-Sibilot D, Molinier O, Corre R, Monnet I, Gounant V, Rivière F, Janicot H, Gervais R, Locher C, Milleron B, Tran Q, Lebitasy MP, Morin F, Creveuil C, Parienti JJ, Scherpereel A; French Cooperative Thoracic Intergroup (IFCT)
Lancet 2016 Apr 2;387(10026):1405-1414. Epub 2015 Dec 21 doi: 10.1016/S0140-6736(15)01238-6. PMID: 26719230
Single-dose dexamethasone for the prevention of pemetrexed associated cutaneous adverse reactions.
Elsoueidi R, Lander MJ, Richa EM, Adane ED
J Oncol Pharm Pract 2016 Apr;22(2):271-4. Epub 2015 Apr 22 doi: 10.1177/1078155215583523. PMID: 25908647
Malignant pleural mesothelioma.
Hughes RS
Am J Med Sci 2005 Jan;329(1):29-44. doi: 10.1097/00000441-200501000-00007. PMID: 15654178

Diagnosis

Updates in Management of Malignant Pleural Mesothelioma.
John A, O'Sullivan H, Popat S
Curr Treat Options Oncol 2023 Dec;24(12):1758-1789. Epub 2023 Nov 17 doi: 10.1007/s11864-023-01148-2. PMID: 37975977
Immune checkpoint inhibitors for unresectable malignant pleural mesothelioma.
Metro G, Signorelli D, Pizzutilo EG, Giannetta L, Cerea G, Garaffa M, Friedlaender A, Addeo A, Mandarano M, Bellezza G, Roila F
Hum Vaccin Immunother 2021 Sep 2;17(9):2972-2980. Epub 2021 May 18 doi: 10.1080/21645515.2021.1917933. PMID: 34003722Free PMC Article
SEOM clinical guidelines for the treatment of malignant pleural mesothelioma (2020).
Nadal E, Bosch-Barrera J, Cedrés S, Coves J, García-Campelo R, Guirado M, López-Castro R, Ortega AL, Vicente D, de Castro-Carpeño J
Clin Transl Oncol 2021 May;23(5):980-987. Epub 2021 Feb 4 doi: 10.1007/s12094-020-02532-2. PMID: 33538989Free PMC Article
Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label, phase 3 trial.
Zalcman G, Mazieres J, Margery J, Greillier L, Audigier-Valette C, Moro-Sibilot D, Molinier O, Corre R, Monnet I, Gounant V, Rivière F, Janicot H, Gervais R, Locher C, Milleron B, Tran Q, Lebitasy MP, Morin F, Creveuil C, Parienti JJ, Scherpereel A; French Cooperative Thoracic Intergroup (IFCT)
Lancet 2016 Apr 2;387(10026):1405-1414. Epub 2015 Dec 21 doi: 10.1016/S0140-6736(15)01238-6. PMID: 26719230
Malignant pleural mesothelioma.
Tsao AS, Wistuba I, Roth JA, Kindler HL
J Clin Oncol 2009 Apr 20;27(12):2081-90. Epub 2009 Mar 2 doi: 10.1200/JCO.2008.19.8523. PMID: 19255316Free PMC Article

Therapy

First-line nivolumab plus ipilimumab versus chemotherapy in patients with unresectable malignant pleural mesothelioma: 3-year outcomes from CheckMate 743.
Peters S, Scherpereel A, Cornelissen R, Oulkhouir Y, Greillier L, Kaplan MA, Talbot T, Monnet I, Hiret S, Baas P, Nowak AK, Fujimoto N, Tsao AS, Mansfield AS, Popat S, Zhang X, Hu N, Balli D, Spires T, Zalcman G
Ann Oncol 2022 May;33(5):488-499. Epub 2022 Feb 3 doi: 10.1016/j.annonc.2022.01.074. PMID: 35124183
New Era for Malignant Pleural Mesothelioma: Updates on Therapeutic Options.
Tsao AS, Pass HI, Rimner A, Mansfield AS
J Clin Oncol 2022 Feb 20;40(6):681-692. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01567. PMID: 34985934Free PMC Article
Immune checkpoint inhibitors for unresectable malignant pleural mesothelioma.
Metro G, Signorelli D, Pizzutilo EG, Giannetta L, Cerea G, Garaffa M, Friedlaender A, Addeo A, Mandarano M, Bellezza G, Roila F
Hum Vaccin Immunother 2021 Sep 2;17(9):2972-2980. Epub 2021 May 18 doi: 10.1080/21645515.2021.1917933. PMID: 34003722Free PMC Article
SEOM clinical guidelines for the treatment of malignant pleural mesothelioma (2020).
Nadal E, Bosch-Barrera J, Cedrés S, Coves J, García-Campelo R, Guirado M, López-Castro R, Ortega AL, Vicente D, de Castro-Carpeño J
Clin Transl Oncol 2021 May;23(5):980-987. Epub 2021 Feb 4 doi: 10.1007/s12094-020-02532-2. PMID: 33538989Free PMC Article
First-line nivolumab plus ipilimumab in unresectable malignant pleural mesothelioma (CheckMate 743): a multicentre, randomised, open-label, phase 3 trial.
Baas P, Scherpereel A, Nowak AK, Fujimoto N, Peters S, Tsao AS, Mansfield AS, Popat S, Jahan T, Antonia S, Oulkhouir Y, Bautista Y, Cornelissen R, Greillier L, Grossi F, Kowalski D, Rodríguez-Cid J, Aanur P, Oukessou A, Baudelet C, Zalcman G
Lancet 2021 Jan 30;397(10272):375-386. Epub 2021 Jan 21 doi: 10.1016/S0140-6736(20)32714-8. PMID: 33485464

Prognosis

Immunotherapy of mesothelioma: the evolving change of a long-standing therapeutic dream.
Calabrò L, Bronte G, Grosso F, Cerbone L, Delmonte A, Nicolini F, Mazza M, Di Giacomo AM, Covre A, Lofiego MF, Crinò L, Maio M
Front Immunol 2023;14:1333661. Epub 2024 Jan 8 doi: 10.3389/fimmu.2023.1333661. PMID: 38259475Free PMC Article
New Era for Malignant Pleural Mesothelioma: Updates on Therapeutic Options.
Tsao AS, Pass HI, Rimner A, Mansfield AS
J Clin Oncol 2022 Feb 20;40(6):681-692. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01567. PMID: 34985934Free PMC Article
SEOM clinical guidelines for the treatment of malignant pleural mesothelioma (2020).
Nadal E, Bosch-Barrera J, Cedrés S, Coves J, García-Campelo R, Guirado M, López-Castro R, Ortega AL, Vicente D, de Castro-Carpeño J
Clin Transl Oncol 2021 May;23(5):980-987. Epub 2021 Feb 4 doi: 10.1007/s12094-020-02532-2. PMID: 33538989Free PMC Article
Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label, phase 3 trial.
Zalcman G, Mazieres J, Margery J, Greillier L, Audigier-Valette C, Moro-Sibilot D, Molinier O, Corre R, Monnet I, Gounant V, Rivière F, Janicot H, Gervais R, Locher C, Milleron B, Tran Q, Lebitasy MP, Morin F, Creveuil C, Parienti JJ, Scherpereel A; French Cooperative Thoracic Intergroup (IFCT)
Lancet 2016 Apr 2;387(10026):1405-1414. Epub 2015 Dec 21 doi: 10.1016/S0140-6736(15)01238-6. PMID: 26719230
Immune checkpoint blockade in malignant mesothelioma.
Calabrò L, Maio M
Semin Oncol 2015 Jun;42(3):418-22. Epub 2015 Feb 24 doi: 10.1053/j.seminoncol.2015.02.001. PMID: 25965359

Clinical prediction guides

First-line nivolumab plus ipilimumab versus chemotherapy in patients with unresectable malignant pleural mesothelioma: 3-year outcomes from CheckMate 743.
Peters S, Scherpereel A, Cornelissen R, Oulkhouir Y, Greillier L, Kaplan MA, Talbot T, Monnet I, Hiret S, Baas P, Nowak AK, Fujimoto N, Tsao AS, Mansfield AS, Popat S, Zhang X, Hu N, Balli D, Spires T, Zalcman G
Ann Oncol 2022 May;33(5):488-499. Epub 2022 Feb 3 doi: 10.1016/j.annonc.2022.01.074. PMID: 35124183
New Era for Malignant Pleural Mesothelioma: Updates on Therapeutic Options.
Tsao AS, Pass HI, Rimner A, Mansfield AS
J Clin Oncol 2022 Feb 20;40(6):681-692. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01567. PMID: 34985934Free PMC Article
Immune Checkpoint Inhibition for Unresectable Malignant Pleural Mesothelioma.
Cui W, Popat S
Drugs 2021 Jun;81(9):971-984. Epub 2021 Jun 9 doi: 10.1007/s40265-021-01506-0. PMID: 34106454
Updates in the diagnosis and treatment of malignant pleural mesothelioma.
Katzman D, Sterman DH
Curr Opin Pulm Med 2018 Jul;24(4):319-326. doi: 10.1097/MCP.0000000000000489. PMID: 29553973
Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label, phase 3 trial.
Zalcman G, Mazieres J, Margery J, Greillier L, Audigier-Valette C, Moro-Sibilot D, Molinier O, Corre R, Monnet I, Gounant V, Rivière F, Janicot H, Gervais R, Locher C, Milleron B, Tran Q, Lebitasy MP, Morin F, Creveuil C, Parienti JJ, Scherpereel A; French Cooperative Thoracic Intergroup (IFCT)
Lancet 2016 Apr 2;387(10026):1405-1414. Epub 2015 Dec 21 doi: 10.1016/S0140-6736(15)01238-6. PMID: 26719230

Recent systematic reviews

Evaluation of first-line and salvage therapies for unresectable malignant mesothelioma: A systematic review and network meta-analysis.
Zhuang W, Liu L, Sun B, Bai H, Wang Z, Duan J, Wan R, Ma Z, Zhong J, Wang J
Crit Rev Oncol Hematol 2024 Jun;198:104372. Epub 2024 Apr 26 doi: 10.1016/j.critrevonc.2024.104372. PMID: 38677356
Meta-Analysis on the Combination of Chemotherapy With Programmed Death-Ligand 1 and Programmed Cell Death Protein 1 Blockade as First-Line Treatment for Unresectable Pleural Mesothelioma.
Tagliamento M, Di Maio M, Remon J, Bironzo P, Genova C, Facchinetti F, Aldea M, Le Péchoux C, Novello S, Barlesi F, Besse B, Planchard D
J Thorac Oncol 2024 Jan;19(1):166-172. Epub 2023 Aug 9 doi: 10.1016/j.jtho.2023.08.004. PMID: 37567387
Pemetrexed disodium in combination with cisplatin versus other cytotoxic agents or supportive care for the treatment of malignant pleural mesothelioma.
Green J, Dundar Y, Dodd S, Dickson R, Walley T
Cochrane Database Syst Rev 2007 Jan 24;2007(1):CD005574. doi: 10.1002/14651858.CD005574.pub2. PMID: 17253564Free PMC Article
Pemetrexed disodium for the treatment of malignant pleural mesothelioma: a systematic review and economic evaluation.
Dundar Y, Bagust A, Dickson R, Dodd S, Green J, Haycox A, Hill R, McLeod C, Walley T
Health Technol Assess 2007 Jan;11(1):1-90. doi: 10.3310/hta11010. PMID: 17181984
Activity of chemotherapy and immunotherapy on malignant mesothelioma: a systematic review of the literature with meta-analysis.
Berghmans T, Paesmans M, Lalami Y, Louviaux I, Luce S, Mascaux C, Meert AP, Sculier JP
Lung Cancer 2002 Nov;38(2):111-21. doi: 10.1016/s0169-5002(02)00180-0. PMID: 12399121

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...