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Unresectable Pleural Malignant Mesothelioma

MedGen UID:
1661826
•Concept ID:
C4743579
•
Neoplastic Process

Definition

Malignant mesothelioma of the pleura that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Pleural Malignant Mesothelioma

Professional guidelines

PubMed

Nivolumab for the treatment of unresectable pleural mesothelioma.
Hotta K, Fujimoto N, Kozuki T, Aoe K, Kiura K
Expert Opin Biol Ther 2020 Feb;20(2):109-114. Epub 2019 Dec 16 doi: 10.1080/14712598.2020.1703945. PMID: 31825692
Integration of Tumor-Treating Fields into the Multidisciplinary Management of Patients with Solid Malignancies.
Wang Y, Pandey M, Ballo MT
Oncologist 2019 Dec;24(12):e1426-e1436. Epub 2019 Aug 23 doi: 10.1634/theoncologist.2017-0603. PMID: 31444292Free PMC Article
Systemic chemotherapy in the management of malignant peritoneal mesothelioma.
Garcia-Carbonero R, Paz-Ares L
Eur J Surg Oncol 2006 Aug;32(6):676-81. Epub 2006 Apr 17 doi: 10.1016/j.ejso.2006.03.009. PMID: 16616827

Recent clinical studies

Etiology

First-line nivolumab plus ipilimumab versus chemotherapy for the treatment of unresectable malignant pleural mesothelioma: patient-reported outcomes in CheckMate 743.
Scherpereel A, Antonia S, Bautista Y, Grossi F, Kowalski D, Zalcman G, Nowak AK, Fujimoto N, Peters S, Tsao AS, Mansfield AS, Popat S, Sun X, Lawrance R, Zhang X, Daumont MJ, Bennett B, McKenna M, Baas P
Lung Cancer 2022 May;167:8-16. Epub 2022 Mar 21 doi: 10.1016/j.lungcan.2022.03.012. PMID: 35367910
First-line nivolumab plus ipilimumab versus chemotherapy in patients with unresectable malignant pleural mesothelioma: 3-year outcomes from CheckMate 743.
Peters S, Scherpereel A, Cornelissen R, Oulkhouir Y, Greillier L, Kaplan MA, Talbot T, Monnet I, Hiret S, Baas P, Nowak AK, Fujimoto N, Tsao AS, Mansfield AS, Popat S, Zhang X, Hu N, Balli D, Spires T, Zalcman G
Ann Oncol 2022 May;33(5):488-499. Epub 2022 Feb 3 doi: 10.1016/j.annonc.2022.01.074. PMID: 35124183
First-line nivolumab plus ipilimumab in unresectable malignant pleural mesothelioma (CheckMate 743): a multicentre, randomised, open-label, phase 3 trial.
Baas P, Scherpereel A, Nowak AK, Fujimoto N, Peters S, Tsao AS, Mansfield AS, Popat S, Jahan T, Antonia S, Oulkhouir Y, Bautista Y, Cornelissen R, Greillier L, Grossi F, Kowalski D, Rodríguez-Cid J, Aanur P, Oukessou A, Baudelet C, Zalcman G
Lancet 2021 Jan 30;397(10272):375-386. Epub 2021 Jan 21 doi: 10.1016/S0140-6736(20)32714-8. PMID: 33485464
Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label, phase 3 trial.
Zalcman G, Mazieres J, Margery J, Greillier L, Audigier-Valette C, Moro-Sibilot D, Molinier O, Corre R, Monnet I, Gounant V, Rivière F, Janicot H, Gervais R, Locher C, Milleron B, Tran Q, Lebitasy MP, Morin F, Creveuil C, Parienti JJ, Scherpereel A; French Cooperative Thoracic Intergroup (IFCT)
Lancet 2016 Apr 2;387(10026):1405-1414. Epub 2015 Dec 21 doi: 10.1016/S0140-6736(15)01238-6. PMID: 26719230
Malignant pleural mesothelioma.
Hughes RS
Am J Med Sci 2005 Jan;329(1):29-44. doi: 10.1097/00000441-200501000-00007. PMID: 15654178

Diagnosis

Updates in Management of Malignant Pleural Mesothelioma.
John A, O'Sullivan H, Popat S
Curr Treat Options Oncol 2023 Dec;24(12):1758-1789. Epub 2023 Nov 17 doi: 10.1007/s11864-023-01148-2. PMID: 37975977
Updates in the diagnosis and treatment of malignant pleural mesothelioma.
Katzman D, Sterman DH
Curr Opin Pulm Med 2018 Jul;24(4):319-326. doi: 10.1097/MCP.0000000000000489. PMID: 29553973
Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label, phase 3 trial.
Zalcman G, Mazieres J, Margery J, Greillier L, Audigier-Valette C, Moro-Sibilot D, Molinier O, Corre R, Monnet I, Gounant V, Rivière F, Janicot H, Gervais R, Locher C, Milleron B, Tran Q, Lebitasy MP, Morin F, Creveuil C, Parienti JJ, Scherpereel A; French Cooperative Thoracic Intergroup (IFCT)
Lancet 2016 Apr 2;387(10026):1405-1414. Epub 2015 Dec 21 doi: 10.1016/S0140-6736(15)01238-6. PMID: 26719230
Malignant pleural mesothelioma.
Tsao AS, Wistuba I, Roth JA, Kindler HL
J Clin Oncol 2009 Apr 20;27(12):2081-90. Epub 2009 Mar 2 doi: 10.1200/JCO.2008.19.8523. PMID: 19255316Free PMC Article
Malignant pleural mesothelioma.
Hughes RS
Am J Med Sci 2005 Jan;329(1):29-44. doi: 10.1097/00000441-200501000-00007. PMID: 15654178

Therapy

Updates in Management of Malignant Pleural Mesothelioma.
John A, O'Sullivan H, Popat S
Curr Treat Options Oncol 2023 Dec;24(12):1758-1789. Epub 2023 Nov 17 doi: 10.1007/s11864-023-01148-2. PMID: 37975977
First-line nivolumab plus ipilimumab versus chemotherapy in patients with unresectable malignant pleural mesothelioma: 3-year outcomes from CheckMate 743.
Peters S, Scherpereel A, Cornelissen R, Oulkhouir Y, Greillier L, Kaplan MA, Talbot T, Monnet I, Hiret S, Baas P, Nowak AK, Fujimoto N, Tsao AS, Mansfield AS, Popat S, Zhang X, Hu N, Balli D, Spires T, Zalcman G
Ann Oncol 2022 May;33(5):488-499. Epub 2022 Feb 3 doi: 10.1016/j.annonc.2022.01.074. PMID: 35124183
New Era for Malignant Pleural Mesothelioma: Updates on Therapeutic Options.
Tsao AS, Pass HI, Rimner A, Mansfield AS
J Clin Oncol 2022 Feb 20;40(6):681-692. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01567. PMID: 34985934Free PMC Article
First-line nivolumab plus ipilimumab in unresectable malignant pleural mesothelioma (CheckMate 743): a multicentre, randomised, open-label, phase 3 trial.
Baas P, Scherpereel A, Nowak AK, Fujimoto N, Peters S, Tsao AS, Mansfield AS, Popat S, Jahan T, Antonia S, Oulkhouir Y, Bautista Y, Cornelissen R, Greillier L, Grossi F, Kowalski D, Rodríguez-Cid J, Aanur P, Oukessou A, Baudelet C, Zalcman G
Lancet 2021 Jan 30;397(10272):375-386. Epub 2021 Jan 21 doi: 10.1016/S0140-6736(20)32714-8. PMID: 33485464
Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label, phase 3 trial.
Zalcman G, Mazieres J, Margery J, Greillier L, Audigier-Valette C, Moro-Sibilot D, Molinier O, Corre R, Monnet I, Gounant V, Rivière F, Janicot H, Gervais R, Locher C, Milleron B, Tran Q, Lebitasy MP, Morin F, Creveuil C, Parienti JJ, Scherpereel A; French Cooperative Thoracic Intergroup (IFCT)
Lancet 2016 Apr 2;387(10026):1405-1414. Epub 2015 Dec 21 doi: 10.1016/S0140-6736(15)01238-6. PMID: 26719230

Prognosis

New Era for Malignant Pleural Mesothelioma: Updates on Therapeutic Options.
Tsao AS, Pass HI, Rimner A, Mansfield AS
J Clin Oncol 2022 Feb 20;40(6):681-692. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01567. PMID: 34985934Free PMC Article
Immune Checkpoint Inhibition for Unresectable Malignant Pleural Mesothelioma.
Cui W, Popat S
Drugs 2021 Jun;81(9):971-984. Epub 2021 Jun 9 doi: 10.1007/s40265-021-01506-0. PMID: 34106454
Updates in the diagnosis and treatment of malignant pleural mesothelioma.
Katzman D, Sterman DH
Curr Opin Pulm Med 2018 Jul;24(4):319-326. doi: 10.1097/MCP.0000000000000489. PMID: 29553973
Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label, phase 3 trial.
Zalcman G, Mazieres J, Margery J, Greillier L, Audigier-Valette C, Moro-Sibilot D, Molinier O, Corre R, Monnet I, Gounant V, Rivière F, Janicot H, Gervais R, Locher C, Milleron B, Tran Q, Lebitasy MP, Morin F, Creveuil C, Parienti JJ, Scherpereel A; French Cooperative Thoracic Intergroup (IFCT)
Lancet 2016 Apr 2;387(10026):1405-1414. Epub 2015 Dec 21 doi: 10.1016/S0140-6736(15)01238-6. PMID: 26719230
Malignant pleural mesothelioma.
Hughes RS
Am J Med Sci 2005 Jan;329(1):29-44. doi: 10.1097/00000441-200501000-00007. PMID: 15654178

Clinical prediction guides

First-line nivolumab plus ipilimumab versus chemotherapy in patients with unresectable malignant pleural mesothelioma: 3-year outcomes from CheckMate 743.
Peters S, Scherpereel A, Cornelissen R, Oulkhouir Y, Greillier L, Kaplan MA, Talbot T, Monnet I, Hiret S, Baas P, Nowak AK, Fujimoto N, Tsao AS, Mansfield AS, Popat S, Zhang X, Hu N, Balli D, Spires T, Zalcman G
Ann Oncol 2022 May;33(5):488-499. Epub 2022 Feb 3 doi: 10.1016/j.annonc.2022.01.074. PMID: 35124183
New Era for Malignant Pleural Mesothelioma: Updates on Therapeutic Options.
Tsao AS, Pass HI, Rimner A, Mansfield AS
J Clin Oncol 2022 Feb 20;40(6):681-692. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01567. PMID: 34985934Free PMC Article
Immune Checkpoint Inhibition for Unresectable Malignant Pleural Mesothelioma.
Cui W, Popat S
Drugs 2021 Jun;81(9):971-984. Epub 2021 Jun 9 doi: 10.1007/s40265-021-01506-0. PMID: 34106454
Updates in the diagnosis and treatment of malignant pleural mesothelioma.
Katzman D, Sterman DH
Curr Opin Pulm Med 2018 Jul;24(4):319-326. doi: 10.1097/MCP.0000000000000489. PMID: 29553973
Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label, phase 3 trial.
Zalcman G, Mazieres J, Margery J, Greillier L, Audigier-Valette C, Moro-Sibilot D, Molinier O, Corre R, Monnet I, Gounant V, Rivière F, Janicot H, Gervais R, Locher C, Milleron B, Tran Q, Lebitasy MP, Morin F, Creveuil C, Parienti JJ, Scherpereel A; French Cooperative Thoracic Intergroup (IFCT)
Lancet 2016 Apr 2;387(10026):1405-1414. Epub 2015 Dec 21 doi: 10.1016/S0140-6736(15)01238-6. PMID: 26719230

Recent systematic reviews

Meta-Analysis on the Combination of Chemotherapy With Programmed Death-Ligand 1 and Programmed Cell Death Protein 1 Blockade as First-Line Treatment for Unresectable Pleural Mesothelioma.
Tagliamento M, Di Maio M, Remon J, Bironzo P, Genova C, Facchinetti F, Aldea M, Le Péchoux C, Novello S, Barlesi F, Besse B, Planchard D
J Thorac Oncol 2024 Jan;19(1):166-172. Epub 2023 Aug 9 doi: 10.1016/j.jtho.2023.08.004. PMID: 37567387
Pemetrexed disodium in combination with cisplatin versus other cytotoxic agents or supportive care for the treatment of malignant pleural mesothelioma.
Green J, Dundar Y, Dodd S, Dickson R, Walley T
Cochrane Database Syst Rev 2007 Jan 24;2007(1):CD005574. doi: 10.1002/14651858.CD005574.pub2. PMID: 17253564Free PMC Article
Pemetrexed disodium for the treatment of malignant pleural mesothelioma: a systematic review and economic evaluation.
Dundar Y, Bagust A, Dickson R, Dodd S, Green J, Haycox A, Hill R, McLeod C, Walley T
Health Technol Assess 2007 Jan;11(1):1-90. doi: 10.3310/hta11010. PMID: 17181984
Activity of chemotherapy and immunotherapy on malignant mesothelioma: a systematic review of the literature with meta-analysis.
Berghmans T, Paesmans M, Lalami Y, Louviaux I, Luce S, Mascaux C, Meert AP, Sculier JP
Lung Cancer 2002 Nov;38(2):111-21. doi: 10.1016/s0169-5002(02)00180-0. PMID: 12399121

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