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Refractory Malignant Neoplasm of Multiple Primary Sites

MedGen UID:
1661967
Concept ID:
C4725805
Neoplastic Process

Definition

Malignant neoplasm of multiple primary sites that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Malignant Neoplasm of Multiple Primary Sites

Professional guidelines

PubMed

Melani C, Jaffe ES, Wilson WH
Blood 2020 Apr 16;135(16):1344-1352. doi: 10.1182/blood.2019000933. PMID: 32107539Free PMC Article
Soumerai JD, Hellmann MD, Feng Y, Sohani AR, Toomey CE, Barnes JA, Takvorian RW, Neuberg D, Hochberg EP, Abramson JS
Leuk Lymphoma 2014 Mar;55(3):538-43. Epub 2013 Jul 29 doi: 10.3109/10428194.2013.810738. PMID: 23734654
Gronlund B, Høgdall C, Hilden J, Engelholm SA, Høgdall EV, Hansen HH
J Clin Oncol 2004 Oct 15;22(20):4051-8. Epub 2004 Sep 13 doi: 10.1200/JCO.2004.10.028. PMID: 15364966

Recent clinical studies

Etiology

Mi JQ, Zhao W, Jing H, Fu W, Hu J, Chen L, Zhang Y, Yao D, Chen D, Schecter JM, Yang F, Tian X, Sun H, Zhuang SH, Ren J, Fan X, Jin J, Niu T, Chen SJ
J Clin Oncol 2023 Feb 20;41(6):1275-1284. Epub 2022 Oct 21 doi: 10.1200/JCO.22.00690. PMID: 36269898
Zhao WH, Wang BY, Chen LJ, Fu WJ, Xu J, Liu J, Jin SW, Chen YX, Cao XM, Yang Y, Zhang YL, Wang FX, Zhang PY, Lei B, Gu LF, Wang JL, Zhang H, Bai J, Xu Y, Zhu H, Du J, Jiang H, Fan XH, Li JY, Hou J, Chen Z, Zhang WG, Mi JQ, Chen SJ, He AL
J Hematol Oncol 2022 Jul 6;15(1):86. doi: 10.1186/s13045-022-01301-8. PMID: 35794616Free PMC Article
Patel SP, Mayerson E, Chae YK, Strosberg J, Wang J, Konda B, Hayward J, McLeod CM, Chen HX, Sharon E, Othus M, Ryan CW, Plets M, Blanke CD, Kurzrock R
Cancer 2021 Sep 1;127(17):3194-3201. Epub 2021 Apr 21 doi: 10.1002/cncr.33591. PMID: 33882143Free PMC Article
Dimopoulos M, Quach H, Mateos MV, Landgren O, Leleu X, Siegel D, Weisel K, Yang H, Klippel Z, Zahlten-Kumeli A, Usmani SZ
Lancet 2020 Jul 18;396(10245):186-197. doi: 10.1016/S0140-6736(20)30734-0. PMID: 32682484
Moreau P, Mateos MV, Berenson JR, Weisel K, Lazzaro A, Song K, Dimopoulos MA, Huang M, Zahlten-Kumeli A, Stewart AK
Lancet Oncol 2018 Jul;19(7):953-964. Epub 2018 Jun 1 doi: 10.1016/S1470-2045(18)30354-1. PMID: 29866475

Diagnosis

Ayto R, Annibali O, Biedermann P, Roset M, Sánchez E, Kotb R
Eur J Haematol 2024 Jun;112(6):889-899. Epub 2024 Feb 23 doi: 10.1111/ejh.14180. PMID: 38389468
Mai EK, Goldschmid H, Miah K, Bertsch U, Besemer B, Hänel M, Krzykalla J, Fenk R, Schlenzka J, Munder M, Dürig J, Blau IW, Huhn S, Hose D, Jauch A, Kunz C, Mann C, Weinhold N, Scheid C, Schroers R, von Metzler I, Schieferdecker A, Thomalla J, Reimer P, Mahlberg R, Graeven U, Kremers S, Martens UM, Kunz C, Hensel M, Benner A, Seidel-Glätzer A, Weisel KC, Raab MS, Salwender HJ; German-speaking Myeloma Multicenter Group (GMMG) HD6 investigators
Lancet Haematol 2024 Feb;11(2):e101-e113. doi: 10.1016/S2352-3026(23)00366-6. PMID: 38302221
Hawley JE, Obradovic AZ, Dallos MC, Lim EA, Runcie K, Ager CR, McKiernan J, Anderson CB, Decastro GJ, Weintraub J, Virk R, Lowy I, Hu J, Chaimowitz MG, Guo XV, Zhang Y, Haffner MC, Worley J, Stein MN, Califano A, Drake CG
Cancer Cell 2023 Nov 13;41(11):1972-1988.e5. Epub 2023 Nov 2 doi: 10.1016/j.ccell.2023.10.006. PMID: 37922910Free PMC Article
Melani C, Jaffe ES, Wilson WH
Blood 2020 Apr 16;135(16):1344-1352. doi: 10.1182/blood.2019000933. PMID: 32107539Free PMC Article
Srivastava M, Torosyan Y, Raffeld M, Eidelman O, Pollard HB, Bubendorf L
Int J Cancer 2007 Dec 15;121(12):2628-36. doi: 10.1002/ijc.23008. PMID: 17708571

Therapy

Hawley JE, Obradovic AZ, Dallos MC, Lim EA, Runcie K, Ager CR, McKiernan J, Anderson CB, Decastro GJ, Weintraub J, Virk R, Lowy I, Hu J, Chaimowitz MG, Guo XV, Zhang Y, Haffner MC, Worley J, Stein MN, Califano A, Drake CG
Cancer Cell 2023 Nov 13;41(11):1972-1988.e5. Epub 2023 Nov 2 doi: 10.1016/j.ccell.2023.10.006. PMID: 37922910Free PMC Article
Mi JQ, Zhao W, Jing H, Fu W, Hu J, Chen L, Zhang Y, Yao D, Chen D, Schecter JM, Yang F, Tian X, Sun H, Zhuang SH, Ren J, Fan X, Jin J, Niu T, Chen SJ
J Clin Oncol 2023 Feb 20;41(6):1275-1284. Epub 2022 Oct 21 doi: 10.1200/JCO.22.00690. PMID: 36269898
Zhao WH, Wang BY, Chen LJ, Fu WJ, Xu J, Liu J, Jin SW, Chen YX, Cao XM, Yang Y, Zhang YL, Wang FX, Zhang PY, Lei B, Gu LF, Wang JL, Zhang H, Bai J, Xu Y, Zhu H, Du J, Jiang H, Fan XH, Li JY, Hou J, Chen Z, Zhang WG, Mi JQ, Chen SJ, He AL
J Hematol Oncol 2022 Jul 6;15(1):86. doi: 10.1186/s13045-022-01301-8. PMID: 35794616Free PMC Article
Patel SP, Mayerson E, Chae YK, Strosberg J, Wang J, Konda B, Hayward J, McLeod CM, Chen HX, Sharon E, Othus M, Ryan CW, Plets M, Blanke CD, Kurzrock R
Cancer 2021 Sep 1;127(17):3194-3201. Epub 2021 Apr 21 doi: 10.1002/cncr.33591. PMID: 33882143Free PMC Article
Dimopoulos M, Quach H, Mateos MV, Landgren O, Leleu X, Siegel D, Weisel K, Yang H, Klippel Z, Zahlten-Kumeli A, Usmani SZ
Lancet 2020 Jul 18;396(10245):186-197. doi: 10.1016/S0140-6736(20)30734-0. PMID: 32682484

Prognosis

Zhao WH, Wang BY, Chen LJ, Fu WJ, Xu J, Liu J, Jin SW, Chen YX, Cao XM, Yang Y, Zhang YL, Wang FX, Zhang PY, Lei B, Gu LF, Wang JL, Zhang H, Bai J, Xu Y, Zhu H, Du J, Jiang H, Fan XH, Li JY, Hou J, Chen Z, Zhang WG, Mi JQ, Chen SJ, He AL
J Hematol Oncol 2022 Jul 6;15(1):86. doi: 10.1186/s13045-022-01301-8. PMID: 35794616Free PMC Article
Chen J, Ji Q, Bai C, Zheng X, Zhang Y, Shi F, Li X, Tang P, Xu Z, Huang R, Huang T, Pan Y, Fan S, Zhou J, Su W
Thyroid 2020 Sep;30(9):1245-1253. Epub 2020 Apr 6 doi: 10.1089/thy.2019.0453. PMID: 32075524
Paudel N, Schulze D, Gentzler RD, Evens AM, Helenowski I, Dillehay G, Frankfurt O, Mehta J, Donnelly ED, Gordon LI, Winter JN, Mittal BB
Int J Radiat Oncol Biol Phys 2019 Jun 1;104(2):436-446. Epub 2019 Feb 11 doi: 10.1016/j.ijrobp.2019.02.007. PMID: 30763660
Moreau P, Mateos MV, Berenson JR, Weisel K, Lazzaro A, Song K, Dimopoulos MA, Huang M, Zahlten-Kumeli A, Stewart AK
Lancet Oncol 2018 Jul;19(7):953-964. Epub 2018 Jun 1 doi: 10.1016/S1470-2045(18)30354-1. PMID: 29866475
Leung OC, Poon WL, Nyaw SF, Luk SH
Hong Kong Med J 2013 Aug;19(4):317-22. Epub 2013 Apr 3 doi: 10.12809/hkmj133743. PMID: 23568935

Clinical prediction guides

Ayto R, Annibali O, Biedermann P, Roset M, Sánchez E, Kotb R
Eur J Haematol 2024 Jun;112(6):889-899. Epub 2024 Feb 23 doi: 10.1111/ejh.14180. PMID: 38389468
Hawley JE, Obradovic AZ, Dallos MC, Lim EA, Runcie K, Ager CR, McKiernan J, Anderson CB, Decastro GJ, Weintraub J, Virk R, Lowy I, Hu J, Chaimowitz MG, Guo XV, Zhang Y, Haffner MC, Worley J, Stein MN, Califano A, Drake CG
Cancer Cell 2023 Nov 13;41(11):1972-1988.e5. Epub 2023 Nov 2 doi: 10.1016/j.ccell.2023.10.006. PMID: 37922910Free PMC Article
Zhao WH, Wang BY, Chen LJ, Fu WJ, Xu J, Liu J, Jin SW, Chen YX, Cao XM, Yang Y, Zhang YL, Wang FX, Zhang PY, Lei B, Gu LF, Wang JL, Zhang H, Bai J, Xu Y, Zhu H, Du J, Jiang H, Fan XH, Li JY, Hou J, Chen Z, Zhang WG, Mi JQ, Chen SJ, He AL
J Hematol Oncol 2022 Jul 6;15(1):86. doi: 10.1186/s13045-022-01301-8. PMID: 35794616Free PMC Article
Mateos MV, Nahi H, Legiec W, Grosicki S, Vorobyev V, Spicka I, Hungria V, Korenkova S, Bahlis N, Flogegard M, Bladé J, Moreau P, Kaiser M, Iida S, Laubach J, Magen H, Cavo M, Hulin C, White D, De Stefano V, Clemens PL, Masterson T, Lantz K, O'Rourke L, Heuck C, Qin X, Parasrampuria DA, Yuan Z, Xu S, Qi M, Usmani SZ
Lancet Haematol 2020 May;7(5):e370-e380. Epub 2020 Mar 23 doi: 10.1016/S2352-3026(20)30070-3. PMID: 32213342
Rodriguez GI, Jones RE, Orenberg EK, Stoltz ML, Brooks DJ
Clin Cancer Res 2002 Sep;8(9):2828-34. PMID: 12231523

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