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Perivascular infiltrate containing CD8+ T cells

MedGen UID:
1662300
•Concept ID:
C4748318
•
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPerivascular infiltrate containing CD8+ T cells

Recent clinical studies

Etiology

Lichen striatus versus linear lichen planus: a comparison of clinicopathological features, immunoprofile of infiltrated cells, and epidermal proliferation and differentiation.
Zhou Y, Yu ZZ, Peng J, Yang PP, Li SJ, Fan YM
Int J Dermatol 2016 Apr;55(4):e204-10. Epub 2016 Jan 19 doi: 10.1111/ijd.13143. PMID: 26785261
Brain CD8+ and cytotoxic T lymphocytes are associated with, and may be specific for, human immunodeficiency virus type 1 encephalitis in patients with acquired immunodeficiency syndrome.
Petito CK, Torres-Muñoz JE, Zielger F, McCarthy M
J Neurovirol 2006 Aug;12(4):272-83. doi: 10.1080/13550280600879204. PMID: 16966218
Differentiation and clonality of lesional lymphocytes in small plaque parapsoriasis.
Haeffner AC, Smoller BR, Zepter K, Wood GS
Arch Dermatol 1995 Mar;131(3):321-4. PMID: 7887662

Diagnosis

Perivascular lymphocytic aggregates in hip prosthesis-associated adverse local tissue reactions demonstrate Th1 and Th2 activity and exhausted CD8(+) cell responses.
Eltit F, Mohammad N, Medina I, Haegert A, Duncan CP, Garbuz DS, Greidanus NV, Masri BA, Ng TL, Wang R, Cox ME
J Orthop Res 2021 Dec;39(12):2581-2594. Epub 2021 Feb 15 doi: 10.1002/jor.24998. PMID: 33506972
Perivascular tissue resident memory T cells as therapeutic target in multiple sclerosis.
Smolders J, Fransen NL, Hsiao CC, Hamann J, Huitinga I
Expert Rev Neurother 2020 Aug;20(8):835-848. Epub 2020 Jun 30 doi: 10.1080/14737175.2020.1776609. PMID: 32476499
Immunopathology of Fatal Human Variegated Squirrel Bornavirus 1 Encephalitis, Germany, 2011-2013.
Tappe D, Schmidt-Chanasit J, Rauch J, Allartz P, Herden C
Emerg Infect Dis 2019 Jun;25(6):1058-1065. doi: 10.3201/eid2506.181082. PMID: 31107210Free PMC Article
Update on PML and PML-IRIS occurring in multiple sclerosis patients treated with natalizumab.
Kleinschmidt-DeMasters BK, Miravalle A, Schowinsky J, Corboy J, Vollmer T
J Neuropathol Exp Neurol 2012 Jul;71(7):604-17. doi: 10.1097/NEN.0b013e31825caf2c. PMID: 22710964
Brain CD8+ and cytotoxic T lymphocytes are associated with, and may be specific for, human immunodeficiency virus type 1 encephalitis in patients with acquired immunodeficiency syndrome.
Petito CK, Torres-Muñoz JE, Zielger F, McCarthy M
J Neurovirol 2006 Aug;12(4):272-83. doi: 10.1080/13550280600879204. PMID: 16966218

Therapy

Perivascular lymphocytic aggregates in hip prosthesis-associated adverse local tissue reactions demonstrate Th1 and Th2 activity and exhausted CD8(+) cell responses.
Eltit F, Mohammad N, Medina I, Haegert A, Duncan CP, Garbuz DS, Greidanus NV, Masri BA, Ng TL, Wang R, Cox ME
J Orthop Res 2021 Dec;39(12):2581-2594. Epub 2021 Feb 15 doi: 10.1002/jor.24998. PMID: 33506972
Eruption of lymphocyte recovery with atypical lymphocytes mimicking a primary cutaneous T-cell lymphoma: a series of 12 patients.
Hurabielle C, Sbidian E, Beltraminelli H, Bouchindhomme B, Chassagne-Clément C, Balme B, Bossard C, Delfau-Larue MH, Wolkenstein P, Chosidow O, Cordonnier C, Toma A, Pautas C, Ortonne N
Hum Pathol 2018 Jan;71:100-108. Epub 2017 Oct 28 doi: 10.1016/j.humpath.2017.10.018. PMID: 29107664
Update on PML and PML-IRIS occurring in multiple sclerosis patients treated with natalizumab.
Kleinschmidt-DeMasters BK, Miravalle A, Schowinsky J, Corboy J, Vollmer T
J Neuropathol Exp Neurol 2012 Jul;71(7):604-17. doi: 10.1097/NEN.0b013e31825caf2c. PMID: 22710964
Pediatric AIDS-associated lymphocytic interstitial pneumonia and pulmonary arterio-occlusive disease: role of VCAM-1/VLA-4 adhesion pathway and human herpesviruses.
Brodie SJ, de la Rosa C, Howe JG, Crouch J, Travis WD, Diem K
Am J Pathol 1999 May;154(5):1453-64. doi: 10.1016/S0002-9440(10)65400-4. PMID: 10329599Free PMC Article
Predominant CD8+ infiltrate in limb biopsies of individuals with filarial lymphedema and elephantiasis.
Freedman DO, Horn TD, Maia e Silva CM, Braga C, Maciel A
Am J Trop Med Hyg 1995 Dec;53(6):633-8. PMID: 8561266

Prognosis

B cell rich meningeal inflammation associates with increased spinal cord pathology in multiple sclerosis.
Reali C, Magliozzi R, Roncaroli F, Nicholas R, Howell OW, Reynolds R
Brain Pathol 2020 Jul;30(4):779-793. Epub 2020 Apr 26 doi: 10.1111/bpa.12841. PMID: 32243032Free PMC Article
Differentiation and clonality of lesional lymphocytes in small plaque parapsoriasis.
Haeffner AC, Smoller BR, Zepter K, Wood GS
Arch Dermatol 1995 Mar;131(3):321-4. PMID: 7887662

Clinical prediction guides

Perivascular lymphocytic aggregates in hip prosthesis-associated adverse local tissue reactions demonstrate Th1 and Th2 activity and exhausted CD8(+) cell responses.
Eltit F, Mohammad N, Medina I, Haegert A, Duncan CP, Garbuz DS, Greidanus NV, Masri BA, Ng TL, Wang R, Cox ME
J Orthop Res 2021 Dec;39(12):2581-2594. Epub 2021 Feb 15 doi: 10.1002/jor.24998. PMID: 33506972
Perivascular tissue resident memory T cells as therapeutic target in multiple sclerosis.
Smolders J, Fransen NL, Hsiao CC, Hamann J, Huitinga I
Expert Rev Neurother 2020 Aug;20(8):835-848. Epub 2020 Jun 30 doi: 10.1080/14737175.2020.1776609. PMID: 32476499
Site-specific analysis of inflammatory markers in discoid lupus erythematosus skin.
Thorpe RB, Gray A, Kumar KR, Susa JS, Chong BF
ScientificWorldJournal 2014;2014:925805. Epub 2014 Mar 11 doi: 10.1155/2014/925805. PMID: 24744689Free PMC Article
Perforin and granzyme B may contribute to skin inflammation in atopic dermatitis and psoriasis.
Yawalkar N, Schmid S, Braathen LR, Pichler WJ
Br J Dermatol 2001 Jun;144(6):1133-9. doi: 10.1046/j.1365-2133.2001.04222.x. PMID: 11422032
Predominant CD8+ infiltrate in limb biopsies of individuals with filarial lymphedema and elephantiasis.
Freedman DO, Horn TD, Maia e Silva CM, Braga C, Maciel A
Am J Trop Med Hyg 1995 Dec;53(6):633-8. PMID: 8561266

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