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Metastatic Colorectal Carcinoma

MedGen UID:
1662385
•Concept ID:
C4744564
•
Neoplastic Process

Definition

A carcinoma that arises from the colon or rectum and has metastasized to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Colorectal Carcinoma

Professional guidelines

PubMed

Management of Metastatic Colorectal Carcinoma in Older Adults: Balancing Risks and Benefits of Novel Therapies.
Correa E, Lindsay T, Dotan E
Drugs Aging 2021 Aug;38(8):639-654. Epub 2021 Jun 18 doi: 10.1007/s40266-021-00869-z. PMID: 34143421Free PMC Article
Bevacizumab treatment in metastatic colorectal carcinoma - an economic perspective.
Sehnalová I, Říhová B, Demlová R
Ceska Slov Farm 2019 Summer;68(2):43-47. PMID: 31331174
Understanding the role of primary tumour localisation in colorectal cancer treatment and outcomes.
Stintzing S, Tejpar S, Gibbs P, Thiebach L, Lenz HJ
Eur J Cancer 2017 Oct;84:69-80. Epub 2017 Aug 5 doi: 10.1016/j.ejca.2017.07.016. PMID: 28787661Free PMC Article

Recent clinical studies

Etiology

Construction and validation of nomograms combined with novel machine learning algorithms to predict early death of patients with metastatic colorectal cancer.
Zhang Y, Zhang Z, Wei L, Wei S
Front Public Health 2022;10:1008137. Epub 2022 Dec 20 doi: 10.3389/fpubh.2022.1008137. PMID: 36605237Free PMC Article
Molecular Genetics and the Role of Molecularly Targeted Agents in Metastatic Colorectal Carcinoma.
Naeem A, Tun AM, Guevara E
J Gastrointest Cancer 2020 Jun;51(2):387-400. doi: 10.1007/s12029-019-00272-3. PMID: 31273629
Tumor mutational burden is predictive of response to immune checkpoint inhibitors in MSI-high metastatic colorectal cancer.
Schrock AB, Ouyang C, Sandhu J, Sokol E, Jin D, Ross JS, Miller VA, Lim D, Amanam I, Chao J, Catenacci D, Cho M, Braiteh F, Klempner SJ, Ali SM, Fakih M
Ann Oncol 2019 Jul 1;30(7):1096-1103. doi: 10.1093/annonc/mdz134. PMID: 31038663
Ramucirumab versus placebo in combination with second-line FOLFIRI in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine (RAISE): a randomised, double-blind, multicentre, phase 3 study.
Tabernero J, Yoshino T, Cohn AL, Obermannova R, Bodoky G, Garcia-Carbonero R, Ciuleanu TE, Portnoy DC, Van Cutsem E, Grothey A, Prausová J, Garcia-Alfonso P, Yamazaki K, Clingan PR, Lonardi S, Kim TW, Simms L, Chang SC, Nasroulah F; RAISE Study Investigators
Lancet Oncol 2015 May;16(5):499-508. Epub 2015 Apr 12 doi: 10.1016/S1470-2045(15)70127-0. PMID: 25877855
Metastasis of colorectal carcinoma to the testes: clinical presentation and possible pathways.
Hatoum HA, Abi Saad GS, Otrock ZK, Barada KA, Shamseddine AI
Int J Clin Oncol 2011 Jun;16(3):203-9. Epub 2010 Nov 11 doi: 10.1007/s10147-010-0140-z. PMID: 21069550

Diagnosis

Construction and validation of nomograms combined with novel machine learning algorithms to predict early death of patients with metastatic colorectal cancer.
Zhang Y, Zhang Z, Wei L, Wei S
Front Public Health 2022;10:1008137. Epub 2022 Dec 20 doi: 10.3389/fpubh.2022.1008137. PMID: 36605237Free PMC Article
BRAF testing in metastatic colorectal carcinoma and novel, chemotherapy-free therapeutic options.
Hummel M, Hegewisch-Becker S, Neumann JHL, Vogel A
Pathologe 2021 Nov;42(Suppl 1):98-109. Epub 2021 Jul 14 doi: 10.1007/s00292-021-00946-5. PMID: 34259881Free PMC Article
ChIP-seq of plasma cell-free nucleosomes identifies gene expression programs of the cells of origin.
Sadeh R, Sharkia I, Fialkoff G, Rahat A, Gutin J, Chappleboim A, Nitzan M, Fox-Fisher I, Neiman D, Meler G, Kamari Z, Yaish D, Peretz T, Hubert A, Cohen JE, Salah A, Temper M, Grinshpun A, Maoz M, Abu-Gazala S, Ben Ya'acov A, Shteyer E, Safadi R, Kaplan T, Shemer R, Planer D, Galun E, Glaser B, Zick A, Dor Y, Friedman N
Nat Biotechnol 2021 May;39(5):586-598. Epub 2021 Jan 11 doi: 10.1038/s41587-020-00775-6. PMID: 33432199Free PMC Article
Pulmonary enteric adenocarcinoma.
Handa Y, Kai Y, Ikeda T, Mukaida H, Egawa H, Kaneko M
Gen Thorac Cardiovasc Surg 2016 Dec;64(12):749-751. Epub 2015 Jul 3 doi: 10.1007/s11748-015-0569-0. PMID: 26139021
KRAS testing in metastatic colorectal carcinoma: challenges, controversies, breakthroughs and beyond.
Malapelle U, Carlomagno C, de Luca C, Bellevicine C, Troncone G
J Clin Pathol 2014 Jan;67(1):1-9. Epub 2013 Sep 10 doi: 10.1136/jclinpath-2013-201835. PMID: 24022727

Therapy

Construction and validation of nomograms combined with novel machine learning algorithms to predict early death of patients with metastatic colorectal cancer.
Zhang Y, Zhang Z, Wei L, Wei S
Front Public Health 2022;10:1008137. Epub 2022 Dec 20 doi: 10.3389/fpubh.2022.1008137. PMID: 36605237Free PMC Article
BRAF testing in metastatic colorectal carcinoma and novel, chemotherapy-free therapeutic options.
Hummel M, Hegewisch-Becker S, Neumann JHL, Vogel A
Pathologe 2021 Nov;42(Suppl 1):98-109. Epub 2021 Jul 14 doi: 10.1007/s00292-021-00946-5. PMID: 34259881Free PMC Article
FDA Approval Summary: Pembrolizumab for the First-line Treatment of Patients with MSI-H/dMMR Advanced Unresectable or Metastatic Colorectal Carcinoma.
Casak SJ, Marcus L, Fashoyin-Aje L, Mushti SL, Cheng J, Shen YL, Pierce WF, Her L, Goldberg KB, Theoret MR, Kluetz PG, Pazdur R, Lemery SJ
Clin Cancer Res 2021 Sep 1;27(17):4680-4684. Epub 2021 Apr 12 doi: 10.1158/1078-0432.CCR-21-0557. PMID: 33846198Free PMC Article
Sarcopenia in Metastatic Colorectal Carcinoma.
Büchler T, Hornová J
Klin Onkol 2019 Fall;32(6):406-410. doi: 10.14735/amko2019406. PMID: 31842559
Ramucirumab versus placebo in combination with second-line FOLFIRI in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine (RAISE): a randomised, double-blind, multicentre, phase 3 study.
Tabernero J, Yoshino T, Cohn AL, Obermannova R, Bodoky G, Garcia-Carbonero R, Ciuleanu TE, Portnoy DC, Van Cutsem E, Grothey A, Prausová J, Garcia-Alfonso P, Yamazaki K, Clingan PR, Lonardi S, Kim TW, Simms L, Chang SC, Nasroulah F; RAISE Study Investigators
Lancet Oncol 2015 May;16(5):499-508. Epub 2015 Apr 12 doi: 10.1016/S1470-2045(15)70127-0. PMID: 25877855

Prognosis

Construction and validation of nomograms combined with novel machine learning algorithms to predict early death of patients with metastatic colorectal cancer.
Zhang Y, Zhang Z, Wei L, Wei S
Front Public Health 2022;10:1008137. Epub 2022 Dec 20 doi: 10.3389/fpubh.2022.1008137. PMID: 36605237Free PMC Article
BRAF testing in metastatic colorectal carcinoma and novel, chemotherapy-free therapeutic options.
Hummel M, Hegewisch-Becker S, Neumann JHL, Vogel A
Pathologe 2021 Nov;42(Suppl 1):98-109. Epub 2021 Jul 14 doi: 10.1007/s00292-021-00946-5. PMID: 34259881Free PMC Article
The Role of BRAF in Metastatic Colorectal Carcinoma-Past, Present, and Future.
Djanani A, Eller S, Öfner D, Troppmair J, Maglione M
Int J Mol Sci 2020 Nov 26;21(23) doi: 10.3390/ijms21239001. PMID: 33256240Free PMC Article
Sarcopenia in Metastatic Colorectal Carcinoma.
Büchler T, Hornová J
Klin Onkol 2019 Fall;32(6):406-410. doi: 10.14735/amko2019406. PMID: 31842559
Tumor mutational burden is predictive of response to immune checkpoint inhibitors in MSI-high metastatic colorectal cancer.
Schrock AB, Ouyang C, Sandhu J, Sokol E, Jin D, Ross JS, Miller VA, Lim D, Amanam I, Chao J, Catenacci D, Cho M, Braiteh F, Klempner SJ, Ali SM, Fakih M
Ann Oncol 2019 Jul 1;30(7):1096-1103. doi: 10.1093/annonc/mdz134. PMID: 31038663

Clinical prediction guides

Construction and validation of nomograms combined with novel machine learning algorithms to predict early death of patients with metastatic colorectal cancer.
Zhang Y, Zhang Z, Wei L, Wei S
Front Public Health 2022;10:1008137. Epub 2022 Dec 20 doi: 10.3389/fpubh.2022.1008137. PMID: 36605237Free PMC Article
Sarcopenia in Metastatic Colorectal Carcinoma.
Büchler T, Hornová J
Klin Onkol 2019 Fall;32(6):406-410. doi: 10.14735/amko2019406. PMID: 31842559
Tumor mutational burden is predictive of response to immune checkpoint inhibitors in MSI-high metastatic colorectal cancer.
Schrock AB, Ouyang C, Sandhu J, Sokol E, Jin D, Ross JS, Miller VA, Lim D, Amanam I, Chao J, Catenacci D, Cho M, Braiteh F, Klempner SJ, Ali SM, Fakih M
Ann Oncol 2019 Jul 1;30(7):1096-1103. doi: 10.1093/annonc/mdz134. PMID: 31038663
Pharmacogenomics of cetuximab in metastatic colorectal carcinoma.
Silvestris N, Vincenzi B, Brunetti AE, Loupakis F, Dell'Aquila E, Russo A, Scartozzi M, Giampieri R, Cascinu S, Lorusso V, Tonini G, Falcone A, Santini D
Pharmacogenomics 2014 Sep;15(13):1701-15. doi: 10.2217/pgs.14.124. PMID: 25410895
Clinical implementation of KRAS testing in metastatic colorectal carcinoma: the pathologist's perspective.
Ross JS
Arch Pathol Lab Med 2012 Oct;136(10):1298-307. Epub 2012 Jan 24 doi: 10.5858/arpa.2011-0478-RA. PMID: 22272560

Recent systematic reviews

Combining Selective Internal Radiation Therapy with Immunotherapy in Treating Hepatocellular Carcinoma and Hepatic Colorectal Metastases: A Systematic Review.
Ramdhani K, Smits MLJ, Lam MGEH, Braat AJAT
Cancer Biother Radiopharm 2023 May;38(4):216-224. Epub 2023 Jan 2 doi: 10.1089/cbr.2022.0071. PMID: 36595357
Comparison of efficacy and safety of S-1 and capecitabine in patients with metastatic colorectal carcinoma: A systematic review and meta-analysis.
Chen J, Wang J, Xu T
Medicine (Baltimore) 2019 Jul;98(30):e16667. doi: 10.1097/MD.0000000000016667. PMID: 31348323Free PMC Article
Efficacy and safety assessment of S-1-based regimens comparing to intravenous fluorouracil-based ones in Asian patients with metastatic colorectal carcinoma: A system review and meta-analysis.
Chen J, Wang J
Medicine (Baltimore) 2019 Jun;98(23):e15999. doi: 10.1097/MD.0000000000015999. PMID: 31169742Free PMC Article
Update review of skin adverse events during treatment of lung cancer and colorectal carcinoma with epidermal growth receptor factor inhibitors.
Peng Y, Li Q, Zhang J, Shen W, Zhang X, Sun C, Cui H
Biosci Trends 2019 Jan 22;12(6):537-552. Epub 2018 Dec 17 doi: 10.5582/bst.2018.01246. PMID: 30555112
Extended RAS Gene Mutation Testing in Metastatic Colorectal Carcinoma to Predict Response to Anti-Epidermal Growth Factor Receptor Monoclonal Antibody Therapy: American Society of Clinical Oncology Provisional Clinical Opinion Update 2015.
Allegra CJ, Rumble RB, Hamilton SR, Mangu PB, Roach N, Hantel A, Schilsky RL
J Clin Oncol 2016 Jan 10;34(2):179-85. Epub 2015 Oct 5 doi: 10.1200/JCO.2015.63.9674. PMID: 26438111

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