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Refractory Acute Leukemia

MedGen UID:
1662593
Concept ID:
C4725027
Neoplastic Process

Definition

Acute leukemia that does not respond to treatment. [from NCI]

Professional guidelines

PubMed

Soliman R, Heneghan C, Bolous NS, Sidhom I, Ahmed S, Roberts N, Oke J, Elhaddad A
Expert Rev Hematol 2022 Apr;15(4):345-357. Epub 2022 May 4 doi: 10.1080/17474086.2022.2069096. PMID: 35485262
Campbell CT, Haladyna JN, Drubin DA, Thomson TM, Maria MJ, Yamauchi T, Waters NJ, Olhava EJ, Pollock RM, Smith JJ, Copeland RA, Blakemore SJ, Bernt KM, Daigle SR
Mol Cancer Ther 2017 Aug;16(8):1669-1679. Epub 2017 Apr 20 doi: 10.1158/1535-7163.MCT-16-0693. PMID: 28428443
Leblanc T, Deméocq F, Leverger G, Baruchel A, Lemerle S, Vannier JP, Nelken B, Guillot T, Schaison G
Med Pediatr Oncol 1994;22(2):119-24. doi: 10.1002/mpo.2950220211. PMID: 8259097

Recent clinical studies

Etiology

Mustafa O, Abdalla K, AlAzmi AA, Elimam N, Abrar MB, Jastaniah W
J Oncol Pharm Pract 2019 Dec;25(8):1831-1838. Epub 2018 Dec 5 doi: 10.1177/1078155218817816. PMID: 30518307
Orgel E, Auletta JJ
Pediatr Hematol Oncol 2017 Sep-Oct;34(6-7):409-417. Epub 2017 Nov 30 doi: 10.1080/08880018.2017.1395936. PMID: 29190169Free PMC Article
Yamamoto C, Ito S, Mashima K, Umino K, Minakata D, Yamasaki R, Kawasaki Y, Sugimoto M, Nakano H, Ashizawa M, Okazuka K, Hatano K, Sato K, Oh I, Fujiwara S, Ohmine K, Suzuki T, Muroi K, Kanda Y
Leuk Lymphoma 2016 Nov;57(11):2541-7. Epub 2016 Feb 25 doi: 10.3109/10428194.2016.1153087. PMID: 26917050
Darwish M, Megason G, Bond M, Hellriegel E, Robertson P Jr, Grasela T, Phillips L
Curr Med Res Opin 2014 Nov;30(11):2305-15. Epub 2014 Aug 11 doi: 10.1185/03007995.2014.941976. PMID: 25105914
Buaboonnam J, Cao X, Pauley JL, Pui CH, Ribeiro RC, Rubnitz JE, Inaba H
Pediatr Blood Cancer 2013 Jul;60(7):1161-4. Epub 2013 Jan 17 doi: 10.1002/pbc.24470. PMID: 23335430Free PMC Article

Diagnosis

Kurt H, Zheng L, Kantarjian HM, Tang G, Ravandi-Kashani F, Garcia-Manero G, Gong Z, Amin HM, Konoplev SN, Routbort MJ, Han X, Wang W, Medeiros LJ, Hu S
Mod Pathol 2018 Jul;31(7):1141-1154. Epub 2018 Feb 14 doi: 10.1038/s41379-018-0014-x. PMID: 29449681
Abbi KK, Rybka W, Ehmann WC, Claxton DF
Clin Lymphoma Myeloma Leuk 2015 Jan;15(1):41-6. Epub 2014 Jun 11 doi: 10.1016/j.clml.2014.06.005. PMID: 25085441
Kaufmann SH, Karp JE, Litzow MR, Mesa RA, Hogan W, Steensma DP, Flatten KS, Loegering DA, Schneider PA, Peterson KL, Maurer MJ, Smith BD, Greer J, Chen Y, Reid JM, Ivy SP, Ames MM, Adjei AA, Erlichman C, Karnitz LM
Haematologica 2011 Nov;96(11):1619-26. Epub 2011 Jul 26 doi: 10.3324/haematol.2011.049551. PMID: 21791475Free PMC Article
Seiter K, Katragadda S, Ponce D, Rasul M, Ahmed N
J Hematol Oncol 2009 May 22;2:21. doi: 10.1186/1756-8722-2-21. PMID: 19463179Free PMC Article
Amadori S, Tribalto M, Pacilli L, De Laurentis C, Papa G, Mandelli F
Cancer Treat Rep 1980 Aug-Sep;64(8-9):939-42. PMID: 6934851

Therapy

Kurt H, Zheng L, Kantarjian HM, Tang G, Ravandi-Kashani F, Garcia-Manero G, Gong Z, Amin HM, Konoplev SN, Routbort MJ, Han X, Wang W, Medeiros LJ, Hu S
Mod Pathol 2018 Jul;31(7):1141-1154. Epub 2018 Feb 14 doi: 10.1038/s41379-018-0014-x. PMID: 29449681
Habringer S, Lapa C, Herhaus P, Schottelius M, Istvanffy R, Steiger K, Slotta-Huspenina J, Schirbel A, Hänscheid H, Kircher S, Buck AK, Götze K, Vick B, Jeremias I, Schwaiger M, Peschel C, Oostendorp R, Wester HJ, Grigoleit GU, Keller U
Theranostics 2018;8(2):369-383. Epub 2018 Jan 1 doi: 10.7150/thno.21397. PMID: 29290814Free PMC Article
Yamamoto C, Ito S, Mashima K, Umino K, Minakata D, Yamasaki R, Kawasaki Y, Sugimoto M, Nakano H, Ashizawa M, Okazuka K, Hatano K, Sato K, Oh I, Fujiwara S, Ohmine K, Suzuki T, Muroi K, Kanda Y
Leuk Lymphoma 2016 Nov;57(11):2541-7. Epub 2016 Feb 25 doi: 10.3109/10428194.2016.1153087. PMID: 26917050
Seiter K, Katragadda S, Ponce D, Rasul M, Ahmed N
J Hematol Oncol 2009 May 22;2:21. doi: 10.1186/1756-8722-2-21. PMID: 19463179Free PMC Article
Larson RA
Semin Oncol 2007 Dec;34(6 Suppl 5):S13-20. doi: 10.1053/j.seminoncol.2007.11.002. PMID: 18086342

Prognosis

Ogasawara M, Miyashita M, Yamagishi Y, Ota S
Ther Apher Dial 2022 Jun;26(3):537-547. Epub 2022 Mar 10 doi: 10.1111/1744-9987.13828. PMID: 35249263
Kobayashi S, Kanda Y, Konuma T, Inamoto Y, Matsumoto K, Uchida N, Ikegame K, Miyamoto T, Doki N, Nakamae H, Katayama Y, Takahashi S, Shiratori S, Saito S, Kawakita T, Kanda J, Fukuda T, Atsuta Y, Kimura F
Bone Marrow Transplant 2022 Jan;57(1):43-50. Epub 2021 Oct 8 doi: 10.1038/s41409-021-01485-6. PMID: 34625663
Ding G, Chen H
Sci China Life Sci 2016 Jul;59(7):673-7. Epub 2016 May 3 doi: 10.1007/s11427-016-0017-3. PMID: 27142351
Darwish M, Megason G, Bond M, Hellriegel E, Robertson P Jr, Grasela T, Phillips L
Curr Med Res Opin 2014 Nov;30(11):2305-15. Epub 2014 Aug 11 doi: 10.1185/03007995.2014.941976. PMID: 25105914
Buaboonnam J, Cao X, Pauley JL, Pui CH, Ribeiro RC, Rubnitz JE, Inaba H
Pediatr Blood Cancer 2013 Jul;60(7):1161-4. Epub 2013 Jan 17 doi: 10.1002/pbc.24470. PMID: 23335430Free PMC Article

Clinical prediction guides

Ogasawara M, Miyashita M, Yamagishi Y, Ota S
Ther Apher Dial 2022 Jun;26(3):537-547. Epub 2022 Mar 10 doi: 10.1111/1744-9987.13828. PMID: 35249263
Kurt H, Zheng L, Kantarjian HM, Tang G, Ravandi-Kashani F, Garcia-Manero G, Gong Z, Amin HM, Konoplev SN, Routbort MJ, Han X, Wang W, Medeiros LJ, Hu S
Mod Pathol 2018 Jul;31(7):1141-1154. Epub 2018 Feb 14 doi: 10.1038/s41379-018-0014-x. PMID: 29449681
Darwish M, Megason G, Bond M, Hellriegel E, Robertson P Jr, Grasela T, Phillips L
Curr Med Res Opin 2014 Nov;30(11):2305-15. Epub 2014 Aug 11 doi: 10.1185/03007995.2014.941976. PMID: 25105914
Grupp SA, Kalos M, Barrett D, Aplenc R, Porter DL, Rheingold SR, Teachey DT, Chew A, Hauck B, Wright JF, Milone MC, Levine BL, June CH
N Engl J Med 2013 Apr 18;368(16):1509-1518. Epub 2013 Mar 25 doi: 10.1056/NEJMoa1215134. PMID: 23527958Free PMC Article
Freund M, Link H, Diedrich H, LeBlanc S, Wilke HJ, Poliwoda H
Cancer Chemother Pharmacol 1991;28(6):487-90. doi: 10.1007/BF00685829. PMID: 1934254

Recent systematic reviews

Soliman R, Heneghan C, Bolous NS, Sidhom I, Ahmed S, Roberts N, Oke J, Elhaddad A
Expert Rev Hematol 2022 Apr;15(4):345-357. Epub 2022 May 4 doi: 10.1080/17474086.2022.2069096. PMID: 35485262

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