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Unresectable Melanoma

MedGen UID:
1662618
Concept ID:
C4725093
Neoplastic Process

Definition

Melanoma which is not amenable to surgical resection. [from NCI]

Professional guidelines

PubMed

Rumancik B, Mark L
Otolaryngol Clin North Am 2021 Apr;54(2):425-438. Epub 2021 Feb 15 doi: 10.1016/j.otc.2020.11.014. PMID: 33602521
Khoja L, Hogg D
Expert Rev Anticancer Ther 2015 Mar;15(3):265-76. doi: 10.1586/14737140.2015.1014343. PMID: 25711514
Corrie P, Hategan M, Fife K, Parkinson C
Br Med Bull 2014 Sep;111(1):149-62. doi: 10.1093/bmb/ldu019. PMID: 25190764

Recent clinical studies

Etiology

Noviello TMR, Di Giacomo AM, Caruso FP, Covre A, Mortarini R, Scala G, Costa MC, Coral S, Fridman WH, Sautès-Fridman C, Brich S, Pruneri G, Simonetti E, Lofiego MF, Tufano R, Bedognetti D, Anichini A, Maio M, Ceccarelli M
Nat Commun 2023 Sep 22;14(1):5914. doi: 10.1038/s41467-023-40994-4. PMID: 37739939Free PMC Article
Ugurel S, Gutzmer R
J Dtsch Dermatol Ges 2023 Apr;21(4):343-347. Epub 2023 Mar 31 doi: 10.1111/ddg.15053. PMID: 36999586
Tawbi HA, Schadendorf D, Lipson EJ, Ascierto PA, Matamala L, Castillo Gutiérrez E, Rutkowski P, Gogas HJ, Lao CD, De Menezes JJ, Dalle S, Arance A, Grob JJ, Srivastava S, Abaskharoun M, Hamilton M, Keidel S, Simonsen KL, Sobiesk AM, Li B, Hodi FS, Long GV; RELATIVITY-047 Investigators
N Engl J Med 2022 Jan 6;386(1):24-34. doi: 10.1056/NEJMoa2109970. PMID: 34986285Free PMC Article
In GK, Thomas JS, Silk AW
Hematol Oncol Clin North Am 2021 Oct;35(5):991-1008. Epub 2021 Jul 16 doi: 10.1016/j.hoc.2021.05.008. PMID: 34281755
Mueller KL, Theoret MR, Lemery SJ, Amiri-Kordestani L, Ariyan CE, Atkins MB, Berry DA, Blank CU, DeMichele AM, Forde PM, Ibrahim N, Keegan P, Mitchell TC, Moss RA, Robert C, Sridhara R, Taube JM, Tetzlaff MT, Wargo JA, Flaherty KT, Kaplan MJ, Topalian SL, Ward AF, Hurlbert MS
Clin Cancer Res 2021 Jan 15;27(2):394-401. Epub 2020 Nov 13 doi: 10.1158/1078-0432.CCR-20-3285. PMID: 33188142

Diagnosis

Ugurel S, Gutzmer R
J Dtsch Dermatol Ges 2023 Apr;21(4):343-347. Epub 2023 Mar 31 doi: 10.1111/ddg.15053. PMID: 36999586
In GK, Thomas JS, Silk AW
Hematol Oncol Clin North Am 2021 Oct;35(5):991-1008. Epub 2021 Jul 16 doi: 10.1016/j.hoc.2021.05.008. PMID: 34281755
Franklin C, Livingstone E, Roesch A, Schilling B, Schadendorf D
Eur J Surg Oncol 2017 Mar;43(3):604-611. Epub 2016 Sep 2 doi: 10.1016/j.ejso.2016.07.145. PMID: 27769635
Millet A, Martin AR, Ronco C, Rocchi S, Benhida R
Med Res Rev 2017 Jan;37(1):98-148. Epub 2016 Aug 29 doi: 10.1002/med.21404. PMID: 27569556
Corrie P, Hategan M, Fife K, Parkinson C
Br Med Bull 2014 Sep;111(1):149-62. doi: 10.1093/bmb/ldu019. PMID: 25190764

Therapy

Chesney JA, Ribas A, Long GV, Kirkwood JM, Dummer R, Puzanov I, Hoeller C, Gajewski TF, Gutzmer R, Rutkowski P, Demidov L, Arenberger P, Shin SJ, Ferrucci PF, Haydon A, Hyngstrom J, van Thienen JV, Haferkamp S, Guilera JM, Rapoport BL, VanderWalde A, Diede SJ, Anderson JR, Treichel S, Chan EL, Bhatta S, Gansert J, Hodi FS, Gogas H
J Clin Oncol 2023 Jan 20;41(3):528-540. Epub 2022 Aug 23 doi: 10.1200/JCO.22.00343. PMID: 35998300Free PMC Article
Tawbi HA, Schadendorf D, Lipson EJ, Ascierto PA, Matamala L, Castillo Gutiérrez E, Rutkowski P, Gogas HJ, Lao CD, De Menezes JJ, Dalle S, Arance A, Grob JJ, Srivastava S, Abaskharoun M, Hamilton M, Keidel S, Simonsen KL, Sobiesk AM, Li B, Hodi FS, Long GV; RELATIVITY-047 Investigators
N Engl J Med 2022 Jan 6;386(1):24-34. doi: 10.1056/NEJMoa2109970. PMID: 34986285Free PMC Article
Sahin U, Oehm P, Derhovanessian E, Jabulowsky RA, Vormehr M, Gold M, Maurus D, Schwarck-Kokarakis D, Kuhn AN, Omokoko T, Kranz LM, Diken M, Kreiter S, Haas H, Attig S, Rae R, Cuk K, Kemmer-Brück A, Breitkreuz A, Tolliver C, Caspar J, Quinkhardt J, Hebich L, Stein M, Hohberger A, Vogler I, Liebig I, Renken S, Sikorski J, Leierer M, Müller V, Mitzel-Rink H, Miederer M, Huber C, Grabbe S, Utikal J, Pinter A, Kaufmann R, Hassel JC, Loquai C, Türeci Ö
Nature 2020 Sep;585(7823):107-112. Epub 2020 Jul 29 doi: 10.1038/s41586-020-2537-9. PMID: 32728218
Kwok G, Yau TC, Chiu JW, Tse E, Kwong YL
Hum Vaccin Immunother 2016 Nov;12(11):2777-2789. Epub 2016 Jul 11 doi: 10.1080/21645515.2016.1199310. PMID: 27398650Free PMC Article
Buchbinder EI, Desai A
Am J Clin Oncol 2016 Feb;39(1):98-106. doi: 10.1097/COC.0000000000000239. PMID: 26558876Free PMC Article

Prognosis

Noviello TMR, Di Giacomo AM, Caruso FP, Covre A, Mortarini R, Scala G, Costa MC, Coral S, Fridman WH, Sautès-Fridman C, Brich S, Pruneri G, Simonetti E, Lofiego MF, Tufano R, Bedognetti D, Anichini A, Maio M, Ceccarelli M
Nat Commun 2023 Sep 22;14(1):5914. doi: 10.1038/s41467-023-40994-4. PMID: 37739939Free PMC Article
Ugurel S, Gutzmer R
J Dtsch Dermatol Ges 2023 Apr;21(4):343-347. Epub 2023 Mar 31 doi: 10.1111/ddg.15053. PMID: 36999586
Franklin C, Livingstone E, Roesch A, Schilling B, Schadendorf D
Eur J Surg Oncol 2017 Mar;43(3):604-611. Epub 2016 Sep 2 doi: 10.1016/j.ejso.2016.07.145. PMID: 27769635
Millet A, Martin AR, Ronco C, Rocchi S, Benhida R
Med Res Rev 2017 Jan;37(1):98-148. Epub 2016 Aug 29 doi: 10.1002/med.21404. PMID: 27569556
Kwok G, Yau TC, Chiu JW, Tse E, Kwong YL
Hum Vaccin Immunother 2016 Nov;12(11):2777-2789. Epub 2016 Jul 11 doi: 10.1080/21645515.2016.1199310. PMID: 27398650Free PMC Article

Clinical prediction guides

Thomas B, Burns M, Pervanas H, Ciurescu D, Dima L
Am J Ther 2023 Nov-Dec 01;30(6):e526-e534. doi: 10.1097/MJT.0000000000001680. PMID: 37921680
Andtbacka RHI, Curti B, Daniels GA, Hallmeyer S, Whitman ED, Lutzky J, Spitler LE, Zhou K, Bommareddy PK, Grose M, Wang M, Wu C, Kaufman HL
J Clin Oncol 2021 Dec 1;39(34):3829-3838. Epub 2021 Aug 31 doi: 10.1200/JCO.20.03246. PMID: 34464163
Zaremba A, Philip M, Hassel JC, Glutsch V, Fiocco Z, Loquai C, Rafei-Shamsabadi D, Gutzmer R, Utikal J, Haferkamp S, Reinhardt L, Kähler KC, Weishaupt C, Moreira A, Thoms KM, Wilhelm T, Pföhler C, Roesch A, Ugurel S, Zimmer L, Stadtler N, Sucker A, Kiecker F, Heinzerling L, Meier F, Meiss F, Schlaak M, Schilling B, Horn S, Schadendorf D, Livingstone E
Eur J Cancer 2021 Jul;152:139-154. Epub 2021 Jun 5 doi: 10.1016/j.ejca.2021.04.032. PMID: 34102453
Di Giacomo AM, Covre A, Finotello F, Rieder D, Danielli R, Sigalotti L, Giannarelli D, Petitprez F, Lacroix L, Valente M, Cutaia O, Fazio C, Amato G, Lazzeri A, Monterisi S, Miracco C, Coral S, Anichini A, Bock C, Nemc A, Oganesian A, Lowder J, Azab M, Fridman WH, Sautès-Fridman C, Trajanoski Z, Maio M
Clin Cancer Res 2019 Dec 15;25(24):7351-7362. Epub 2019 Sep 17 doi: 10.1158/1078-0432.CCR-19-1335. PMID: 31530631
Kwok G, Yau TC, Chiu JW, Tse E, Kwong YL
Hum Vaccin Immunother 2016 Nov;12(11):2777-2789. Epub 2016 Jul 11 doi: 10.1080/21645515.2016.1199310. PMID: 27398650Free PMC Article

Recent systematic reviews

Wang C, Lu N, Yan L, Li Y
Virol J 2023 Nov 2;20(1):252. doi: 10.1186/s12985-023-02220-x. PMID: 37919738Free PMC Article
Li Y, Liang X, Li H, Chen X
Int Immunopharmacol 2023 Feb;115:109657. Epub 2023 Jan 4 doi: 10.1016/j.intimp.2022.109657. PMID: 36608446
Zhu Y, Cheng H, Zhong M, Hu Y, Li Q, Gao X, Liu S
J Cancer Res Ther 2021 Dec;17(7):1679-1688. doi: 10.4103/jcrt.jcrt_1669_21. PMID: 35381739
Menshawy A, Eltonob AA, Barkat SA, Ghanem A, Mniesy MM, Mohamed I, Abdel-Maboud M, Mattar OM, Elfil M, Bahbah EI, Elgebaly A
Melanoma Res 2018 Oct;28(5):371-379. doi: 10.1097/CMR.0000000000000467. PMID: 29957656

Supplemental Content

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