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Refractory Colon Carcinoma

MedGen UID:
1663185
•Concept ID:
C4727189
•
Neoplastic Process

Definition

Colon carcinoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Colon Carcinoma

Professional guidelines

PubMed

Combination Treatment of Intratumoral Vidutolimod, Radiosurgery, Nivolumab, and Ipilimumab for Microsatellite Stable Colorectal Carcinoma With Liver Metastases.
Margalit O, Lieberman S, Redinsky I, Halparin S, Honig N, Raskin S, Ben-Ayun M, Shacham-Shmueli E, Halpern N, Urban D, Ackerstein A, Shulman K, Ben-Ami E, Semenisty V, Purim O, Yarom N, Golan T, Boursi B, Appel S, Symon Z, Berger R, Mauro D, Krieg AM, Lawrence YR
Clin Colorectal Cancer 2023 Dec;22(4):442-449.e1. Epub 2023 Aug 9 doi: 10.1016/j.clcc.2023.08.004. PMID: 37657954
New Treatment Strategy Targeting Galectin-1 against Thyroid Cancer.
Gheysen L, Soumoy L, Trelcat A, Verset L, Journe F, Saussez S
Cells 2021 May 5;10(5) doi: 10.3390/cells10051112. PMID: 34063063Free PMC Article
Clinical manifestations, pathophysiology, treatment and outcome of inflammatory bowel diseases in older people.
Butter M, Weiler S, Biedermann L, Scharl M, Rogler G, Bischoff-Ferrari HA, Misselwitz B
Maturitas 2018 Apr;110:71-78. Epub 2018 Jan 31 doi: 10.1016/j.maturitas.2018.01.015. PMID: 29563038

Recent clinical studies

Etiology

Alternative Lengthening of Telomeres in Cancer Confers a Vulnerability to Reactivation of p53 Function.
Macha SJ, Koneru B, Burrow TA, Zhu C, Savitski D, Rahman RL, Ronaghan CA, Nance J, McCoy K, Eslinger C, Reynolds CP
Cancer Res 2022 Sep 16;82(18):3345-3358. doi: 10.1158/0008-5472.CAN-22-0125. PMID: 35947641Free PMC Article
Ulcerative Colitis-Diagnostic and Therapeutic Algorithms.
Kucharzik T, Koletzko S, Kannengiesser K, Dignass A
Dtsch Arztebl Int 2020 Aug 17;117(33-34):564-574. doi: 10.3238/arztebl.2020.0564. PMID: 33148393Free PMC Article
Regorafenib dose-optimisation in patients with refractory metastatic colorectal cancer (ReDOS): a randomised, multicentre, open-label, phase 2 study.
Bekaii-Saab TS, Ou FS, Ahn DH, Boland PM, Ciombor KK, Heying EN, Dockter TJ, Jacobs NL, Pasche BC, Cleary JM, Meyers JP, Desnoyers RJ, McCune JS, Pedersen K, Barzi A, Chiorean EG, Sloan J, Lacouture ME, Lenz HJ, Grothey A
Lancet Oncol 2019 Aug;20(8):1070-1082. Epub 2019 Jun 28 doi: 10.1016/S1470-2045(19)30272-4. PMID: 31262657Free PMC Article
Inflammatory bowel disease in liver transplanted patients.
Filipec Kanizaj T, Mijic M
World J Gastroenterol 2017 May 14;23(18):3214-3227. doi: 10.3748/wjg.v23.i18.3214. PMID: 28566881Free PMC Article
Colorectal manifestations of endocrine disease.
Sharma S, Longo WE, Baniadam B, Vernava AM 3rd
Dis Colon Rectum 1995 Mar;38(3):318-23. doi: 10.1007/BF02055611. PMID: 7882801

Diagnosis

N-glycosylation Regulates Intrinsic IFN-γ Resistance in Colorectal Cancer: Implications for Immunotherapy.
Krug J, Rodrian G, Petter K, Yang H, Khoziainova S, Guo W, Bénard A, Merkel S, Gellert S, Maschauer S, Spermann M, Waldner M, Bailey P, Pilarsky C, Liebl A, Tripal P, Christoph J, Naschberger E, Croner R, Schellerer VS, Becker C, Hartmann A, Tüting T, Prante O, Grützmann R, Grivennikov SI, Stürzl M, Britzen-Laurent N
Gastroenterology 2023 Mar;164(3):392-406.e5. Epub 2022 Nov 17 doi: 10.1053/j.gastro.2022.11.018. PMID: 36402190Free PMC Article
Alternative Lengthening of Telomeres in Cancer Confers a Vulnerability to Reactivation of p53 Function.
Macha SJ, Koneru B, Burrow TA, Zhu C, Savitski D, Rahman RL, Ronaghan CA, Nance J, McCoy K, Eslinger C, Reynolds CP
Cancer Res 2022 Sep 16;82(18):3345-3358. doi: 10.1158/0008-5472.CAN-22-0125. PMID: 35947641Free PMC Article
Ulcerative Colitis-Diagnostic and Therapeutic Algorithms.
Kucharzik T, Koletzko S, Kannengiesser K, Dignass A
Dtsch Arztebl Int 2020 Aug 17;117(33-34):564-574. doi: 10.3238/arztebl.2020.0564. PMID: 33148393Free PMC Article
The KRAS(G12C) Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients.
Hallin J, Engstrom LD, Hargis L, Calinisan A, Aranda R, Briere DM, Sudhakar N, Bowcut V, Baer BR, Ballard JA, Burkard MR, Fell JB, Fischer JP, Vigers GP, Xue Y, Gatto S, Fernandez-Banet J, Pavlicek A, Velastagui K, Chao RC, Barton J, Pierobon M, Baldelli E, Patricoin EF 3rd, Cassidy DP, Marx MA, Rybkin II, Johnson ML, Ou SI, Lito P, Papadopoulos KP, Jänne PA, Olson P, Christensen JG
Cancer Discov 2020 Jan;10(1):54-71. Epub 2019 Oct 28 doi: 10.1158/2159-8290.CD-19-1167. PMID: 31658955Free PMC Article
Clinical aspects of ulcerative colitis in mainland China.
Zheng JJ
Chin J Dig Dis 2006;7(2):71-5. doi: 10.1111/j.1443-9573.2006.00251.x. PMID: 16643333

Therapy

Ulcerative Colitis-Diagnostic and Therapeutic Algorithms.
Kucharzik T, Koletzko S, Kannengiesser K, Dignass A
Dtsch Arztebl Int 2020 Aug 17;117(33-34):564-574. doi: 10.3238/arztebl.2020.0564. PMID: 33148393Free PMC Article
The KRAS(G12C) Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients.
Hallin J, Engstrom LD, Hargis L, Calinisan A, Aranda R, Briere DM, Sudhakar N, Bowcut V, Baer BR, Ballard JA, Burkard MR, Fell JB, Fischer JP, Vigers GP, Xue Y, Gatto S, Fernandez-Banet J, Pavlicek A, Velastagui K, Chao RC, Barton J, Pierobon M, Baldelli E, Patricoin EF 3rd, Cassidy DP, Marx MA, Rybkin II, Johnson ML, Ou SI, Lito P, Papadopoulos KP, Jänne PA, Olson P, Christensen JG
Cancer Discov 2020 Jan;10(1):54-71. Epub 2019 Oct 28 doi: 10.1158/2159-8290.CD-19-1167. PMID: 31658955Free PMC Article
Regorafenib dose-optimisation in patients with refractory metastatic colorectal cancer (ReDOS): a randomised, multicentre, open-label, phase 2 study.
Bekaii-Saab TS, Ou FS, Ahn DH, Boland PM, Ciombor KK, Heying EN, Dockter TJ, Jacobs NL, Pasche BC, Cleary JM, Meyers JP, Desnoyers RJ, McCune JS, Pedersen K, Barzi A, Chiorean EG, Sloan J, Lacouture ME, Lenz HJ, Grothey A
Lancet Oncol 2019 Aug;20(8):1070-1082. Epub 2019 Jun 28 doi: 10.1016/S1470-2045(19)30272-4. PMID: 31262657Free PMC Article
TroVax in colorectal cancer.
Rowe J, Cen P
Hum Vaccin Immunother 2014;10(11):3196-200. doi: 10.4161/21645515.2014.973323. PMID: 25483641Free PMC Article
Thalidomide in cancer.
Singhal S, Mehta J
Biomed Pharmacother 2002 Feb;56(1):4-12. doi: 10.1016/s0753-3322(01)00146-9. PMID: 11905508

Prognosis

N-glycosylation Regulates Intrinsic IFN-γ Resistance in Colorectal Cancer: Implications for Immunotherapy.
Krug J, Rodrian G, Petter K, Yang H, Khoziainova S, Guo W, Bénard A, Merkel S, Gellert S, Maschauer S, Spermann M, Waldner M, Bailey P, Pilarsky C, Liebl A, Tripal P, Christoph J, Naschberger E, Croner R, Schellerer VS, Becker C, Hartmann A, Tüting T, Prante O, Grützmann R, Grivennikov SI, Stürzl M, Britzen-Laurent N
Gastroenterology 2023 Mar;164(3):392-406.e5. Epub 2022 Nov 17 doi: 10.1053/j.gastro.2022.11.018. PMID: 36402190Free PMC Article
Clinicopathological and Molecular Characteristics of Colorectal Signet Ring Cell Carcinoma: A Review.
An Y, Zhou J, Lin G, Wu H, Cong L, Li Y, Qiu X, Shi W
Pathol Oncol Res 2021;27:1609859. Epub 2021 Jul 26 doi: 10.3389/pore.2021.1609859. PMID: 34381313Free PMC Article
Ulcerative Colitis-Diagnostic and Therapeutic Algorithms.
Kucharzik T, Koletzko S, Kannengiesser K, Dignass A
Dtsch Arztebl Int 2020 Aug 17;117(33-34):564-574. doi: 10.3238/arztebl.2020.0564. PMID: 33148393Free PMC Article
The KRAS(G12C) Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients.
Hallin J, Engstrom LD, Hargis L, Calinisan A, Aranda R, Briere DM, Sudhakar N, Bowcut V, Baer BR, Ballard JA, Burkard MR, Fell JB, Fischer JP, Vigers GP, Xue Y, Gatto S, Fernandez-Banet J, Pavlicek A, Velastagui K, Chao RC, Barton J, Pierobon M, Baldelli E, Patricoin EF 3rd, Cassidy DP, Marx MA, Rybkin II, Johnson ML, Ou SI, Lito P, Papadopoulos KP, Jänne PA, Olson P, Christensen JG
Cancer Discov 2020 Jan;10(1):54-71. Epub 2019 Oct 28 doi: 10.1158/2159-8290.CD-19-1167. PMID: 31658955Free PMC Article
TroVax in colorectal cancer.
Rowe J, Cen P
Hum Vaccin Immunother 2014;10(11):3196-200. doi: 10.4161/21645515.2014.973323. PMID: 25483641Free PMC Article

Clinical prediction guides

N-glycosylation Regulates Intrinsic IFN-γ Resistance in Colorectal Cancer: Implications for Immunotherapy.
Krug J, Rodrian G, Petter K, Yang H, Khoziainova S, Guo W, Bénard A, Merkel S, Gellert S, Maschauer S, Spermann M, Waldner M, Bailey P, Pilarsky C, Liebl A, Tripal P, Christoph J, Naschberger E, Croner R, Schellerer VS, Becker C, Hartmann A, Tüting T, Prante O, Grützmann R, Grivennikov SI, Stürzl M, Britzen-Laurent N
Gastroenterology 2023 Mar;164(3):392-406.e5. Epub 2022 Nov 17 doi: 10.1053/j.gastro.2022.11.018. PMID: 36402190Free PMC Article
Clinicopathological and Molecular Characteristics of Colorectal Signet Ring Cell Carcinoma: A Review.
An Y, Zhou J, Lin G, Wu H, Cong L, Li Y, Qiu X, Shi W
Pathol Oncol Res 2021;27:1609859. Epub 2021 Jul 26 doi: 10.3389/pore.2021.1609859. PMID: 34381313Free PMC Article
The KRAS(G12C) Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients.
Hallin J, Engstrom LD, Hargis L, Calinisan A, Aranda R, Briere DM, Sudhakar N, Bowcut V, Baer BR, Ballard JA, Burkard MR, Fell JB, Fischer JP, Vigers GP, Xue Y, Gatto S, Fernandez-Banet J, Pavlicek A, Velastagui K, Chao RC, Barton J, Pierobon M, Baldelli E, Patricoin EF 3rd, Cassidy DP, Marx MA, Rybkin II, Johnson ML, Ou SI, Lito P, Papadopoulos KP, Jänne PA, Olson P, Christensen JG
Cancer Discov 2020 Jan;10(1):54-71. Epub 2019 Oct 28 doi: 10.1158/2159-8290.CD-19-1167. PMID: 31658955Free PMC Article
TroVax in colorectal cancer.
Rowe J, Cen P
Hum Vaccin Immunother 2014;10(11):3196-200. doi: 10.4161/21645515.2014.973323. PMID: 25483641Free PMC Article
KRAS mutation testing in colorectal cancer.
Plesec TP, Hunt JL
Adv Anat Pathol 2009 Jul;16(4):196-203. doi: 10.1097/PAP.0b013e3181a9d4ed. PMID: 19546608

Recent systematic reviews

Systematic review of cuff and pouch cancer in patients with ileal pelvic pouch for ulcerative colitis.
Selvaggi F, Pellino G, Canonico S, Sciaudone G
Inflamm Bowel Dis 2014 Jul;20(7):1296-308. doi: 10.1097/MIB.0000000000000026. PMID: 24681656

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