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Recurrent Severe Aplastic Anemia

MedGen UID:
1663591
Concept ID:
C4727149
Disease or Syndrome
Synonym: Relapsed Severe Aplastic Anemia

Definition

The reemergence of severe aplastic anemia after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Severe Aplastic Anemia

Professional guidelines

PubMed

Pierri F, Dufour C
Expert Rev Hematol 2019 Oct;12(10):809-819. Epub 2019 Jul 24 doi: 10.1080/17474086.2019.1645003. PMID: 31311355
Clucas DB, Fox LC, Wood EM, Hong FS, Gibson J, Bajel A, Szer J, Blombery P, McQuilten ZK, Hiwase D, Firkin F, Cole-Sinclair MF; Australian Aplastic Anaemia Registry Steering Committee
Intern Med J 2019 Feb;49(2):152-159. doi: 10.1111/imj.14140. PMID: 30324755
Georges GE, Doney K, Storb R
Blood Adv 2018 Aug 14;2(15):2020-2028. doi: 10.1182/bloodadvances.2018021162. PMID: 30108110Free PMC Article

Recent clinical studies

Etiology

DeZern AE, Eapen M, Wu J, Talano JA, Solh M, Dávila Saldaña BJ, Karanes C, Horwitz ME, Mallhi K, Arai S, Farhadfar N, Hexner E, Westervelt P, Antin JH, Deeg HJ, Leifer E, Brodsky RA, Logan BR, Horowitz MM, Jones RJ, Pulsipher MA
Lancet Haematol 2022 Sep;9(9):e660-e669. Epub 2022 Jul 27 doi: 10.1016/S2352-3026(22)00206-X. PMID: 35907408Free PMC Article
Patel BA, Townsley DM, Scheinberg P
Semin Hematol 2022 Jan;59(1):21-29. Epub 2022 Jan 19 doi: 10.1053/j.seminhematol.2022.01.002. PMID: 35491055
Georges GE, Doney K, Storb R
Blood Adv 2018 Aug 14;2(15):2020-2028. doi: 10.1182/bloodadvances.2018021162. PMID: 30108110Free PMC Article
Desmond R, Townsley DM, Dunbar C, Young NS
Semin Hematol 2015 Jan;52(1):31-7. Epub 2014 Oct 31 doi: 10.1053/j.seminhematol.2014.10.002. PMID: 25578417Free PMC Article
Scaringi C, De Sanctis V, Minniti G, Enrici RM
Onkologie 2013;36(7-8):444-9. Epub 2013 Jul 8 doi: 10.1159/000353752. PMID: 23921765

Diagnosis

Zhang J, Liu T, Duan Y, Chang Y, Chang L, Liu C, Chen X, Cheng X, Li T, Yang W, Chen X, Guo Y, Chen Y, Zou Y, Zhang L, Zhu X, Zhang Y
J Autoimmun 2023 Apr;136:103026. Epub 2023 Mar 29 doi: 10.1016/j.jaut.2023.103026. PMID: 37001436
Wang ZJ, Chen HB, Zhou F, Yu H, Wu XY, Shen YQ, Qiu YN, Jin RM
Curr Med Sci 2022 Apr;42(2):379-386. Epub 2022 Mar 8 doi: 10.1007/s11596-022-2519-2. PMID: 35258748
Clucas DB, Fox LC, Wood EM, Hong FS, Gibson J, Bajel A, Szer J, Blombery P, McQuilten ZK, Hiwase D, Firkin F, Cole-Sinclair MF; Australian Aplastic Anaemia Registry Steering Committee
Intern Med J 2019 Feb;49(2):152-159. doi: 10.1111/imj.14140. PMID: 30324755
Georges GE, Doney K, Storb R
Blood Adv 2018 Aug 14;2(15):2020-2028. doi: 10.1182/bloodadvances.2018021162. PMID: 30108110Free PMC Article
Scaringi C, De Sanctis V, Minniti G, Enrici RM
Onkologie 2013;36(7-8):444-9. Epub 2013 Jul 8 doi: 10.1159/000353752. PMID: 23921765

Therapy

Aggarwal N, Manley AL, Shalhoub R, Durrani J, Rios O, Lotter J, Patel BA, Wu CO, Young NS, Groarke EM
Am J Hematol 2023 Jun;98(6):932-939. Epub 2023 Apr 6 doi: 10.1002/ajh.26924. PMID: 37021397Free PMC Article
DeZern AE, Eapen M, Wu J, Talano JA, Solh M, Dávila Saldaña BJ, Karanes C, Horwitz ME, Mallhi K, Arai S, Farhadfar N, Hexner E, Westervelt P, Antin JH, Deeg HJ, Leifer E, Brodsky RA, Logan BR, Horowitz MM, Jones RJ, Pulsipher MA
Lancet Haematol 2022 Sep;9(9):e660-e669. Epub 2022 Jul 27 doi: 10.1016/S2352-3026(22)00206-X. PMID: 35907408Free PMC Article
Siddiqui S, Cox J, Herzig R, Palaniyandi S, Hildebrandt GC, Munker R
Indian J Med Res 2019 Sep;150(3):221-227. doi: 10.4103/ijmr.IJMR_752_19. PMID: 31719292Free PMC Article
Desmond R, Townsley DM, Dunbar C, Young NS
Semin Hematol 2015 Jan;52(1):31-7. Epub 2014 Oct 31 doi: 10.1053/j.seminhematol.2014.10.002. PMID: 25578417Free PMC Article
Scaringi C, De Sanctis V, Minniti G, Enrici RM
Onkologie 2013;36(7-8):444-9. Epub 2013 Jul 8 doi: 10.1159/000353752. PMID: 23921765

Prognosis

Röth A, Bertram S, Schroeder T, Haverkamp T, Voigt S, Holtkamp C, Klump H, Wörmann B, Reinhardt HC, Alashkar F
Eur J Haematol 2022 Aug;109(2):186-194. Epub 2022 Jun 1 doi: 10.1111/ejh.13788. PMID: 35592930Free PMC Article
Siddiqui S, Cox J, Herzig R, Palaniyandi S, Hildebrandt GC, Munker R
Indian J Med Res 2019 Sep;150(3):221-227. doi: 10.4103/ijmr.IJMR_752_19. PMID: 31719292Free PMC Article
Pierri F, Dufour C
Expert Rev Hematol 2019 Oct;12(10):809-819. Epub 2019 Jul 24 doi: 10.1080/17474086.2019.1645003. PMID: 31311355
Scaringi C, De Sanctis V, Minniti G, Enrici RM
Onkologie 2013;36(7-8):444-9. Epub 2013 Jul 8 doi: 10.1159/000353752. PMID: 23921765
Scheinberg P
Int J Hematol 2013 May;97(5):553-7. Epub 2013 May 1 doi: 10.1007/s12185-013-1332-x. PMID: 23636667

Clinical prediction guides

Aggarwal N, Manley AL, Shalhoub R, Durrani J, Rios O, Lotter J, Patel BA, Wu CO, Young NS, Groarke EM
Am J Hematol 2023 Jun;98(6):932-939. Epub 2023 Apr 6 doi: 10.1002/ajh.26924. PMID: 37021397Free PMC Article
DeZern AE, Eapen M, Wu J, Talano JA, Solh M, Dávila Saldaña BJ, Karanes C, Horwitz ME, Mallhi K, Arai S, Farhadfar N, Hexner E, Westervelt P, Antin JH, Deeg HJ, Leifer E, Brodsky RA, Logan BR, Horowitz MM, Jones RJ, Pulsipher MA
Lancet Haematol 2022 Sep;9(9):e660-e669. Epub 2022 Jul 27 doi: 10.1016/S2352-3026(22)00206-X. PMID: 35907408Free PMC Article
Röth A, Bertram S, Schroeder T, Haverkamp T, Voigt S, Holtkamp C, Klump H, Wörmann B, Reinhardt HC, Alashkar F
Eur J Haematol 2022 Aug;109(2):186-194. Epub 2022 Jun 1 doi: 10.1111/ejh.13788. PMID: 35592930Free PMC Article
Scheinberg P
Int J Hematol 2013 May;97(5):553-7. Epub 2013 May 1 doi: 10.1007/s12185-013-1332-x. PMID: 23636667
Afable MG 2nd, Shaik M, Sugimoto Y, Elson P, Clemente M, Makishima H, Sekeres MA, Lichtin A, Advani A, Kalaycio M, Tiu RV, O'Keefe CL, Maciejewski JP
Haematologica 2011 Sep;96(9):1269-75. Epub 2011 May 23 doi: 10.3324/haematol.2011.042622. PMID: 21606164Free PMC Article

Recent systematic reviews

Martí-Carvajal AJ, Anand V, Cardona AF, Solà I
Cochrane Database Syst Rev 2014 Oct 30;(10):CD010340. doi: 10.1002/14651858.CD010340.pub2. PMID: 25356860

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