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Advanced Melanoma

MedGen UID:
1663701
Concept ID:
C4727838
Neoplastic Process

Definition

Melanoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Professional guidelines

PubMed

Bender MJ, McPherson AC, Phelps CM, Pandey SP, Laughlin CR, Shapira JH, Medina Sanchez L, Rana M, Richie TG, Mims TS, Gocher-Demske AM, Cervantes-Barragan L, Mullett SJ, Gelhaus SL, Bruno TC, Cannon N, McCulloch JA, Vignali DAA, Hinterleitner R, Joglekar AV, Pierre JF, Lee STM, Davar D, Zarour HM, Meisel M
Cell 2023 Apr 27;186(9):1846-1862.e26. Epub 2023 Apr 6 doi: 10.1016/j.cell.2023.03.011. PMID: 37028428Free PMC Article
Biermann J, Melms JC, Amin AD, Wang Y, Caprio LA, Karz A, Tagore S, Barrera I, Ibarra-Arellano MA, Andreatta M, Fullerton BT, Gretarsson KH, Sahu V, Mangipudy VS, Nguyen TTT, Nair A, Rogava M, Ho P, Koch PD, Banu M, Humala N, Mahajan A, Walsh ZH, Shah SB, Vaccaro DH, Caldwell B, Mu M, Wünnemann F, Chazotte M, Berhe S, Luoma AM, Driver J, Ingham M, Khan SA, Rapisuwon S, Slingluff CL Jr, Eigentler T, Röcken M, Carvajal R, Atkins MB, Davies MA, Agustinus A, Bakhoum SF, Azizi E, Siegelin M, Lu C, Carmona SJ, Hibshoosh H, Ribas A, Canoll P, Bruce JN, Bi WL, Agrawal P, Schapiro D, Hernando E, Macosko EZ, Chen F, Schwartz GK, Izar B
Cell 2022 Jul 7;185(14):2591-2608.e30. doi: 10.1016/j.cell.2022.06.007. PMID: 35803246Free PMC Article
Villani A, Potestio L, Fabbrocini G, Troncone G, Malapelle U, Scalvenzi M
Int J Mol Sci 2022 Jun 7;23(12) doi: 10.3390/ijms23126388. PMID: 35742834Free PMC Article

Recent clinical studies

Etiology

Rohaan MW, Borch TH, van den Berg JH, Met Ö, Kessels R, Geukes Foppen MH, Stoltenborg Granhøj J, Nuijen B, Nijenhuis C, Jedema I, van Zon M, Scheij S, Beijnen JH, Hansen M, Voermans C, Noringriis IM, Monberg TJ, Holmstroem RB, Wever LDV, van Dijk M, Grijpink-Ongering LG, Valkenet LHM, Torres Acosta A, Karger M, Borgers JSW, Ten Ham RMT, Retèl VP, van Harten WH, Lalezari F, van Tinteren H, van der Veldt AAM, Hospers GAP, Stevense-den Boer MAM, Suijkerbuijk KPM, Aarts MJB, Piersma D, van den Eertwegh AJM, de Groot JB, Vreugdenhil G, Kapiteijn E, Boers-Sonderen MJ, Fiets WE, van den Berkmortel FWPJ, Ellebaek E, Hölmich LR, van Akkooi ACJ, van Houdt WJ, Wouters MWJM, van Thienen JV, Blank CU, Meerveld-Eggink A, Klobuch S, Wilgenhof S, Schumacher TN, Donia M, Svane IM, Haanen JBAG
N Engl J Med 2022 Dec 8;387(23):2113-2125. doi: 10.1056/NEJMoa2210233. PMID: 36477031
Carlino MS, Larkin J, Long GV
Lancet 2021 Sep 11;398(10304):1002-1014. doi: 10.1016/S0140-6736(21)01206-X. PMID: 34509219
Jenkins RW, Fisher DE
J Invest Dermatol 2021 Jan;141(1):23-31. Epub 2020 Apr 5 doi: 10.1016/j.jid.2020.03.943. PMID: 32268150Free PMC Article
Larkin J, Chiarion-Sileni V, Gonzalez R, Grob JJ, Rutkowski P, Lao CD, Cowey CL, Schadendorf D, Wagstaff J, Dummer R, Ferrucci PF, Smylie M, Hogg D, Hill A, Márquez-Rodas I, Haanen J, Guidoboni M, Maio M, Schöffski P, Carlino MS, Lebbé C, McArthur G, Ascierto PA, Daniels GA, Long GV, Bastholt L, Rizzo JI, Balogh A, Moshyk A, Hodi FS, Wolchok JD
N Engl J Med 2019 Oct 17;381(16):1535-1546. Epub 2019 Sep 28 doi: 10.1056/NEJMoa1910836. PMID: 31562797
Robert C, Schachter J, Long GV, Arance A, Grob JJ, Mortier L, Daud A, Carlino MS, McNeil C, Lotem M, Larkin J, Lorigan P, Neyns B, Blank CU, Hamid O, Mateus C, Shapira-Frommer R, Kosh M, Zhou H, Ibrahim N, Ebbinghaus S, Ribas A; KEYNOTE-006 investigators
N Engl J Med 2015 Jun 25;372(26):2521-32. Epub 2015 Apr 19 doi: 10.1056/NEJMoa1503093. PMID: 25891173

Diagnosis

Long GV, Swetter SM, Menzies AM, Gershenwald JE, Scolyer RA
Lancet 2023 Aug 5;402(10400):485-502. Epub 2023 Jul 24 doi: 10.1016/S0140-6736(23)00821-8. PMID: 37499671
Villani A, Potestio L, Fabbrocini G, Troncone G, Malapelle U, Scalvenzi M
Int J Mol Sci 2022 Jun 7;23(12) doi: 10.3390/ijms23126388. PMID: 35742834Free PMC Article
Carlino MS, Larkin J, Long GV
Lancet 2021 Sep 11;398(10304):1002-1014. doi: 10.1016/S0140-6736(21)01206-X. PMID: 34509219
Eddy K, Chen S
Int J Mol Sci 2020 Nov 26;21(23) doi: 10.3390/ijms21238984. PMID: 33256089Free PMC Article
Hartman RI, Lin JY
Hematol Oncol Clin North Am 2019 Feb;33(1):25-38. doi: 10.1016/j.hoc.2018.09.005. PMID: 30497675

Therapy

Carlino MS, Larkin J, Long GV
Lancet 2021 Sep 11;398(10304):1002-1014. doi: 10.1016/S0140-6736(21)01206-X. PMID: 34509219
Davar D, Dzutsev AK, McCulloch JA, Rodrigues RR, Chauvin JM, Morrison RM, Deblasio RN, Menna C, Ding Q, Pagliano O, Zidi B, Zhang S, Badger JH, Vetizou M, Cole AM, Fernandes MR, Prescott S, Costa RGF, Balaji AK, Morgun A, Vujkovic-Cvijin I, Wang H, Borhani AA, Schwartz MB, Dubner HM, Ernst SJ, Rose A, Najjar YG, Belkaid Y, Kirkwood JM, Trinchieri G, Zarour HM
Science 2021 Feb 5;371(6529):595-602. doi: 10.1126/science.abf3363. PMID: 33542131Free PMC Article
Larkin J, Chiarion-Sileni V, Gonzalez R, Grob JJ, Rutkowski P, Lao CD, Cowey CL, Schadendorf D, Wagstaff J, Dummer R, Ferrucci PF, Smylie M, Hogg D, Hill A, Márquez-Rodas I, Haanen J, Guidoboni M, Maio M, Schöffski P, Carlino MS, Lebbé C, McArthur G, Ascierto PA, Daniels GA, Long GV, Bastholt L, Rizzo JI, Balogh A, Moshyk A, Hodi FS, Wolchok JD
N Engl J Med 2019 Oct 17;381(16):1535-1546. Epub 2019 Sep 28 doi: 10.1056/NEJMoa1910836. PMID: 31562797
Namikawa K, Yamazaki N
Curr Treat Options Oncol 2019 Jan 24;20(1):7. doi: 10.1007/s11864-019-0607-8. PMID: 30675668Free PMC Article
Schadendorf D, van Akkooi ACJ, Berking C, Griewank KG, Gutzmer R, Hauschild A, Stang A, Roesch A, Ugurel S
Lancet 2018 Sep 15;392(10151):971-984. doi: 10.1016/S0140-6736(18)31559-9. PMID: 30238891

Prognosis

Amaria RN, Postow M, Burton EM, Tetzlaff MT, Ross MI, Torres-Cabala C, Glitza IC, Duan F, Milton DR, Busam K, Simpson L, McQuade JL, Wong MK, Gershenwald JE, Lee JE, Goepfert RP, Keung EZ, Fisher SB, Betof-Warner A, Shoushtari AN, Callahan M, Coit D, Bartlett EK, Bello D, Momtaz P, Nicholas C, Gu A, Zhang X, Korivi BR, Patnana M, Patel SP, Diab A, Lucci A, Prieto VG, Davies MA, Allison JP, Sharma P, Wargo JA, Ariyan C, Tawbi HA
Nature 2022 Nov;611(7934):155-160. Epub 2022 Oct 26 doi: 10.1038/s41586-022-05368-8. PMID: 36289334Free PMC Article
Larkin J, Chiarion-Sileni V, Gonzalez R, Grob JJ, Rutkowski P, Lao CD, Cowey CL, Schadendorf D, Wagstaff J, Dummer R, Ferrucci PF, Smylie M, Hogg D, Hill A, Márquez-Rodas I, Haanen J, Guidoboni M, Maio M, Schöffski P, Carlino MS, Lebbé C, McArthur G, Ascierto PA, Daniels GA, Long GV, Bastholt L, Rizzo JI, Balogh A, Moshyk A, Hodi FS, Wolchok JD
N Engl J Med 2019 Oct 17;381(16):1535-1546. Epub 2019 Sep 28 doi: 10.1056/NEJMoa1910836. PMID: 31562797
Schadendorf D, van Akkooi ACJ, Berking C, Griewank KG, Gutzmer R, Hauschild A, Stang A, Roesch A, Ugurel S
Lancet 2018 Sep 15;392(10151):971-984. doi: 10.1016/S0140-6736(18)31559-9. PMID: 30238891
Wolchok JD, Chiarion-Sileni V, Gonzalez R, Rutkowski P, Grob JJ, Cowey CL, Lao CD, Wagstaff J, Schadendorf D, Ferrucci PF, Smylie M, Dummer R, Hill A, Hogg D, Haanen J, Carlino MS, Bechter O, Maio M, Marquez-Rodas I, Guidoboni M, McArthur G, Lebbé C, Ascierto PA, Long GV, Cebon J, Sosman J, Postow MA, Callahan MK, Walker D, Rollin L, Bhore R, Hodi FS, Larkin J
N Engl J Med 2017 Oct 5;377(14):1345-1356. Epub 2017 Sep 11 doi: 10.1056/NEJMoa1709684. PMID: 28889792Free PMC Article
Robert C, Long GV, Brady B, Dutriaux C, Maio M, Mortier L, Hassel JC, Rutkowski P, McNeil C, Kalinka-Warzocha E, Savage KJ, Hernberg MM, Lebbé C, Charles J, Mihalcioiu C, Chiarion-Sileni V, Mauch C, Cognetti F, Arance A, Schmidt H, Schadendorf D, Gogas H, Lundgren-Eriksson L, Horak C, Sharkey B, Waxman IM, Atkinson V, Ascierto PA
N Engl J Med 2015 Jan 22;372(4):320-30. Epub 2014 Nov 16 doi: 10.1056/NEJMoa1412082. PMID: 25399552

Clinical prediction guides

Betof Warner A, Corrie PG, Hamid O
Clin Cancer Res 2023 May 15;29(10):1835-1854. doi: 10.1158/1078-0432.CCR-22-1922. PMID: 36485001Free PMC Article
Huang AC, Zappasodi R
Nat Immunol 2022 May;23(5):660-670. Epub 2022 Mar 3 doi: 10.1038/s41590-022-01141-1. PMID: 35241833Free PMC Article
Jenkins RW, Fisher DE
J Invest Dermatol 2021 Jan;141(1):23-31. Epub 2020 Apr 5 doi: 10.1016/j.jid.2020.03.943. PMID: 32268150Free PMC Article
Larkin J, Chiarion-Sileni V, Gonzalez R, Grob JJ, Rutkowski P, Lao CD, Cowey CL, Schadendorf D, Wagstaff J, Dummer R, Ferrucci PF, Smylie M, Hogg D, Hill A, Márquez-Rodas I, Haanen J, Guidoboni M, Maio M, Schöffski P, Carlino MS, Lebbé C, McArthur G, Ascierto PA, Daniels GA, Long GV, Bastholt L, Rizzo JI, Balogh A, Moshyk A, Hodi FS, Wolchok JD
N Engl J Med 2019 Oct 17;381(16):1535-1546. Epub 2019 Sep 28 doi: 10.1056/NEJMoa1910836. PMID: 31562797
Kwok G, Yau TC, Chiu JW, Tse E, Kwong YL
Hum Vaccin Immunother 2016 Nov;12(11):2777-2789. Epub 2016 Jul 11 doi: 10.1080/21645515.2016.1199310. PMID: 27398650Free PMC Article

Recent systematic reviews

Boutros A, Tanda ET, Croce E, Catalano F, Ceppi M, Bruzzone M, Cecchi F, Arecco L, Fraguglia M, Pronzato P, Genova C, Del Mastro L, Lambertini M, Spagnolo F
Eur J Cancer 2023 Jul;188:64-79. Epub 2023 Apr 24 doi: 10.1016/j.ejca.2023.04.010. PMID: 37196485
Dafni U, Michielin O, Lluesma SM, Tsourti Z, Polydoropoulou V, Karlis D, Besser MJ, Haanen J, Svane IM, Ohashi PS, Kammula US, Orcurto A, Zimmermann S, Trueb L, Klebanoff CA, Lotze MT, Kandalaft LE, Coukos G
Ann Oncol 2019 Dec 1;30(12):1902-1913. doi: 10.1093/annonc/mdz398. PMID: 31566658
da Silveira Nogueira Lima JP, Georgieva M, Haaland B, de Lima Lopes G
Cancer Med 2017 Jun;6(6):1143-1153. Epub 2017 May 1 doi: 10.1002/cam4.1001. PMID: 28463413Free PMC Article
Dunn J, Watson M, Aitken JF, Hyde MK
Psychooncology 2017 Nov;26(11):1722-1731. Epub 2016 Nov 7 doi: 10.1002/pon.4290. PMID: 27696578
Francis SO, Mahlberg MJ, Johnson KR, Ming ME, Dellavalle RP
J Am Acad Dermatol 2006 Nov;55(5):849-61. Epub 2006 Sep 18 doi: 10.1016/j.jaad.2006.04.014. PMID: 17052492

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