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Unresectable Desmoid Fibromatosis

MedGen UID:
1663716
•Concept ID:
C4744431
•
Neoplastic Process
Synonyms: Unresectable Desmoid Tumor; Unresectable Desmoid-Type Fibromatosis

Definition

Desmoid fibromatosis that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Desmoid Fibromatosis

Professional guidelines

PubMed

Management of unresectable and recurrent intra-abdominal desmoid tumors treated with ultrasound-guided high-intensity focused ultrasound: A retrospective single-center study.
Yang Y, Zhang J, Pan Y
Medicine (Baltimore) 2022 Aug 26;101(34):e30201. doi: 10.1097/MD.0000000000030201. PMID: 36042615Free PMC Article
Current management and recent progress in desmoid tumors.
Zhou MY, Bui NQ, Charville GW, Ghanouni P, Ganjoo KN
Cancer Treat Res Commun 2022;31:100562. Epub 2022 Apr 16 doi: 10.1016/j.ctarc.2022.100562. PMID: 35460976
Radiotherapy in the treatment of primary or recurrent unresectable desmoid tumors of the neck.
Niu X, Jiang R, Hu C
Cancer Invest 2019;37(8):387-392. Epub 2019 Sep 2 doi: 10.1080/07357907.2019.1656731. PMID: 31474159

Recent clinical studies

Etiology

Management of unresectable and recurrent intra-abdominal desmoid tumors treated with ultrasound-guided high-intensity focused ultrasound: A retrospective single-center study.
Yang Y, Zhang J, Pan Y
Medicine (Baltimore) 2022 Aug 26;101(34):e30201. doi: 10.1097/MD.0000000000030201. PMID: 36042615Free PMC Article
Current management and recent progress in desmoid tumors.
Zhou MY, Bui NQ, Charville GW, Ghanouni P, Ganjoo KN
Cancer Treat Res Commun 2022;31:100562. Epub 2022 Apr 16 doi: 10.1016/j.ctarc.2022.100562. PMID: 35460976
Desmoid tumors of the head and neck in the pediatric population: Has anything changed?
Zhao CX, Dombrowski ND, Perez-Atayde AR, Robson CD, Afshar S, Janeway KA, Rahbar R
Int J Pediatr Otorhinolaryngol 2021 Jan;140:110511. Epub 2020 Nov 18 doi: 10.1016/j.ijporl.2020.110511. PMID: 33271436
Combination chemotherapy with methotrexate and vinblastine for surgically unresectable, aggressive fibromatosis.
Park KH, Choi YJ, Kim KW, Ro KH, Kang CH, Song SH, Park JH
Jpn J Clin Oncol 2016 Sep;46(9):845-9. Epub 2016 Jun 30 doi: 10.1093/jjco/hyw081. PMID: 27365524
CTNNB1 Mutations and Estrogen Receptor Expression in Neuromuscular Choristoma and Its Associated Fibromatosis.
Carter JM, Howe BM, Hawse JR, Giannini C, Spinner RJ, Fritchie KJ
Am J Surg Pathol 2016 Oct;40(10):1368-74. doi: 10.1097/PAS.0000000000000673. PMID: 27259010

Diagnosis

Desmoid tumors of the head and neck in the pediatric population: Has anything changed?
Zhao CX, Dombrowski ND, Perez-Atayde AR, Robson CD, Afshar S, Janeway KA, Rahbar R
Int J Pediatr Otorhinolaryngol 2021 Jan;140:110511. Epub 2020 Nov 18 doi: 10.1016/j.ijporl.2020.110511. PMID: 33271436
Optimal radiotherapy strategy for primary or recurrent fibromatosis and long-term results.
Choi SH, Yoon HI, Kim SH, Kim SK, Shin KH, Suh CO
PLoS One 2018;13(5):e0198134. Epub 2018 May 29 doi: 10.1371/journal.pone.0198134. PMID: 29813130Free PMC Article
Radiation Therapy for Aggressive Fibromatosis: The Association Between Local Control and Age.
Bates JE, Morris CG, Iovino NM, Rutenberg M, Zlotecki RA, Gibbs CP, Scarborough M, Indelicato DJ
Int J Radiat Oncol Biol Phys 2018 Mar 15;100(4):997-1003. Epub 2017 Dec 21 doi: 10.1016/j.ijrobp.2017.12.259. PMID: 29485080
Combination chemotherapy with methotrexate and vinblastine for surgically unresectable, aggressive fibromatosis.
Park KH, Choi YJ, Kim KW, Ro KH, Kang CH, Song SH, Park JH
Jpn J Clin Oncol 2016 Sep;46(9):845-9. Epub 2016 Jun 30 doi: 10.1093/jjco/hyw081. PMID: 27365524
Aggressive fibromatosis.
Mendenhall WM, Zlotecki RA, Morris CG, Hochwald SN, Scarborough MT
Am J Clin Oncol 2005 Apr;28(2):211-5. doi: 10.1097/01.coc.0000144817.78549.53. PMID: 15803019

Therapy

Management of unresectable and recurrent intra-abdominal desmoid tumors treated with ultrasound-guided high-intensity focused ultrasound: A retrospective single-center study.
Yang Y, Zhang J, Pan Y
Medicine (Baltimore) 2022 Aug 26;101(34):e30201. doi: 10.1097/MD.0000000000030201. PMID: 36042615Free PMC Article
Current management and recent progress in desmoid tumors.
Zhou MY, Bui NQ, Charville GW, Ghanouni P, Ganjoo KN
Cancer Treat Res Commun 2022;31:100562. Epub 2022 Apr 16 doi: 10.1016/j.ctarc.2022.100562. PMID: 35460976
Combination chemotherapy with methotrexate and vinblastine for surgically unresectable, aggressive fibromatosis.
Park KH, Choi YJ, Kim KW, Ro KH, Kang CH, Song SH, Park JH
Jpn J Clin Oncol 2016 Sep;46(9):845-9. Epub 2016 Jun 30 doi: 10.1093/jjco/hyw081. PMID: 27365524
Unresectable desmoid tumours causing obstructive uropathy in familial adenomatous polyposis.
Soon JL, Lau WK, Seow-Choen F, Cheng CW
Asian J Surg 2005 Jul;28(3):233-7. doi: 10.1016/S1015-9584(09)60351-1. PMID: 16024324
Use of doxorubicin and dacarbazine for the management of unresectable intra-abdominal desmoid tumors in Gardner's syndrome.
Lynch HT, Fitzgibbons R Jr, Chong S, Cavalieri J, Lynch J, Wallace F, Patel S
Dis Colon Rectum 1994 Mar;37(3):260-7. doi: 10.1007/BF02048164. PMID: 8137673

Prognosis

Optimal radiotherapy strategy for primary or recurrent fibromatosis and long-term results.
Choi SH, Yoon HI, Kim SH, Kim SK, Shin KH, Suh CO
PLoS One 2018;13(5):e0198134. Epub 2018 May 29 doi: 10.1371/journal.pone.0198134. PMID: 29813130Free PMC Article
CTNNB1 Mutations and Estrogen Receptor Expression in Neuromuscular Choristoma and Its Associated Fibromatosis.
Carter JM, Howe BM, Hawse JR, Giannini C, Spinner RJ, Fritchie KJ
Am J Surg Pathol 2016 Oct;40(10):1368-74. doi: 10.1097/PAS.0000000000000673. PMID: 27259010
Imatinib for progressive and recurrent aggressive fibromatosis (desmoid tumors): an FNCLCC/French Sarcoma Group phase II trial with a long-term follow-up.
Penel N, Le Cesne A, Bui BN, Perol D, Brain EG, Ray-Coquard I, Guillemet C, Chevreau C, Cupissol D, Chabaud S, Jimenez M, Duffaud F, Piperno-Neumann S, Mignot L, Blay JY
Ann Oncol 2011 Feb;22(2):452-7. Epub 2010 Jul 9 doi: 10.1093/annonc/mdq341. PMID: 20622000
Agressive fibromatosis involving the mandible--case report and review of the literature.
Seper L, Bürger H, Vormoor J, Joos U, Kleinheinz J
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005 Jan;99(1):30-8. doi: 10.1016/j.tripleo.2004.03.026. PMID: 15599346
Desmoid tumor: prognostic factors and outcome after surgery, radiation therapy, or combined surgery and radiation therapy.
Ballo MT, Zagars GK, Pollack A, Pisters PW, Pollack RA
J Clin Oncol 1999 Jan;17(1):158-67. doi: 10.1200/JCO.1999.17.1.158. PMID: 10458229

Clinical prediction guides

Desmoid tumors of the head and neck in the pediatric population: Has anything changed?
Zhao CX, Dombrowski ND, Perez-Atayde AR, Robson CD, Afshar S, Janeway KA, Rahbar R
Int J Pediatr Otorhinolaryngol 2021 Jan;140:110511. Epub 2020 Nov 18 doi: 10.1016/j.ijporl.2020.110511. PMID: 33271436
Optimal radiotherapy strategy for primary or recurrent fibromatosis and long-term results.
Choi SH, Yoon HI, Kim SH, Kim SK, Shin KH, Suh CO
PLoS One 2018;13(5):e0198134. Epub 2018 May 29 doi: 10.1371/journal.pone.0198134. PMID: 29813130Free PMC Article
Combination chemotherapy with methotrexate and vinblastine for surgically unresectable, aggressive fibromatosis.
Park KH, Choi YJ, Kim KW, Ro KH, Kang CH, Song SH, Park JH
Jpn J Clin Oncol 2016 Sep;46(9):845-9. Epub 2016 Jun 30 doi: 10.1093/jjco/hyw081. PMID: 27365524
Imatinib for progressive and recurrent aggressive fibromatosis (desmoid tumors): an FNCLCC/French Sarcoma Group phase II trial with a long-term follow-up.
Penel N, Le Cesne A, Bui BN, Perol D, Brain EG, Ray-Coquard I, Guillemet C, Chevreau C, Cupissol D, Chabaud S, Jimenez M, Duffaud F, Piperno-Neumann S, Mignot L, Blay JY
Ann Oncol 2011 Feb;22(2):452-7. Epub 2010 Jul 9 doi: 10.1093/annonc/mdq341. PMID: 20622000
Current ideas in desmoid tumours.
Sturt NJ, Clark SK
Fam Cancer 2006;5(3):275-85; discussion 287-8. doi: 10.1007/s10689-005-5675-1. PMID: 16998673

Recent systematic reviews

Definitive radiation therapy in patients with unresectable desmoid tumors: a systematic review.
Matsunobu T, Kunisada T, Ozaki T, Iwamoto Y, Yoshida M, Nishida Y
Jpn J Clin Oncol 2020 May 5;50(5):568-573. doi: 10.1093/jjco/hyaa007. PMID: 32115624

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