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Locally Advanced Pancreatic Adenocarcinoma

MedGen UID:
1664239
Concept ID:
C4744700
Neoplastic Process

Definition

A pancreatic adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Professional guidelines

PubMed

Attiyeh MA, Amini A, Chung V, Melstrom LG
J Surg Oncol 2021 May;123(6):1395-1404. doi: 10.1002/jso.26415. PMID: 33831247
Salgado M, Arévalo S, Hernando O, Martínez A, Yaya R, Hidalgo M
Clin Transl Oncol 2018 Feb;20(2):113-118. Epub 2017 Jun 13 doi: 10.1007/s12094-017-1679-1. PMID: 28612202
Pollom EL, Koong AC, Ko AH
Hematol Oncol Clin North Am 2015 Aug;29(4):741-59. Epub 2015 May 30 doi: 10.1016/j.hoc.2015.04.005. PMID: 26226908

Recent clinical studies

Etiology

Sugumar K, Hurtado A, Naik I, Hue JJ, Rothermel LD, Ammori JB, Hardacre JM, Winter JM, Ocuin LM
HPB (Oxford) 2022 May;24(5):586-595. Epub 2021 Dec 24 doi: 10.1016/j.hpb.2021.12.014. PMID: 35000842
Wainberg ZA, Bekaii-Saab T, Boland PM, Dayyani F, Macarulla T, Mody K, Belanger B, Maxwell F, Moore Y, Thiagalingam A, Wang T, Zhang B, Dean A
Eur J Cancer 2021 Jul;151:14-24. Epub 2021 May 4 doi: 10.1016/j.ejca.2021.03.028. PMID: 33957442
Rosumeck N, Timmermann L, Klein F, Bahra M, Stintzig S, Malinka T, Pelzer U
Medicina (Kaunas) 2021 Jan 18;57(1) doi: 10.3390/medicina57010077. PMID: 33477505Free PMC Article
Kunzmann V, Siveke JT, Algül H, Goekkurt E, Siegler G, Martens U, Waldschmidt D, Pelzer U, Fuchs M, Kullmann F, Boeck S, Ettrich TJ, Held S, Keller R, Klein I, Germer CT, Stein H, Friess H, Bahra M, Jakobs R, Hartlapp I, Heinemann V; German Pancreatic Cancer Working Group (AIO-PAK) and NEOLAP investigators
Lancet Gastroenterol Hepatol 2021 Feb;6(2):128-138. Epub 2020 Dec 16 doi: 10.1016/S2468-1253(20)30330-7. PMID: 33338442
Cassinotto C, Mouries A, Lafourcade JP, Terrebonne E, Belleannée G, Blanc JF, Lapuyade B, Vendrely V, Laurent C, Chiche L, Wagner T, Sa-Cunha A, Gaye D, Trillaud H, Laurent F, Montaudon M
Radiology 2014 Oct;273(1):108-16. Epub 2014 Jun 24 doi: 10.1148/radiol.14132914. PMID: 24960211

Diagnosis

Polyakov AN, Patyutko YI, Kudashkin NE, Kantieva DM, Romanova KA, Nasonova EA, Korshak AV, Egenov OA, Podluzhnyi DV
Khirurgiia (Mosk) 2023;(10):29-38. doi: 10.17116/hirurgia202310129. PMID: 37916555
Sugumar K, Hurtado A, Naik I, Hue JJ, Rothermel LD, Ammori JB, Hardacre JM, Winter JM, Ocuin LM
HPB (Oxford) 2022 May;24(5):586-595. Epub 2021 Dec 24 doi: 10.1016/j.hpb.2021.12.014. PMID: 35000842
Wainberg ZA, Bekaii-Saab T, Boland PM, Dayyani F, Macarulla T, Mody K, Belanger B, Maxwell F, Moore Y, Thiagalingam A, Wang T, Zhang B, Dean A
Eur J Cancer 2021 Jul;151:14-24. Epub 2021 May 4 doi: 10.1016/j.ejca.2021.03.028. PMID: 33957442
Mattiucci GC, Boldrini L, Nardangeli A, D'Aviero A, Buwenge M, Cellini F, Deodato F, Dinapoli N, Frascino V, Macchia G, Morganti AG, Valentini V
J Cancer Res Clin Oncol 2021 Mar;147(3):661-667. Epub 2020 Oct 1 doi: 10.1007/s00432-020-03411-7. PMID: 33001271
Salgado M, Arévalo S, Hernando O, Martínez A, Yaya R, Hidalgo M
Clin Transl Oncol 2018 Feb;20(2):113-118. Epub 2017 Jun 13 doi: 10.1007/s12094-017-1679-1. PMID: 28612202

Therapy

Ejlsmark MW, Schytte T, Bernchou U, Bahij R, Weber B, Mortensen MB, Pfeiffer P
Curr Oncol 2023 Jul 18;30(7):6820-6837. doi: 10.3390/curroncol30070499. PMID: 37504359Free PMC Article
D'Onofrio M, Beleù A, Sarno A, De Robertis R, Paiella S, Viviani E, Frigerio I, Girelli R, Salvia R, Bassi C
Ultraschall Med 2022 Aug;43(4):380-386. Epub 2020 Aug 14 doi: 10.1055/a-1178-0474. PMID: 32797463
Wainberg ZA, Bekaii-Saab T, Boland PM, Dayyani F, Macarulla T, Mody K, Belanger B, Maxwell F, Moore Y, Thiagalingam A, Wang T, Zhang B, Dean A
Eur J Cancer 2021 Jul;151:14-24. Epub 2021 May 4 doi: 10.1016/j.ejca.2021.03.028. PMID: 33957442
Kunzmann V, Siveke JT, Algül H, Goekkurt E, Siegler G, Martens U, Waldschmidt D, Pelzer U, Fuchs M, Kullmann F, Boeck S, Ettrich TJ, Held S, Keller R, Klein I, Germer CT, Stein H, Friess H, Bahra M, Jakobs R, Hartlapp I, Heinemann V; German Pancreatic Cancer Working Group (AIO-PAK) and NEOLAP investigators
Lancet Gastroenterol Hepatol 2021 Feb;6(2):128-138. Epub 2020 Dec 16 doi: 10.1016/S2468-1253(20)30330-7. PMID: 33338442
Garnier J, Ewald J, Marchese U, Gilabert M, Moureau-Zabotto L, Giovannini M, Poizat F, Delpero JR, Turrini O
Eur J Surg Oncol 2020 Aug;46(8):1510-1515. Epub 2020 Feb 27 doi: 10.1016/j.ejso.2020.02.037. PMID: 32146053

Prognosis

Abdelrahman AM, Goenka AH, Alva-Ruiz R, Yonkus JA, Leiting JL, Graham RP, Merrell KW, Thiels CA, Hallemeier CL, Warner SG, Haddock MG, Grotz TE, Tran NH, Smoot RL, Ma WW, Cleary SP, McWilliams RR, Nagorney DM, Halfdanarson TR, Kendrick ML, Truty MJ
J Natl Compr Canc Netw 2022 Sep;20(9):1023-1032.e3. doi: 10.6004/jnccn.2022.7041. PMID: 36075389
Rosumeck N, Timmermann L, Klein F, Bahra M, Stintzig S, Malinka T, Pelzer U
Medicina (Kaunas) 2021 Jan 18;57(1) doi: 10.3390/medicina57010077. PMID: 33477505Free PMC Article
Kunzmann V, Siveke JT, Algül H, Goekkurt E, Siegler G, Martens U, Waldschmidt D, Pelzer U, Fuchs M, Kullmann F, Boeck S, Ettrich TJ, Held S, Keller R, Klein I, Germer CT, Stein H, Friess H, Bahra M, Jakobs R, Hartlapp I, Heinemann V; German Pancreatic Cancer Working Group (AIO-PAK) and NEOLAP investigators
Lancet Gastroenterol Hepatol 2021 Feb;6(2):128-138. Epub 2020 Dec 16 doi: 10.1016/S2468-1253(20)30330-7. PMID: 33338442
Salgado M, Arévalo S, Hernando O, Martínez A, Yaya R, Hidalgo M
Clin Transl Oncol 2018 Feb;20(2):113-118. Epub 2017 Jun 13 doi: 10.1007/s12094-017-1679-1. PMID: 28612202
Cassinotto C, Mouries A, Lafourcade JP, Terrebonne E, Belleannée G, Blanc JF, Lapuyade B, Vendrely V, Laurent C, Chiche L, Wagner T, Sa-Cunha A, Gaye D, Trillaud H, Laurent F, Montaudon M
Radiology 2014 Oct;273(1):108-16. Epub 2014 Jun 24 doi: 10.1148/radiol.14132914. PMID: 24960211

Clinical prediction guides

Abdelrahman AM, Goenka AH, Alva-Ruiz R, Yonkus JA, Leiting JL, Graham RP, Merrell KW, Thiels CA, Hallemeier CL, Warner SG, Haddock MG, Grotz TE, Tran NH, Smoot RL, Ma WW, Cleary SP, McWilliams RR, Nagorney DM, Halfdanarson TR, Kendrick ML, Truty MJ
J Natl Compr Canc Netw 2022 Sep;20(9):1023-1032.e3. doi: 10.6004/jnccn.2022.7041. PMID: 36075389
Gudmundsdottir H, Tomlinson JL, Graham RP, Thiels CA, Warner SG, Smoot RL, Kendrick ML, Nagorney DM, Halfdanarson TR, Habermann EB, Truty MJ, Cleary SP
HPB (Oxford) 2022 Jul;24(7):1186-1193. Epub 2021 Dec 31 doi: 10.1016/j.hpb.2021.12.016. PMID: 35078716
Wainberg ZA, Bekaii-Saab T, Boland PM, Dayyani F, Macarulla T, Mody K, Belanger B, Maxwell F, Moore Y, Thiagalingam A, Wang T, Zhang B, Dean A
Eur J Cancer 2021 Jul;151:14-24. Epub 2021 May 4 doi: 10.1016/j.ejca.2021.03.028. PMID: 33957442
Rosumeck N, Timmermann L, Klein F, Bahra M, Stintzig S, Malinka T, Pelzer U
Medicina (Kaunas) 2021 Jan 18;57(1) doi: 10.3390/medicina57010077. PMID: 33477505Free PMC Article
Garnier J, Ewald J, Marchese U, Gilabert M, Moureau-Zabotto L, Giovannini M, Poizat F, Delpero JR, Turrini O
Eur J Surg Oncol 2020 Aug;46(8):1510-1515. Epub 2020 Feb 27 doi: 10.1016/j.ejso.2020.02.037. PMID: 32146053

Recent systematic reviews

Vornhülz M, Anton S, Eross B, Szakács Z, Hegyi P, Regel I, Belka C, Niyazi M, Mayerle J, Beyer G
Radiat Oncol 2022 Jun 17;17(1):108. doi: 10.1186/s13014-022-02076-5. PMID: 35715808Free PMC Article
Sugumar K, Hurtado A, Naik I, Hue JJ, Rothermel LD, Ammori JB, Hardacre JM, Winter JM, Ocuin LM
HPB (Oxford) 2022 May;24(5):586-595. Epub 2021 Dec 24 doi: 10.1016/j.hpb.2021.12.014. PMID: 35000842
Attard JA, Farrugia A, Pathanki A, Roberts KJ, Dasari B, Isaac J, Ma YT, Chatzizacharias NA
Pancreas 2020 Nov/Dec;49(10):1264-1275. doi: 10.1097/MPA.0000000000001694. PMID: 33122513

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