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HHV8-Related Lymphoproliferative Disorder

MedGen UID:
1664303
Concept ID:
C4725702
Disease or Syndrome
Synonyms: HHV8-Associated Lymphoproliferative Disorder; KSHV/HHV8-Related Lymphoproliferative Disorder

Definition

A lymphoproliferative disorder caused by the human herpesvirus 8 (HHV8). This category includes the following: HHV8-positive multicentric Castleman disease; HHV8-positive diffuse large B-cell lymphoma, not otherwise specified; primary effusion lymphoma; and germinotropic lymphoproliferative disorders. [from NCI]

Recent clinical studies

Etiology

Takeuchi K
J Clin Exp Hematop 2022;62(2):79-84. doi: 10.3960/jslrt.22011. PMID: 35768240Free PMC Article
Nishimura MF, Nishimura Y, Nishikori A, Yoshino T, Sato Y
J Clin Exp Hematop 2022 Jun 28;62(2):60-72. Epub 2022 Apr 27 doi: 10.3960/jslrt.21036. PMID: 35474035Free PMC Article
Kobayashi Y, Kamitsuji Y, Kuroda J, Tsunoda S, Uoshima N, Kimura S, Wada K, Matsumoto Y, Nomura K, Horiike S, Shimazaki C, Yoshikawa T, Taniwaki M
Acta Haematol 2007;117(3):132-44. Epub 2006 Nov 29 doi: 10.1159/000097460. PMID: 17135726

Diagnosis

Nishimura MF, Nishimura Y, Nishikori A, Yoshino T, Sato Y
J Clin Exp Hematop 2022 Jun 28;62(2):60-72. Epub 2022 Apr 27 doi: 10.3960/jslrt.21036. PMID: 35474035Free PMC Article
Carne S, Smit E, Price N, Paul J, Guiver M, Tedder R
J Clin Virol 2019 Jul;116:7-10. Epub 2019 Mar 22 doi: 10.1016/j.jcv.2019.03.013. PMID: 30991238
Gonzalez-Farre B, Martinez D, Lopez-Guerra M, Xipell M, Monclus E, Rovira J, Garcia F, Lopez-Guillermo A, Colomo L, Campo E, Martinez A
Mod Pathol 2017 May;30(5):745-760. Epub 2017 Jan 13 doi: 10.1038/modpathol.2016.233. PMID: 28084335
Riva G, Luppi M, Barozzi P, Forghieri F, Potenza L
Blood 2012 Nov 15;120(20):4150-9. Epub 2012 Sep 11 doi: 10.1182/blood-2012-04-421412. PMID: 22968461
Boivin G, Côté S, Cloutier N, Abed Y, Maguigad M, Routy JP
J Med Virol 2002 Nov;68(3):399-403. doi: 10.1002/jmv.10217. PMID: 12226828

Therapy

Bedier H, Lin J, Julien LA, Routy JP
BMJ Case Rep 2021 Jan 28;14(1) doi: 10.1136/bcr-2020-238644. PMID: 33509877Free PMC Article
Campogiani L, Cerva C, Maffongelli G, Teti E, Pupo L, Vaccarini S, Cantonetti M, Pennica A, Andreoni M, Sarmati L
AIDS Res Ther 2019 Jul 27;16(1):15. doi: 10.1186/s12981-019-0230-6. PMID: 31351487Free PMC Article
Chen J, Mehraj V, Szabo J, Routy B, Michel RP, Routy JP
Curr Oncol 2018 Dec;25(6):e592-e596. Epub 2018 Dec 1 doi: 10.3747/co.25.4119. PMID: 30607128Free PMC Article
Patier de la Peña JL, González-García A, Prieto Pareja E, Norman FF, Rojas Marcos J, Benito Paniagua D
Rev Clin Esp (Barc) 2014 Mar;214(2):e15-7. Epub 2013 Dec 21 doi: 10.1016/j.rce.2013.11.009. PMID: 24365755
Riva G, Luppi M, Barozzi P, Forghieri F, Potenza L
Blood 2012 Nov 15;120(20):4150-9. Epub 2012 Sep 11 doi: 10.1182/blood-2012-04-421412. PMID: 22968461

Prognosis

Fraticelli S, Lucioni M, Neri G, Marchiori D, Cristinelli C, Merli M, Monaco R, Borra T, Lazzaro A, Uccella S, Arcaini L, Paulli M
Int J Mol Sci 2023 Apr 25;24(9) doi: 10.3390/ijms24097813. PMID: 37175521Free PMC Article
Granai M, Facchetti M, Mancini V, Goedhals J, Sherriff A, Mundo L, Bellan C, Amato T, Sorrentino E, Ungari M, Raphael M, Leoncini L, Facchetti F, Lazzi S
Histopathology 2021 Dec;79(6):1099-1107. Epub 2021 Oct 4 doi: 10.1111/his.14551. PMID: 34431125Free PMC Article
Gonzalez-Farre B, Martinez D, Lopez-Guerra M, Xipell M, Monclus E, Rovira J, Garcia F, Lopez-Guillermo A, Colomo L, Campo E, Martinez A
Mod Pathol 2017 May;30(5):745-760. Epub 2017 Jan 13 doi: 10.1038/modpathol.2016.233. PMID: 28084335
Yamada M, Katano H, Yotsumoto M, Hashimoto H, Muramatsu T, Shiotsuka M, Fukutake K, Kuroda M
Int J Clin Exp Pathol 2014;7(9):6415-8. Epub 2014 Aug 15 PMID: 25337302Free PMC Article
Tedeschi R, Marus A, Bidoli E, Simonelli C, De Paoli P
J Clin Virol 2008 Nov;43(3):255-9. Epub 2008 Aug 23 doi: 10.1016/j.jcv.2008.07.005. PMID: 18723390

Clinical prediction guides

Gonzalez-Farre B, Martinez D, Lopez-Guerra M, Xipell M, Monclus E, Rovira J, Garcia F, Lopez-Guillermo A, Colomo L, Campo E, Martinez A
Mod Pathol 2017 May;30(5):745-760. Epub 2017 Jan 13 doi: 10.1038/modpathol.2016.233. PMID: 28084335

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