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HHV8-Related Lymphoproliferative Disorder

MedGen UID:
1664303
•Concept ID:
C4725702
•
Disease or Syndrome
Synonym: HHV8-Associated Lymphoproliferative Disorder

Definition

A lymphoproliferative disorder caused by the human herpesvirus HHV8. This category includes HHV8-positive multicentric Castleman disease, HHV8-positive diffuse large B-cell lymphoma, not otherwise specified, and germinotropic lymphoproliferative disorders. [from NCI]

Recent clinical studies

Etiology

Idiopathic plasmacytic lymphadenopathy: A conceptual history along with a translation of the original Japanese article published in 1980.
Takeuchi K
J Clin Exp Hematop 2022;62(2):79-84. doi: 10.3960/jslrt.22011. PMID: 35768240Free PMC Article
Historical and pathological overview of Castleman disease.
Nishimura MF, Nishimura Y, Nishikori A, Yoshino T, Sato Y
J Clin Exp Hematop 2022 Jun 28;62(2):60-72. Epub 2022 Apr 27 doi: 10.3960/jslrt.21036. PMID: 35474035Free PMC Article
Comparison of human herpes virus 8 related primary effusion lymphoma with human herpes virus 8 unrelated primary effusion lymphoma-like lymphoma on the basis of HIV: report of 2 cases and review of 212 cases in the literature.
Kobayashi Y, Kamitsuji Y, Kuroda J, Tsunoda S, Uoshima N, Kimura S, Wada K, Matsumoto Y, Nomura K, Horiike S, Shimazaki C, Yoshikawa T, Taniwaki M
Acta Haematol 2007;117(3):132-44. Epub 2006 Nov 29 doi: 10.1159/000097460. PMID: 17135726

Diagnosis

Idiopathic plasmacytic lymphadenopathy: A conceptual history along with a translation of the original Japanese article published in 1980.
Takeuchi K
J Clin Exp Hematop 2022;62(2):79-84. doi: 10.3960/jslrt.22011. PMID: 35768240Free PMC Article
Historical and pathological overview of Castleman disease.
Nishimura MF, Nishimura Y, Nishikori A, Yoshino T, Sato Y
J Clin Exp Hematop 2022 Jun 28;62(2):60-72. Epub 2022 Apr 27 doi: 10.3960/jslrt.21036. PMID: 35474035Free PMC Article
Human Herpes-8 virus copy to cell ratio: A diagnostic tool in primary effusion lymphoma.
Carne S, Smit E, Price N, Paul J, Guiver M, Tedder R
J Clin Virol 2019 Jul;116:7-10. Epub 2019 Mar 22 doi: 10.1016/j.jcv.2019.03.013. PMID: 30991238
HHV8-related lymphoid proliferations: a broad spectrum of lesions from reactive lymphoid hyperplasia to overt lymphoma.
Gonzalez-Farre B, Martinez D, Lopez-Guerra M, Xipell M, Monclus E, Rovira J, Garcia F, Lopez-Guillermo A, Colomo L, Campo E, Martinez A
Mod Pathol 2017 May;30(5):745-760. Epub 2017 Jan 13 doi: 10.1038/modpathol.2016.233. PMID: 28084335
How I treat HHV8/KSHV-related diseases in posttransplant patients.
Riva G, Luppi M, Barozzi P, Forghieri F, Potenza L
Blood 2012 Nov 15;120(20):4150-9. Epub 2012 Sep 11 doi: 10.1182/blood-2012-04-421412. PMID: 22968461

Therapy

Concurrent development of HIV-negative Kaposi's sarcoma and mycosis fungoides in an elderly Inuit from Canada.
Bedier H, Lin J, Julien LA, Routy JP
BMJ Case Rep 2021 Jan 28;14(1) doi: 10.1136/bcr-2020-238644. PMID: 33509877Free PMC Article
Remission of an HHV8-related extracavitary primary effusion lymphoma in an HIV-positive patient during antiretroviral treatment containing dolutegravir.
Campogiani L, Cerva C, Maffongelli G, Teti E, Pupo L, Vaccarini S, Cantonetti M, Pennica A, Andreoni M, Sarmati L
AIDS Res Ther 2019 Jul 27;16(1):15. doi: 10.1186/s12981-019-0230-6. PMID: 31351487Free PMC Article
Multiple remissions of extracavitary primary effusion lymphoma treated with a single cycle of liposomal doxorubicin in a patient infected with HIV.
Chen J, Mehraj V, Szabo J, Routy B, Michel RP, Routy JP
Curr Oncol 2018 Dec;25(6):e592-e596. Epub 2018 Dec 1 doi: 10.3747/co.25.4119. PMID: 30607128Free PMC Article
Parsonage-Turner syndrome during the treatment of HIV/HHV8-related multicentric Castleman disease.
Patier de la Peña JL, González-García A, Prieto Pareja E, Norman FF, Rojas Marcos J, Benito Paniagua D
Rev Clin Esp (Barc) 2014 Mar;214(2):e15-7. Epub 2013 Dec 21 doi: 10.1016/j.rce.2013.11.009. PMID: 24365755
How I treat HHV8/KSHV-related diseases in posttransplant patients.
Riva G, Luppi M, Barozzi P, Forghieri F, Potenza L
Blood 2012 Nov 15;120(20):4150-9. Epub 2012 Sep 11 doi: 10.1182/blood-2012-04-421412. PMID: 22968461

Prognosis

T-Cells Subsets in Castleman Disease: Analysis of 28 Cases Including Unicentric, Multicentric and HHV8-Related Clinical Forms.
Fraticelli S, Lucioni M, Neri G, Marchiori D, Cristinelli C, Merli M, Monaco R, Borra T, Lazzaro A, Uccella S, Arcaini L, Paulli M
Int J Mol Sci 2023 Apr 25;24(9) doi: 10.3390/ijms24097813. PMID: 37175521Free PMC Article
Epstein-Barr virus reactivation influences clonal evolution in human herpesvirus-8-related lymphoproliferative disorders.
Granai M, Facchetti M, Mancini V, Goedhals J, Sherriff A, Mundo L, Bellan C, Amato T, Sorrentino E, Ungari M, Raphael M, Leoncini L, Facchetti F, Lazzi S
Histopathology 2021 Dec;79(6):1099-1107. Epub 2021 Oct 4 doi: 10.1111/his.14551. PMID: 34431125Free PMC Article
Remission of an HHV8-related extracavitary primary effusion lymphoma in an HIV-positive patient during antiretroviral treatment containing dolutegravir.
Campogiani L, Cerva C, Maffongelli G, Teti E, Pupo L, Vaccarini S, Cantonetti M, Pennica A, Andreoni M, Sarmati L
AIDS Res Ther 2019 Jul 27;16(1):15. doi: 10.1186/s12981-019-0230-6. PMID: 31351487Free PMC Article
HHV8-related lymphoid proliferations: a broad spectrum of lesions from reactive lymphoid hyperplasia to overt lymphoma.
Gonzalez-Farre B, Martinez D, Lopez-Guerra M, Xipell M, Monclus E, Rovira J, Garcia F, Lopez-Guillermo A, Colomo L, Campo E, Martinez A
Mod Pathol 2017 May;30(5):745-760. Epub 2017 Jan 13 doi: 10.1038/modpathol.2016.233. PMID: 28084335
Human herpesvirus 8 DNA quantification in matched plasma and PBMCs samples of patients with HHV8-related lymphoproliferative diseases.
Tedeschi R, Marus A, Bidoli E, Simonelli C, De Paoli P
J Clin Virol 2008 Nov;43(3):255-9. Epub 2008 Aug 23 doi: 10.1016/j.jcv.2008.07.005. PMID: 18723390

Clinical prediction guides

HHV8-related lymphoid proliferations: a broad spectrum of lesions from reactive lymphoid hyperplasia to overt lymphoma.
Gonzalez-Farre B, Martinez D, Lopez-Guerra M, Xipell M, Monclus E, Rovira J, Garcia F, Lopez-Guillermo A, Colomo L, Campo E, Martinez A
Mod Pathol 2017 May;30(5):745-760. Epub 2017 Jan 13 doi: 10.1038/modpathol.2016.233. PMID: 28084335

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