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Cutaneous Melanoma of the Extremity

MedGen UID:
1664542
•Concept ID:
C4743979
•
Neoplastic Process
Synonyms: Primary Cutaneous Melanoma of the Extremity; Primary Extremity Melanoma; Primary Melanoma of the Extremity

Definition

A cutaneous melanoma that arises from the upper or lower extremity. [from NCI]

Professional guidelines

PubMed

Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142
In-transit metastatic cutaneous melanoma: current management and future directions.
Patel A, Carr MJ, Sun J, Zager JS
Clin Exp Metastasis 2022 Feb;39(1):201-211. Epub 2021 May 17 doi: 10.1007/s10585-021-10100-3. PMID: 33999365
Primary excision margins, sentinel lymph node biopsy, and completion lymph node dissection in cutaneous melanoma: a clinical practice guideline.
Wright FC, Souter LH, Kellett S, Easson A, Murray C, Toye J, McCready D, Nessim C, Ghazarian D, Hong NJL, Johnson S, Goldstein DP, Petrella T; Melanoma Disease Site Group
Curr Oncol 2019 Aug;26(4):e541-e550. Epub 2019 Aug 1 doi: 10.3747/co.26.4885. PMID: 31548823Free PMC Article

Recent clinical studies

Etiology

Melanoma.
Usatine RP, Heath CR
J Fam Pract 2022 May;71(4):178-179. doi: 10.12788/jfp.0410. PMID: 35730705
Melanoma of the Hands and Feet (With Reconstruction).
Ruffolo AM, Sampath AJ, Kozlow JH, Neumeister MW
Clin Plast Surg 2021 Oct;48(4):687-698. Epub 2021 Jun 27 doi: 10.1016/j.cps.2021.05.009. PMID: 34503729
Primary excision margins, sentinel lymph node biopsy, and completion lymph node dissection in cutaneous melanoma: a clinical practice guideline.
Wright FC, Souter LH, Kellett S, Easson A, Murray C, Toye J, McCready D, Nessim C, Ghazarian D, Hong NJL, Johnson S, Goldstein DP, Petrella T; Melanoma Disease Site Group
Curr Oncol 2019 Aug;26(4):e541-e550. Epub 2019 Aug 1 doi: 10.3747/co.26.4885. PMID: 31548823Free PMC Article
Diagnosis and treatment of in-transit melanoma metastases.
Testori A, Ribero S, Bataille V
Eur J Surg Oncol 2017 Mar;43(3):544-560. Epub 2016 Oct 27 doi: 10.1016/j.ejso.2016.10.005. PMID: 27923593
Nail-bed melanoma.
Klausner JM, Inbar M, Gutman M, Weiss G, Skornick Y, Chaichik S, Rozin RR
J Surg Oncol 1987 Mar;34(3):208-10. doi: 10.1002/jso.2930340317. PMID: 3821128

Diagnosis

Melanoma.
Usatine RP, Heath CR
J Fam Pract 2022 May;71(4):178-179. doi: 10.12788/jfp.0410. PMID: 35730705
More than just acral melanoma: the controversies of defining the disease.
Bernardes SS, Ferreira I, Elder DE, Nobre AB, Martínez-Said H, Adams DJ, Robles-Espinoza CD, Possik PA
J Pathol Clin Res 2021 Nov;7(6):531-541. Epub 2021 Jul 2 doi: 10.1002/cjp2.233. PMID: 34213090Free PMC Article
Primary excision margins, sentinel lymph node biopsy, and completion lymph node dissection in cutaneous melanoma: a clinical practice guideline.
Wright FC, Souter LH, Kellett S, Easson A, Murray C, Toye J, McCready D, Nessim C, Ghazarian D, Hong NJL, Johnson S, Goldstein DP, Petrella T; Melanoma Disease Site Group
Curr Oncol 2019 Aug;26(4):e541-e550. Epub 2019 Aug 1 doi: 10.3747/co.26.4885. PMID: 31548823Free PMC Article
Early detection of acral melanoma: A review of clinical, dermoscopic, histopathologic, and molecular characteristics.
Darmawan CC, Jo G, Montenegro SE, Kwak Y, Cheol L, Cho KH, Mun JH
J Am Acad Dermatol 2019 Sep;81(3):805-812. Epub 2019 Feb 5 doi: 10.1016/j.jaad.2019.01.081. PMID: 30731177
Acral Lentiginous Melanoma.
Goydos JS, Shoen SL
Cancer Treat Res 2016;167:321-9. doi: 10.1007/978-3-319-22539-5_14. PMID: 26601870

Therapy

Dendritic cell vaccines targeting tumor blood vessel antigens in combination with dasatinib induce therapeutic immune responses in patients with checkpoint-refractory advanced melanoma.
Storkus WJ, Maurer D, Lin Y, Ding F, Bose A, Lowe D, Rose A, DeMark M, Karapetyan L, Taylor JL, Chelvanambi M, Fecek RJ, Filderman JN, Looney TJ, Miller L, Linch E, Lowman GM, Kalinski P, Butterfield LH, Tarhini A, Tawbi H, Kirkwood JM
J Immunother Cancer 2021 Nov;9(11) doi: 10.1136/jitc-2021-003675. PMID: 34782430Free PMC Article
The ban of the ipsilateral limb as a skin graft donor site after melanoma excision: A critical review.
Hage JJ, van Akkooi ACJ
J Plast Reconstr Aesthet Surg 2021 Jun;74(6):1303-1308. Epub 2021 Jan 8 doi: 10.1016/j.bjps.2020.12.078. PMID: 33483262
Primary excision margins, sentinel lymph node biopsy, and completion lymph node dissection in cutaneous melanoma: a clinical practice guideline.
Wright FC, Souter LH, Kellett S, Easson A, Murray C, Toye J, McCready D, Nessim C, Ghazarian D, Hong NJL, Johnson S, Goldstein DP, Petrella T; Melanoma Disease Site Group
Curr Oncol 2019 Aug;26(4):e541-e550. Epub 2019 Aug 1 doi: 10.3747/co.26.4885. PMID: 31548823Free PMC Article
Diagnosis and treatment of in-transit melanoma metastases.
Testori A, Ribero S, Bataille V
Eur J Surg Oncol 2017 Mar;43(3):544-560. Epub 2016 Oct 27 doi: 10.1016/j.ejso.2016.10.005. PMID: 27923593
The role of regional chemotherapy in the management of extremity soft tissue malignancies.
Smith HG, Hayes AJ
Eur J Surg Oncol 2016 Jan;42(1):7-17. Epub 2015 Sep 4 doi: 10.1016/j.ejso.2015.08.165. PMID: 26382102

Prognosis

Plantar Melanoma: An Investigation of Its Incidence.
An M, Blekher L, Liu M, Pitre M, Shaner R, Silva D, Vlahovic TC
Clin Podiatr Med Surg 2021 Oct;38(4):595-599. doi: 10.1016/j.cpm.2021.06.012. PMID: 34538438
More than just acral melanoma: the controversies of defining the disease.
Bernardes SS, Ferreira I, Elder DE, Nobre AB, Martínez-Said H, Adams DJ, Robles-Espinoza CD, Possik PA
J Pathol Clin Res 2021 Nov;7(6):531-541. Epub 2021 Jul 2 doi: 10.1002/cjp2.233. PMID: 34213090Free PMC Article
Early detection of acral melanoma: A review of clinical, dermoscopic, histopathologic, and molecular characteristics.
Darmawan CC, Jo G, Montenegro SE, Kwak Y, Cheol L, Cho KH, Mun JH
J Am Acad Dermatol 2019 Sep;81(3):805-812. Epub 2019 Feb 5 doi: 10.1016/j.jaad.2019.01.081. PMID: 30731177
Subungual Melanoma of the Hand.
Chakera AH, Quinn MJ, Lo S, Drummond M, Haydu LE, Bond JS, Stretch JR, Saw RPM, Lee KJ, McCarthy WH, Scolyer RA, Thompson JF
Ann Surg Oncol 2019 Apr;26(4):1035-1043. Epub 2018 Dec 18 doi: 10.1245/s10434-018-07094-w. PMID: 30565042
Nail-bed melanoma.
Klausner JM, Inbar M, Gutman M, Weiss G, Skornick Y, Chaichik S, Rozin RR
J Surg Oncol 1987 Mar;34(3):208-10. doi: 10.1002/jso.2930340317. PMID: 3821128

Clinical prediction guides

More than just acral melanoma: the controversies of defining the disease.
Bernardes SS, Ferreira I, Elder DE, Nobre AB, Martínez-Said H, Adams DJ, Robles-Espinoza CD, Possik PA
J Pathol Clin Res 2021 Nov;7(6):531-541. Epub 2021 Jul 2 doi: 10.1002/cjp2.233. PMID: 34213090Free PMC Article
The ban of the ipsilateral limb as a skin graft donor site after melanoma excision: A critical review.
Hage JJ, van Akkooi ACJ
J Plast Reconstr Aesthet Surg 2021 Jun;74(6):1303-1308. Epub 2021 Jan 8 doi: 10.1016/j.bjps.2020.12.078. PMID: 33483262
Primary excision margins, sentinel lymph node biopsy, and completion lymph node dissection in cutaneous melanoma: a clinical practice guideline.
Wright FC, Souter LH, Kellett S, Easson A, Murray C, Toye J, McCready D, Nessim C, Ghazarian D, Hong NJL, Johnson S, Goldstein DP, Petrella T; Melanoma Disease Site Group
Curr Oncol 2019 Aug;26(4):e541-e550. Epub 2019 Aug 1 doi: 10.3747/co.26.4885. PMID: 31548823Free PMC Article
Sentinel Lymph Node Biopsy and Complete Lymph Node Dissection for Melanoma.
Falk Delgado A, Zommorodi S, Falk Delgado A
Curr Oncol Rep 2019 Apr 26;21(6):54. doi: 10.1007/s11912-019-0798-y. PMID: 31028497Free PMC Article
Subungual Melanoma of the Hand.
Chakera AH, Quinn MJ, Lo S, Drummond M, Haydu LE, Bond JS, Stretch JR, Saw RPM, Lee KJ, McCarthy WH, Scolyer RA, Thompson JF
Ann Surg Oncol 2019 Apr;26(4):1035-1043. Epub 2018 Dec 18 doi: 10.1245/s10434-018-07094-w. PMID: 30565042

Recent systematic reviews

Hyperthermia in the treatment of high-risk soft tissue sarcomas: a systematic review.
Veltsista PD, Oberacker E, Ademaj A, Corradini S, Eckert F, Flörcken A, Kaul D, Lindner LH, Issels R, Ott OJ, Pink D, Potkrajcic V, Reichardt P, Roohani S, Spalek MJ, Riesterer O, Zips D, Ghadjar P
Int J Hyperthermia 2023;40(1):2236337. doi: 10.1080/02656736.2023.2236337. PMID: 37468132
Metastases to the nail unit and distal phalanx: a systematic review.
Curtis KL, Lipner SR
Arch Dermatol Res 2023 Apr;315(3):347-358. Epub 2022 Oct 19 doi: 10.1007/s00403-022-02411-6. PMID: 36260150
Balloon cell melanoma: a systematic review.
Wei G, Hennessy K, Kevin Heard L, Gaudi S, Mhaskar R, Patel RR, Bennett AE
Int J Dermatol 2022 Mar;61(3):266-277. Epub 2021 Mar 1 doi: 10.1111/ijd.15448. PMID: 33645660
Melanoma of the hand and foot: epidemiological, prognostic and genetic features. A systematic review.
Durbec F, Martin L, Derancourt C, Grange F
Br J Dermatol 2012 Apr;166(4):727-39. doi: 10.1111/j.1365-2133.2011.10772.x. PMID: 22175696
Isolated limb perfusion for malignant melanoma: systematic review on effectiveness and safety.
Moreno-Ramirez D, de la Cruz-Merino L, Ferrandiz L, Villegas-Portero R, Nieto-Garcia A
Oncologist 2010;15(4):416-27. Epub 2010 Mar 26 doi: 10.1634/theoncologist.2009-0325. PMID: 20348274Free PMC Article

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