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Refractory Mediastinal Lymphoma

MedGen UID:
1664882
•Concept ID:
C4727075
•
Neoplastic Process
Synonym: Refractory Primary Mediastinal Lymphoma

Definition

Mediastinal lymphoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Mediastinal Lymphoma

Professional guidelines

PubMed

Diagnosis and management of lymphoblastic lymphoma in children, adolescents and young adults.
Temple WC, Mueller S, Hermiston ML, Burkhardt B
Best Pract Res Clin Haematol 2023 Mar;36(1):101449. Epub 2023 Feb 16 doi: 10.1016/j.beha.2023.101449. PMID: 36907639
Primary Mediastinal B-Cell Lymphoma: A 2021 Update on Genetics, Diagnosis, and Novel Therapeutics.
Ahmed Z, Afridi SS, Shahid Z, Zamani Z, Rehman S, Aiman W, Khan M, Mir MA, Awan FT, Anwer F, Iftikhar R
Clin Lymphoma Myeloma Leuk 2021 Nov;21(11):e865-e875. Epub 2021 Jun 24 doi: 10.1016/j.clml.2021.06.012. PMID: 34330673
Treatment of relapsed/refractory paediatric aggressive B-cell non-Hodgkin lymphoma.
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616

Recent clinical studies

Etiology

Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study.
Abramson JS, Palomba ML, Gordon LI, Lunning MA, Wang M, Arnason J, Mehta A, Purev E, Maloney DG, Andreadis C, Sehgal A, Solomon SR, Ghosh N, Albertson TM, Garcia J, Kostic A, Mallaney M, Ogasawara K, Newhall K, Kim Y, Li D, Siddiqi T
Lancet 2020 Sep 19;396(10254):839-852. Epub 2020 Sep 1 doi: 10.1016/S0140-6736(20)31366-0. PMID: 32888407
Treatment of relapsed/refractory paediatric aggressive B-cell non-Hodgkin lymphoma.
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
Pembrolizumab in Relapsed or Refractory Primary Mediastinal Large B-Cell Lymphoma.
Armand P, Rodig S, Melnichenko V, Thieblemont C, Bouabdallah K, Tumyan G, Özcan M, Portino S, Fogliatto L, Caballero MD, Walewski J, Gulbas Z, Ribrag V, Christian B, Perini GF, Salles G, Svoboda J, Zain J, Patel S, Chen PH, Ligon AH, Ouyang J, Neuberg D, Redd R, Chatterjee A, Balakumaran A, Orlowski R, Shipp M, Zinzani PL
J Clin Oncol 2019 Dec 1;37(34):3291-3299. Epub 2019 Oct 14 doi: 10.1200/JCO.19.01389. PMID: 31609651Free PMC Article
Nivolumab Combined With Brentuximab Vedotin for Relapsed/Refractory Primary Mediastinal Large B-Cell Lymphoma: Efficacy and Safety From the Phase II CheckMate 436 Study.
Zinzani PL, Santoro A, Gritti G, Brice P, Barr PM, Kuruvilla J, Cunningham D, Kline J, Johnson NA, Mehta-Shah N, Manley T, Francis S, Sharma M, Moskowitz AJ
J Clin Oncol 2019 Nov 20;37(33):3081-3089. Epub 2019 Aug 9 doi: 10.1200/JCO.19.01492. PMID: 31398081Free PMC Article
Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1-2 trial.
Locke FL, Ghobadi A, Jacobson CA, Miklos DB, Lekakis LJ, Oluwole OO, Lin Y, Braunschweig I, Hill BT, Timmerman JM, Deol A, Reagan PM, Stiff P, Flinn IW, Farooq U, Goy A, McSweeney PA, Munoz J, Siddiqi T, Chavez JC, Herrera AF, Bartlett NL, Wiezorek JS, Navale L, Xue A, Jiang Y, Bot A, Rossi JM, Kim JJ, Go WY, Neelapu SS
Lancet Oncol 2019 Jan;20(1):31-42. Epub 2018 Dec 2 doi: 10.1016/S1470-2045(18)30864-7. PMID: 30518502Free PMC Article

Diagnosis

Diagnosis and management of lymphoblastic lymphoma in children, adolescents and young adults.
Temple WC, Mueller S, Hermiston ML, Burkhardt B
Best Pract Res Clin Haematol 2023 Mar;36(1):101449. Epub 2023 Feb 16 doi: 10.1016/j.beha.2023.101449. PMID: 36907639
Primary mediastinal large B-cell lymphoma.
Savage KJ
Blood 2022 Sep 1;140(9):955-970. doi: 10.1182/blood.2020008376. PMID: 34496020
Primary Mediastinal B-Cell Lymphoma: A 2021 Update on Genetics, Diagnosis, and Novel Therapeutics.
Ahmed Z, Afridi SS, Shahid Z, Zamani Z, Rehman S, Aiman W, Khan M, Mir MA, Awan FT, Anwer F, Iftikhar R
Clin Lymphoma Myeloma Leuk 2021 Nov;21(11):e865-e875. Epub 2021 Jun 24 doi: 10.1016/j.clml.2021.06.012. PMID: 34330673
Treatment of relapsed/refractory paediatric aggressive B-cell non-Hodgkin lymphoma.
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
Lymphoblastic lymphoma in children and adolescents: review of current challenges and future opportunities.
Burkhardt B, Hermiston ML
Br J Haematol 2019 Jun;185(6):1158-1170. Epub 2019 Feb 27 doi: 10.1111/bjh.15793. PMID: 30809797

Therapy

Primary mediastinal large B-cell lymphoma.
Savage KJ
Blood 2022 Sep 1;140(9):955-970. doi: 10.1182/blood.2020008376. PMID: 34496020
Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study.
Abramson JS, Palomba ML, Gordon LI, Lunning MA, Wang M, Arnason J, Mehta A, Purev E, Maloney DG, Andreadis C, Sehgal A, Solomon SR, Ghosh N, Albertson TM, Garcia J, Kostic A, Mallaney M, Ogasawara K, Newhall K, Kim Y, Li D, Siddiqi T
Lancet 2020 Sep 19;396(10254):839-852. Epub 2020 Sep 1 doi: 10.1016/S0140-6736(20)31366-0. PMID: 32888407
Treatment of relapsed/refractory paediatric aggressive B-cell non-Hodgkin lymphoma.
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1-2 trial.
Locke FL, Ghobadi A, Jacobson CA, Miklos DB, Lekakis LJ, Oluwole OO, Lin Y, Braunschweig I, Hill BT, Timmerman JM, Deol A, Reagan PM, Stiff P, Flinn IW, Farooq U, Goy A, McSweeney PA, Munoz J, Siddiqi T, Chavez JC, Herrera AF, Bartlett NL, Wiezorek JS, Navale L, Xue A, Jiang Y, Bot A, Rossi JM, Kim JJ, Go WY, Neelapu SS
Lancet Oncol 2019 Jan;20(1):31-42. Epub 2018 Dec 2 doi: 10.1016/S1470-2045(18)30864-7. PMID: 30518502Free PMC Article
Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma.
Neelapu SS, Locke FL, Bartlett NL, Lekakis LJ, Miklos DB, Jacobson CA, Braunschweig I, Oluwole OO, Siddiqi T, Lin Y, Timmerman JM, Stiff PJ, Friedberg JW, Flinn IW, Goy A, Hill BT, Smith MR, Deol A, Farooq U, McSweeney P, Munoz J, Avivi I, Castro JE, Westin JR, Chavez JC, Ghobadi A, Komanduri KV, Levy R, Jacobsen ED, Witzig TE, Reagan P, Bot A, Rossi J, Navale L, Jiang Y, Aycock J, Elias M, Chang D, Wiezorek J, Go WY
N Engl J Med 2017 Dec 28;377(26):2531-2544. Epub 2017 Dec 10 doi: 10.1056/NEJMoa1707447. PMID: 29226797Free PMC Article

Prognosis

Diagnosis and management of lymphoblastic lymphoma in children, adolescents and young adults.
Temple WC, Mueller S, Hermiston ML, Burkhardt B
Best Pract Res Clin Haematol 2023 Mar;36(1):101449. Epub 2023 Feb 16 doi: 10.1016/j.beha.2023.101449. PMID: 36907639
Treatment of relapsed/refractory paediatric aggressive B-cell non-Hodgkin lymphoma.
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
Lymphoblastic lymphoma in children and adolescents: review of current challenges and future opportunities.
Burkhardt B, Hermiston ML
Br J Haematol 2019 Jun;185(6):1158-1170. Epub 2019 Feb 27 doi: 10.1111/bjh.15793. PMID: 30809797
Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1-2 trial.
Locke FL, Ghobadi A, Jacobson CA, Miklos DB, Lekakis LJ, Oluwole OO, Lin Y, Braunschweig I, Hill BT, Timmerman JM, Deol A, Reagan PM, Stiff P, Flinn IW, Farooq U, Goy A, McSweeney PA, Munoz J, Siddiqi T, Chavez JC, Herrera AF, Bartlett NL, Wiezorek JS, Navale L, Xue A, Jiang Y, Bot A, Rossi JM, Kim JJ, Go WY, Neelapu SS
Lancet Oncol 2019 Jan;20(1):31-42. Epub 2018 Dec 2 doi: 10.1016/S1470-2045(18)30864-7. PMID: 30518502Free PMC Article
Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma.
Neelapu SS, Locke FL, Bartlett NL, Lekakis LJ, Miklos DB, Jacobson CA, Braunschweig I, Oluwole OO, Siddiqi T, Lin Y, Timmerman JM, Stiff PJ, Friedberg JW, Flinn IW, Goy A, Hill BT, Smith MR, Deol A, Farooq U, McSweeney P, Munoz J, Avivi I, Castro JE, Westin JR, Chavez JC, Ghobadi A, Komanduri KV, Levy R, Jacobsen ED, Witzig TE, Reagan P, Bot A, Rossi J, Navale L, Jiang Y, Aycock J, Elias M, Chang D, Wiezorek J, Go WY
N Engl J Med 2017 Dec 28;377(26):2531-2544. Epub 2017 Dec 10 doi: 10.1056/NEJMoa1707447. PMID: 29226797Free PMC Article

Clinical prediction guides

Nivolumab combined with brentuximab vedotin for R/R primary mediastinal large B-cell lymphoma: a 3-year follow-up.
Zinzani PL, Santoro A, Gritti G, Brice P, Barr PM, Kuruvilla J, Cunningham D, Kline J, Johnson NA, Mehta-Shah N, Lisano J, Wen R, Akyol A, Moskowitz AJ
Blood Adv 2023 Sep 26;7(18):5272-5280. doi: 10.1182/bloodadvances.2023010254. PMID: 37352266Free PMC Article
Ibrutinib plus RICE or RVICI for relapsed/refractory mature B-cell non-Hodgkin lymphoma in children and young adults: SPARKLE trial.
Burke GAA, Vinti L, Kabickova E, Beishuizen A, Tacyildiz N, Uyttebroeck A, Kang HJ, Luisi F, Minard-Colin V, Burkhardt B, Tamegnon M, Sun S, Curtis M, Deshpande S, Nottage K, Howes A, Srinivasan S, Bhojwani D, Norris R, Cairo M
Blood Adv 2023 Feb 28;7(4):602-610. doi: 10.1182/bloodadvances.2022008802. PMID: 36541957Free PMC Article
Interim FDG-PET Imaging in Lymphoma.
Gallamini A, Zwarthoed C
Semin Nucl Med 2018 Jan;48(1):17-27. Epub 2017 Oct 14 doi: 10.1053/j.semnuclmed.2017.09.002. PMID: 29195613
PD-1 expression and clinical PD-1 blockade in B-cell lymphomas.
Xu-Monette ZY, Zhou J, Young KH
Blood 2018 Jan 4;131(1):68-83. Epub 2017 Nov 8 doi: 10.1182/blood-2017-07-740993. PMID: 29118007Free PMC Article
A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: cancer and leukemia group B study 8811.
Larson RA, Dodge RK, Burns CP, Lee EJ, Stone RM, Schulman P, Duggan D, Davey FR, Sobol RE, Frankel SR
Blood 1995 Apr 15;85(8):2025-37. PMID: 7718875

Recent systematic reviews

Primary Mediastinal B Cell Lymphoma in the Positron-Emission Tomography Era Executive Summary of the American Radium Society Appropriate Use Criteria.
Hoppe BS, Advani R, Milgrom SA, Bakst RL, Ballas LK, Dabaja BS, Flowers CR, Ha CS, Mansur DB, Metzger ML, Pinnix CC, Plastaras JP, Roberts KB, Smith SM, Terezakis SA, Kirwan JM, Constine LS
Int J Radiat Oncol Biol Phys 2021 Sep 1;111(1):36-44. Epub 2021 Mar 24 doi: 10.1016/j.ijrobp.2021.03.035. PMID: 33774076
Relapsed/refractory primary mediastinal large B-cell lymphoma: a structured review of epidemiology, treatment guidelines and real-world treatment practices.
Takyar J, Raut M, Borse R, Balakumaran A, Sehgal M
Expert Rev Hematol 2020 Mar;13(3):275-287. Epub 2020 Jan 28 doi: 10.1080/17474086.2020.1716725. PMID: 31951774
Brentuximab vedotin for treatment of non-Hodgkin lymphomas: A systematic review.
Berger GK, McBride A, Lawson S, Royball K, Yun S, Gee K, Bin Riaz I, Saleh AA, Puvvada S, Anwer F
Crit Rev Oncol Hematol 2017 Jan;109:42-50. Epub 2016 Nov 21 doi: 10.1016/j.critrevonc.2016.11.009. PMID: 28010897Free PMC Article

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