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Squamous cell carcinoma (mostly on sun-exposed areas)

MedGen UID:
1665492
•Concept ID:
C4748877
•
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSquamous cell carcinoma (mostly on sun-exposed areas)

Professional guidelines

PubMed

Real-world approach to actinic keratosis management: practical treatment algorithm for office-based dermatology.
Dirschka T, Gupta G, Micali G, Stockfleth E, Basset-Séguin N, Del Marmol V, Dummer R, Jemec GBE, Malvehy J, Peris K, Puig S, Stratigos AJ, Zalaudek I, Pellacani G
J Dermatolog Treat 2017 Aug;28(5):431-442. Epub 2016 Nov 13 doi: 10.1080/09546634.2016.1254328. PMID: 27796187
Managing actinic keratosis in primary care.
Salmon N, Tidman MJ
Practitioner 2016 Oct;260(1797):25-9. PMID: 29016090
Nonmelanoma skin cancer in solid organ transplant recipients: update on epidemiology, risk factors, and management.
Tessari G, Girolomoni G
Dermatol Surg 2012 Oct;38(10):1622-30. Epub 2012 Jul 17 doi: 10.1111/j.1524-4725.2012.02520.x. PMID: 22805312

Recent clinical studies

Etiology

Hide-and-seek: Neurotropic squamous cell carcinoma of the periorbital region - a series of five cases and review of the literature.
Morandi EM, Rauchenwald T, Puelzl P, Zelger BW, Zelger BG, Henninger B, Pierer G, Wolfram D
J Dtsch Dermatol Ges 2021 Nov;19(11):1571-1580. doi: 10.1111/ddg.14582. PMID: 34811913Free PMC Article
Actinic keratosis: where do we stand and where is the future going to take us?
Cramer P, Stockfleth E
Expert Opin Emerg Drugs 2020 Mar;25(1):49-58. Epub 2020 Feb 20 doi: 10.1080/14728214.2020.1730810. PMID: 32067498
Drug-Induced Photosensitivity-An Update: Culprit Drugs, Prevention and Management.
Blakely KM, Drucker AM, Rosen CF
Drug Saf 2019 Jul;42(7):827-847. doi: 10.1007/s40264-019-00806-5. PMID: 30888626
Managing actinic keratosis in primary care.
Salmon N, Tidman MJ
Practitioner 2016 Oct;260(1797):25-9. PMID: 29016090
Cutaneous squamous cell carcinoma.
Garcia-Zuazaga J, Olbricht SM
Adv Dermatol 2008;24:33-57. doi: 10.1016/j.yadr.2008.09.007. PMID: 19256304

Diagnosis

Current therapies for actinic keratosis.
Dianzani C, Conforti C, Giuffrida R, Corneli P, di Meo N, Farinazzo E, Moret A, Magaton Rizzi G, Zalaudek I
Int J Dermatol 2020 Jun;59(6):677-684. Epub 2020 Feb 3 doi: 10.1111/ijd.14767. PMID: 32012240
Drug-Induced Photosensitivity-An Update: Culprit Drugs, Prevention and Management.
Blakely KM, Drucker AM, Rosen CF
Drug Saf 2019 Jul;42(7):827-847. doi: 10.1007/s40264-019-00806-5. PMID: 30888626
Real-world approach to actinic keratosis management: practical treatment algorithm for office-based dermatology.
Dirschka T, Gupta G, Micali G, Stockfleth E, Basset-Séguin N, Del Marmol V, Dummer R, Jemec GBE, Malvehy J, Peris K, Puig S, Stratigos AJ, Zalaudek I, Pellacani G
J Dermatolog Treat 2017 Aug;28(5):431-442. Epub 2016 Nov 13 doi: 10.1080/09546634.2016.1254328. PMID: 27796187
Keratoacanthoma: a distinct entity?
Gleich T, Chiticariu E, Huber M, Hohl D
Exp Dermatol 2016 Feb;25(2):85-91. Epub 2015 Dec 4 doi: 10.1111/exd.12880. PMID: 26476131
Cutaneous squamous cell carcinoma.
Garcia-Zuazaga J, Olbricht SM
Adv Dermatol 2008;24:33-57. doi: 10.1016/j.yadr.2008.09.007. PMID: 19256304

Therapy

Actinic keratosis: where do we stand and where is the future going to take us?
Cramer P, Stockfleth E
Expert Opin Emerg Drugs 2020 Mar;25(1):49-58. Epub 2020 Feb 20 doi: 10.1080/14728214.2020.1730810. PMID: 32067498
Current therapies for actinic keratosis.
Dianzani C, Conforti C, Giuffrida R, Corneli P, di Meo N, Farinazzo E, Moret A, Magaton Rizzi G, Zalaudek I
Int J Dermatol 2020 Jun;59(6):677-684. Epub 2020 Feb 3 doi: 10.1111/ijd.14767. PMID: 32012240
Drug-Induced Photosensitivity-An Update: Culprit Drugs, Prevention and Management.
Blakely KM, Drucker AM, Rosen CF
Drug Saf 2019 Jul;42(7):827-847. doi: 10.1007/s40264-019-00806-5. PMID: 30888626
Real-world approach to actinic keratosis management: practical treatment algorithm for office-based dermatology.
Dirschka T, Gupta G, Micali G, Stockfleth E, Basset-Séguin N, Del Marmol V, Dummer R, Jemec GBE, Malvehy J, Peris K, Puig S, Stratigos AJ, Zalaudek I, Pellacani G
J Dermatolog Treat 2017 Aug;28(5):431-442. Epub 2016 Nov 13 doi: 10.1080/09546634.2016.1254328. PMID: 27796187
Keratoacanthoma: a distinct entity?
Gleich T, Chiticariu E, Huber M, Hohl D
Exp Dermatol 2016 Feb;25(2):85-91. Epub 2015 Dec 4 doi: 10.1111/exd.12880. PMID: 26476131

Prognosis

Hide-and-seek: Neurotropic squamous cell carcinoma of the periorbital region - a series of five cases and review of the literature.
Morandi EM, Rauchenwald T, Puelzl P, Zelger BW, Zelger BG, Henninger B, Pierer G, Wolfram D
J Dtsch Dermatol Ges 2021 Nov;19(11):1571-1580. doi: 10.1111/ddg.14582. PMID: 34811913Free PMC Article
Chronic sun exposure-related fusion oncogenes EGFR-PPARGC1A in cutaneous squamous cell carcinoma.
Egashira S, Jinnin M, Ajino M, Shimozono N, Okamoto S, Tasaki Y, Hirano A, Ide M, Kajihara I, Aoi J, Harada M, Igata T, Masuguchi S, Fukushima S, Ihn H
Sci Rep 2017 Oct 4;7(1):12654. doi: 10.1038/s41598-017-12836-z. PMID: 28978917Free PMC Article
Claw foot A case report.
Innocenti A, Ciancio F, Taverna C, Tanini S, Portincasa A, Parisi D, Innocenti M, De Giorgi V
Ann Ital Chir 2017;88:368-370. PMID: 28632148
Managing actinic keratosis in primary care.
Salmon N, Tidman MJ
Practitioner 2016 Oct;260(1797):25-9. PMID: 29016090
Cutaneous squamous cell carcinoma.
Garcia-Zuazaga J, Olbricht SM
Adv Dermatol 2008;24:33-57. doi: 10.1016/j.yadr.2008.09.007. PMID: 19256304

Clinical prediction guides

CD8/PD-L1 immunohistochemical reactivity and gene alterations in cutaneous squamous cell carcinoma.
Nishida H, Kondo Y, Kusaba T, Kawamura K, Oyama Y, Daa T
PLoS One 2023;18(2):e0281647. Epub 2023 Feb 13 doi: 10.1371/journal.pone.0281647. PMID: 36780540Free PMC Article
Chronic sun exposure-related fusion oncogenes EGFR-PPARGC1A in cutaneous squamous cell carcinoma.
Egashira S, Jinnin M, Ajino M, Shimozono N, Okamoto S, Tasaki Y, Hirano A, Ide M, Kajihara I, Aoi J, Harada M, Igata T, Masuguchi S, Fukushima S, Ihn H
Sci Rep 2017 Oct 4;7(1):12654. doi: 10.1038/s41598-017-12836-z. PMID: 28978917Free PMC Article
Claw foot A case report.
Innocenti A, Ciancio F, Taverna C, Tanini S, Portincasa A, Parisi D, Innocenti M, De Giorgi V
Ann Ital Chir 2017;88:368-370. PMID: 28632148
Skin cancer associated with the use of sorafenib and sunitinib for renal cell carcinoma.
Breaker K, Naam M, La Rosa FG, Flaig IP, Flaig TW
Dermatol Surg 2013 Jul;39(7):981-7. Epub 2013 Mar 6 doi: 10.1111/dsu.12184. PMID: 23464361
P16 is overexpressed in cutaneous carcinomas located on sun-exposed areas.
Conscience I, Jovenin N, Coissard C, Lorenzato M, Durlach A, Grange F, Birembaut P, Clavel C, Bernard P
Eur J Dermatol 2006 Sep-Oct;16(5):518-22. PMID: 17101472

Recent systematic reviews

Management of actinic keratosis at specific body sites in patients at high risk of carcinoma lesions: expert consensus from the AKTeam™ of expert clinicians.
Richard MA, Amici JM, Basset-Seguin N, Claudel JP, Cribier B, Dreno B
J Eur Acad Dermatol Venereol 2018 Mar;32(3):339-346. Epub 2018 Jan 15 doi: 10.1111/jdv.14753. PMID: 29235161
A qualitative systematic review of the efficacy of sun protection education in organ transplant recipients.
Wu SZ, Jiang P, DeCaro JE, Bordeaux JS
J Am Acad Dermatol 2016 Dec;75(6):1238-1244.e5. Epub 2016 Jul 27 doi: 10.1016/j.jaad.2016.06.031. PMID: 27476105

Supplemental Content

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