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Metastatic Nasopharyngeal Undifferentiated Carcinoma

MedGen UID:
1665937
•Concept ID:
C4744551
•
Neoplastic Process

Definition

An undifferentiated carcinoma that arises from the nasopharynx and has metastasized to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Nasopharyngeal Undifferentiated Carcinoma

Professional guidelines

PubMed

Recurrent/Metastatic Nasopharyngeal Carcinoma Treatment from Present to Future: Where Are We and Where Are We Heading?
Juarez-Vignon Whaley JJ, Afkhami M, Onyshchenko M, Massarelli E, Sampath S, Amini A, Bell D, Villaflor VM
Curr Treat Options Oncol 2023 Sep;24(9):1138-1166. Epub 2023 Jun 15 doi: 10.1007/s11864-023-01101-3. PMID: 37318724Free PMC Article
Chemotherapy in Combination With Radiotherapy for Definitive-Intent Treatment of Stage II-IVA Nasopharyngeal Carcinoma: CSCO and ASCO Guideline.
Chen YP, Ismaila N, Chua MLK, Colevas AD, Haddad R, Huang SH, Wee JTS, Whitley AC, Yi JL, Yom SS, Chan ATC, Hu CS, Lang JY, Le QT, Lee AWM, Lee N, Lin JC, Ma B, Morgan TJ, Shah J, Sun Y, Ma J
J Clin Oncol 2021 Mar 1;39(7):840-859. Epub 2021 Jan 6 doi: 10.1200/JCO.20.03237. PMID: 33405943
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Recent clinical studies

Etiology

Evolutionary route of nasopharyngeal carcinoma metastasis and its clinical significance.
Lin M, Zhang XL, You R, Liu YP, Cai HM, Liu LZ, Liu XF, Zou X, Xie YL, Zou RH, Zhang YN, Sun R, Feng WY, Wang HY, Tao GH, Li HJ, Huang WJ, Zhang C, Huang PY, Wang J, Zhao Q, Yang Q, Zhang HW, Liu T, Li HF, Jiang XB, Tang J, Gu YK, Yu T, Wang ZQ, Feng L, Kang TB, Zuo ZX, Chen MY
Nat Commun 2023 Feb 4;14(1):610. doi: 10.1038/s41467-023-35995-2. PMID: 36739462Free PMC Article
Efficacy, Safety, and Correlative Biomarkers of Toripalimab in Previously Treated Recurrent or Metastatic Nasopharyngeal Carcinoma: A Phase II Clinical Trial (POLARIS-02).
Wang FH, Wei XL, Feng J, Li Q, Xu N, Hu XC, Liao W, Jiang Y, Lin XY, Zhang QY, Yuan XL, Huang HX, Chen Y, Dai GH, Shi JH, Shen L, Yang SJ, Shu YQ, Liu YP, Wang W, Wu H, Feng H, Yao S, Xu RH
J Clin Oncol 2021 Mar 1;39(7):704-712. Epub 2021 Jan 25 doi: 10.1200/JCO.20.02712. PMID: 33492986Free PMC Article
Nasopharyngeal carcinoma.
Chen YP, Chan ATC, Le QT, Blanchard P, Sun Y, Ma J
Lancet 2019 Jul 6;394(10192):64-80. Epub 2019 Jun 6 doi: 10.1016/S0140-6736(19)30956-0. PMID: 31178151
Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Diagnosis

Immunotherapy for nasopharyngeal carcinoma: Current status and prospects (Review).
Huang H, Yao Y, Deng X, Huang Z, Chen Y, Wang Z, Hong H, Huang H, Lin T
Int J Oncol 2023 Aug;63(2) Epub 2023 Jul 7 doi: 10.3892/ijo.2023.5545. PMID: 37417358Free PMC Article
Immunotherapeutic approaches in EBV-associated nasopharyngeal carcinoma.
Li W, Duan X, Chen X, Zhan M, Peng H, Meng Y, Li X, Li XY, Pang G, Dou X
Front Immunol 2022;13:1079515. Epub 2023 Jan 11 doi: 10.3389/fimmu.2022.1079515. PMID: 36713430Free PMC Article
Nasopharyngeal carcinoma.
Chen YP, Chan ATC, Le QT, Blanchard P, Sun Y, Ma J
Lancet 2019 Jul 6;394(10192):64-80. Epub 2019 Jun 6 doi: 10.1016/S0140-6736(19)30956-0. PMID: 31178151
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243
Nasopharyngeal carcinoma.
Chua MLK, Wee JTS, Hui EP, Chan ATC
Lancet 2016 Mar 5;387(10022):1012-1024. Epub 2015 Aug 28 doi: 10.1016/S0140-6736(15)00055-0. PMID: 26321262

Therapy

Toripalimab Plus Chemotherapy for Recurrent or Metastatic Nasopharyngeal Carcinoma: The JUPITER-02 Randomized Clinical Trial.
Mai HQ, Chen QY, Chen D, Hu C, Yang K, Wen J, Li J, Shi Y, Jin F, Xu R, Pan J, Qu S, Li P, Hu C, Liu YC, Jiang Y, He X, Wang HM, Lim WT, Liao W, He X, Chen X, Wang S, Yuan X, Li Q, Lin X, Jing S, Chen Y, Lu Y, Hsieh CY, Yang MH, Yen CJ, Samol J, Luo X, Wang X, Tang X, Feng H, Yao S, Keegan P, Xu RH
JAMA 2023 Nov 28;330(20):1961-1970. doi: 10.1001/jama.2023.20181. PMID: 38015220Free PMC Article
Immunotherapy for nasopharyngeal carcinoma: Current status and prospects (Review).
Huang H, Yao Y, Deng X, Huang Z, Chen Y, Wang Z, Hong H, Huang H, Lin T
Int J Oncol 2023 Aug;63(2) Epub 2023 Jul 7 doi: 10.3892/ijo.2023.5545. PMID: 37417358Free PMC Article
Efficacy, Safety, and Correlative Biomarkers of Toripalimab in Previously Treated Recurrent or Metastatic Nasopharyngeal Carcinoma: A Phase II Clinical Trial (POLARIS-02).
Wang FH, Wei XL, Feng J, Li Q, Xu N, Hu XC, Liao W, Jiang Y, Lin XY, Zhang QY, Yuan XL, Huang HX, Chen Y, Dai GH, Shi JH, Shen L, Yang SJ, Shu YQ, Liu YP, Wang W, Wu H, Feng H, Yao S, Xu RH
J Clin Oncol 2021 Mar 1;39(7):704-712. Epub 2021 Jan 25 doi: 10.1200/JCO.20.02712. PMID: 33492986Free PMC Article
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243
Nasopharyngeal carcinoma.
Chua MLK, Wee JTS, Hui EP, Chan ATC
Lancet 2016 Mar 5;387(10022):1012-1024. Epub 2015 Aug 28 doi: 10.1016/S0140-6736(15)00055-0. PMID: 26321262

Prognosis

Refining the 8th edition TNM classification for EBV related nasopharyngeal carcinoma.
Du XJ, Wang GY, Zhu XD, Han YQ, Lei F, Shen LF, Yang KY, Chen L, Mao YP, Tang LL, Li L, Wu Z, Xu GQ, Zhou Q, Huang J, Guo R, Zhang Y, Liu X, Zhou GQ, Li WF, Xu C, Lin L, Chen YP, Chen FP, Liang XY, Chen SY, Li SQ, Cui CY, Li JB, Ren J, Chen MY, Liu LZ, Sun Y, Ma J
Cancer Cell 2024 Mar 11;42(3):464-473.e3. Epub 2024 Jan 18 doi: 10.1016/j.ccell.2023.12.020. PMID: 38242125
Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546
Antitumor Activity of Nivolumab in Recurrent and Metastatic Nasopharyngeal Carcinoma: An International, Multicenter Study of the Mayo Clinic Phase 2 Consortium (NCI-9742).
Ma BBY, Lim WT, Goh BC, Hui EP, Lo KW, Pettinger A, Foster NR, Riess JW, Agulnik M, Chang AYC, Chopra A, Kish JA, Chung CH, Adkins DR, Cullen KJ, Gitlitz BJ, Lim DW, To KF, Chan KCA, Lo YMD, King AD, Erlichman C, Yin J, Costello BA, Chan ATC
J Clin Oncol 2018 May 10;36(14):1412-1418. Epub 2018 Mar 27 doi: 10.1200/JCO.2017.77.0388. PMID: 29584545Free PMC Article
Nasopharyngeal carcinoma: a review.
Petersson F
Semin Diagn Pathol 2015 Jan;32(1):54-73. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.021. PMID: 25769204
Nasopharyngeal carcinoma.
Wei WI, Sham JS
Lancet 2005 Jun 11-17;365(9476):2041-54. doi: 10.1016/S0140-6736(05)66698-6. PMID: 15950718

Clinical prediction guides

Effect of Radiotherapy Alone vs Radiotherapy With Concurrent Chemoradiotherapy on Survival Without Disease Relapse in Patients With Low-risk Nasopharyngeal Carcinoma: A Randomized Clinical Trial.
Tang LL, Guo R, Zhang N, Deng B, Chen L, Cheng ZB, Huang J, Hu WH, Huang SH, Luo WJ, Liang JH, Zheng YM, Zhang F, Mao YP, Li WF, Zhou GQ, Liu X, Chen YP, Xu C, Lin L, Liu Q, Du XJ, Zhang Y, Sun Y, Ma J
JAMA 2022 Aug 23;328(8):728-736. doi: 10.1001/jama.2022.13997. PMID: 35997729Free PMC Article
DNTTIP1 promotes nasopharyngeal carcinoma metastasis via recruiting HDAC1 to DUSP2 promoter and activating ERK signaling pathway.
Ding S, Gao Y, Lv D, Tao Y, Liu S, Chen C, Huang Z, Zheng S, Hu Y, Chow LK, Wei Y, Feng P, Dai W, Wang X, Xia Y
EBioMedicine 2022 Jul;81:104100. Epub 2022 Jun 8 doi: 10.1016/j.ebiom.2022.104100. PMID: 35689852Free PMC Article
Efficacy, Safety, and Correlative Biomarkers of Toripalimab in Previously Treated Recurrent or Metastatic Nasopharyngeal Carcinoma: A Phase II Clinical Trial (POLARIS-02).
Wang FH, Wei XL, Feng J, Li Q, Xu N, Hu XC, Liao W, Jiang Y, Lin XY, Zhang QY, Yuan XL, Huang HX, Chen Y, Dai GH, Shi JH, Shen L, Yang SJ, Shu YQ, Liu YP, Wang W, Wu H, Feng H, Yao S, Xu RH
J Clin Oncol 2021 Mar 1;39(7):704-712. Epub 2021 Jan 25 doi: 10.1200/JCO.20.02712. PMID: 33492986Free PMC Article
Nasopharyngeal carcinoma.
Chen YP, Chan ATC, Le QT, Blanchard P, Sun Y, Ma J
Lancet 2019 Jul 6;394(10192):64-80. Epub 2019 Jun 6 doi: 10.1016/S0140-6736(19)30956-0. PMID: 31178151
Development and validation of a gene expression-based signature to predict distant metastasis in locoregionally advanced nasopharyngeal carcinoma: a retrospective, multicentre, cohort study.
Tang XR, Li YQ, Liang SB, Jiang W, Liu F, Ge WX, Tang LL, Mao YP, He QM, Yang XJ, Zhang Y, Wen X, Zhang J, Wang YQ, Zhang PP, Sun Y, Yun JP, Zeng J, Li L, Liu LZ, Liu N, Ma J
Lancet Oncol 2018 Mar;19(3):382-393. Epub 2018 Feb 7 doi: 10.1016/S1470-2045(18)30080-9. PMID: 29428165

Recent systematic reviews

Efficacy and safety of PD-1 inhibitors in recurrent or metastatic nasopharyngeal carcinoma patients after failure of platinum-containing regimens: a systematic review and meta-analysis.
Luo J, Xiao W, Hua F, Cao Y, Wang D, Wang X
BMC Cancer 2023 Nov 30;23(1):1172. doi: 10.1186/s12885-023-11318-y. PMID: 38037076Free PMC Article
Upper-neck irradiation versus standard whole-neck irradiation in nasopharyngeal carcinoma: A systematic review and meta-analysis.
De Felice F, Marchetti C, Serpone M, Camarda A, Vischioni B, Ingargiola R, Musio D, Orlandi E
Tumori 2023 Dec;109(6):529-536. Epub 2023 Feb 16 doi: 10.1177/03008916231154765. PMID: 36794709
Chemotherapy in Combination With Radiotherapy for Definitive-Intent Treatment of Stage II-IVA Nasopharyngeal Carcinoma: CSCO and ASCO Guideline.
Chen YP, Ismaila N, Chua MLK, Colevas AD, Haddad R, Huang SH, Wee JTS, Whitley AC, Yi JL, Yom SS, Chan ATC, Hu CS, Lang JY, Le QT, Lee AWM, Lee N, Lin JC, Ma B, Morgan TJ, Shah J, Sun Y, Ma J
J Clin Oncol 2021 Mar 1;39(7):840-859. Epub 2021 Jan 6 doi: 10.1200/JCO.20.03237. PMID: 33405943
Systemic therapies for recurrent or metastatic nasopharyngeal carcinoma: a systematic review.
Prawira A, Oosting SF, Chen TW, Delos Santos KA, Saluja R, Wang L, Siu LL, Chan KKW, Hansen AR
Br J Cancer 2017 Dec 5;117(12):1743-1752. Epub 2017 Oct 24 doi: 10.1038/bjc.2017.357. PMID: 29065104Free PMC Article
Screening for nasopharyngeal cancer.
Yang S, Wu S, Zhou J, Chen XY
Cochrane Database Syst Rev 2015 Nov 6;2015(11):CD008423. doi: 10.1002/14651858.CD008423.pub2. PMID: 26544798Free PMC Article

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