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BRAF Gene Rearrangement

MedGen UID:
1666418
Concept ID:
C4727483
Cell or Molecular Dysfunction
Synonyms: B-RAF Gene Rearrangement; B-RAF1 Gene Rearrangement; BRAF Rearrangement; Positive; v-raf Murine Sarcoma Viral Oncogene Homolog B1 Gene Rearrangement

Definition

A molecular abnormality indicating rearrangement of the BRAF gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBRAF Gene Rearrangement

Professional guidelines

PubMed

Chen S, Gu J, Wu K, Zhao X, Lu Y
Cancer Biol Med 2024 Jun 15;21(6):473-83. doi: 10.20892/j.issn.2095-3941.2024.0026. PMID: 38940668Free PMC Article
Bellur S, Khosla AA, Ozair A, Kotecha R, McDermott MW, Ahluwalia MS
Semin Neurol 2023 Dec;43(6):845-858. Epub 2023 Nov 27 doi: 10.1055/s-0043-1776782. PMID: 38011864
Soo R, Mery L, Bardot A, Kanesvaran R, Keong TC, Pongnikorn D, Prasongsook N, Hutajulu SH, Irawan C, Manan AA, Thiagarajan M, Sripan P, Peters S, Storm H, Bray F, Stahel R
ESMO Open 2022 Oct;7(5):100560. Epub 2022 Aug 18 doi: 10.1016/j.esmoop.2022.100560. PMID: 35988454Free PMC Article

Recent clinical studies

Etiology

Chui MH, Chang JC, Zhang Y, Zehir A, Schram AM, Konner J, Drilon AE, Da Cruz Paula A, Weigelt B, Grisham RN
JCO Precis Oncol 2021;5 Epub 2021 Sep 16 doi: 10.1200/PO.21.00055. PMID: 34568720Free PMC Article
Ganapathi KA, Brown LE, Prakash S, Bhargava P
Pathology 2021 Apr;53(3):349-366. Epub 2021 Mar 5 doi: 10.1016/j.pathol.2021.01.002. PMID: 33685720
Dickson BC, Antonescu CR, Demicco EG, Leong DI, Anderson ND, Swanson D, Zhang L, Fletcher CDM, Hornick JL
Mod Pathol 2021 Jun;34(6):1116-1124. Epub 2021 Mar 1 doi: 10.1038/s41379-021-00783-0. PMID: 33649458Free PMC Article
Ryall S, Zapotocky M, Fukuoka K, Nobre L, Guerreiro Stucklin A, Bennett J, Siddaway R, Li C, Pajovic S, Arnoldo A, Kowalski PE, Johnson M, Sheth J, Lassaletta A, Tatevossian RG, Orisme W, Qaddoumi I, Surrey LF, Li MM, Waanders AJ, Gilheeney S, Rosenblum M, Bale T, Tsang DS, Laperriere N, Kulkarni A, Ibrahim GM, Drake J, Dirks P, Taylor MD, Rutka JT, Laughlin S, Shroff M, Shago M, Hazrati LN, D'Arcy C, Ramaswamy V, Bartels U, Huang A, Bouffet E, Karajannis MA, Santi M, Ellison DW, Tabori U, Hawkins C
Cancer Cell 2020 Apr 13;37(4):569-583.e5. doi: 10.1016/j.ccell.2020.03.011. PMID: 32289278Free PMC Article
Barlesi F, Mazieres J, Merlio JP, Debieuvre D, Mosser J, Lena H, Ouafik L, Besse B, Rouquette I, Westeel V, Escande F, Monnet I, Lemoine A, Veillon R, Blons H, Audigier-Valette C, Bringuier PP, Lamy R, Beau-Faller M, Pujol JL, Sabourin JC, Penault-Llorca F, Denis MG, Lantuejoul S, Morin F, Tran Q, Missy P, Langlais A, Milleron B, Cadranel J, Soria JC, Zalcman G; Biomarkers France contributors
Lancet 2016 Apr 2;387(10026):1415-1426. Epub 2016 Jan 15 doi: 10.1016/S0140-6736(16)00004-0. PMID: 26777916

Diagnosis

Kasi PM, Lee JK, Pasquina LW, Decker B, Vanden Borre P, Pavlick DC, Allen JM, Parachoniak C, Quintanilha JCF, Graf RP, Schrock AB, Oxnard GR, Lovly CM, Tukachinsky H, Subbiah V
Clin Cancer Res 2024 Feb 16;30(4):836-848. doi: 10.1158/1078-0432.CCR-23-2693. PMID: 38060240Free PMC Article
Tan AC, Tan DSW
J Clin Oncol 2022 Feb 20;40(6):611-625. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01626. PMID: 34985916
Ryall S, Zapotocky M, Fukuoka K, Nobre L, Guerreiro Stucklin A, Bennett J, Siddaway R, Li C, Pajovic S, Arnoldo A, Kowalski PE, Johnson M, Sheth J, Lassaletta A, Tatevossian RG, Orisme W, Qaddoumi I, Surrey LF, Li MM, Waanders AJ, Gilheeney S, Rosenblum M, Bale T, Tsang DS, Laperriere N, Kulkarni A, Ibrahim GM, Drake J, Dirks P, Taylor MD, Rutka JT, Laughlin S, Shroff M, Shago M, Hazrati LN, D'Arcy C, Ramaswamy V, Bartels U, Huang A, Bouffet E, Karajannis MA, Santi M, Ellison DW, Tabori U, Hawkins C
Cancer Cell 2020 Apr 13;37(4):569-583.e5. doi: 10.1016/j.ccell.2020.03.011. PMID: 32289278Free PMC Article
Poller DN, Glaysher S
Cytopathology 2017 Dec;28(6):475-481. doi: 10.1111/cyt.12492. PMID: 29165888
Zheng Z, Liebers M, Zhelyazkova B, Cao Y, Panditi D, Lynch KD, Chen J, Robinson HE, Shim HS, Chmielecki J, Pao W, Engelman JA, Iafrate AJ, Le LP
Nat Med 2014 Dec;20(12):1479-84. Epub 2014 Nov 10 doi: 10.1038/nm.3729. PMID: 25384085

Therapy

Bellur S, Khosla AA, Ozair A, Kotecha R, McDermott MW, Ahluwalia MS
Semin Neurol 2023 Dec;43(6):845-858. Epub 2023 Nov 27 doi: 10.1055/s-0043-1776782. PMID: 38011864
Tan AC, Tan DSW
J Clin Oncol 2022 Feb 20;40(6):611-625. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01626. PMID: 34985916
Liu J, Liu Y, Lin Y, Liang J
Endocrinol Metab (Seoul) 2019 Sep;34(3):215-225. doi: 10.3803/EnM.2019.34.3.215. PMID: 31565873Free PMC Article
Drilon A, Hu ZI, Lai GGY, Tan DSW
Nat Rev Clin Oncol 2018 Mar;15(3):151-167. Epub 2017 Nov 14 doi: 10.1038/nrclinonc.2017.175. PMID: 29134959Free PMC Article
Madureira P, de Mello RA
Mol Diagn Ther 2014 Jun;18(3):285-91. doi: 10.1007/s40291-013-0081-0. PMID: 24403169

Prognosis

Bulanova Pekova B, Sykorova V, Mastnikova K, Vaclavikova E, Moravcova J, Vlcek P, Lancova L, Lastuvka P, Katra R, Bavor P, Kodetova D, Chovanec M, Drozenova J, Matej R, Astl J, Hlozek J, Hrabal P, Vcelak J, Bendlova B
Endocr Relat Cancer 2023 Dec 1;30(12) Epub 2023 Oct 26 doi: 10.1530/ERC-23-0117. PMID: 37882481Free PMC Article
Baranov E, Nowak JA
Surg Pathol Clin 2023 Dec;16(4):635-650. Epub 2023 Jul 23 doi: 10.1016/j.path.2023.05.002. PMID: 37863556
Tan AC, Tan DSW
J Clin Oncol 2022 Feb 20;40(6):611-625. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01626. PMID: 34985916
Poller DN, Glaysher S
Cytopathology 2017 Dec;28(6):475-481. doi: 10.1111/cyt.12492. PMID: 29165888
Rahbari R, Zhang L, Kebebew E
Future Oncol 2010 Nov;6(11):1771-9. doi: 10.2217/fon.10.127. PMID: 21142662Free PMC Article

Clinical prediction guides

Baranov E, Nowak JA
Surg Pathol Clin 2023 Dec;16(4):635-650. Epub 2023 Jul 23 doi: 10.1016/j.path.2023.05.002. PMID: 37863556
Tan AC, Tan DSW
J Clin Oncol 2022 Feb 20;40(6):611-625. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01626. PMID: 34985916
Drilon A, Hu ZI, Lai GGY, Tan DSW
Nat Rev Clin Oncol 2018 Mar;15(3):151-167. Epub 2017 Nov 14 doi: 10.1038/nrclinonc.2017.175. PMID: 29134959Free PMC Article
Appin CL, Brat DJ
Mol Aspects Med 2015 Nov;45:87-96. Epub 2015 May 21 doi: 10.1016/j.mam.2015.05.002. PMID: 26004297
Sholl LM
Arch Pathol Lab Med 2015 Apr;139(4):469-80. Epub 2014 Sep 25 doi: 10.5858/arpa.2014-0128-RA. PMID: 25255293

Recent systematic reviews

Labourier E, Fahey TJ 3rd
Diagn Cytopathol 2021 Apr;49(4):E175-E180. Epub 2020 Oct 14 doi: 10.1002/dc.24637. PMID: 33052631Free PMC Article
Malapelle U, Muscarella LA, Pisapia P, Rossi A
Expert Opin Investig Drugs 2020 Apr;29(4):363-372. Epub 2020 Feb 26 doi: 10.1080/13543784.2020.1732922. PMID: 32073317
Suurmeijer AJH, Dickson BC, Swanson D, Zhang L, Sung YS, Cotzia P, Fletcher CDM, Antonescu CR
Genes Chromosomes Cancer 2018 Dec;57(12):611-621. Epub 2018 Oct 1 doi: 10.1002/gcc.22671. PMID: 30276917Free PMC Article
Lam AK, Saremi N
Endocr Relat Cancer 2017 Apr;24(4):R109-R121. doi: 10.1530/ERC-17-0014. PMID: 28314770
Vuong HG, Altibi AM, Abdelhamid AH, Ngoc PU, Quan VD, Tantawi MY, Elfil M, Vu TL, Elgebaly A, Oishi N, Nakazawa T, Hirayama K, Katoh R, Huy NT, Kondo T
Oncotarget 2017 Feb 7;8(6):10637-10649. doi: 10.18632/oncotarget.12885. PMID: 27793009Free PMC Article

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