U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

BRAF Gene Rearrangement

MedGen UID:
1666418
•Concept ID:
C4727483
•
Cell or Molecular Dysfunction
Synonyms: B-RAF Gene Rearrangement; B-RAF1 Gene Rearrangement; BRAF Rearrangement; Positive; v-raf Murine Sarcoma Viral Oncogene Homolog B1 Gene Rearrangement

Definition

A molecular abnormality indicating rearrangement of the BRAF gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBRAF Gene Rearrangement

Professional guidelines

PubMed

Diagnostic work-up and systemic treatment for advanced non-squamous non-small-cell lung cancer in four Southeast Asian countries.
Soo R, Mery L, Bardot A, Kanesvaran R, Keong TC, Pongnikorn D, Prasongsook N, Hutajulu SH, Irawan C, Manan AA, Thiagarajan M, Sripan P, Peters S, Storm H, Bray F, Stahel R
ESMO Open 2022 Oct;7(5):100560. Epub 2022 Aug 18 doi: 10.1016/j.esmoop.2022.100560. PMID: 35988454Free PMC Article
Management of advanced non-small cell lung cancers with known mutations or rearrangements: latest evidence and treatment approaches.
Shea M, Costa DB, Rangachari D
Ther Adv Respir Dis 2016 Apr;10(2):113-29. Epub 2015 Nov 30 doi: 10.1177/1753465815617871. PMID: 26620497Free PMC Article
The landscape of EGFR pathways and personalized management of non-small-cell lung cancer.
Cheng L, Zhang S, Alexander R, Yao Y, MacLennan GT, Pan CX, Huang J, Wang M, Montironi R, Lopez-Beltran A
Future Oncol 2011 Apr;7(4):519-41. doi: 10.2217/fon.11.25. PMID: 21463141

Recent clinical studies

Etiology

New developments in non-Hodgkin lymphoid malignancies.
Ganapathi KA, Brown LE, Prakash S, Bhargava P
Pathology 2021 Apr;53(3):349-366. Epub 2021 Mar 5 doi: 10.1016/j.pathol.2021.01.002. PMID: 33685720
Integrated Molecular and Clinical Analysis of 1,000 Pediatric Low-Grade Gliomas.
Ryall S, Zapotocky M, Fukuoka K, Nobre L, Guerreiro Stucklin A, Bennett J, Siddaway R, Li C, Pajovic S, Arnoldo A, Kowalski PE, Johnson M, Sheth J, Lassaletta A, Tatevossian RG, Orisme W, Qaddoumi I, Surrey LF, Li MM, Waanders AJ, Gilheeney S, Rosenblum M, Bale T, Tsang DS, Laperriere N, Kulkarni A, Ibrahim GM, Drake J, Dirks P, Taylor MD, Rutka JT, Laughlin S, Shroff M, Shago M, Hazrati LN, D'Arcy C, Ramaswamy V, Bartels U, Huang A, Bouffet E, Karajannis MA, Santi M, Ellison DW, Tabori U, Hawkins C
Cancer Cell 2020 Apr 13;37(4):569-583.e5. doi: 10.1016/j.ccell.2020.03.011. PMID: 32289278Free PMC Article
Radioactive Iodine-Refractory Differentiated Thyroid Cancer and Redifferentiation Therapy.
Liu J, Liu Y, Lin Y, Liang J
Endocrinol Metab (Seoul) 2019 Sep;34(3):215-225. doi: 10.3803/EnM.2019.34.3.215. PMID: 31565873Free PMC Article
Genomic Signature of Driver Genes Identified by Target Next-Generation Sequencing in Chinese Non-Small Cell Lung Cancer.
Wen S, Dai L, Wang L, Wang W, Wu D, Wang K, He Z, Wang A, Chen H, Zhang P, Dong X, Dong YA, Wang K, Yao M, Wang M
Oncologist 2019 Nov;24(11):e1070-e1081. Epub 2019 Mar 22 doi: 10.1634/theoncologist.2018-0572. PMID: 30902917Free PMC Article
Routine molecular profiling of patients with advanced non-small-cell lung cancer: results of a 1-year nationwide programme of the French Cooperative Thoracic Intergroup (IFCT).
Barlesi F, Mazieres J, Merlio JP, Debieuvre D, Mosser J, Lena H, Ouafik L, Besse B, Rouquette I, Westeel V, Escande F, Monnet I, Lemoine A, Veillon R, Blons H, Audigier-Valette C, Bringuier PP, Lamy R, Beau-Faller M, Pujol JL, Sabourin JC, Penault-Llorca F, Denis MG, Lantuejoul S, Morin F, Tran Q, Missy P, Langlais A, Milleron B, Cadranel J, Soria JC, Zalcman G; Biomarkers France contributors
Lancet 2016 Apr 2;387(10026):1415-1426. Epub 2016 Jan 15 doi: 10.1016/S0140-6736(16)00004-0. PMID: 26777916

Diagnosis

Targeted Therapies for Lung Cancer Patients With Oncogenic Driver Molecular Alterations.
Tan AC, Tan DSW
J Clin Oncol 2022 Feb 20;40(6):611-625. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01626. PMID: 34985916
New developments in non-Hodgkin lymphoid malignancies.
Ganapathi KA, Brown LE, Prakash S, Bhargava P
Pathology 2021 Apr;53(3):349-366. Epub 2021 Mar 5 doi: 10.1016/j.pathol.2021.01.002. PMID: 33685720
Integrated Molecular and Clinical Analysis of 1,000 Pediatric Low-Grade Gliomas.
Ryall S, Zapotocky M, Fukuoka K, Nobre L, Guerreiro Stucklin A, Bennett J, Siddaway R, Li C, Pajovic S, Arnoldo A, Kowalski PE, Johnson M, Sheth J, Lassaletta A, Tatevossian RG, Orisme W, Qaddoumi I, Surrey LF, Li MM, Waanders AJ, Gilheeney S, Rosenblum M, Bale T, Tsang DS, Laperriere N, Kulkarni A, Ibrahim GM, Drake J, Dirks P, Taylor MD, Rutka JT, Laughlin S, Shroff M, Shago M, Hazrati LN, D'Arcy C, Ramaswamy V, Bartels U, Huang A, Bouffet E, Karajannis MA, Santi M, Ellison DW, Tabori U, Hawkins C
Cancer Cell 2020 Apr 13;37(4):569-583.e5. doi: 10.1016/j.ccell.2020.03.011. PMID: 32289278Free PMC Article
Molecular pathology and thyroid FNA.
Poller DN, Glaysher S
Cytopathology 2017 Dec;28(6):475-481. doi: 10.1111/cyt.12492. PMID: 29165888
Anchored multiplex PCR for targeted next-generation sequencing.
Zheng Z, Liebers M, Zhelyazkova B, Cao Y, Panditi D, Lynch KD, Chen J, Robinson HE, Shim HS, Chmielecki J, Pao W, Engelman JA, Iafrate AJ, Le LP
Nat Med 2014 Dec;20(12):1479-84. Epub 2014 Nov 10 doi: 10.1038/nm.3729. PMID: 25384085

Therapy

Targeted Therapies for Lung Cancer Patients With Oncogenic Driver Molecular Alterations.
Tan AC, Tan DSW
J Clin Oncol 2022 Feb 20;40(6):611-625. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01626. PMID: 34985916
Radioactive Iodine-Refractory Differentiated Thyroid Cancer and Redifferentiation Therapy.
Liu J, Liu Y, Lin Y, Liang J
Endocrinol Metab (Seoul) 2019 Sep;34(3):215-225. doi: 10.3803/EnM.2019.34.3.215. PMID: 31565873Free PMC Article
Personalized therapy for lung cancer: striking a moving target.
Pakkala S, Ramalingam SS
JCI Insight 2018 Aug 9;3(15) doi: 10.1172/jci.insight.120858. PMID: 30089719Free PMC Article
Targeting RET-driven cancers: lessons from evolving preclinical and clinical landscapes.
Drilon A, Hu ZI, Lai GGY, Tan DSW
Nat Rev Clin Oncol 2018 Mar;15(3):151-167. Epub 2017 Nov 14 doi: 10.1038/nrclinonc.2017.175. PMID: 29134959Free PMC Article
BRAF and MEK gene rearrangements in melanoma: implications for targeted therapy.
Madureira P, de Mello RA
Mol Diagn Ther 2014 Jun;18(3):285-91. doi: 10.1007/s40291-013-0081-0. PMID: 24403169

Prognosis

Pathologic Evaluation of Therapeutic Biomarkers in Colorectal Adenocarcinoma.
Baranov E, Nowak JA
Surg Pathol Clin 2023 Dec;16(4):635-650. Epub 2023 Jul 23 doi: 10.1016/j.path.2023.05.002. PMID: 37863556
Targeted Therapies for Lung Cancer Patients With Oncogenic Driver Molecular Alterations.
Tan AC, Tan DSW
J Clin Oncol 2022 Feb 20;40(6):611-625. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01626. PMID: 34985916
Spectrum of BRAF Mutations and Gene Rearrangements in Ovarian Serous Carcinoma.
Chui MH, Chang JC, Zhang Y, Zehir A, Schram AM, Konner J, Drilon AE, Da Cruz Paula A, Weigelt B, Grisham RN
JCO Precis Oncol 2021;5 Epub 2021 Sep 16 doi: 10.1200/PO.21.00055. PMID: 34568720Free PMC Article
Molecular pathology and thyroid FNA.
Poller DN, Glaysher S
Cytopathology 2017 Dec;28(6):475-481. doi: 10.1111/cyt.12492. PMID: 29165888
Thyroid cancer gender disparity.
Rahbari R, Zhang L, Kebebew E
Future Oncol 2010 Nov;6(11):1771-9. doi: 10.2217/fon.10.127. PMID: 21142662Free PMC Article

Clinical prediction guides

Pathologic Evaluation of Therapeutic Biomarkers in Colorectal Adenocarcinoma.
Baranov E, Nowak JA
Surg Pathol Clin 2023 Dec;16(4):635-650. Epub 2023 Jul 23 doi: 10.1016/j.path.2023.05.002. PMID: 37863556
Targeted Therapies for Lung Cancer Patients With Oncogenic Driver Molecular Alterations.
Tan AC, Tan DSW
J Clin Oncol 2022 Feb 20;40(6):611-625. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01626. PMID: 34985916
A Narrative Review of Genetic Alterations in Primary Thyroid Epithelial Cancer.
Romei C, Elisei R
Int J Mol Sci 2021 Feb 9;22(4) doi: 10.3390/ijms22041726. PMID: 33572167Free PMC Article
Targeting RET-driven cancers: lessons from evolving preclinical and clinical landscapes.
Drilon A, Hu ZI, Lai GGY, Tan DSW
Nat Rev Clin Oncol 2018 Mar;15(3):151-167. Epub 2017 Nov 14 doi: 10.1038/nrclinonc.2017.175. PMID: 29134959Free PMC Article
Biomarker-driven diagnosis of diffuse gliomas.
Appin CL, Brat DJ
Mol Aspects Med 2015 Nov;45:87-96. Epub 2015 May 21 doi: 10.1016/j.mam.2015.05.002. PMID: 26004297

Recent systematic reviews

Preoperative molecular testing in thyroid nodules with Bethesda VI cytology: Clinical experience and review of the literature.
Labourier E, Fahey TJ 3rd
Diagn Cytopathol 2021 Apr;49(4):E175-E180. Epub 2020 Oct 14 doi: 10.1002/dc.24637. PMID: 33052631Free PMC Article
Targeting emerging molecular alterations in the treatment of non-small cell lung cancer: current challenges and the way forward.
Malapelle U, Muscarella LA, Pisapia P, Rossi A
Expert Opin Investig Drugs 2020 Apr;29(4):363-372. Epub 2020 Feb 26 doi: 10.1080/13543784.2020.1732922. PMID: 32073317
A novel group of spindle cell tumors defined by S100 and CD34 co-expression shows recurrent fusions involving RAF1, BRAF, and NTRK1/2 genes.
Suurmeijer AJH, Dickson BC, Swanson D, Zhang L, Sung YS, Cotzia P, Fletcher CDM, Antonescu CR
Genes Chromosomes Cancer 2018 Dec;57(12):611-621. Epub 2018 Oct 1 doi: 10.1002/gcc.22671. PMID: 30276917Free PMC Article
Cribriform-morular variant of papillary thyroid carcinoma: a distinctive type of thyroid cancer.
Lam AK, Saremi N
Endocr Relat Cancer 2017 Apr;24(4):R109-R121. doi: 10.1530/ERC-17-0014. PMID: 28314770
The changing characteristics and molecular profiles of papillary thyroid carcinoma over time: a systematic review.
Vuong HG, Altibi AM, Abdelhamid AH, Ngoc PU, Quan VD, Tantawi MY, Elfil M, Vu TL, Elgebaly A, Oishi N, Nakazawa T, Hirayama K, Katoh R, Huy NT, Kondo T
Oncotarget 2017 Feb 7;8(6):10637-10649. doi: 10.18632/oncotarget.12885. PMID: 27793009Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...