U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pituitary Hyperplasia

MedGen UID:
1666905
•Concept ID:
C3670571
•
Disease or Syndrome
Synonym: Pituitary Gland Hyperplasia

Definition

A rare condition characterized by hyperplasia and hypertrophy of the pituitary gland. It is caused by hypersecretion of hypothalamic stimulating hormones. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPituitary Hyperplasia

Professional guidelines

PubMed

The diagnosis and management of Cushing's syndrome in pregnancy.
Hamblin R, Coulden A, Fountas A, Karavitaki N
J Neuroendocrinol 2022 Aug;34(8):e13118. Epub 2022 May 1 doi: 10.1111/jne.13118. PMID: 35491087Free PMC Article
Management of pituitary incidentaloma.
Boguszewski CL, de Castro Musolino NR, Kasuki L
Best Pract Res Clin Endocrinol Metab 2019 Apr;33(2):101268. Epub 2019 Apr 13 doi: 10.1016/j.beem.2019.04.002. PMID: 31027975
Results of treatment of pituitary disease in multiple endocrine neoplasia, type I.
O'Brien T, O'Riordan DS, Gharib H, Scheithauer BW, Ebersold MJ, van Heerden JA
Neurosurgery 1996 Aug;39(2):273-8; discussion 278-9. doi: 10.1097/00006123-199608000-00008. PMID: 8832664

Recent clinical studies

Etiology

The diagnosis and management of Cushing's syndrome in pregnancy.
Hamblin R, Coulden A, Fountas A, Karavitaki N
J Neuroendocrinol 2022 Aug;34(8):e13118. Epub 2022 May 1 doi: 10.1111/jne.13118. PMID: 35491087Free PMC Article
Pituitary hyperplasia in childhood primary hypothyroidism: a review.
Sapkota S, Karn M, Sapkota S
Childs Nerv Syst 2021 Mar;37(3):749-762. Epub 2021 Jan 6 doi: 10.1007/s00381-020-05014-6. PMID: 33404718
Comprehensive Evaluation of Rare Pituitary Lesions: A Single Tertiary Care Pituitary Center Experience and Review of the Literature.
Cossu G, Brouland JP, La Rosa S, Camponovo C, Viaroli E, Daniel RT, Messerer M
Endocr Pathol 2019 Sep;30(3):219-236. doi: 10.1007/s12022-019-09581-6. PMID: 31209729
Management of pituitary incidentaloma.
Boguszewski CL, de Castro Musolino NR, Kasuki L
Best Pract Res Clin Endocrinol Metab 2019 Apr;33(2):101268. Epub 2019 Apr 13 doi: 10.1016/j.beem.2019.04.002. PMID: 31027975
Pituitary adenoma with paraganglioma/pheochromocytoma (3PAs) and succinate dehydrogenase defects in humans and mice.
Xekouki P, Szarek E, Bullova P, Giubellino A, Quezado M, Mastroyannis SA, Mastorakos P, Wassif CA, Raygada M, Rentia N, Dye L, Cougnoux A, Koziol D, Sierra Mde L, Lyssikatos C, Belyavskaya E, Malchoff C, Moline J, Eng C, Maher LJ 3rd, Pacak K, Lodish M, Stratakis CA
J Clin Endocrinol Metab 2015 May;100(5):E710-9. Epub 2015 Feb 19 doi: 10.1210/jc.2014-4297. PMID: 25695889Free PMC Article

Diagnosis

The diagnosis and management of Cushing's syndrome in pregnancy.
Hamblin R, Coulden A, Fountas A, Karavitaki N
J Neuroendocrinol 2022 Aug;34(8):e13118. Epub 2022 May 1 doi: 10.1111/jne.13118. PMID: 35491087Free PMC Article
Familial pituitary tumors.
Alband N, Korbonits M
Handb Clin Neurol 2014;124:339-60. doi: 10.1016/B978-0-444-59602-4.00023-X. PMID: 25248598
Acromegaly.
Chanson P, Salenave S
Orphanet J Rare Dis 2008 Jun 25;3:17. doi: 10.1186/1750-1172-3-17. PMID: 18578866Free PMC Article
Pituitary hyperplasia.
Horvath E, Kovacs K, Scheithauer BW
Pituitary 1999 May;1(3-4):169-79. doi: 10.1023/a:1009952930425. PMID: 11081195
Pituitary hyperplasia.
Horvath E
Pathol Res Pract 1988 Sep;183(5):623-5. doi: 10.1016/S0344-0338(88)80026-8. PMID: 2853334

Therapy

Pituitary Hyperplasia, Hormonal Changes and Prolactinoma Development in Males Exposed to Estrogens-An Insight From Translational Studies.
Šošić-Jurjević B, Ajdžanović V, Miljić D, Trifunović S, Filipović B, Stanković S, Bolevich S, Jakovljević V, Milošević V
Int J Mol Sci 2020 Mar 16;21(6) doi: 10.3390/ijms21062024. PMID: 32188093Free PMC Article
Primary hypothyroidism in a child leads to pituitary hyperplasia: A case report and literature review.
Cao J, Lei T, Chen F, Zhang C, Ma C, Huang H
Medicine (Baltimore) 2018 Oct;97(42):e12703. doi: 10.1097/MD.0000000000012703. PMID: 30334955Free PMC Article
Ultrasonic morphology of uterus and ovaries in girls with pituitary hyperplasia secondary to primary hypothyroidism.
Hu Y, Wang Q, Li G, Sun X, Liu C
Horm Metab Res 2013 Sep;45(9):669-74. Epub 2013 May 13 doi: 10.1055/s-0033-1345141. PMID: 23670347
Pituitary hyperplasia in children with short stature and primary hypothyroidism.
Aijing X, Tang L
Indian Pediatr 2010 Oct;47(10):877-80. Epub 2010 Mar 15 doi: 10.1007/s13312-010-0149-4. PMID: 20453264
Etiological diagnosis of hyperprolactinemia.
Cortet-Rudelli C, Sapin R, Bonneville JF, Brue T
Ann Endocrinol (Paris) 2007 Jun;68(2-3):98-105. Epub 2007 May 23 doi: 10.1016/j.ando.2007.03.013. PMID: 17524347

Prognosis

Acromegaly Caused by Ectopic Growth Hormone Releasing Hormone Secretion: A Review.
Zendran I, Gut G, Kałużny M, Zawadzka K, Bolanowski M
Front Endocrinol (Lausanne) 2022;13:867965. Epub 2022 Jun 9 doi: 10.3389/fendo.2022.867965. PMID: 35757397Free PMC Article
Primary hypothyroidism with pituitary hyperplasia characterized by hypogonadotropic hypogonadism: a case report and review of the literature.
Yu W, Wu N
Ann Palliat Med 2020 Nov;9(6):4359-4370. Epub 2020 Nov 10 doi: 10.21037/apm-20-1828. PMID: 33183016
Management of pituitary incidentaloma.
Boguszewski CL, de Castro Musolino NR, Kasuki L
Best Pract Res Clin Endocrinol Metab 2019 Apr;33(2):101268. Epub 2019 Apr 13 doi: 10.1016/j.beem.2019.04.002. PMID: 31027975
Acromegaly.
Chanson P, Salenave S
Orphanet J Rare Dis 2008 Jun 25;3:17. doi: 10.1186/1750-1172-3-17. PMID: 18578866Free PMC Article
Magnetic resonance imaging of the hypothalamus-pituitary unit in childrensuspected of hypopituitarism: who, how and when toinvestigate.
Maghnie M, Ghirardello S, Genovese E
J Endocrinol Invest 2004 May;27(5):496-509. doi: 10.1007/BF03345298. PMID: 15279086

Clinical prediction guides

Gigantism: X-linked acrogigantism and GPR101 mutations.
Iacovazzo D, Korbonits M
Growth Horm IGF Res 2016 Oct-Dec;30-31:64-69. Epub 2016 Sep 29 doi: 10.1016/j.ghir.2016.09.007. PMID: 27743704
Neurology of the pituitary.
Samarasinghe S, Emanuele MA, Mazhari A
Handb Clin Neurol 2014;120:685-701. doi: 10.1016/B978-0-7020-4087-0.00047-4. PMID: 24365347
Magnetic resonance imaging of the hypothalamus-pituitary unit in childrensuspected of hypopituitarism: who, how and when toinvestigate.
Maghnie M, Ghirardello S, Genovese E
J Endocrinol Invest 2004 May;27(5):496-509. doi: 10.1007/BF03345298. PMID: 15279086
Angiotensin and calcium signaling in the pituitary and hypothalamus.
Suárez C, Tornadú IG, Cristina C, Vela J, Iglesias AG, Libertun C, Díaz-Torga G, Becu-Villalobos D
Cell Mol Neurobiol 2002 Jun;22(3):315-33. doi: 10.1023/a:1020772018703. PMID: 12469873
Cushing's syndrome: new variants and association with empty sella syndrome.
Mancini A, Calabrò F, Lagonigro G, Saporosi A, Colosimo C Jr, Anile C, Maira G, De Marinis L
J Nucl Med Allied Sci 1990 Apr-Jun;34(2):59-66. PMID: 2246674

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...