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Crooke Cell Tumor

MedGen UID:
1667201
•Concept ID:
C4727593
•
Neoplastic Process
Synonym: Crooke Cell Adenoma

Definition

A corticotroph pituitary tumor composed of cells with Crooke hyaline change. Ring-like cytokeratin expression is typical of these neoplasms. ACTH expression is dislocated to the cell periphery and juxtanuclear region. Ultrastructurally, intermediate filaments are arranged in a ring-like pattern. (WHO) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCrooke Cell Tumor

Professional guidelines

PubMed

High-risk pituitary adenomas and strategies for predicting response to treatment.
Kontogeorgos G, Thodou E, Osamura RY, Lloyd RV
Hormones (Athens) 2022 Mar;21(1):1-14. Epub 2022 Jan 21 doi: 10.1007/s42000-021-00333-y. PMID: 35061210
Role of intravesical mitomycin C in management of superficial bladder tumors.
Bracken RB, Swanson DA, Johnson DE, De Furia D, von Eschenbach AC, Crooke S
Urology 1980 Jul;16(1):11-5. doi: 10.1016/0090-4295(80)90322-2. PMID: 7395004

Recent clinical studies

Etiology

Prevalence and clinical characteristics of Crooke's cell adenomas in 101 patients with T-PIT-positive pituitary adenomas: Case series and literature review.
Zhu D, Wang Z, Tian T, Wu X, He D, Zhu Y, Liu D, Wang H
Front Endocrinol (Lausanne) 2022;13:947085. Epub 2022 Aug 19 doi: 10.3389/fendo.2022.947085. PMID: 36060980Free PMC Article
High-risk pituitary adenomas and strategies for predicting response to treatment.
Kontogeorgos G, Thodou E, Osamura RY, Lloyd RV
Hormones (Athens) 2022 Mar;21(1):1-14. Epub 2022 Jan 21 doi: 10.1007/s42000-021-00333-y. PMID: 35061210
Functioning Crooke Cell Adenomas: Case Series and Literature Review.
Giraldi EA, Neill SG, Mendoza P, Saindane A, Oyesiku NM, Ioachimescu AG
World Neurosurg 2022 Feb;158:e754-e765. Epub 2021 Nov 18 doi: 10.1016/j.wneu.2021.11.049. PMID: 34800730
Aggressive pituitary tumors in the young and elderly.
Tatsi C, Stratakis CA
Rev Endocr Metab Disord 2020 Jun;21(2):213-223. doi: 10.1007/s11154-019-09534-8. PMID: 31912365
Overview of the 2017 WHO Classification of Pituitary Tumors.
Mete O, Lopes MB
Endocr Pathol 2017 Sep;28(3):228-243. doi: 10.1007/s12022-017-9498-z. PMID: 28766057

Diagnosis

Prevalence and clinical characteristics of Crooke's cell adenomas in 101 patients with T-PIT-positive pituitary adenomas: Case series and literature review.
Zhu D, Wang Z, Tian T, Wu X, He D, Zhu Y, Liu D, Wang H
Front Endocrinol (Lausanne) 2022;13:947085. Epub 2022 Aug 19 doi: 10.3389/fendo.2022.947085. PMID: 36060980Free PMC Article
Recent Understanding and Future Directions of Recurrent Corticotroph Tumors.
Hinojosa-Amaya JM, Lam-Chung CE, Cuevas-Ramos D
Front Endocrinol (Lausanne) 2021;12:657382. Epub 2021 Apr 26 doi: 10.3389/fendo.2021.657382. PMID: 33986726Free PMC Article
Invasive Crooke cell adenoma in a patient with diffuse large B-cell lymphoma.
Schwann K, Bogiatzi C, Algird A, Lu JQ
J Clin Neurosci 2020 Mar;73:318-321. Epub 2020 Jan 11 doi: 10.1016/j.jocn.2020.01.014. PMID: 31937501
Clinically Silent Adrenocorticotropic Hormone-Positive Crooke Cell Adenoma: Case Report and Review of Literature.
Todnem N, Ward A, Segar S, Rojiani AM, Rahimi SY
World Neurosurg 2018 Nov;119:197-200. Epub 2018 Aug 2 doi: 10.1016/j.wneu.2018.07.233. PMID: 30077745
Crooke's cell tumors of the pituitary.
Di Ieva A, Davidson JM, Syro LV, Rotondo F, Montoya JF, Horvath E, Cusimano MD, Kovacs K
Neurosurgery 2015 May;76(5):616-22. doi: 10.1227/NEU.0000000000000657. PMID: 25635886

Therapy

Successful reduction of ACTH secretion in a case of intractable Cushing's disease with pituitary Crooke's cell adenoma by combined modality therapy including temozolomide.
Tanaka S, Yamamoto M, Morita M, Takeno A, Kanazawa I, Yamaguchi T, Yamada S, Inoshita N, Oki Y, Kurosaki M, Sugimoto T
Endocr J 2019 Aug 29;66(8):701-708. Epub 2019 May 25 doi: 10.1507/endocrj.EJ18-0547. PMID: 31130573
Temozolomide therapy for aggressive pituitary Crooke's cell corticotropinoma causing Cushing's Disease - a case report with literature review.
Gilis-Januszewska A, Wilusz M, Pantofliński J, Turek-Jabrocka R, Sokołowski G, Sowa-Staszczak A, Kluczyński Ł, Pach D, Zieliński G, Hubalewska-Dydejczyk A
Endokrynol Pol 2018;69(3):306-312. Epub 2018 Jan 10 doi: 10.5603/EP.a2018.0011. PMID: 29319131
Depletion of Airway Submucosal Glands and TP63(+)KRT5(+) Basal Cells in Obliterative Bronchiolitis.
Swatek AM, Lynch TJ, Crooke AK, Anderson PJ, Tyler SR, Brooks L, Ivanovic M, Klesney-Tait JA, Eberlein M, Pena T, Meyerholz DK, Engelhardt JF, Parekh KR
Am J Respir Crit Care Med 2018 Apr 15;197(8):1045-1057. doi: 10.1164/rccm.201707-1368OC. PMID: 29236513Free PMC Article
Etoposide (VP-16-213).
Issell BF, Crooke ST
Cancer Treat Rev 1979 Jun;6(2):107-24. doi: 10.1016/s0305-7372(79)80045-6. PMID: 385138
Bleomycin, a review.
Crooke ST, Bradner WT
J Med 1976;7(5):333-428. PMID: 64579

Prognosis

Pathology of Crooke Cells in the Human Pituitaries: A Timely Review.
Osamura RY, Inomoto C, Tahara S, Oyama KI, Matsuno A, Teramoto A
Appl Immunohistochem Mol Morphol 2023 Aug 1;31(7):485-489. Epub 2022 Oct 17 doi: 10.1097/PAI.0000000000001070. PMID: 36251979
Determinants of Clinical Behavior and Prognosis in Cushing's Disease: A Quest for Useful Biomarkers.
Hernández-Ramírez LC
Rev Invest Clin 2022;74(5):244-257. doi: 10.24875/RIC.22000184. PMID: 36328029
High-risk pituitary adenomas and strategies for predicting response to treatment.
Kontogeorgos G, Thodou E, Osamura RY, Lloyd RV
Hormones (Athens) 2022 Mar;21(1):1-14. Epub 2022 Jan 21 doi: 10.1007/s42000-021-00333-y. PMID: 35061210
Functioning Crooke Cell Adenomas: Case Series and Literature Review.
Giraldi EA, Neill SG, Mendoza P, Saindane A, Oyesiku NM, Ioachimescu AG
World Neurosurg 2022 Feb;158:e754-e765. Epub 2021 Nov 18 doi: 10.1016/j.wneu.2021.11.049. PMID: 34800730
Crooke's cell tumors of the pituitary.
Di Ieva A, Davidson JM, Syro LV, Rotondo F, Montoya JF, Horvath E, Cusimano MD, Kovacs K
Neurosurgery 2015 May;76(5):616-22. doi: 10.1227/NEU.0000000000000657. PMID: 25635886

Clinical prediction guides

Pathology of Crooke Cells in the Human Pituitaries: A Timely Review.
Osamura RY, Inomoto C, Tahara S, Oyama KI, Matsuno A, Teramoto A
Appl Immunohistochem Mol Morphol 2023 Aug 1;31(7):485-489. Epub 2022 Oct 17 doi: 10.1097/PAI.0000000000001070. PMID: 36251979
High-risk pituitary adenomas and strategies for predicting response to treatment.
Kontogeorgos G, Thodou E, Osamura RY, Lloyd RV
Hormones (Athens) 2022 Mar;21(1):1-14. Epub 2022 Jan 21 doi: 10.1007/s42000-021-00333-y. PMID: 35061210
Clinical Significance of Granulation Pattern in Corticotroph Pituitary Adenomas.
Doğanşen SÇ, Bilgiç B, Yalin GY, Tanrikulu S, Yarman S
Turk Patoloji Derg 2019;35(1):9-14. doi: 10.5146/tjpath.2018.01434. PMID: 30035294
Temozolomide therapy for aggressive pituitary Crooke's cell corticotropinoma causing Cushing's Disease - a case report with literature review.
Gilis-Januszewska A, Wilusz M, Pantofliński J, Turek-Jabrocka R, Sokołowski G, Sowa-Staszczak A, Kluczyński Ł, Pach D, Zieliński G, Hubalewska-Dydejczyk A
Endokrynol Pol 2018;69(3):306-312. Epub 2018 Jan 10 doi: 10.5603/EP.a2018.0011. PMID: 29319131
Increased expression of the microRNA 106b~25 cluster and its host gene MCM7 in corticotroph pituitary adenomas is associated with tumor invasion and Crooke's cell morphology.
Garbicz F, Mehlich D, Rak B, Sajjad E, Maksymowicz M, Paskal W, Zieliński G, Włodarski PK
Pituitary 2017 Aug;20(4):450-463. doi: 10.1007/s11102-017-0805-y. PMID: 28432562Free PMC Article

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