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Refractory Malignant Brain Neoplasm

MedGen UID:
1667258
•Concept ID:
C4727431
•
Neoplastic Process

Definition

A malignant brain neoplasm that is resistant to treatment. [from NCI]

Professional guidelines

PubMed

Evidence-based expert consensus on the management of primary central nervous system lymphoma in China.
Chen T, Liu Y, Wang Y, Chang Q, Wu J, Wang Z, Geng D, Yu JT, Li Y, Li XQ, Chen H, Zhuang D, Li J, Wang B, Jiang T, Lyu L, Song Y, Qiu X, Li W, Lin S, Zhang X, Lu D, Lei J, Chen Y, Mao Y
J Hematol Oncol 2022 Sep 29;15(1):136. doi: 10.1186/s13045-022-01356-7. PMID: 36176002Free PMC Article
Clinical Assessment and Management of Delirium in the Palliative Care Setting.
Bush SH, Tierney S, Lawlor PG
Drugs 2017 Oct;77(15):1623-1643. doi: 10.1007/s40265-017-0804-3. PMID: 28864877Free PMC Article
Management of Intracranial Pressure.
Freeman WD
Continuum (Minneap Minn) 2015 Oct;21(5 Neurocritical Care):1299-323. doi: 10.1212/CON.0000000000000235. PMID: 26426232

Recent clinical studies

Etiology

Treatment Options for Recurrent Primary CNS Lymphoma.
Kaulen LD, Baehring JM
Curr Treat Options Oncol 2022 Nov;23(11):1548-1565. Epub 2022 Oct 7 doi: 10.1007/s11864-022-01016-5. PMID: 36205806
Cytokines in CAR T Cell-Associated Neurotoxicity.
Gust J, Ponce R, Liles WC, Garden GA, Turtle CJ
Front Immunol 2020;11:577027. Epub 2020 Dec 16 doi: 10.3389/fimmu.2020.577027. PMID: 33391257Free PMC Article
Molecular stratifications, biomarker candidates and new therapeutic options in current medulloblastoma treatment approaches.
Menyhárt O, Győrffy B
Cancer Metastasis Rev 2020 Mar;39(1):211-233. doi: 10.1007/s10555-020-09854-1. PMID: 31970590Free PMC Article
Medulloblastoma in the age of molecular subgroups: a review.
Juraschka K, Taylor MD
J Neurosurg Pediatr 2019 Oct 1;24(4):353-363. doi: 10.3171/2019.5.PEDS18381. PMID: 31574483
Brain Tumors.
McFaline-Figueroa JR, Lee EQ
Am J Med 2018 Aug;131(8):874-882. Epub 2018 Jan 31 doi: 10.1016/j.amjmed.2017.12.039. PMID: 29371158

Diagnosis

Treatment Options for Recurrent Primary CNS Lymphoma.
Kaulen LD, Baehring JM
Curr Treat Options Oncol 2022 Nov;23(11):1548-1565. Epub 2022 Oct 7 doi: 10.1007/s11864-022-01016-5. PMID: 36205806
Immunotherapy approaches for the treatment of diffuse midline gliomas.
Bernstock JD, Hoffman SE, Kappel AD, Valdes PA, Essayed W, Klinger NV, Kang KD, Totsch SK, Olsen HE, Schlappi CW, Filipski K, Gessler FA, Baird L, Filbin MG, Hashizume R, Becher OJ, Friedman GK
Oncoimmunology 2022;11(1):2124058. Epub 2022 Sep 26 doi: 10.1080/2162402X.2022.2124058. PMID: 36185807Free PMC Article
Somatostatin Analogs in Clinical Practice: a Review.
Gomes-Porras M, Cárdenas-Salas J, Álvarez-Escolá C
Int J Mol Sci 2020 Feb 29;21(5) doi: 10.3390/ijms21051682. PMID: 32121432Free PMC Article
Molecular stratifications, biomarker candidates and new therapeutic options in current medulloblastoma treatment approaches.
Menyhárt O, Győrffy B
Cancer Metastasis Rev 2020 Mar;39(1):211-233. doi: 10.1007/s10555-020-09854-1. PMID: 31970590Free PMC Article
Brain Tumors.
McFaline-Figueroa JR, Lee EQ
Am J Med 2018 Aug;131(8):874-882. Epub 2018 Jan 31 doi: 10.1016/j.amjmed.2017.12.039. PMID: 29371158

Therapy

Treatment Options for Recurrent Primary CNS Lymphoma.
Kaulen LD, Baehring JM
Curr Treat Options Oncol 2022 Nov;23(11):1548-1565. Epub 2022 Oct 7 doi: 10.1007/s11864-022-01016-5. PMID: 36205806
Immunotherapy approaches for the treatment of diffuse midline gliomas.
Bernstock JD, Hoffman SE, Kappel AD, Valdes PA, Essayed W, Klinger NV, Kang KD, Totsch SK, Olsen HE, Schlappi CW, Filipski K, Gessler FA, Baird L, Filbin MG, Hashizume R, Becher OJ, Friedman GK
Oncoimmunology 2022;11(1):2124058. Epub 2022 Sep 26 doi: 10.1080/2162402X.2022.2124058. PMID: 36185807Free PMC Article
Dabrafenib plus trametinib in patients with BRAF(V600E)-mutant low-grade and high-grade glioma (ROAR): a multicentre, open-label, single-arm, phase 2, basket trial.
Wen PY, Stein A, van den Bent M, De Greve J, Wick A, de Vos FYFL, von Bubnoff N, van Linde ME, Lai A, Prager GW, Campone M, Fasolo A, Lopez-Martin JA, Kim TM, Mason WP, Hofheinz RD, Blay JY, Cho DC, Gazzah A, Pouessel D, Yachnin J, Boran A, Burgess P, Ilankumaran P, Gasal E, Subbiah V
Lancet Oncol 2022 Jan;23(1):53-64. Epub 2021 Nov 24 doi: 10.1016/S1470-2045(21)00578-7. PMID: 34838156
FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS.
Ferraro GB, Ali A, Luengo A, Kodack DP, Deik A, Abbott KL, Bezwada D, Blanc L, Prideaux B, Jin X, Posada JM, Chen J, Chin CR, Amoozgar Z, Ferreira R, Chen IX, Naxerova K, Ng C, Westermark AM, Duquette M, Roberge S, Lindeman NI, Lyssiotis CA, Nielsen J, Housman DE, Duda DG, Brachtel E, Golub TR, Cantley LC, Asara JM, Davidson SM, Fukumura D, Dartois VA, Clish CB, Jain RK, Vander Heiden MG
Nat Cancer 2021 Apr;2(4):414-428. Epub 2021 Apr 1 doi: 10.1038/s43018-021-00183-y. PMID: 34179825Free PMC Article
Molecular stratifications, biomarker candidates and new therapeutic options in current medulloblastoma treatment approaches.
Menyhárt O, Győrffy B
Cancer Metastasis Rev 2020 Mar;39(1):211-233. doi: 10.1007/s10555-020-09854-1. PMID: 31970590Free PMC Article

Prognosis

Immunotherapy approaches for the treatment of diffuse midline gliomas.
Bernstock JD, Hoffman SE, Kappel AD, Valdes PA, Essayed W, Klinger NV, Kang KD, Totsch SK, Olsen HE, Schlappi CW, Filipski K, Gessler FA, Baird L, Filbin MG, Hashizume R, Becher OJ, Friedman GK
Oncoimmunology 2022;11(1):2124058. Epub 2022 Sep 26 doi: 10.1080/2162402X.2022.2124058. PMID: 36185807Free PMC Article
Molecular stratifications, biomarker candidates and new therapeutic options in current medulloblastoma treatment approaches.
Menyhárt O, Győrffy B
Cancer Metastasis Rev 2020 Mar;39(1):211-233. doi: 10.1007/s10555-020-09854-1. PMID: 31970590Free PMC Article
Medulloblastoma in the age of molecular subgroups: a review.
Juraschka K, Taylor MD
J Neurosurg Pediatr 2019 Oct 1;24(4):353-363. doi: 10.3171/2019.5.PEDS18381. PMID: 31574483
Brain Tumors.
McFaline-Figueroa JR, Lee EQ
Am J Med 2018 Aug;131(8):874-882. Epub 2018 Jan 31 doi: 10.1016/j.amjmed.2017.12.039. PMID: 29371158
Primary CNS Lymphoma.
Grommes C, DeAngelis LM
J Clin Oncol 2017 Jul 20;35(21):2410-2418. Epub 2017 Jun 22 doi: 10.1200/JCO.2017.72.7602. PMID: 28640701Free PMC Article

Clinical prediction guides

Central Nervous System Lymphomas.
Grommes C
Continuum (Minneap Minn) 2020 Dec;26(6):1476-1494. doi: 10.1212/CON.0000000000000936. PMID: 33273169
A unique CDK4/6 inhibitor: Current and future therapeutic strategies of abemaciclib.
Chong QY, Kok ZH, Bui NL, Xiang X, Wong AL, Yong WP, Sethi G, Lobie PE, Wang L, Goh BC
Pharmacol Res 2020 Jun;156:104686. Epub 2020 Feb 14 doi: 10.1016/j.phrs.2020.104686. PMID: 32068118
Molecular stratifications, biomarker candidates and new therapeutic options in current medulloblastoma treatment approaches.
Menyhárt O, Győrffy B
Cancer Metastasis Rev 2020 Mar;39(1):211-233. doi: 10.1007/s10555-020-09854-1. PMID: 31970590Free PMC Article
Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial.
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Lancet Oncol 2019 Jul;20(7):1011-1022. Epub 2019 May 28 doi: 10.1016/S1470-2045(19)30277-3. PMID: 31151904Free PMC Article
Targeting the Warburg effect for cancer treatment: Ketogenic diets for management of glioma.
Poff A, Koutnik AP, Egan KM, Sahebjam S, D'Agostino D, Kumar NB
Semin Cancer Biol 2019 Jun;56:135-148. Epub 2017 Dec 30 doi: 10.1016/j.semcancer.2017.12.011. PMID: 29294371Free PMC Article

Recent systematic reviews

Aggressive PitNETs and Potential Target Therapies: A Systematic Review of Molecular and Genetic Pathways.
Serioli S, Agostini L, Pietrantoni A, Valeri F, Costanza F, Chiloiro S, Buffoli B, Piazza A, Poliani PL, Peris-Celda M, Iavarone F, Gaudino S, Gessi M, Schinzari G, Mattogno PP, Giampietro A, De Marinis L, Pontecorvi A, Fontanella MM, Lauretti L, Rindi G, Olivi A, Bianchi A, Doglietto F
Int J Mol Sci 2023 Oct 29;24(21) doi: 10.3390/ijms242115719. PMID: 37958702Free PMC Article
Somatostatin analogues in treatment-refractory meningioma: a systematic review with meta-analysis of individual patient data.
Jensen LR, Maier AD, Lomstein A, Graillon T, Hrachova M, Bota D, Ruiz-Patiño A, Arrieta O, Cardona AF, Rudà R, Furtner J, Roeckle U, Clement P, Preusser M, Scheie D, Broholm H, Kristensen BW, Skjøth-Rasmussen J, Ziebell M, Munch TN, Fugleholm K, Walter MA, Mathiesen T, Mirian C
Neurosurg Rev 2022 Oct;45(5):3067-3081. Epub 2022 Aug 19 doi: 10.1007/s10143-022-01849-6. PMID: 35984552
Management strategies for pediatric patients with tectal gliomas: a systematic review.
Bauman MMJ, Bhandarkar AR, Zheng CR, Riviere-Cazaux C, Beeler CJ, Naylor RM, Daniels DJ
Neurosurg Rev 2022 Apr;45(2):1031-1039. Epub 2021 Oct 5 doi: 10.1007/s10143-021-01653-8. PMID: 34609665
Medulloblastoma in children and adolescents: a systematic review of contemporary phase I and II clinical trials and biology update.
Bautista F, Fioravantti V, de Rojas T, Carceller F, Madero L, Lassaletta A, Moreno L
Cancer Med 2017 Nov;6(11):2606-2624. Epub 2017 Oct 4 doi: 10.1002/cam4.1171. PMID: 28980418Free PMC Article
Gene expression in prolactinomas: a systematic review.
Seltzer J, Scotton TC, Kang K, Zada G, Carmichael JD
Pituitary 2016 Feb;19(1):93-104. doi: 10.1007/s11102-015-0674-1. PMID: 26238304

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