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Recurrent Pancreatic Ductal Adenocarcinoma

MedGen UID:
1667480
•Concept ID:
C4727399
•
Neoplastic Process

Definition

The reemergence of pancreatic ductal adenocarcinoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Pancreatic Ductal Adenocarcinoma

Professional guidelines

PubMed

International evidence-based Kyoto guidelines for the management of intraductal papillary mucinous neoplasm of the pancreas.
Ohtsuka T, Fernandez-Del Castillo C, Furukawa T, Hijioka S, Jang JY, Lennon AM, Miyasaka Y, Ohno E, Salvia R, Wolfgang CL, Wood LD
Pancreatology 2024 Mar;24(2):255-270. Epub 2023 Dec 28 doi: 10.1016/j.pan.2023.12.009. PMID: 38182527
Recent Developments in the Treatment of Pancreatic Cancer.
Paulino J, Mansinho H
Acta Med Port 2023 Oct 2;36(10):670-678. doi: 10.20344/amp.19957. PMID: 37788655
Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment.
Hwang WL, Jagadeesh KA, Guo JA, Hoffman HI, Yadollahpour P, Reeves JW, Mohan R, Drokhlyansky E, Van Wittenberghe N, Ashenberg O, Farhi SL, Schapiro D, Divakar P, Miller E, Zollinger DR, Eng G, Schenkel JM, Su J, Shiau C, Yu P, Freed-Pastor WA, Abbondanza D, Mehta A, Gould J, Lambden C, Porter CBM, Tsankov A, Dionne D, Waldman J, Cuoco MS, Nguyen L, Delorey T, Phillips D, Barth JL, Kem M, Rodrigues C, Ciprani D, Roldan J, Zelga P, Jorgji V, Chen JH, Ely Z, Zhao D, Fuhrman K, Fropf R, Beechem JM, Loeffler JS, Ryan DP, Weekes CD, Ferrone CR, Qadan M, Aryee MJ, Jain RK, Neuberg DS, Wo JY, Hong TS, Xavier R, Aguirre AJ, Rozenblatt-Rosen O, Mino-Kenudson M, Castillo CF, Liss AS, Ting DT, Jacks T, Regev A
Nat Genet 2022 Aug;54(8):1178-1191. Epub 2022 Jul 28 doi: 10.1038/s41588-022-01134-8. PMID: 35902743Free PMC Article

Recent clinical studies

Etiology

Sintilimab Plus Modified FOLFIRINOX in Metastatic or Recurrent Pancreatic Cancer: The Randomized Phase II CISPD3 Trial.
Fu Q, Chen Y, Huang D, Guo C, Zhang X, Xiao W, Xue X, Zhang Q, Li X, Gao S, Que R, Shen Y, Wu J, Zhang M, Bai X, Liang T
Ann Surg Oncol 2023 Aug;30(8):5071-5080. Epub 2023 Apr 13 doi: 10.1245/s10434-023-13383-w. PMID: 37052821
Detection, Treatment, and Survival of Pancreatic Cancer Recurrence in the Netherlands: A Nationwide Analysis.
Daamen LA, Groot VP, Besselink MG, Bosscha K, Busch OR, Cirkel GA, van Dam RM, Festen S, Groot Koerkamp B, Haj Mohammad N, van der Harst E, de Hingh IHJT, Intven MPW, Kazemier G, Los M, Meijer GJ, de Meijer VE, Nieuwenhuijs VB, Pranger BK, Raicu MG, Schreinemakers JMJ, Stommel MWJ, Verdonk RC, Verkooijen HM, Molenaar IQ, van Santvoort HC; Dutch Pancreatic Cancer Group
Ann Surg 2022 Apr 1;275(4):769-775. doi: 10.1097/SLA.0000000000004093. PMID: 32773631
The Path to Whipple Reconstruction for Pancreatic Adenocarcinoma: Trans-Mesocolon or Through Ligament of Treitz?
Gamboa AC, Zaidi MY, Lee RM, Sarmiento JM, Kooby DA, Russell MC, Cardona K, Maithel SK
J Gastrointest Surg 2020 Sep;24(9):2046-2053. Epub 2019 Aug 29 doi: 10.1007/s11605-019-04377-9. PMID: 31468334Free PMC Article
Selective reoperation for locally recurrent or metastatic pancreatic ductal adenocarcinoma following primary pancreatic resection.
Thomas RM, Truty MJ, Nogueras-Gonzalez GM, Fleming JB, Vauthey JN, Pisters PW, Lee JE, Rice DC, Hofstetter WL, Wolff RA, Varadhachary GR, Wang H, Katz MH
J Gastrointest Surg 2012 Sep;16(9):1696-704. Epub 2012 May 30 doi: 10.1007/s11605-012-1912-8. PMID: 22644446Free PMC Article
Surgery for recurrent pancreatic ductal adenocarcinoma.
Kleeff J, Reiser C, Hinz U, Bachmann J, Debus J, Jaeger D, Friess H, Büchler MW
Ann Surg 2007 Apr;245(4):566-72. doi: 10.1097/01.sla.0000245845.06772.7d. PMID: 17414605Free PMC Article

Diagnosis

Detection, Treatment, and Survival of Pancreatic Cancer Recurrence in the Netherlands: A Nationwide Analysis.
Daamen LA, Groot VP, Besselink MG, Bosscha K, Busch OR, Cirkel GA, van Dam RM, Festen S, Groot Koerkamp B, Haj Mohammad N, van der Harst E, de Hingh IHJT, Intven MPW, Kazemier G, Los M, Meijer GJ, de Meijer VE, Nieuwenhuijs VB, Pranger BK, Raicu MG, Schreinemakers JMJ, Stommel MWJ, Verdonk RC, Verkooijen HM, Molenaar IQ, van Santvoort HC; Dutch Pancreatic Cancer Group
Ann Surg 2022 Apr 1;275(4):769-775. doi: 10.1097/SLA.0000000000004093. PMID: 32773631
Overall survival of patients with recurrent pancreatic cancer treated with systemic therapy: a retrospective study.
Gbolahan OB, Tong Y, Sehdev A, O'Neil B, Shahda S
BMC Cancer 2019 May 17;19(1):468. doi: 10.1186/s12885-019-5630-4. PMID: 31101022Free PMC Article

Therapy

Sintilimab Plus Modified FOLFIRINOX in Metastatic or Recurrent Pancreatic Cancer: The Randomized Phase II CISPD3 Trial.
Fu Q, Chen Y, Huang D, Guo C, Zhang X, Xiao W, Xue X, Zhang Q, Li X, Gao S, Que R, Shen Y, Wu J, Zhang M, Bai X, Liang T
Ann Surg Oncol 2023 Aug;30(8):5071-5080. Epub 2023 Apr 13 doi: 10.1245/s10434-023-13383-w. PMID: 37052821
The Prognostic Utility of a Geriatric Assessment for Patients with Pancreatic Cancer Receiving Gemcitabine-based Chemotherapy: A Prospective Observational Study.
Kitamura H, Nakazawa J, Nagashima F, Andou M, Furuse J
Intern Med 2023 Jun 1;62(11):1573-1580. Epub 2022 Oct 12 doi: 10.2169/internalmedicine.9689-22. PMID: 36223928Free PMC Article
Overall survival of patients with recurrent pancreatic cancer treated with systemic therapy: a retrospective study.
Gbolahan OB, Tong Y, Sehdev A, O'Neil B, Shahda S
BMC Cancer 2019 May 17;19(1):468. doi: 10.1186/s12885-019-5630-4. PMID: 31101022Free PMC Article

Prognosis

The Prognostic Utility of a Geriatric Assessment for Patients with Pancreatic Cancer Receiving Gemcitabine-based Chemotherapy: A Prospective Observational Study.
Kitamura H, Nakazawa J, Nagashima F, Andou M, Furuse J
Intern Med 2023 Jun 1;62(11):1573-1580. Epub 2022 Oct 12 doi: 10.2169/internalmedicine.9689-22. PMID: 36223928Free PMC Article
Second pancreatectomy for recurrent pancreatic ductal adenocarcinoma in the remnant pancreas: A pooled analysis.
Zhou Y, Song A, Wu L, Si X, Li Y
Pancreatology 2016 Nov-Dec;16(6):1124-1128. Epub 2016 Sep 29 doi: 10.1016/j.pan.2016.09.015. PMID: 27717684
Surgery for recurrent pancreatic ductal adenocarcinoma.
Kleeff J, Reiser C, Hinz U, Bachmann J, Debus J, Jaeger D, Friess H, Büchler MW
Ann Surg 2007 Apr;245(4):566-72. doi: 10.1097/01.sla.0000245845.06772.7d. PMID: 17414605Free PMC Article

Clinical prediction guides

Sintilimab Plus Modified FOLFIRINOX in Metastatic or Recurrent Pancreatic Cancer: The Randomized Phase II CISPD3 Trial.
Fu Q, Chen Y, Huang D, Guo C, Zhang X, Xiao W, Xue X, Zhang Q, Li X, Gao S, Que R, Shen Y, Wu J, Zhang M, Bai X, Liang T
Ann Surg Oncol 2023 Aug;30(8):5071-5080. Epub 2023 Apr 13 doi: 10.1245/s10434-023-13383-w. PMID: 37052821
The Prognostic Utility of a Geriatric Assessment for Patients with Pancreatic Cancer Receiving Gemcitabine-based Chemotherapy: A Prospective Observational Study.
Kitamura H, Nakazawa J, Nagashima F, Andou M, Furuse J
Intern Med 2023 Jun 1;62(11):1573-1580. Epub 2022 Oct 12 doi: 10.2169/internalmedicine.9689-22. PMID: 36223928Free PMC Article
Detection, Treatment, and Survival of Pancreatic Cancer Recurrence in the Netherlands: A Nationwide Analysis.
Daamen LA, Groot VP, Besselink MG, Bosscha K, Busch OR, Cirkel GA, van Dam RM, Festen S, Groot Koerkamp B, Haj Mohammad N, van der Harst E, de Hingh IHJT, Intven MPW, Kazemier G, Los M, Meijer GJ, de Meijer VE, Nieuwenhuijs VB, Pranger BK, Raicu MG, Schreinemakers JMJ, Stommel MWJ, Verdonk RC, Verkooijen HM, Molenaar IQ, van Santvoort HC; Dutch Pancreatic Cancer Group
Ann Surg 2022 Apr 1;275(4):769-775. doi: 10.1097/SLA.0000000000004093. PMID: 32773631
Overall survival of patients with recurrent pancreatic cancer treated with systemic therapy: a retrospective study.
Gbolahan OB, Tong Y, Sehdev A, O'Neil B, Shahda S
BMC Cancer 2019 May 17;19(1):468. doi: 10.1186/s12885-019-5630-4. PMID: 31101022Free PMC Article
Comparative analysis of tumorbiology and CD133 positivity in primary and recurrent pancreatic ductal adenocarcinoma.
Welsch T, Keleg S, Bergmann F, Degrate L, Bauer S, Schmidt J
Clin Exp Metastasis 2009;26(7):701-11. Epub 2009 Jun 2 doi: 10.1007/s10585-009-9269-4. PMID: 19488831

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