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Melanoma of Unknown Primary

MedGen UID:
1667560
•Concept ID:
C4745280
•
Neoplastic Process
Synonym: Melanoma of Unknown Primary Origin

Definition

A melanoma which has metastasized from an unknown primary anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMelanoma of Unknown Primary

Professional guidelines

PubMed

Multidisciplinary Care for Melanoma of Unknown Primary: Experience in the Era of Molecular Profiling.
De Andrade JP, Wong P, O'Leary MP, Parekh V, Amini A, Schoellhammer HF, Margolin KA, Afkhami M, Melstrom LG
Ann Surg Oncol 2020 Dec;27(13):5240-5247. Epub 2020 Sep 9 doi: 10.1245/s10434-020-09112-2. PMID: 32909128
Treatment Outcomes for Metastatic Melanoma of Unknown Primary in the New Era: A Single-Institution Study and Review of the Literature.
Utter K, Goldman C, Weiss SA, Shapiro RL, Berman RS, Wilson MA, Pavlick AC, Osman I
Oncology 2017;93(4):249-258. Epub 2017 Jul 27 doi: 10.1159/000478050. PMID: 28746931Free PMC Article
Unknown Primary Melanoma: Worldwide Survey on Clinical Management.
Ribero S, Pampena R, Bataille V, Moscarella E, Thomas L, Quaglino P, Potenza C, Van Akkooi ACJ, Testori A, Nathan P, Puig S, Zalaudek I, Argenziano G, Longo C
Dermatology 2016;232(6):704-707. Epub 2017 Jan 5 doi: 10.1159/000453592. PMID: 28052277

Recent clinical studies

Etiology

Brain metastases in adult patients with melanoma of unknown primary in the Netherlands (2011-2020).
Padilla CS, Ho VKY, Mooijenkind TWAN, Louwman MWJ, de Vos FYFL, Bekkenk MW, Minnaard WA, Loef C, van Zanten SEMV
J Neurooncol 2023 May;163(1):239-248. Epub 2023 May 12 doi: 10.1007/s11060-023-04335-1. PMID: 37169949
Survival after lymphadenectomy of nodal metastases from melanoma of unknown primary site.
Gullestad HP, Ryder T, Goscinski M
J Plast Surg Hand Surg 2023 Feb-Dec;57(1-6):109-114. Epub 2021 Dec 8 doi: 10.1080/2000656X.2021.2010739. PMID: 34878354
Multidisciplinary Care for Melanoma of Unknown Primary: Experience in the Era of Molecular Profiling.
De Andrade JP, Wong P, O'Leary MP, Parekh V, Amini A, Schoellhammer HF, Margolin KA, Afkhami M, Melstrom LG
Ann Surg Oncol 2020 Dec;27(13):5240-5247. Epub 2020 Sep 9 doi: 10.1245/s10434-020-09112-2. PMID: 32909128
Treatment Outcomes for Metastatic Melanoma of Unknown Primary in the New Era: A Single-Institution Study and Review of the Literature.
Utter K, Goldman C, Weiss SA, Shapiro RL, Berman RS, Wilson MA, Pavlick AC, Osman I
Oncology 2017;93(4):249-258. Epub 2017 Jul 27 doi: 10.1159/000478050. PMID: 28746931Free PMC Article
Melanoma of unknown primary: experience at Massachusetts General Hospital and Dana-Farber Cancer Institute.
Katz KA, Jonasch E, Hodi FS, Soiffer R, Kwitkiwski K, Sober AJ, Haluska FG
Melanoma Res 2005 Feb;15(1):77-82. doi: 10.1097/00008390-200502000-00013. PMID: 15714125

Diagnosis

Gastric Melanoma of Unknown Primary.
Cortellini F, Marasco G, Renzulli M, Vasuri F, Ricciardiello L
J Gastrointestin Liver Dis 2021 Mar 12;30(1):14. doi: 10.15403/jgld-3420. PMID: 33723546
Melanoma of unknown primary: New perspectives for an old story.
Boussios S, Rassy E, Samartzis E, Moschetta M, Sheriff M, Pérez-Fidalgo JA, Pavlidis N
Crit Rev Oncol Hematol 2021 Feb;158:103208. Epub 2020 Dec 28 doi: 10.1016/j.critrevonc.2020.103208. PMID: 33383207
Melanoma of unknown primary in the pancreas: should it be considered primary?
Jin Y, Ran C, Li F, Cheng N
BMC Surg 2020 Apr 16;20(1):76. doi: 10.1186/s12893-020-00731-w. PMID: 32299408Free PMC Article
Parotid melanoma of unknown primary.
Scott JF, Thompson CL, Vyas R, Honda K, Zender C, Rezaee R, Lavertu P, Koon H, Cooper KD, Gerstenblith MR
J Cancer Res Clin Oncol 2016 Jul;142(7):1529-37. Epub 2016 Apr 13 doi: 10.1007/s00432-016-2156-x. PMID: 27075178
Melanoma of unknown primary: experience at Massachusetts General Hospital and Dana-Farber Cancer Institute.
Katz KA, Jonasch E, Hodi FS, Soiffer R, Kwitkiwski K, Sober AJ, Haluska FG
Melanoma Res 2005 Feb;15(1):77-82. doi: 10.1097/00008390-200502000-00013. PMID: 15714125

Therapy

Improved prognosis and evidence of enhanced immunogenicity in tumor and circulation of high-risk melanoma patients with unknown primary.
Tarhini AA, Lee SJ, Tan AC, El Naqa IM, Stephen Hodi F, Butterfield LH, LaFramboise WA, Storkus WJ, Karunamurthy AD, Conejo-Garcia JR, Hwu P, Streicher H, Sondak VK, Kirkwood JM
J Immunother Cancer 2022 Jan;10(1) doi: 10.1136/jitc-2021-004310. PMID: 35074904Free PMC Article
Clinical outcome of patients with metastatic melanoma of unknown primary in the era of novel therapy.
Verver D, Grünhagen DJ, van Akkooi ACJ, Aarts MJB, van den Berkmortel FWPJ, van den Eertwegh AJM, de Groot JWB, Boers-Sonderen MJ, Haanen JBAG, Hospers GAP, Kapiteijn E, Piersma D, van Rijn RS, Suijkerbuijk KPM, Tije AJT, Vreugdenhil G, Verhoef C, van der Veldt AAM
Cancer Immunol Immunother 2021 Nov;70(11):3123-3135. Epub 2021 Mar 27 doi: 10.1007/s00262-021-02871-1. PMID: 33774697Free PMC Article
Survival and therapeutic response in patients with melanoma of unknown and known primary: a single-centre retrospective analysis.
Ludwig SV, F Cheng P, Mangana J, Braun R, Dummer R, Koelblinger P
Eur J Dermatol 2020 Dec 1;30(6):699-709. doi: 10.1684/ejd.2020.3929. PMID: 33459260
Treatment Outcomes for Metastatic Melanoma of Unknown Primary in the New Era: A Single-Institution Study and Review of the Literature.
Utter K, Goldman C, Weiss SA, Shapiro RL, Berman RS, Wilson MA, Pavlick AC, Osman I
Oncology 2017;93(4):249-258. Epub 2017 Jul 27 doi: 10.1159/000478050. PMID: 28746931Free PMC Article
Metastatic melanomas of unknown primary show better prognosis than those of known primary: a systematic review and meta-analysis of observational studies.
Bae JM, Choi YY, Kim DS, Lee JH, Jang HS, Lee JH, Kim H, Oh BH, Roh MR, Nam KA, Chung KY
J Am Acad Dermatol 2015 Jan;72(1):59-70. Epub 2014 Nov 1 doi: 10.1016/j.jaad.2014.09.029. PMID: 25440435

Prognosis

Brain metastases in adult patients with melanoma of unknown primary in the Netherlands (2011-2020).
Padilla CS, Ho VKY, Mooijenkind TWAN, Louwman MWJ, de Vos FYFL, Bekkenk MW, Minnaard WA, Loef C, van Zanten SEMV
J Neurooncol 2023 May;163(1):239-248. Epub 2023 May 12 doi: 10.1007/s11060-023-04335-1. PMID: 37169949
Survival after lymphadenectomy of nodal metastases from melanoma of unknown primary site.
Gullestad HP, Ryder T, Goscinski M
J Plast Surg Hand Surg 2023 Feb-Dec;57(1-6):109-114. Epub 2021 Dec 8 doi: 10.1080/2000656X.2021.2010739. PMID: 34878354
Melanoma of unknown primary: New perspectives for an old story.
Boussios S, Rassy E, Samartzis E, Moschetta M, Sheriff M, Pérez-Fidalgo JA, Pavlidis N
Crit Rev Oncol Hematol 2021 Feb;158:103208. Epub 2020 Dec 28 doi: 10.1016/j.critrevonc.2020.103208. PMID: 33383207
Melanoma of unknown primary.
Song Y, Karakousis GC
J Surg Oncol 2019 Jan;119(2):232-241. Epub 2018 Nov 27 doi: 10.1002/jso.25302. PMID: 30481368
Melanoma of unknown primary: experience at Massachusetts General Hospital and Dana-Farber Cancer Institute.
Katz KA, Jonasch E, Hodi FS, Soiffer R, Kwitkiwski K, Sober AJ, Haluska FG
Melanoma Res 2005 Feb;15(1):77-82. doi: 10.1097/00008390-200502000-00013. PMID: 15714125

Clinical prediction guides

Brain metastases in adult patients with melanoma of unknown primary in the Netherlands (2011-2020).
Padilla CS, Ho VKY, Mooijenkind TWAN, Louwman MWJ, de Vos FYFL, Bekkenk MW, Minnaard WA, Loef C, van Zanten SEMV
J Neurooncol 2023 May;163(1):239-248. Epub 2023 May 12 doi: 10.1007/s11060-023-04335-1. PMID: 37169949
Impact of systemic therapies in metastatic melanoma of unknown primary: A study from MELBASE, a French multicentric prospective cohort.
Rousset P, Dalle S, Mortier L, Dereure O, Dalac S, Dutriaux C, Leccia MT, Legoupil D, Brunet-Possenti F, De Quatrebarbes J, Grob JJ, Saiag P, Maubec E, Stoebner PE, Granel-Brocard F, Arnault JP, Allayous C, Oriano B, Lebbe C, Montaudié H
J Am Acad Dermatol 2023 Apr;88(4):808-815. Epub 2022 Dec 19 doi: 10.1016/j.jaad.2022.11.040. PMID: 36543626
Survival after lymphadenectomy of nodal metastases from melanoma of unknown primary site.
Gullestad HP, Ryder T, Goscinski M
J Plast Surg Hand Surg 2023 Feb-Dec;57(1-6):109-114. Epub 2021 Dec 8 doi: 10.1080/2000656X.2021.2010739. PMID: 34878354
Treatment Outcomes for Metastatic Melanoma of Unknown Primary in the New Era: A Single-Institution Study and Review of the Literature.
Utter K, Goldman C, Weiss SA, Shapiro RL, Berman RS, Wilson MA, Pavlick AC, Osman I
Oncology 2017;93(4):249-258. Epub 2017 Jul 27 doi: 10.1159/000478050. PMID: 28746931Free PMC Article
Malignant melanoma of unknown primary site. To make the long story short. A systematic review of the literature.
Kamposioras K, Pentheroudakis G, Pectasides D, Pavlidis N
Crit Rev Oncol Hematol 2011 May;78(2):112-26. Epub 2010 May 31 doi: 10.1016/j.critrevonc.2010.04.007. PMID: 20570171

Recent systematic reviews

Metastatic melanomas of unknown primary show better prognosis than those of known primary: a systematic review and meta-analysis of observational studies.
Bae JM, Choi YY, Kim DS, Lee JH, Jang HS, Lee JH, Kim H, Oh BH, Roh MR, Nam KA, Chung KY
J Am Acad Dermatol 2015 Jan;72(1):59-70. Epub 2014 Nov 1 doi: 10.1016/j.jaad.2014.09.029. PMID: 25440435
Malignant melanoma of unknown primary site. To make the long story short. A systematic review of the literature.
Kamposioras K, Pentheroudakis G, Pectasides D, Pavlidis N
Crit Rev Oncol Hematol 2011 May;78(2):112-26. Epub 2010 May 31 doi: 10.1016/j.critrevonc.2010.04.007. PMID: 20570171

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