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Metastatic Adrenal Cortical Carcinoma

MedGen UID:
1667758
•Concept ID:
C4744547
•
Neoplastic Process
Synonym: Metastatic Adrenal Cortex Carcinoma

Definition

A carcinoma that arises from the adrenal cortex and has metastasized to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Adrenal Cortical Carcinoma

Professional guidelines

PubMed

Drugs in the medical treatment of Cushing's syndrome.
Schteingart DE
Expert Opin Emerg Drugs 2009 Dec;14(4):661-71. doi: 10.1517/14728210903413522. PMID: 19939210
5-Fluorouracil, doxorubicin, and cisplatin as treatment for adrenal cortical carcinoma.
Schlumberger M, Brugieres L, Gicquel C, Travagli JP, Droz JP, Parmentier C
Cancer 1991 Jun 15;67(12):2997-3000. doi: 10.1002/1097-0142(19910615)67:12<2997::aid-cncr2820671211>3.0.co;2-#. PMID: 2044046

Recent clinical studies

Etiology

Combined lenvatinib and pembrolizumab as salvage therapy in advanced adrenal cortical carcinoma.
Bedrose S, Miller KC, Altameemi L, Ali MS, Nassar S, Garg N, Daher M, Eaton KD, Yorio JT, Daniel DB, Campbell M, Bible KC, Ryder M, Chintakuntlawar AV, Habra MA
J Immunother Cancer 2020 Jul;8(2) doi: 10.1136/jitc-2020-001009. PMID: 32737143Free PMC Article
Interpretation of core biopsy of liver mass lesions: A comparison study between cytopathologist and gastrointestinal pathologist.
Washburn ER, Yang Z
Ann Diagn Pathol 2019 Jun;40:152-160. Epub 2019 May 5 doi: 10.1016/j.anndiagpath.2019.05.001. PMID: 31100645
Adrenal cortical carcinoma: a case of late pulmonary metastasis.
Dang C, Mohamed H, Mandal A, Salem F
J Natl Med Assoc 2001 Jan;93(1):37-9. PMID: 12653379Free PMC Article
5-Fluorouracil, doxorubicin, and cisplatin as treatment for adrenal cortical carcinoma.
Schlumberger M, Brugieres L, Gicquel C, Travagli JP, Droz JP, Parmentier C
Cancer 1991 Jun 15;67(12):2997-3000. doi: 10.1002/1097-0142(19910615)67:12<2997::aid-cncr2820671211>3.0.co;2-#. PMID: 2044046
CAP (cyclophosphamide, doxorubicin, and cisplatin) regimen in adrenal cortical carcinoma.
van Slooten H, van Oosterom AT
Cancer Treat Rep 1983 Apr;67(4):377-9. PMID: 6687835

Diagnosis

Successful administration of mitotane (O, p'-DDD) in pediatric oncology.
Strobbe G, Fraipont F, Raimbault S, Mercier S, Stala T, Naveau M, Villain A, Sakji I, Defachelles AS, Feutry F, Marliot G
J Oncol Pharm Pract 2022 Oct;28(7):1637-1640. Epub 2022 Jan 31 doi: 10.1177/10781552221076795. PMID: 35098802
Hypoglycemia in a Patient with Hypercortisolism and Adrenocortical Carcinoma: A Paradoxical Entity.
Khadka S, Mandal S, Kasireddy V, Ghimire S, Maganti T, Mols-Kowalczewski B
J Adolesc Young Adult Oncol 2022 Feb;11(1):122-125. Epub 2021 May 12 doi: 10.1089/jayao.2020.0229. PMID: 33978483
Combined lenvatinib and pembrolizumab as salvage therapy in advanced adrenal cortical carcinoma.
Bedrose S, Miller KC, Altameemi L, Ali MS, Nassar S, Garg N, Daher M, Eaton KD, Yorio JT, Daniel DB, Campbell M, Bible KC, Ryder M, Chintakuntlawar AV, Habra MA
J Immunother Cancer 2020 Jul;8(2) doi: 10.1136/jitc-2020-001009. PMID: 32737143Free PMC Article
Interpretation of core biopsy of liver mass lesions: A comparison study between cytopathologist and gastrointestinal pathologist.
Washburn ER, Yang Z
Ann Diagn Pathol 2019 Jun;40:152-160. Epub 2019 May 5 doi: 10.1016/j.anndiagpath.2019.05.001. PMID: 31100645
Adrenal cortical carcinoma metastatic to the breast.
Gasilionis V, Ersahin C, Gabram S, Bova D, Branch J, Rajan P
J Clin Pathol 2006 May;59(5):546-7. doi: 10.1136/jcp.2005.028092. PMID: 16644887Free PMC Article

Therapy

Successful administration of mitotane (O, p'-DDD) in pediatric oncology.
Strobbe G, Fraipont F, Raimbault S, Mercier S, Stala T, Naveau M, Villain A, Sakji I, Defachelles AS, Feutry F, Marliot G
J Oncol Pharm Pract 2022 Oct;28(7):1637-1640. Epub 2022 Jan 31 doi: 10.1177/10781552221076795. PMID: 35098802
Combined lenvatinib and pembrolizumab as salvage therapy in advanced adrenal cortical carcinoma.
Bedrose S, Miller KC, Altameemi L, Ali MS, Nassar S, Garg N, Daher M, Eaton KD, Yorio JT, Daniel DB, Campbell M, Bible KC, Ryder M, Chintakuntlawar AV, Habra MA
J Immunother Cancer 2020 Jul;8(2) doi: 10.1136/jitc-2020-001009. PMID: 32737143Free PMC Article
Metastatic Adrenal Cortical Carcinoma Responding to Octreotide: A Case Report.
Wang X, Zhou N, Xiao Y, Zhu W, Bai C, Zhao L
Oncologist 2019 Aug;24(8):e793-e797. Epub 2019 May 9 doi: 10.1634/theoncologist.2018-0855. PMID: 31073023Free PMC Article
Drugs in the medical treatment of Cushing's syndrome.
Schteingart DE
Expert Opin Emerg Drugs 2009 Dec;14(4):661-71. doi: 10.1517/14728210903413522. PMID: 19939210
5-Fluorouracil, doxorubicin, and cisplatin as treatment for adrenal cortical carcinoma.
Schlumberger M, Brugieres L, Gicquel C, Travagli JP, Droz JP, Parmentier C
Cancer 1991 Jun 15;67(12):2997-3000. doi: 10.1002/1097-0142(19910615)67:12<2997::aid-cncr2820671211>3.0.co;2-#. PMID: 2044046

Prognosis

Hypoglycemia in a Patient with Hypercortisolism and Adrenocortical Carcinoma: A Paradoxical Entity.
Khadka S, Mandal S, Kasireddy V, Ghimire S, Maganti T, Mols-Kowalczewski B
J Adolesc Young Adult Oncol 2022 Feb;11(1):122-125. Epub 2021 May 12 doi: 10.1089/jayao.2020.0229. PMID: 33978483
Combined lenvatinib and pembrolizumab as salvage therapy in advanced adrenal cortical carcinoma.
Bedrose S, Miller KC, Altameemi L, Ali MS, Nassar S, Garg N, Daher M, Eaton KD, Yorio JT, Daniel DB, Campbell M, Bible KC, Ryder M, Chintakuntlawar AV, Habra MA
J Immunother Cancer 2020 Jul;8(2) doi: 10.1136/jitc-2020-001009. PMID: 32737143Free PMC Article
The construction and analysis of tumor-infiltrating immune cells and ceRNA networks in metastatic adrenal cortical carcinoma.
Huang R, Liu Z, Tian T, Song D, Yan P, Yin H, Hu P, Zhu X, Liu Y, Li Z, Meng T, Zhang J, Huang Z
Biosci Rep 2020 Mar 27;40(3) doi: 10.1042/BSR20200049. PMID: 32175564Free PMC Article
Metastatic Adrenal Cortical Carcinoma Responding to Octreotide: A Case Report.
Wang X, Zhou N, Xiao Y, Zhu W, Bai C, Zhao L
Oncologist 2019 Aug;24(8):e793-e797. Epub 2019 May 9 doi: 10.1634/theoncologist.2018-0855. PMID: 31073023Free PMC Article
Metastatic adrenal cortical carcinoma to T12 vertebrae.
Lee D, Yanamadala V, Shankar GM, Shin JH
J Clin Neurosci 2016 May;27:166-9. Epub 2016 Jan 4 doi: 10.1016/j.jocn.2015.11.009. PMID: 26765762

Clinical prediction guides

Combined lenvatinib and pembrolizumab as salvage therapy in advanced adrenal cortical carcinoma.
Bedrose S, Miller KC, Altameemi L, Ali MS, Nassar S, Garg N, Daher M, Eaton KD, Yorio JT, Daniel DB, Campbell M, Bible KC, Ryder M, Chintakuntlawar AV, Habra MA
J Immunother Cancer 2020 Jul;8(2) doi: 10.1136/jitc-2020-001009. PMID: 32737143Free PMC Article
The construction and analysis of tumor-infiltrating immune cells and ceRNA networks in metastatic adrenal cortical carcinoma.
Huang R, Liu Z, Tian T, Song D, Yan P, Yin H, Hu P, Zhu X, Liu Y, Li Z, Meng T, Zhang J, Huang Z
Biosci Rep 2020 Mar 27;40(3) doi: 10.1042/BSR20200049. PMID: 32175564Free PMC Article
Spontaneously regressing adrenocortical carcinoma in a newborn. A case report with DNA ploidy analysis.
Saracco S, Abramowsky C, Taylor S, Silverman RA, Berman BW
Cancer 1988 Aug 1;62(3):507-11. doi: 10.1002/1097-0142(19880801)62:3<507::aid-cncr2820620311>3.0.co;2-8. PMID: 3390790
5-Fluorouracil, doxorubicin, and cisplatin regimen in adrenal cortical carcinoma.
Schlumberger M, Ostronoff M, Bellaiche M, Rougier P, Droz JP, Parmentier C
Cancer 1988 Apr 15;61(8):1492-4. doi: 10.1002/1097-0142(19880415)61:8<1492::aid-cncr2820610803>3.0.co;2-1. PMID: 3349416
CAP (cyclophosphamide, doxorubicin, and cisplatin) regimen in adrenal cortical carcinoma.
van Slooten H, van Oosterom AT
Cancer Treat Rep 1983 Apr;67(4):377-9. PMID: 6687835

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