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Metastatic Oral Cavity Carcinoma

MedGen UID:
1668602
•Concept ID:
C4744557
•
Neoplastic Process

Definition

A carcinoma that arises from the oral cavity and has metastasized to another anatomic site. [from NCI]

Professional guidelines

PubMed

Current opinions on diagnosis and treatment of adenoid cystic carcinoma.
Fang Y, Peng Z, Wang Y, Gao K, Liu Y, Fan R, Zhang H, Xie Z, Jiang W
Oral Oncol 2022 Jul;130:105945. Epub 2022 Jun 2 doi: 10.1016/j.oraloncology.2022.105945. PMID: 35662026
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Recent clinical studies

Etiology

Primary and recurrent regional metastases for lateralized oral cavity squamous cell carcinoma.
Contrera KJ, Huang AT, Shenson JA, Tang C, Roberts D, Myers JN, Weber RS, Lai SY, Williams M, El-Hallal M, Jacob D, Zafereo M
Surg Oncol 2022 Sep;44:101804. Epub 2022 Jul 30 doi: 10.1016/j.suronc.2022.101804. PMID: 35932620
Clear Cell Neoplasms of Salivary Glands: A Diagnostic Challenge.
Skalova A, Leivo I, Hellquist H, Simpson RHW, Vander Poorten V, Willems SM, Mosaieby E, Slouka D, Ferlito A
Adv Anat Pathol 2022 Jul 1;29(4):217-226. Epub 2022 Mar 7 doi: 10.1097/PAP.0000000000000339. PMID: 35249992
Overview of oral cavity squamous cell carcinoma: Risk factors, mechanisms, and diagnostics.
Chamoli A, Gosavi AS, Shirwadkar UP, Wangdale KV, Behera SK, Kurrey NK, Kalia K, Mandoli A
Oral Oncol 2021 Oct;121:105451. Epub 2021 Jul 28 doi: 10.1016/j.oraloncology.2021.105451. PMID: 34329869
Management of recurrent and metastatic oral cavity cancer: Raising the bar a step higher.
Szturz P, Vermorken JB
Oral Oncol 2020 Feb;101:104492. Epub 2019 Dec 11 doi: 10.1016/j.oraloncology.2019.104492. PMID: 31837576
Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546

Diagnosis

Current opinions on diagnosis and treatment of adenoid cystic carcinoma.
Fang Y, Peng Z, Wang Y, Gao K, Liu Y, Fan R, Zhang H, Xie Z, Jiang W
Oral Oncol 2022 Jul;130:105945. Epub 2022 Jun 2 doi: 10.1016/j.oraloncology.2022.105945. PMID: 35662026
Clear Cell Neoplasms of Salivary Glands: A Diagnostic Challenge.
Skalova A, Leivo I, Hellquist H, Simpson RHW, Vander Poorten V, Willems SM, Mosaieby E, Slouka D, Ferlito A
Adv Anat Pathol 2022 Jul 1;29(4):217-226. Epub 2022 Mar 7 doi: 10.1097/PAP.0000000000000339. PMID: 35249992
Overview of oral cavity squamous cell carcinoma: Risk factors, mechanisms, and diagnostics.
Chamoli A, Gosavi AS, Shirwadkar UP, Wangdale KV, Behera SK, Kurrey NK, Kalia K, Mandoli A
Oral Oncol 2021 Oct;121:105451. Epub 2021 Jul 28 doi: 10.1016/j.oraloncology.2021.105451. PMID: 34329869
Management of recurrent and metastatic oral cavity cancer: Raising the bar a step higher.
Szturz P, Vermorken JB
Oral Oncol 2020 Feb;101:104492. Epub 2019 Dec 11 doi: 10.1016/j.oraloncology.2019.104492. PMID: 31837576
Perspectives on oral squamous cell carcinoma prevention-proliferation, position, progression and prediction.
Thomson PJ
J Oral Pathol Med 2018 Oct;47(9):803-807. Epub 2018 May 27 doi: 10.1111/jop.12733. PMID: 29752860

Therapy

Phase II Clinical Trial of Neoadjuvant and Adjuvant Pembrolizumab in Resectable Local-Regionally Advanced Head and Neck Squamous Cell Carcinoma.
Wise-Draper TM, Gulati S, Palackdharry S, Hinrichs BH, Worden FP, Old MO, Dunlap NE, Kaczmar JM, Patil Y, Riaz MK, Tang A, Mark J, Zender C, Gillenwater AM, Bell D, Kurtzweil N, Mathews M, Allen CL, Mierzwa ML, Casper K, Jandarov R, Medvedovic M, Lee JJ, Harun N, Takiar V, Gillison M
Clin Cancer Res 2022 Apr 1;28(7):1345-1352. doi: 10.1158/1078-0432.CCR-21-3351. PMID: 35338369Free PMC Article
The primary site of head and neck squamous cell carcinoma predicts survival benefits of EGFR inhibitors: A systematic review and meta-analysis.
Nie D, Wang X, Sun M, Feng Z, Pei F, Liu W, Wang Z, Han F
Radiother Oncol 2021 May;158:13-20. Epub 2021 Feb 13 doi: 10.1016/j.radonc.2021.02.001. PMID: 33587969
Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Prognosis

PET Imaging of Oral Cavity and Oropharyngeal Cancers.
Marcus C, Subramaniam RM
PET Clin 2022 Apr;17(2):223-234. Epub 2022 Mar 4 doi: 10.1016/j.cpet.2021.12.005. PMID: 35256303
Oral microbial dysbiosis and its performance in predicting oral cancer.
Su SC, Chang LC, Huang HD, Peng CY, Chuang CY, Chen YT, Lu MY, Chiu YW, Chen PY, Yang SF
Carcinogenesis 2021 Feb 11;42(1):127-135. doi: 10.1093/carcin/bgaa062. PMID: 32621740
Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546
Perspectives on oral squamous cell carcinoma prevention-proliferation, position, progression and prediction.
Thomson PJ
J Oral Pathol Med 2018 Oct;47(9):803-807. Epub 2018 May 27 doi: 10.1111/jop.12733. PMID: 29752860
MR assessment of oral cavity carcinomas.
Hagiwara M, Nusbaum A, Schmidt BL
Magn Reson Imaging Clin N Am 2012 Aug;20(3):473-94. Epub 2012 Jul 3 doi: 10.1016/j.mric.2012.05.003. PMID: 22877952

Clinical prediction guides

PET Imaging of Oral Cavity and Oropharyngeal Cancers.
Marcus C, Subramaniam RM
PET Clin 2022 Apr;17(2):223-234. Epub 2022 Mar 4 doi: 10.1016/j.cpet.2021.12.005. PMID: 35256303
The primary site of head and neck squamous cell carcinoma predicts survival benefits of EGFR inhibitors: A systematic review and meta-analysis.
Nie D, Wang X, Sun M, Feng Z, Pei F, Liu W, Wang Z, Han F
Radiother Oncol 2021 May;158:13-20. Epub 2021 Feb 13 doi: 10.1016/j.radonc.2021.02.001. PMID: 33587969
Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Management of recurrent and metastatic oral cavity cancer: Raising the bar a step higher.
Szturz P, Vermorken JB
Oral Oncol 2020 Feb;101:104492. Epub 2019 Dec 11 doi: 10.1016/j.oraloncology.2019.104492. PMID: 31837576
Perspectives on oral squamous cell carcinoma prevention-proliferation, position, progression and prediction.
Thomson PJ
J Oral Pathol Med 2018 Oct;47(9):803-807. Epub 2018 May 27 doi: 10.1111/jop.12733. PMID: 29752860

Recent systematic reviews

Occult metastases of oral maxillary squamous cell carcinoma: Systematic review and meta-analysis.
de la Fuente C, Prat-Valero N, Alberola-Ferranti M, Mis-Castell D, Sáez-Barba M, Pujol-Pina R, Pamias-Romero J, Bescós-Atín C
Head Neck 2023 Mar;45(3):733-744. Epub 2022 Dec 14 doi: 10.1002/hed.27276. PMID: 36515647
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
The primary site of head and neck squamous cell carcinoma predicts survival benefits of EGFR inhibitors: A systematic review and meta-analysis.
Nie D, Wang X, Sun M, Feng Z, Pei F, Liu W, Wang Z, Han F
Radiother Oncol 2021 May;158:13-20. Epub 2021 Feb 13 doi: 10.1016/j.radonc.2021.02.001. PMID: 33587969
Identification of inflammatory mediators associated with metastasis of oral squamous cell carcinoma in experimental and clinical studies: systematic review.
Elhousiny M, Miller K, Ariyawadana A, Nimmo A
Clin Exp Metastasis 2019 Dec;36(6):481-492. Epub 2019 Sep 26 doi: 10.1007/s10585-019-09994-x. PMID: 31559586
Cervical metastases of oral maxillary squamous cell carcinoma: A systematic review and meta-analysis.
Zhang WB, Peng X
Head Neck 2016 Apr;38 Suppl 1:E2335-42. Epub 2016 Feb 18 doi: 10.1002/hed.24274. PMID: 26890607

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