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Locally Advanced Unresectable Pancreatic Adenocarcinoma

MedGen UID:
1668759
Concept ID:
C4744358
Neoplastic Process

Definition

A pancreatic adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Unresectable Pancreatic Adenocarcinoma

Professional guidelines

PubMed

Hitchen N, Waldron NR, Deva S, Findlay M, Lawrence B
Asia Pac J Clin Oncol 2023 Oct;19(5):e231-e238. Epub 2022 Sep 16 doi: 10.1111/ajco.13845. PMID: 36114593
Salgado M, Arévalo S, Hernando O, Martínez A, Yaya R, Hidalgo M
Clin Transl Oncol 2018 Feb;20(2):113-118. Epub 2017 Jun 13 doi: 10.1007/s12094-017-1679-1. PMID: 28612202
Narayanan G, Hosein PJ, Beulaygue IC, Froud T, Scheffer HJ, Venkat SR, Echenique AM, Hevert EC, Livingstone AS, Rocha-Lima CM, Merchan JR, Levi JU, Yrizarry JM, Lencioni R
J Vasc Interv Radiol 2017 Mar;28(3):342-348. Epub 2016 Dec 16 doi: 10.1016/j.jvir.2016.10.023. PMID: 27993507

Recent clinical studies

Etiology

Izquierdo-Sanchez L, Lamarca A, La Casta A, Buettner S, Utpatel K, Klümpen HJ, Adeva J, Vogel A, Lleo A, Fabris L, Ponz-Sarvise M, Brustia R, Cardinale V, Braconi C, Vidili G, Jamieson NB, Macias RI, Jonas JP, Marzioni M, Hołówko W, Folseraas T, Kupčinskas J, Sparchez Z, Krawczyk M, Krupa Ł, Scripcariu V, Grazi GL, Landa-Magdalena A, Ijzermans JN, Evert K, Erdmann JI, López-López F, Saborowski A, Scheiter A, Santos-Laso A, Carpino G, Andersen JB, Marin JJ, Alvaro D, Bujanda L, Forner A, Valle JW, Koerkamp BG, Banales JM
J Hepatol 2022 May;76(5):1109-1121. Epub 2022 Feb 12 doi: 10.1016/j.jhep.2021.12.010. PMID: 35167909
Grossberg AJ, Chu LC, Deig CR, Fishman EK, Hwang WL, Maitra A, Marks DL, Mehta A, Nabavizadeh N, Simeone DM, Weekes CD, Thomas CR Jr
CA Cancer J Clin 2020 Sep;70(5):375-403. Epub 2020 Jul 19 doi: 10.3322/caac.21626. PMID: 32683683Free PMC Article
Loveday BPT, Lipton L, Thomson BN
Aust J Gen Pract 2019 Dec;48(12):826-831. doi: 10.31128/AJGP-06-19-4957. PMID: 31774983
O Kane GM, Knox JJ
Curr Probl Cancer 2018 Jan-Feb;42(1):12-25. Epub 2017 Nov 16 doi: 10.1016/j.currproblcancer.2017.10.006. PMID: 29153290
Vincent A, Herman J, Schulick R, Hruban RH, Goggins M
Lancet 2011 Aug 13;378(9791):607-20. Epub 2011 May 26 doi: 10.1016/S0140-6736(10)62307-0. PMID: 21620466Free PMC Article

Diagnosis

Park W, Chawla A, O'Reilly EM
JAMA 2021 Sep 7;326(9):851-862. doi: 10.1001/jama.2021.13027. PMID: 34547082Free PMC Article
Grossberg AJ, Chu LC, Deig CR, Fishman EK, Hwang WL, Maitra A, Marks DL, Mehta A, Nabavizadeh N, Simeone DM, Weekes CD, Thomas CR Jr
CA Cancer J Clin 2020 Sep;70(5):375-403. Epub 2020 Jul 19 doi: 10.3322/caac.21626. PMID: 32683683Free PMC Article
Loveday BPT, Lipton L, Thomson BN
Aust J Gen Pract 2019 Dec;48(12):826-831. doi: 10.31128/AJGP-06-19-4957. PMID: 31774983
Reyngold M, Parikh P, Crane CH
Radiat Oncol 2019 Jun 6;14(1):95. doi: 10.1186/s13014-019-1309-x. PMID: 31171025Free PMC Article
Vincent A, Herman J, Schulick R, Hruban RH, Goggins M
Lancet 2011 Aug 13;378(9791):607-20. Epub 2011 May 26 doi: 10.1016/S0140-6736(10)62307-0. PMID: 21620466Free PMC Article

Therapy

Park W, Chawla A, O'Reilly EM
JAMA 2021 Sep 7;326(9):851-862. doi: 10.1001/jama.2021.13027. PMID: 34547082Free PMC Article
Grossberg AJ, Chu LC, Deig CR, Fishman EK, Hwang WL, Maitra A, Marks DL, Mehta A, Nabavizadeh N, Simeone DM, Weekes CD, Thomas CR Jr
CA Cancer J Clin 2020 Sep;70(5):375-403. Epub 2020 Jul 19 doi: 10.3322/caac.21626. PMID: 32683683Free PMC Article
Loveday BPT, Lipton L, Thomson BN
Aust J Gen Pract 2019 Dec;48(12):826-831. doi: 10.31128/AJGP-06-19-4957. PMID: 31774983
Salgado M, Arévalo S, Hernando O, Martínez A, Yaya R, Hidalgo M
Clin Transl Oncol 2018 Feb;20(2):113-118. Epub 2017 Jun 13 doi: 10.1007/s12094-017-1679-1. PMID: 28612202
Cohen SJ, Pinover WH, Watson JC, Meropol NJ
Curr Treat Options Oncol 2000 Dec;1(5):375-86. doi: 10.1007/s11864-000-0065-2. PMID: 12057145

Prognosis

Izquierdo-Sanchez L, Lamarca A, La Casta A, Buettner S, Utpatel K, Klümpen HJ, Adeva J, Vogel A, Lleo A, Fabris L, Ponz-Sarvise M, Brustia R, Cardinale V, Braconi C, Vidili G, Jamieson NB, Macias RI, Jonas JP, Marzioni M, Hołówko W, Folseraas T, Kupčinskas J, Sparchez Z, Krawczyk M, Krupa Ł, Scripcariu V, Grazi GL, Landa-Magdalena A, Ijzermans JN, Evert K, Erdmann JI, López-López F, Saborowski A, Scheiter A, Santos-Laso A, Carpino G, Andersen JB, Marin JJ, Alvaro D, Bujanda L, Forner A, Valle JW, Koerkamp BG, Banales JM
J Hepatol 2022 May;76(5):1109-1121. Epub 2022 Feb 12 doi: 10.1016/j.jhep.2021.12.010. PMID: 35167909
Park W, Chawla A, O'Reilly EM
JAMA 2021 Sep 7;326(9):851-862. doi: 10.1001/jama.2021.13027. PMID: 34547082Free PMC Article
Buss EJ, Kachnic LA, Horowitz DP
Semin Oncol 2021 Feb;48(1):106-110. Epub 2021 Feb 23 doi: 10.1053/j.seminoncol.2021.02.005. PMID: 33771355
Grossberg AJ, Chu LC, Deig CR, Fishman EK, Hwang WL, Maitra A, Marks DL, Mehta A, Nabavizadeh N, Simeone DM, Weekes CD, Thomas CR Jr
CA Cancer J Clin 2020 Sep;70(5):375-403. Epub 2020 Jul 19 doi: 10.3322/caac.21626. PMID: 32683683Free PMC Article
Salgado M, Arévalo S, Hernando O, Martínez A, Yaya R, Hidalgo M
Clin Transl Oncol 2018 Feb;20(2):113-118. Epub 2017 Jun 13 doi: 10.1007/s12094-017-1679-1. PMID: 28612202

Clinical prediction guides

Polyakov AN, Patyutko YI, Kudashkin NE, Kantieva DM, Romanova KA, Nasonova EA, Korshak AV, Egenov OA, Podluzhnyi DV
Khirurgiia (Mosk) 2023;(10):29-38. doi: 10.17116/hirurgia202310129. PMID: 37916555
Sivapalan L, Kocher HM, Ross-Adams H, Chelala C
Pancreatology 2022 Nov;22(7):925-936. Epub 2022 Jul 21 doi: 10.1016/j.pan.2022.07.010. PMID: 35927150
Izquierdo-Sanchez L, Lamarca A, La Casta A, Buettner S, Utpatel K, Klümpen HJ, Adeva J, Vogel A, Lleo A, Fabris L, Ponz-Sarvise M, Brustia R, Cardinale V, Braconi C, Vidili G, Jamieson NB, Macias RI, Jonas JP, Marzioni M, Hołówko W, Folseraas T, Kupčinskas J, Sparchez Z, Krawczyk M, Krupa Ł, Scripcariu V, Grazi GL, Landa-Magdalena A, Ijzermans JN, Evert K, Erdmann JI, López-López F, Saborowski A, Scheiter A, Santos-Laso A, Carpino G, Andersen JB, Marin JJ, Alvaro D, Bujanda L, Forner A, Valle JW, Koerkamp BG, Banales JM
J Hepatol 2022 May;76(5):1109-1121. Epub 2022 Feb 12 doi: 10.1016/j.jhep.2021.12.010. PMID: 35167909
Park W, Chawla A, O'Reilly EM
JAMA 2021 Sep 7;326(9):851-862. doi: 10.1001/jama.2021.13027. PMID: 34547082Free PMC Article
Lee SY, Sissoko M, Hartshorn KL
Curr Oncol Rep 2016 Oct;18(10):60. doi: 10.1007/s11912-016-0547-4. PMID: 27492426

Recent systematic reviews

Frassini S, Calabretto F, Granieri S, Fugazzola P, Viganò J, Fazzini N, Ansaloni L, Cobianchi L
Eur J Surg Oncol 2022 Sep;48(9):1911-1921. Epub 2022 Jun 2 doi: 10.1016/j.ejso.2022.05.030. PMID: 35688711
Sugumar K, Hurtado A, Naik I, Hue JJ, Rothermel LD, Ammori JB, Hardacre JM, Winter JM, Ocuin LM
HPB (Oxford) 2022 May;24(5):586-595. Epub 2021 Dec 24 doi: 10.1016/j.hpb.2021.12.014. PMID: 35000842
Lindemann J, du Toit L, Kotze U, Bernon M, Krige J, Jonas E
HPB (Oxford) 2021 Feb;23(2):173-186. Epub 2020 Oct 22 doi: 10.1016/j.hpb.2020.09.022. PMID: 33268268
Keane MG, Bramis K, Pereira SP, Fusai GK
World J Gastroenterol 2014 Mar 7;20(9):2267-78. doi: 10.3748/wjg.v20.i9.2267. PMID: 24605026Free PMC Article
Fegrachi S, Besselink MG, van Santvoort HC, van Hillegersberg R, Molenaar IQ
HPB (Oxford) 2014 Feb;16(2):119-23. Epub 2013 Apr 18 doi: 10.1111/hpb.12097. PMID: 23600801Free PMC Article

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