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Neonatal Culture Negative Sepsis, AE

MedGen UID:
1669565
•Concept ID:
C4743797
•
Finding
Synonym: Neonatal Culture Negative Sepsis, Adverse Event

Definition

An adverse event in a newborn characterized by a systemic inflammatory response without identifiable cause. [from NCI]

Professional guidelines

PubMed

The transplacental passage of commonly used intrapartum antibiotics and its impact on the newborn management: A narrative review.
Viel-Theriault I, Fell DB, Grynspan D, Redpath S, Thampi N
Early Hum Dev 2019 Aug;135:6-10. Epub 2019 Jun 6 doi: 10.1016/j.earlhumdev.2019.05.020. PMID: 31177037
Duration of vancomycin treatment for coagulase-negative Staphylococcus sepsis in very low birth weight infants.
Linder N, Lubin D, Hernandez A, Amit L, Ashkenazi S
Br J Clin Pharmacol 2013 Jul;76(1):58-64. doi: 10.1111/bcp.12053. PMID: 23210694Free PMC Article
Management of neonates with suspected or proven early-onset bacterial sepsis.
Polin RA; Committee on Fetus and Newborn
Pediatrics 2012 May;129(5):1006-15. Epub 2012 Apr 30 doi: 10.1542/peds.2012-0541. PMID: 22547779

Recent clinical studies

Etiology

Ten- vs. 14-day antibiotic therapy for culture-positive neonatal sepsis.
Islam K, Khatun N, Das K, Paul S, Ghosh T, Nayek K
J Trop Pediatr 2023 Oct 5;69(6) doi: 10.1093/tropej/fmad036. PMID: 37986651
Prevalence and risk factors for antimicrobial resistance among newborns with gram-negative sepsis.
Solomon S, Akeju O, Odumade OA, Ambachew R, Gebreyohannes Z, Van Wickle K, Abayneh M, Metaferia G, Carvalho MJ, Thomson K, Sands K, Walsh TR, Milton R, Goddard FGB, Bekele D, Chan GJ
PLoS One 2021;16(8):e0255410. Epub 2021 Aug 3 doi: 10.1371/journal.pone.0255410. PMID: 34343185Free PMC Article
Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
Early-Onset Neonatal Sepsis and Antibiotic Use in Northeast Thailand.
Kiatchoosakun P, Jirapradittha J, Sirikarn P, Laopaiboon M, Pattanittum P, Chandrakachorn W, Srirojana S, Jeffery H, Green S, Lumbiganon P; SEA-URCHIN Study Group
Am J Perinatol 2019 Oct;36(12):1295-1303. Epub 2018 Dec 31 doi: 10.1055/s-0038-1676829. PMID: 30597491
Use and misuse of antibiotics in the neonatal intensive care unit.
Tzialla C, Borghesi A, Perotti GF, Garofoli F, Manzoni P, Stronati M
J Matern Fetal Neonatal Med 2012 Oct;25 Suppl 4:35-7. doi: 10.3109/14767058.2012.714987. PMID: 22958010

Diagnosis

Bad bugs: antibiotic-resistant bacteriuria in pregnancy and risk of pyelonephritis.
Denoble A, Reid HW, Krischak M, Rosett H, Sachdeva S, Weaver K, Heine PR, Dotters-Katz S
Am J Obstet Gynecol MFM 2022 Mar;4(2):100540. Epub 2021 Nov 29 doi: 10.1016/j.ajogmf.2021.100540. PMID: 34856419Free PMC Article
Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
Nosocomial pneumonia and sepsis caused by a rare organism Cedecea lapagei in an infant and a review of literature.
Ramaswamy VV, Gummadapu S, Suryanarayana N
BMJ Case Rep 2019 Jul 11;12(7) doi: 10.1136/bcr-2019-229854. PMID: 31300600Free PMC Article
Ending the Culture of Culture-Negative Sepsis in the Neonatal ICU.
Cantey JB, Baird SD
Pediatrics 2017 Oct;140(4) Epub 2017 Sep 19 doi: 10.1542/peds.2017-0044. PMID: 28928289
Intravenous catheter-related infections.
Salzman MB, Rubin LG
Adv Pediatr Infect Dis 1995;10:337-68. PMID: 7718211

Therapy

Ten- vs. 14-day antibiotic therapy for culture-positive neonatal sepsis.
Islam K, Khatun N, Das K, Paul S, Ghosh T, Nayek K
J Trop Pediatr 2023 Oct 5;69(6) doi: 10.1093/tropej/fmad036. PMID: 37986651
Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
Early-Onset Neonatal Sepsis and Antibiotic Use in Northeast Thailand.
Kiatchoosakun P, Jirapradittha J, Sirikarn P, Laopaiboon M, Pattanittum P, Chandrakachorn W, Srirojana S, Jeffery H, Green S, Lumbiganon P; SEA-URCHIN Study Group
Am J Perinatol 2019 Oct;36(12):1295-1303. Epub 2018 Dec 31 doi: 10.1055/s-0038-1676829. PMID: 30597491
Use and misuse of antibiotics in the neonatal intensive care unit.
Tzialla C, Borghesi A, Perotti GF, Garofoli F, Manzoni P, Stronati M
J Matern Fetal Neonatal Med 2012 Oct;25 Suppl 4:35-7. doi: 10.3109/14767058.2012.714987. PMID: 22958010
Intravenous catheter-related infections.
Salzman MB, Rubin LG
Adv Pediatr Infect Dis 1995;10:337-68. PMID: 7718211

Prognosis

Ten- vs. 14-day antibiotic therapy for culture-positive neonatal sepsis.
Islam K, Khatun N, Das K, Paul S, Ghosh T, Nayek K
J Trop Pediatr 2023 Oct 5;69(6) doi: 10.1093/tropej/fmad036. PMID: 37986651
Association between duration of early empiric antibiotics and necrotizing enterocolitis and late-onset sepsis in preterm infants: a multicenter cohort study.
Dierikx TH, Deianova N, Groen J, Vijlbrief DC, Hulzebos C, de Boode WP, d'Haens EJ, Cossey V, Kramer BW, van Weissenbruch MM, de Jonge WJ, Benninga MA, van den Akker CH, van Kaam AH, de Boer NKH, Visser DH, Niemarkt HJ, de Meij TGJ
Eur J Pediatr 2022 Oct;181(10):3715-3724. Epub 2022 Aug 4 doi: 10.1007/s00431-022-04579-5. PMID: 35927379Free PMC Article
The transplacental passage of commonly used intrapartum antibiotics and its impact on the newborn management: A narrative review.
Viel-Theriault I, Fell DB, Grynspan D, Redpath S, Thampi N
Early Hum Dev 2019 Aug;135:6-10. Epub 2019 Jun 6 doi: 10.1016/j.earlhumdev.2019.05.020. PMID: 31177037
Ending the Culture of Culture-Negative Sepsis in the Neonatal ICU.
Cantey JB, Baird SD
Pediatrics 2017 Oct;140(4) Epub 2017 Sep 19 doi: 10.1542/peds.2017-0044. PMID: 28928289
Intravenous catheter-related infections.
Salzman MB, Rubin LG
Adv Pediatr Infect Dis 1995;10:337-68. PMID: 7718211

Clinical prediction guides

Ten- vs. 14-day antibiotic therapy for culture-positive neonatal sepsis.
Islam K, Khatun N, Das K, Paul S, Ghosh T, Nayek K
J Trop Pediatr 2023 Oct 5;69(6) doi: 10.1093/tropej/fmad036. PMID: 37986651
Is Lumbar Puncture Avoidable in Low-Risk Neonates with Suspected Sepsis?
Dalai R, Dutta S, Pal A, Sundaram V, Jayashree M
Am J Perinatol 2022 Jan;39(1):99-105. Epub 2020 Jul 21 doi: 10.1055/s-0040-1714397. PMID: 32693413
Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
The transplacental passage of commonly used intrapartum antibiotics and its impact on the newborn management: A narrative review.
Viel-Theriault I, Fell DB, Grynspan D, Redpath S, Thampi N
Early Hum Dev 2019 Aug;135:6-10. Epub 2019 Jun 6 doi: 10.1016/j.earlhumdev.2019.05.020. PMID: 31177037
Ending the Culture of Culture-Negative Sepsis in the Neonatal ICU.
Cantey JB, Baird SD
Pediatrics 2017 Oct;140(4) Epub 2017 Sep 19 doi: 10.1542/peds.2017-0044. PMID: 28928289

Recent systematic reviews

Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
Prophylactic antibiotics to reduce morbidity and mortality in neonates with umbilical artery catheters.
Inglis GD, Jardine LA, Davies MW
Cochrane Database Syst Rev 2007 Oct 17;2007(4):CD004697. doi: 10.1002/14651858.CD004697.pub3. PMID: 17943827Free PMC Article
Prophylactic antibiotics to reduce morbidity and mortality in ventilated newborn infants.
Inglis GD, Jardine LA, Davies MW
Cochrane Database Syst Rev 2007 Jul 18;2007(3):CD004338. doi: 10.1002/14651858.CD004338.pub3. PMID: 17636752Free PMC Article
Prophylactic antibiotics to reduce morbidity and mortality in neonates with umbilical artery catheters.
Inglis GD, Davies MW
Cochrane Database Syst Rev 2004;(3):CD004697. doi: 10.1002/14651858.CD004697.pub2. PMID: 15266539
Prophylactic antibiotics to reduce morbidity and mortality in ventilated newborn infants.
Inglis GD, Davies MW
Cochrane Database Syst Rev 2004;(1):CD004338. doi: 10.1002/14651858.CD004338.pub2. PMID: 14974065

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