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MCD diffuse large B-cell lymphoma

MedGen UID:
1669702
Concept ID:
C4725002
Neoplastic Process
Synonym: MCD Diffuse Large B-Cell Lymphoma
 
Monarch Initiative: MONDO:0850470

Definition

A diffuse large B-cell lymphoma molecular subtype characterized by the co-occurrence of MYD88 and CD79B gene mutations. Patients who belong in this subtype have an inferior outcome. (NEJM 2018; 378: 1396-407) [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Deng T, Zhang S, Xiao M, Gu J, Huang L, Zhou X
Cancer Med 2024 Feb;13(4):e7005. doi: 10.1002/cam4.7005. PMID: 38457222Free PMC Article

Recent clinical studies

Etiology

Wang Y, Shi Q, Shi ZY, Tian S, Zhang MC, Shen R, Fu D, Dong L, Yi HM, Ouyang BS, Mu RJ, Cheng S, Wang L, Xu PP, Zhao WL
Blood Adv 2024 Apr 9;8(7):1587-1599. doi: 10.1182/bloodadvances.2023011425. PMID: 38170757Free PMC Article
Kim PM, Nejati R, Lu P, Thakkar D, Mackrides N, Dupoux V, Nakhoda S, Baldwin DA, Pei J, Dave SS, Wang YL, Wasik MA
Cold Spring Harb Mol Case Stud 2023 Dec;9(4) Epub 2024 Jan 10 doi: 10.1101/mcs.a006283. PMID: 37730436Free PMC Article
Sang W, Ma Y, Wang X, Ma Y, Shen Z, Gu W, Wang F, Ye J, Zhang C, Miao Y, Xu C, Liu Q, Li B, Tu J, Wang C, Shi Y, Sun S, Yan D, Song X, Sun C, Shao Y, Xu L, Li Z, Ma D, Xu K, Young KH, Liu H
Am J Surg Pathol 2022 Nov 1;46(11):1533-1544. Epub 2022 Aug 26 doi: 10.1097/PAS.0000000000001957. PMID: 36006771
Frauenfeld L, Castrejon-de-Anta N, Ramis-Zaldivar JE, Streich S, Salmerón-Villalobos J, Otto F, Mayer AK, Steinhilber J, Pinyol M, Mankel B, Ramsower C, Bonzheim I, Fend F, Rimsza LM, Salaverria I, Campo E, Balagué O, Quintanilla-Martinez L
Blood Adv 2022 Apr 12;6(7):2361-2372. doi: 10.1182/bloodadvances.2021006034. PMID: 34654055Free PMC Article
Ollila TA, Olszewski AJ
Curr Treat Options Oncol 2018 Jun 21;19(8):38. doi: 10.1007/s11864-018-0555-8. PMID: 29931605Free PMC Article

Diagnosis

Mandato E, Yan Q, Ouyang J, Paczkowska J, Qin Y, Hao Y, Bojarczuk K, Hansen J, Chapuy B, Rodig SJ, Khan SJ, Redd RA, Shipp MA
Blood 2023 Oct 5;142(14):1219-1232. doi: 10.1182/blood.2023019865. PMID: 37467575
Shen R, Fu D, Dong L, Zhang MC, Shi Q, Shi ZY, Cheng S, Wang L, Xu PP, Zhao WL
Signal Transduct Target Ther 2023 Apr 10;8(1):145. doi: 10.1038/s41392-023-01358-y. PMID: 37032379Free PMC Article
Flümann R, Hansen J, Pelzer BW, Nieper P, Lohmann T, Kisis I, Riet T, Kohlhas V, Nguyen PH, Peifer M, Abedpour N, Bosco G, Thomas RK, Kochanek M, Knüfer J, Jonigkeit L, Beleggia F, Holzem A, Büttner R, Lohneis P, Meinel J, Ortmann M, Persigehl T, Hallek M, Calado DP, Chmielewski M, Klein S, Göthert JR, Chapuy B, Zevnik B, Wunderlich FT, von Tresckow B, Jachimowicz RD, Melnick AM, Reinhardt HC, Knittel G
Blood Cancer Discov 2023 Jan 6;4(1):78-97. doi: 10.1158/2643-3230.BCD-22-0007. PMID: 36346827Free PMC Article
Ollila TA, Olszewski AJ
Curr Treat Options Oncol 2018 Jun 21;19(8):38. doi: 10.1007/s11864-018-0555-8. PMID: 29931605Free PMC Article
Katano H
Adv Exp Med Biol 2018;1045:357-376. doi: 10.1007/978-981-10-7230-7_16. PMID: 29896675

Therapy

Wang Y, Shi Q, Shi ZY, Tian S, Zhang MC, Shen R, Fu D, Dong L, Yi HM, Ouyang BS, Mu RJ, Cheng S, Wang L, Xu PP, Zhao WL
Blood Adv 2024 Apr 9;8(7):1587-1599. doi: 10.1182/bloodadvances.2023011425. PMID: 38170757Free PMC Article
Shen R, Fu D, Dong L, Zhang MC, Shi Q, Shi ZY, Cheng S, Wang L, Xu PP, Zhao WL
Signal Transduct Target Ther 2023 Apr 10;8(1):145. doi: 10.1038/s41392-023-01358-y. PMID: 37032379Free PMC Article
Flümann R, Hansen J, Pelzer BW, Nieper P, Lohmann T, Kisis I, Riet T, Kohlhas V, Nguyen PH, Peifer M, Abedpour N, Bosco G, Thomas RK, Kochanek M, Knüfer J, Jonigkeit L, Beleggia F, Holzem A, Büttner R, Lohneis P, Meinel J, Ortmann M, Persigehl T, Hallek M, Calado DP, Chmielewski M, Klein S, Göthert JR, Chapuy B, Zevnik B, Wunderlich FT, von Tresckow B, Jachimowicz RD, Melnick AM, Reinhardt HC, Knittel G
Blood Cancer Discov 2023 Jan 6;4(1):78-97. doi: 10.1158/2643-3230.BCD-22-0007. PMID: 36346827Free PMC Article
Wilson WH, Wright GW, Huang DW, Hodkinson B, Balasubramanian S, Fan Y, Vermeulen J, Shreeve M, Staudt LM
Cancer Cell 2021 Dec 13;39(12):1643-1653.e3. Epub 2021 Nov 4 doi: 10.1016/j.ccell.2021.10.006. PMID: 34739844Free PMC Article
Schmitz R, Wright GW, Huang DW, Johnson CA, Phelan JD, Wang JQ, Roulland S, Kasbekar M, Young RM, Shaffer AL, Hodson DJ, Xiao W, Yu X, Yang Y, Zhao H, Xu W, Liu X, Zhou B, Du W, Chan WC, Jaffe ES, Gascoyne RD, Connors JM, Campo E, Lopez-Guillermo A, Rosenwald A, Ott G, Delabie J, Rimsza LM, Tay Kuang Wei K, Zelenetz AD, Leonard JP, Bartlett NL, Tran B, Shetty J, Zhao Y, Soppet DR, Pittaluga S, Wilson WH, Staudt LM
N Engl J Med 2018 Apr 12;378(15):1396-1407. doi: 10.1056/NEJMoa1801445. PMID: 29641966Free PMC Article

Prognosis

Mandato E, Yan Q, Ouyang J, Paczkowska J, Qin Y, Hao Y, Bojarczuk K, Hansen J, Chapuy B, Rodig SJ, Khan SJ, Redd RA, Shipp MA
Blood 2023 Oct 5;142(14):1219-1232. doi: 10.1182/blood.2023019865. PMID: 37467575
Shen R, Fu D, Dong L, Zhang MC, Shi Q, Shi ZY, Cheng S, Wang L, Xu PP, Zhao WL
Signal Transduct Target Ther 2023 Apr 10;8(1):145. doi: 10.1038/s41392-023-01358-y. PMID: 37032379Free PMC Article
Sang W, Ma Y, Wang X, Ma Y, Shen Z, Gu W, Wang F, Ye J, Zhang C, Miao Y, Xu C, Liu Q, Li B, Tu J, Wang C, Shi Y, Sun S, Yan D, Song X, Sun C, Shao Y, Xu L, Li Z, Ma D, Xu K, Young KH, Liu H
Am J Surg Pathol 2022 Nov 1;46(11):1533-1544. Epub 2022 Aug 26 doi: 10.1097/PAS.0000000000001957. PMID: 36006771
Ollila TA, Olszewski AJ
Curr Treat Options Oncol 2018 Jun 21;19(8):38. doi: 10.1007/s11864-018-0555-8. PMID: 29931605Free PMC Article
Schmitz R, Wright GW, Huang DW, Johnson CA, Phelan JD, Wang JQ, Roulland S, Kasbekar M, Young RM, Shaffer AL, Hodson DJ, Xiao W, Yu X, Yang Y, Zhao H, Xu W, Liu X, Zhou B, Du W, Chan WC, Jaffe ES, Gascoyne RD, Connors JM, Campo E, Lopez-Guillermo A, Rosenwald A, Ott G, Delabie J, Rimsza LM, Tay Kuang Wei K, Zelenetz AD, Leonard JP, Bartlett NL, Tran B, Shetty J, Zhao Y, Soppet DR, Pittaluga S, Wilson WH, Staudt LM
N Engl J Med 2018 Apr 12;378(15):1396-1407. doi: 10.1056/NEJMoa1801445. PMID: 29641966Free PMC Article

Clinical prediction guides

Wang Y, Shi Q, Shi ZY, Tian S, Zhang MC, Shen R, Fu D, Dong L, Yi HM, Ouyang BS, Mu RJ, Cheng S, Wang L, Xu PP, Zhao WL
Blood Adv 2024 Apr 9;8(7):1587-1599. doi: 10.1182/bloodadvances.2023011425. PMID: 38170757Free PMC Article
Delage L, Lambert M, Bardel É, Kundlacz C, Chartoire D, Conchon A, Peugnet AL, Gorka L, Auberger P, Jacquel A, Soussain C, Destaing O, Delecluse HJ, Delecluse S, Merabet S, Traverse-Glehen A, Salles G, Bachy E, Billaud M, Ghesquières H, Genestier L, Rouault JP, Sujobert P
Blood 2023 Mar 9;141(10):1209-1220. doi: 10.1182/blood.2022016943. PMID: 36375119
Castelli R, Schiavon R, Preti C, Ferraris L
Cardiovasc Hematol Disord Drug Targets 2020;20(3):175-180. doi: 10.2174/1871529X20666200415121009. PMID: 32294049Free PMC Article
Ollila TA, Olszewski AJ
Curr Treat Options Oncol 2018 Jun 21;19(8):38. doi: 10.1007/s11864-018-0555-8. PMID: 29931605Free PMC Article
Katano H
Adv Exp Med Biol 2018;1045:357-376. doi: 10.1007/978-981-10-7230-7_16. PMID: 29896675

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