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Unresectable Sarcoma

MedGen UID:
1669987
•Concept ID:
C4724976
•
Neoplastic Process

Definition

A sarcoma which is not amenable to surgical resection. [from NCI]

Professional guidelines

PubMed

Management of In-Transit Metastases.
Queiroz MM, Bertolli E, Belfort FA, Munhoz RR
Curr Oncol Rep 2022 May;24(5):573-583. Epub 2022 Feb 22 doi: 10.1007/s11912-022-01216-0. PMID: 35192119
Management of dermatofibrosarcoma protuberans.
Badhey AK, Tikhtman R, Tang AL
Curr Opin Otolaryngol Head Neck Surg 2021 Aug 1;29(4):278-282. doi: 10.1097/MOO.0000000000000721. PMID: 33993132
A risk-based treatment strategy for non-rhabdomyosarcoma soft-tissue sarcomas in patients younger than 30 years (ARST0332): a Children's Oncology Group prospective study.
Spunt SL, Million L, Chi YY, Anderson J, Tian J, Hibbitts E, Coffin C, McCarville MB, Randall RL, Parham DM, Black JO, Kao SC, Hayes-Jordan A, Wolden S, Laurie F, Speights R, Kawashima E, Skapek SX, Meyer W, Pappo AS, Hawkins DS
Lancet Oncol 2020 Jan;21(1):145-161. Epub 2019 Nov 27 doi: 10.1016/S1470-2045(19)30672-2. PMID: 31786124Free PMC Article

Recent clinical studies

Etiology

High-dose ifosfamide as second- or third-line chemotherapy in refractory bone and soft tissue sarcoma patients.
Lee SH, Chang MH, Baek KK, Han B, Lim T, Lee J, Park JO
Oncology 2011;80(3-4):257-61. Epub 2011 Jul 6 doi: 10.1159/000328795. PMID: 21734417
An intergroup phase III randomized study of doxorubicin and dacarbazine with or without ifosfamide and mesna in advanced soft tissue and bone sarcomas.
Antman K, Crowley J, Balcerzak SP, Rivkin SE, Weiss GR, Elias A, Natale RB, Cooper RM, Barlogie B, Trump DL
J Clin Oncol 1993 Jul;11(7):1276-85. doi: 10.1200/JCO.1993.11.7.1276. PMID: 8315425
Conformal radiotherapy for unresectable retroperitoneal soft tissue sarcoma.
Greiner RH, Munkel G, Blattmann H, Coray A, Kann R, Pedroni E, Thum P
Int J Radiat Oncol Biol Phys 1992;22(2):333-41. doi: 10.1016/0360-3016(92)90051-i. PMID: 1740394

Diagnosis

Concomitant trimodality therapy of re-irradiation, chemotherapy and regional hyperthermia for a pretreated inoperable sarcoma recurrence.
LI M, Andrä C, Niyazi M, Issels RD, Abdel-Rahman S, Oskan F, Manapov F
Tumori 2015 Mar-Apr;101(2):e54-6. doi: 10.5301/tj.5000250. PMID: 25838253
Feasibility of ablation as an alternative to surgical metastasectomy in patients with unresectable sarcoma pulmonary metastases.
Ding JH, Chua TC, Glenn D, Morris DL
Interact Cardiovasc Thorac Surg 2009 Dec;9(6):1051-3. Epub 2009 Sep 18 doi: 10.1510/icvts.2009.218743. PMID: 19767303
Response to mesna, doxorubicin, ifosfamide, and dacarbazine in 108 patients with metastatic or unresectable sarcoma and no prior chemotherapy.
Elias A, Ryan L, Sulkes A, Collins J, Aisner J, Antman KH
J Clin Oncol 1989 Sep;7(9):1208-16. doi: 10.1200/JCO.1989.7.9.1208. PMID: 2504890

Therapy

Undifferentiated and Unresectable Sarcoma With NTRK3-Fusion in a Pediatric Patient Treated With Larotrectinib and Proton Beam Radiotherapy.
Olsen MR, Denu RA, Lyon JB, Gulliver JM, Capitini CM, DeSantes KB
J Pediatr Hematol Oncol 2022 Apr 1;44(3):e770-e774. doi: 10.1097/MPH.0000000000002358. PMID: 34862354Free PMC Article
High-dose ifosfamide as second- or third-line chemotherapy in refractory bone and soft tissue sarcoma patients.
Lee SH, Chang MH, Baek KK, Han B, Lim T, Lee J, Park JO
Oncology 2011;80(3-4):257-61. Epub 2011 Jul 6 doi: 10.1159/000328795. PMID: 21734417
A collaborative approach to isolated limb perfusion.
Fraser M, Marentay P, Berthà R
AORN J 1999 Oct;70(4):642-7, 649, 651-3; quiz 654-8. doi: 10.1016/s0001-2092(06)62439-3. PMID: 10530369
An intergroup phase III randomized study of doxorubicin and dacarbazine with or without ifosfamide and mesna in advanced soft tissue and bone sarcomas.
Antman K, Crowley J, Balcerzak SP, Rivkin SE, Weiss GR, Elias A, Natale RB, Cooper RM, Barlogie B, Trump DL
J Clin Oncol 1993 Jul;11(7):1276-85. doi: 10.1200/JCO.1993.11.7.1276. PMID: 8315425
Response to mesna, doxorubicin, ifosfamide, and dacarbazine in 108 patients with metastatic or unresectable sarcoma and no prior chemotherapy.
Elias A, Ryan L, Sulkes A, Collins J, Aisner J, Antman KH
J Clin Oncol 1989 Sep;7(9):1208-16. doi: 10.1200/JCO.1989.7.9.1208. PMID: 2504890

Prognosis

High-dose ifosfamide as second- or third-line chemotherapy in refractory bone and soft tissue sarcoma patients.
Lee SH, Chang MH, Baek KK, Han B, Lim T, Lee J, Park JO
Oncology 2011;80(3-4):257-61. Epub 2011 Jul 6 doi: 10.1159/000328795. PMID: 21734417
Isolated perfusion of the kidney with tumor necrosis factor for localized renal-cell carcinoma.
Walther MM, Jennings SB, Choyke PL, Andrich M, Hurley K, Linehan WM, Rosenberg SA, Alexander RB
World J Urol 1996;14 Suppl 1:S2-7. doi: 10.1007/BF00182056. PMID: 8738402
Conformal radiotherapy for unresectable retroperitoneal soft tissue sarcoma.
Greiner RH, Munkel G, Blattmann H, Coray A, Kann R, Pedroni E, Thum P
Int J Radiat Oncol Biol Phys 1992;22(2):333-41. doi: 10.1016/0360-3016(92)90051-i. PMID: 1740394

Clinical prediction guides

High-dose ifosfamide as second- or third-line chemotherapy in refractory bone and soft tissue sarcoma patients.
Lee SH, Chang MH, Baek KK, Han B, Lim T, Lee J, Park JO
Oncology 2011;80(3-4):257-61. Epub 2011 Jul 6 doi: 10.1159/000328795. PMID: 21734417
Rapid activation of MDR1 gene expression in human metastatic sarcoma after in vivo exposure to doxorubicin.
Abolhoda A, Wilson AE, Ross H, Danenberg PV, Burt M, Scotto KW
Clin Cancer Res 1999 Nov;5(11):3352-6. PMID: 10589744
An intergroup phase III randomized study of doxorubicin and dacarbazine with or without ifosfamide and mesna in advanced soft tissue and bone sarcomas.
Antman K, Crowley J, Balcerzak SP, Rivkin SE, Weiss GR, Elias A, Natale RB, Cooper RM, Barlogie B, Trump DL
J Clin Oncol 1993 Jul;11(7):1276-85. doi: 10.1200/JCO.1993.11.7.1276. PMID: 8315425
Response to mesna, doxorubicin, ifosfamide, and dacarbazine in 108 patients with metastatic or unresectable sarcoma and no prior chemotherapy.
Elias A, Ryan L, Sulkes A, Collins J, Aisner J, Antman KH
J Clin Oncol 1989 Sep;7(9):1208-16. doi: 10.1200/JCO.1989.7.9.1208. PMID: 2504890
Response to ifosfamide and mesna: 124 previously treated patients with metastatic or unresectable sarcoma.
Antman KH, Ryan L, Elias A, Sherman D, Grier HE
J Clin Oncol 1989 Jan;7(1):126-31. doi: 10.1200/JCO.1989.7.1.126. PMID: 2491883

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