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Benign Genitourinary System Neoplasm

MedGen UID:: 1670038
•Concept ID:: C4744855
•: Neoplastic Process

Definition

A neoplasm that arises from the genitourinary system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBenign Genitourinary System Neoplasm

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Neoplasm by Special Category
        Benign neoplasm
        Benign Genitourinary System Neoplasm
        Benign reproductive system neoplasm
        Adrenal rest tumor
        Benign female reproductive system neoplasm
        Adenomyoma
        Benign neoplasm of placenta
        Benign uterine ligament neoplasm
        Benign vaginal neoplasm
        Fallopian tube benign neoplasm
        Genital Rhabdomyoma
        Mucinous cystadenofibroma
        Ovarian benign neoplasm
        Rete ovarii adenoma
        Uterine benign neoplasm
        Vulvar benign neoplasm
        Benign male reproductive system neoplasm
        Benign neoplasm of epididymis
        Benign neoplasm of penis
        Benign neoplasm of prostate
        Benign neoplasm of testis
        Benign Seminal Vesicle Neoplasm
        Paratesticular Adenomatoid Tumor
        Paratesticular Cellular Angiofibroma
        Paratesticular Deep (Aggressive) Angiomyxoma
        Paratesticular Hemangioma
        Paratesticular Leiomyoma
        Paratesticular lipoma
        Paratesticular Mammary-Type Myofibroblastoma
        Paratesticular Rhabdomyoma
        Paratesticular Schwannoma
        Rete testis adenoma
        Benign sertoli cell tumor
        Benign testicular sertoli cell tumor
        Fibroadenoma of Anogenital Mammary-Type Glands
        Anal Fibroadenoma
        Vulvar Fibroadenoma
        Benign urinary system neoplasm
        Benign urethral neoplasm
        Benign Accessory Urethral Gland Neoplasm
        Urethra leiomyoma
        Urethral Condyloma Acuminatum
        Urethral urothelial papilloma
        Urethral villous adenoma
        Bladder benign neoplasm
        Bladder Benign PEComa
        Bladder Hemangioma
        Bladder leiomyoma
        Bladder squamous papilloma
        Bladder urothelial papilloma
        Urinary bladder neurofibroma
        Urinary bladder villous adenoma
        Kidney benign neoplasm
        Benign neoplasm of renal pelvis
        Childhood Cystic Nephroma
        Juxtaglomerular Cell Tumor
        Kidney Hemangioma
        Kidney lipoma
        Kidney Lymphangioma
        Kidney Schwannoma
        Metanephric Tumor
        Mixed epithelial stromal tumor of the kidney
        Oncocytoma of kidney
        Ossifying Renal Tumor of Infancy
        Renal adenoma
        Renal hamartoma
        Renal leiomyoma
        Ureter benign neoplasm
        Polyp of ureter
        Schwannoma of ureter
        Ureter leiomyoma
        Ureter urothelial papilloma
        Urothelial papilloma
        Inverted urothelial papilloma
        Renal pelvis urothelial papilloma

Professional guidelines

PubMed

Diagnosis and management of uterine fibroids: current trends and future strategies.

Ahmad A, Kumar M, Bhoi NR, Badruddeen, Akhtar J, Khan MI, Ajmal M, Ahmad M
J Basic Clin Physiol Pharmacol 2023 May 1;34(3):291-310. Epub 2023 Mar 30 doi: 10.1515/jbcpp-2022-0219. PMID: 36989026

Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment.

Yang Q, Ciebiera M, Bariani MV, Ali M, Elkafas H, Boyer TG, Al-Hendy A
Endocr Rev 2022 Jul 13;43(4):678-719. doi: 10.1210/endrev/bnab039. PMID: 34741454 Free PMC Article

Update on the Diagnosis and Management of Renal Angiomyolipoma.

Flum AS, Hamoui N, Said MA, Yang XJ, Casalino DD, McGuire BB, Perry KT, Nadler RB
J Urol 2016 Apr;195(4 Pt 1):834-46. Epub 2015 Nov 21 doi: 10.1016/j.juro.2015.07.126. PMID: 26612197

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Recent clinical studies

Etiology

Uterine Myomas: Extravascular Treatment.

Ierardi AM, Carnevale A, Pellegrino F, Stefano GD, Bonelli C, Renzulli M, Giganti M, Carrafiello G
Semin Ultrasound CT MR 2021 Feb;42(1):56-74. Epub 2020 Aug 29 doi: 10.1053/j.sult.2020.08.004. PMID: 33541590

Toward automation of germline variant curation in clinical cancer genetics.

Ravichandran V, Shameer Z, Kemel Y, Walsh M, Cadoo K, Lipkin S, Mandelker D, Zhang L, Stadler Z, Robson M, Offit K, Vijai J
Genet Med 2019 Sep;21(9):2116-2125. Epub 2019 Feb 21 doi: 10.1038/s41436-019-0463-8. PMID: 30787465 Free PMC Article

Uterine Leiomyosarcoma.

Juhasz-Böss I, Gabriel L, Bohle RM, Horn LC, Solomayer EF, Breitbach GP
Oncol Res Treat 2018;41(11):680-686. Epub 2018 Oct 16 doi: 10.1159/000494299. PMID: 30321869

Pediatric urologic oncology.

Grimsby GM, Ritchey ML
Pediatr Clin North Am 2012 Aug;59(4):947-59. Epub 2012 Jun 15 doi: 10.1016/j.pcl.2012.05.018. PMID: 22857841

The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory.

Kurman RJ, Shih IeM
Am J Surg Pathol 2010 Mar;34(3):433-43. doi: 10.1097/PAS.0b013e3181cf3d79. PMID: 20154587 Free PMC Article

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Diagnosis

Mimics of cancer in pregnancy.

Olinger K, Maheshwari E, Shenoy-Bhangle AS, Adejolu M, McGettigan M, Mathew H, Lee KS, Nicola R
Abdom Radiol (NY) 2023 May;48(5):1752-1773. Epub 2022 Dec 29 doi: 10.1007/s00261-022-03783-z. PMID: 36577923

Uterine Adenosarcoma.

Ulrich UA, Denschlag D
Oncol Res Treat 2018;41(11):693-696. Epub 2018 Oct 17 doi: 10.1159/000494067. PMID: 30326467

Uterine Leiomyosarcoma.

Juhasz-Böss I, Gabriel L, Bohle RM, Horn LC, Solomayer EF, Breitbach GP
Oncol Res Treat 2018;41(11):680-686. Epub 2018 Oct 16 doi: 10.1159/000494299. PMID: 30321869

Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria.

Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E
J Natl Cancer Inst 2013 Nov 6;105(21):1607-16. Epub 2013 Oct 17 doi: 10.1093/jnci/djt277. PMID: 24136893

Cervical tumors.

Sahdev A
Semin Ultrasound CT MR 2010 Oct;31(5):399-413. doi: 10.1053/j.sult.2010.07.004. PMID: 20974359

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Therapy

Detection of endometrial cancer using tampon-based collection and methylated DNA markers.

Bakkum-Gamez JN, Sherman ME, Slettedahl SW, Mahoney DW, Lemens MA, Laughlin-Tommaso SK, Hopkins MR, VanOosten A, Shridhar V, Staub JK, Cao X, Foote PH, Clarke MA, Burger KN, Berger CK, O'Connell MC, Doering KA, Podratz KC, DeStephano CC, Schoolmeester JK, Kerr SE, Wentzensen N, Taylor WR, Kisiel JB
Gynecol Oncol 2023 Jul;174:11-20. Epub 2023 May 2 doi: 10.1016/j.ygyno.2023.04.014. PMID: 37141817 Free PMC Article

Endometrial hyperplasia as a risk factor of endometrial cancer.

Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, Wallwiener M
Arch Gynecol Obstet 2022 Aug;306(2):407-421. Epub 2022 Jan 10 doi: 10.1007/s00404-021-06380-5. PMID: 35001185 Free PMC Article

Guideline No. 403: Initial Investigation and Management of Adnexal Masses.

Salvador S, Scott S, Glanc P, Eiriksson L, Jang JH, Sebastianelli A, Dean E
J Obstet Gynaecol Can 2020 Aug;42(8):1021-1029.e3. doi: 10.1016/j.jogc.2019.08.044. PMID: 32736853

Scaffold-Free Endometrial Organoids Respond to Excess Androgens Associated With Polycystic Ovarian Syndrome.

Wiwatpanit T, Murphy AR, Lu Z, Urbanek M, Burdette JE, Woodruff TK, Kim JJ
J Clin Endocrinol Metab 2020 Mar 1;105(3):769-80. doi: 10.1210/clinem/dgz100. PMID: 31614364 Free PMC Article

Uterine Leiomyosarcoma.

Juhasz-Böss I, Gabriel L, Bohle RM, Horn LC, Solomayer EF, Breitbach GP
Oncol Res Treat 2018;41(11):680-686. Epub 2018 Oct 16 doi: 10.1159/000494299. PMID: 30321869

See all (1007)

Prognosis

Common Diagnostic Challenges and Pitfalls in Genitourinary Organs, With Emphasis on Immunohistochemical and Molecular Updates.

Jia L, Deng FM, Kong MX, Wu CL, Yang XJ
Arch Pathol Lab Med 2021 Nov 1;145(11):1387-1404. doi: 10.5858/arpa.2021-0107-RA. PMID: 34673910

Scaffold-Free Endometrial Organoids Respond to Excess Androgens Associated With Polycystic Ovarian Syndrome.

Wiwatpanit T, Murphy AR, Lu Z, Urbanek M, Burdette JE, Woodruff TK, Kim JJ
J Clin Endocrinol Metab 2020 Mar 1;105(3):769-80. doi: 10.1210/clinem/dgz100. PMID: 31614364 Free PMC Article

Uterine Adenosarcoma.

Ulrich UA, Denschlag D
Oncol Res Treat 2018;41(11):693-696. Epub 2018 Oct 17 doi: 10.1159/000494067. PMID: 30326467

Uterine Leiomyosarcoma.

Juhasz-Böss I, Gabriel L, Bohle RM, Horn LC, Solomayer EF, Breitbach GP
Oncol Res Treat 2018;41(11):680-686. Epub 2018 Oct 16 doi: 10.1159/000494299. PMID: 30321869

Pediatric urologic oncology.

Grimsby GM, Ritchey ML
Pediatr Clin North Am 2012 Aug;59(4):947-59. Epub 2012 Jun 15 doi: 10.1016/j.pcl.2012.05.018. PMID: 22857841

See all (2144)

Clinical prediction guides

O-RADS US: A Systematic Review and Meta-Analysis of Category-specific Malignancy Rates.

Lee S, Lee JE, Hwang JA, Shin H
Radiology 2023 Aug;308(2):e223269. doi: 10.1148/radiol.223269. PMID: 37642566

The Microbiome and Prostate Cancer Risk.

Wheeler KM, Liss MA
Curr Urol Rep 2019 Sep 7;20(10):66. doi: 10.1007/s11934-019-0922-4. PMID: 31493090

Uterine Leiomyosarcoma.

Juhasz-Böss I, Gabriel L, Bohle RM, Horn LC, Solomayer EF, Breitbach GP
Oncol Res Treat 2018;41(11):680-686. Epub 2018 Oct 16 doi: 10.1159/000494299. PMID: 30321869

Nephrogenic adenoma.

Amin W, Parwani AV
Pathol Res Pract 2010 Oct 15;206(10):659-62. Epub 2010 Jul 8 doi: 10.1016/j.prp.2010.06.001. PMID: 20619548

Simple ultrasound-based rules for the diagnosis of ovarian cancer.

Timmerman D, Testa AC, Bourne T, Ameye L, Jurkovic D, Van Holsbeke C, Paladini D, Van Calster B, Vergote I, Van Huffel S, Valentin L
Ultrasound Obstet Gynecol 2008 Jun;31(6):681-90. doi: 10.1002/uog.5365. PMID: 18504770

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Recent systematic reviews

O-RADS US: A Systematic Review and Meta-Analysis of Category-specific Malignancy Rates.

Lee S, Lee JE, Hwang JA, Shin H
Radiology 2023 Aug;308(2):e223269. doi: 10.1148/radiol.223269. PMID: 37642566

Molecular Insights in Uterine Leiomyosarcoma: A Systematic Review.

Sparić R, Andjić M, Babović I, Nejković L, Mitrović M, Štulić J, Pupovac M, Tinelli A
Int J Mol Sci 2022 Aug 27;23(17) doi: 10.3390/ijms23179728. PMID: 36077127 Free PMC Article

Endometrial hyperplasia as a risk factor of endometrial cancer.

What is the influence of cyclooxygenase-2 on postmenopausal endometrial polyps?

Pereira AK, Garcia MT, Pinheiro W, Ejzenberg D, Soares JM Jr, Baracat EC
Climacteric 2015;18(4):498-502. Epub 2014 Nov 19 doi: 10.3109/13697137.2014.966240. PMID: 25242379

Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria.

Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E
J Natl Cancer Inst 2013 Nov 6;105(21):1607-16. Epub 2013 Oct 17 doi: 10.1093/jnci/djt277. PMID: 24136893

See all (78)

MedGen

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Benign Genitourinary System Neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

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