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Non-Functioning Corticotroph Pituitary Neuroendocrine Tumor

MedGen UID:
1670304
•Concept ID:
C4743571
•
Neoplastic Process
Synonyms: Nonfunctional Corticotroph Adenoma; Nonfunctioning Corticotroph Adenoma; Silent Corticotroph Adenoma

Definition

Corticotroph pituitary neuroendocrine tumor not associated with a hormonal syndrome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Functioning Corticotroph Pituitary Neuroendocrine Tumor

Professional guidelines

PubMed

Efficacy and safety of temozolomide in the treatment of aggressive pituitary neuroendocrine tumours in Spain.
Lamas C, Cámara R, Fajardo C, Remon-Ruiz P, Biagetti B, Guerrero-Pérez F, Araujo-Castro M, Mora M, Hanzu F, Iglesias P, García-Centeno R, Soto A
Front Endocrinol (Lausanne) 2023;14:1204206. Epub 2023 Aug 31 doi: 10.3389/fendo.2023.1204206. PMID: 37720528Free PMC Article
Molecular characterization of epithelial-mesenchymal transition and medical treatment related-genes in non-functioning pituitary neuroendocrine tumors.
Gil J, Marques-Pamies M, Valassi E, Serra G, Salinas I, Xifra G, Casano-Sancho P, Carrato C, Biagetti B, Sesmilo G, Marcos-Ruiz J, Rodriguez-Lloveras H, Rueda-Pujol A, Aulinas A, Blanco A, Hostalot C, Simó-Servat A, Muñoz F, Rico M, Ibáñez-Domínguez J, Cordero E, Webb SM, Jordà M, Puig-Domingo M
Front Endocrinol (Lausanne) 2023;14:1129213. Epub 2023 Mar 22 doi: 10.3389/fendo.2023.1129213. PMID: 37033229Free PMC Article
Diagnosis and treatment of pituitary adenomas.
Chanson P, Salenave S
Minerva Endocrinol 2004 Dec;29(4):241-75. PMID: 15765032

Recent clinical studies

Etiology

The clinicopathological features and prognosis of silent corticotroph tumors: an updated systematic review and meta-analysis.
Vuong HG, Dunn IF
Endocrine 2023 Dec;82(3):527-535. Epub 2023 Jul 18 doi: 10.1007/s12020-023-03449-w. PMID: 37462809
Clinical Course and Unique Features of Silent Corticotroph Adenomas.
Huang L, Fatterpekar G, Charles S, Golub D, Zagzag D, Agrawal N
World Neurosurg 2022 May;161:e274-e281. Epub 2022 Feb 4 doi: 10.1016/j.wneu.2022.01.119. PMID: 35131523
Radiomics analysis allows for precise prediction of silent corticotroph adenoma among non-functioning pituitary adenomas.
Rui W, Qiao N, Wu Y, Zhang Y, Aili A, Zhang Z, Ye H, Wang Y, Zhao Y, Yao Z
Eur Radiol 2022 Mar;32(3):1570-1578. Epub 2021 Nov 27 doi: 10.1007/s00330-021-08361-3. PMID: 34837512
Transcriptomic analysis identifies a tumor subtype mRNA classifier for invasive non-functioning pituitary neuroendocrine tumor diagnostics.
Bao X, Wang G, Yu S, Sun J, He L, Zhao H, Ma Y, Wang F, Wang X, Wang R, Yu J
Theranostics 2021;11(1):132-146. Epub 2021 Jan 1 doi: 10.7150/thno.47525. PMID: 33391466Free PMC Article
Histopathological classification of non-functioning pituitary neuroendocrine tumors.
Manojlovic-Gacic E, Engström BE, Casar-Borota O
Pituitary 2018 Apr;21(2):119-129. doi: 10.1007/s11102-017-0855-1. PMID: 29275530Free PMC Article

Diagnosis

Radiomics analysis allows for precise prediction of silent corticotroph adenoma among non-functioning pituitary adenomas.
Rui W, Qiao N, Wu Y, Zhang Y, Aili A, Zhang Z, Ye H, Wang Y, Zhao Y, Yao Z
Eur Radiol 2022 Mar;32(3):1570-1578. Epub 2021 Nov 27 doi: 10.1007/s00330-021-08361-3. PMID: 34837512
Transcriptomic analysis identifies a tumor subtype mRNA classifier for invasive non-functioning pituitary neuroendocrine tumor diagnostics.
Bao X, Wang G, Yu S, Sun J, He L, Zhao H, Ma Y, Wang F, Wang X, Wang R, Yu J
Theranostics 2021;11(1):132-146. Epub 2021 Jan 1 doi: 10.7150/thno.47525. PMID: 33391466Free PMC Article
Histopathological classification of non-functioning pituitary neuroendocrine tumors.
Manojlovic-Gacic E, Engström BE, Casar-Borota O
Pituitary 2018 Apr;21(2):119-129. doi: 10.1007/s11102-017-0855-1. PMID: 29275530Free PMC Article
Recent clinical and pathophysiological advances in non-functioning pituitary adenomas.
Korbonits M, Carlsen E
Horm Res 2009 Apr;71 Suppl 2:123-30. Epub 2009 Apr 29 doi: 10.1159/000192449. PMID: 19407508
Diagnosis and treatment of pituitary adenomas.
Chanson P, Salenave S
Minerva Endocrinol 2004 Dec;29(4):241-75. PMID: 15765032

Therapy

Efficacy and safety of temozolomide in the treatment of aggressive pituitary neuroendocrine tumours in Spain.
Lamas C, Cámara R, Fajardo C, Remon-Ruiz P, Biagetti B, Guerrero-Pérez F, Araujo-Castro M, Mora M, Hanzu F, Iglesias P, García-Centeno R, Soto A
Front Endocrinol (Lausanne) 2023;14:1204206. Epub 2023 Aug 31 doi: 10.3389/fendo.2023.1204206. PMID: 37720528Free PMC Article
The clinicopathological features and prognosis of silent corticotroph tumors: an updated systematic review and meta-analysis.
Vuong HG, Dunn IF
Endocrine 2023 Dec;82(3):527-535. Epub 2023 Jul 18 doi: 10.1007/s12020-023-03449-w. PMID: 37462809
Octreotide and pasireotide (dis)similarly inhibit pituitary tumor cells in vitro.
Ibáñez-Costa A, Rivero-Cortés E, Vázquez-Borrego MC, Gahete MD, Jiménez-Reina L, Venegas-Moreno E, de la Riva A, Arráez MÁ, González-Molero I, Schmid HA, Maraver-Selfa S, Gavilán-Villarejo I, García-Arnés JA, Japón MA, Soto-Moreno A, Gálvez MA, Luque RM, Castaño JP
J Endocrinol 2016 Nov;231(2):135-145. Epub 2016 Sep 1 doi: 10.1530/JOE-16-0332. PMID: 27587848
Immediate and delayed postoperative morbidity in functional and non-functioning pituitary adenomas.
Aulinas A, Colom C, Ybarra J, Muñoz F, Tresserras P, Resmini E, Webb SM
Pituitary 2012 Sep;15(3):380-5. doi: 10.1007/s11102-011-0331-2. PMID: 21833618
Combined therapy of somatostatin analogues and dopamine agonists in the treatment of pituitary tumours.
Colao A, Filippella M, Pivonello R, Di Somma C, Faggiano A, Lombardi G
Eur J Endocrinol 2007 Apr;156 Suppl 1:S57-S63. doi: 10.1530/eje.1.02348. PMID: 17413190

Prognosis

The clinicopathological features and prognosis of silent corticotroph tumors: an updated systematic review and meta-analysis.
Vuong HG, Dunn IF
Endocrine 2023 Dec;82(3):527-535. Epub 2023 Jul 18 doi: 10.1007/s12020-023-03449-w. PMID: 37462809
Radiomics analysis allows for precise prediction of silent corticotroph adenoma among non-functioning pituitary adenomas.
Rui W, Qiao N, Wu Y, Zhang Y, Aili A, Zhang Z, Ye H, Wang Y, Zhao Y, Yao Z
Eur Radiol 2022 Mar;32(3):1570-1578. Epub 2021 Nov 27 doi: 10.1007/s00330-021-08361-3. PMID: 34837512
Silent corticotroph adenomas.
Ben-Shlomo A, Cooper O
Pituitary 2018 Apr;21(2):183-193. doi: 10.1007/s11102-018-0864-8. PMID: 29344907
Histopathological classification of non-functioning pituitary neuroendocrine tumors.
Manojlovic-Gacic E, Engström BE, Casar-Borota O
Pituitary 2018 Apr;21(2):119-129. doi: 10.1007/s11102-017-0855-1. PMID: 29275530Free PMC Article
Recent clinical and pathophysiological advances in non-functioning pituitary adenomas.
Korbonits M, Carlsen E
Horm Res 2009 Apr;71 Suppl 2:123-30. Epub 2009 Apr 29 doi: 10.1159/000192449. PMID: 19407508

Clinical prediction guides

Clinical presentation and recurrence of pituitary neuroendocrine tumors: results from a single referral center in Colombia.
Jimenez-Canizales CE, Rojas W, Alonso D, Romero I, Tabares S, Veronesi Zuluaga LA, Modica R, Colao A
J Endocrinol Invest 2023 Nov;46(11):2275-2286. Epub 2023 Mar 31 doi: 10.1007/s40618-023-02080-w. PMID: 37002436
Editorial Comment: Radiomics analysis allows for precise prediction of silent corticotroph adenoma among non-functioning pituitary adenomas.
Bourbonne V
Eur Radiol 2022 Mar;32(3):1475-1476. Epub 2022 Jan 19 doi: 10.1007/s00330-021-08509-1. PMID: 35043292
Radiomics analysis allows for precise prediction of silent corticotroph adenoma among non-functioning pituitary adenomas.
Rui W, Qiao N, Wu Y, Zhang Y, Aili A, Zhang Z, Ye H, Wang Y, Zhao Y, Yao Z
Eur Radiol 2022 Mar;32(3):1570-1578. Epub 2021 Nov 27 doi: 10.1007/s00330-021-08361-3. PMID: 34837512
Histopathological classification of non-functioning pituitary neuroendocrine tumors.
Manojlovic-Gacic E, Engström BE, Casar-Borota O
Pituitary 2018 Apr;21(2):119-129. doi: 10.1007/s11102-017-0855-1. PMID: 29275530Free PMC Article
Recent clinical and pathophysiological advances in non-functioning pituitary adenomas.
Korbonits M, Carlsen E
Horm Res 2009 Apr;71 Suppl 2:123-30. Epub 2009 Apr 29 doi: 10.1159/000192449. PMID: 19407508

Recent systematic reviews

The clinicopathological features and prognosis of silent corticotroph tumors: an updated systematic review and meta-analysis.
Vuong HG, Dunn IF
Endocrine 2023 Dec;82(3):527-535. Epub 2023 Jul 18 doi: 10.1007/s12020-023-03449-w. PMID: 37462809
Reported outcomes in transsphenoidal surgery for pituitary adenomas: a systematic review.
Layard Horsfall H, Lawrence A, Venkatesh A, Loh RTS, Jayapalan R, Koulouri O, Sharma R, Santarius T, Gurnell M, Dorward N, Mannion R, Marcus HJ, Kolias AG
Pituitary 2023 Apr;26(2):171-181. Epub 2023 Mar 2 doi: 10.1007/s11102-023-01303-w. PMID: 36862265Free PMC Article

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