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Thyroid Gland Black Follicular Adenoma

MedGen UID:
1670480
•Concept ID:
C4744476
•
Neoplastic Process

Definition

A thyroid gland follicular adenoma seen in patients treated with minocycline. The tumors have black discoloration visible on macroscopic examination and cytoplasmic accumulation of black pigment. (WHO 2017) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid Gland Black Follicular Adenoma

Recent clinical studies

Etiology

Frequency of thyroid pathologies in the central Black Sea Region: Ultrasound-based field study.
Aktas F, Demir O
Niger J Clin Pract 2023 Aug;26(8):1091-1096. doi: 10.4103/njcp.njcp_678_22. PMID: 37635601
Integrated genomic characterization of papillary thyroid carcinoma.
Cancer Genome Atlas Research Network
Cell 2014 Oct 23;159(3):676-90. doi: 10.1016/j.cell.2014.09.050. PMID: 25417114Free PMC Article
Papillary thyroid carcinoma in black thyroids.
Kandil E, Khalek MA, Ibrahim WG, Alabbas H, Yau CL, Friedlander P, Crawford B, Jaffe BM
Head Neck 2011 Dec;33(12):1735-8. Epub 2011 Mar 17 doi: 10.1002/hed.21656. PMID: 21416546
Prognostic factors and therapeutic strategies for differentiated carcinomas of the thyroid.
Ito Y, Miyauchi A
Endocr J 2009;56(2):177-92. Epub 2008 Aug 13 doi: 10.1507/endocrj.k08e-166. PMID: 18703852
Endocrine gland cancer.
Correa P, Chen VW
Cancer 1995 Jan 1;75(1 Suppl):338-52. doi: 10.1002/1097-0142(19950101)75:1+<338::aid-cncr2820751316>3.0.co;2-f. PMID: 8001005

Diagnosis

Minocycline-induced black thyroid with black pigmentation of the thyroid cartilage, cricoid cartilage, and trachea found during reconstructive surgery for hypopharyngeal cancer.
Kondo T, Nakatsugawa M, Hirai Y, Takeda A, Kikawada N, Aihara Y, Chiba Y, Okimura A, Hirano H, Ogawa Y, Tsukahara K
Auris Nasus Larynx 2022 Apr;49(2):299-303. Epub 2020 Sep 8 doi: 10.1016/j.anl.2020.08.028. PMID: 32912766
Black Thyroid.
Yu NY, Gamez ME
Int J Surg Pathol 2019 Jun;27(4):401-402. Epub 2018 Sep 17 doi: 10.1177/1066896918800773. PMID: 30322317
Antidepressant-Related Black Thyroid.
Barras JL, Sarro R, Bongiovanni M, La Rosa S
Endocr Pathol 2018 Mar;29(1):86-88. doi: 10.1007/s12022-018-9512-0. PMID: 29327319
Papillary thyroid carcinoma in black thyroids.
Kandil E, Khalek MA, Ibrahim WG, Alabbas H, Yau CL, Friedlander P, Crawford B, Jaffe BM
Head Neck 2011 Dec;33(12):1735-8. Epub 2011 Mar 17 doi: 10.1002/hed.21656. PMID: 21416546
Prognostic factors and therapeutic strategies for differentiated carcinomas of the thyroid.
Ito Y, Miyauchi A
Endocr J 2009;56(2):177-92. Epub 2008 Aug 13 doi: 10.1507/endocrj.k08e-166. PMID: 18703852

Therapy

Minocycline-induced black thyroid with black pigmentation of the thyroid cartilage, cricoid cartilage, and trachea found during reconstructive surgery for hypopharyngeal cancer.
Kondo T, Nakatsugawa M, Hirai Y, Takeda A, Kikawada N, Aihara Y, Chiba Y, Okimura A, Hirano H, Ogawa Y, Tsukahara K
Auris Nasus Larynx 2022 Apr;49(2):299-303. Epub 2020 Sep 8 doi: 10.1016/j.anl.2020.08.028. PMID: 32912766
Black Thyroid.
Yu NY, Gamez ME
Int J Surg Pathol 2019 Jun;27(4):401-402. Epub 2018 Sep 17 doi: 10.1177/1066896918800773. PMID: 30322317
Antidepressant-Related Black Thyroid.
Barras JL, Sarro R, Bongiovanni M, La Rosa S
Endocr Pathol 2018 Mar;29(1):86-88. doi: 10.1007/s12022-018-9512-0. PMID: 29327319
Black thyroid.
Bann DV, Goyal N, Crist H, Goldenberg D
Ear Nose Throat J 2014 Oct-Nov;93(10-11):E54-5. doi: 10.1177/014556131409310-1110. PMID: 25397396Free PMC Article
Cancer of the thyroid gland.
Beahrs OH, Pasternak BM
Curr Probl Surg 1969 Dec:1-38. PMID: 4906527

Prognosis

Do carbon nanoparticles really improve thyroid cancer surgery? A retrospective analysis of real-world data.
Liu J, Xu C, Wang R, Han P, Zhao Q, Li H, Bai Y, Liu L, Zhang S, Yao X
World J Surg Oncol 2020 May 2;18(1):84. doi: 10.1186/s12957-020-01852-5. PMID: 32359365Free PMC Article
Significant racial differences in the incidence and behavior of the follicular variant of papillary thyroid carcinoma.
Mehta V, Ow TJ, Kim S, Tharakan T, Schiff B, Smith RV, In H
Head Neck 2019 May;41(5):1403-1411. Epub 2019 Jan 16 doi: 10.1002/hed.25596. PMID: 30652370
Thyroid gland management in total laryngectomy: meta-analysis and surgical recommendations.
Mendelson AA, Al-Khatib TA, Julien M, Payne RJ, Black MJ, Hier MP
Otolaryngol Head Neck Surg 2009 Mar;140(3):298-305. doi: 10.1016/j.otohns.2008.10.031. PMID: 19248932
Prognostic factors and therapeutic strategies for differentiated carcinomas of the thyroid.
Ito Y, Miyauchi A
Endocr J 2009;56(2):177-92. Epub 2008 Aug 13 doi: 10.1507/endocrj.k08e-166. PMID: 18703852
Endocrine gland cancer.
Correa P, Chen VW
Cancer 1995 Jan 1;75(1 Suppl):338-52. doi: 10.1002/1097-0142(19950101)75:1+<338::aid-cncr2820751316>3.0.co;2-f. PMID: 8001005

Clinical prediction guides

Minocycline-induced black thyroid with black pigmentation of the thyroid cartilage, cricoid cartilage, and trachea found during reconstructive surgery for hypopharyngeal cancer.
Kondo T, Nakatsugawa M, Hirai Y, Takeda A, Kikawada N, Aihara Y, Chiba Y, Okimura A, Hirano H, Ogawa Y, Tsukahara K
Auris Nasus Larynx 2022 Apr;49(2):299-303. Epub 2020 Sep 8 doi: 10.1016/j.anl.2020.08.028. PMID: 32912766
Significant racial differences in the incidence and behavior of the follicular variant of papillary thyroid carcinoma.
Mehta V, Ow TJ, Kim S, Tharakan T, Schiff B, Smith RV, In H
Head Neck 2019 May;41(5):1403-1411. Epub 2019 Jan 16 doi: 10.1002/hed.25596. PMID: 30652370
Integrated genomic characterization of papillary thyroid carcinoma.
Cancer Genome Atlas Research Network
Cell 2014 Oct 23;159(3):676-90. doi: 10.1016/j.cell.2014.09.050. PMID: 25417114Free PMC Article
Thyroid gland management in total laryngectomy: meta-analysis and surgical recommendations.
Mendelson AA, Al-Khatib TA, Julien M, Payne RJ, Black MJ, Hier MP
Otolaryngol Head Neck Surg 2009 Mar;140(3):298-305. doi: 10.1016/j.otohns.2008.10.031. PMID: 19248932
Endocrine gland cancer.
Correa P, Chen VW
Cancer 1995 Jan 1;75(1 Suppl):338-52. doi: 10.1002/1097-0142(19950101)75:1+<338::aid-cncr2820751316>3.0.co;2-f. PMID: 8001005

Recent systematic reviews

The Potential Role of Carbon Nanoparticles in Lymph Node Tracing, Recurrent Laryngeal Nerve Identification and Parathyroid Preservation During Thyroid Surgery: A Systematic Review.
Spartalis E, Giannakodimos A, Athanasiadis DI, Chrysikos D, Paschou SA, Schizas D, Patelis N, Papasilekas T, Themistoklis K, Spartalis M, Troupis T, Nikiteas N
Curr Pharm Des 2021;27(21):2505-2511. doi: 10.2174/1381612826666200922154824. PMID: 32962609
Thyroid gland management in total laryngectomy: meta-analysis and surgical recommendations.
Mendelson AA, Al-Khatib TA, Julien M, Payne RJ, Black MJ, Hier MP
Otolaryngol Head Neck Surg 2009 Mar;140(3):298-305. doi: 10.1016/j.otohns.2008.10.031. PMID: 19248932

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