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Age-related clonal hematopoiesis

MedGen UID:
1670618
Concept ID:
C4722404
Finding
Synonyms: Age related Clonal Hematopoiesis; Age-related Clonal Hematopoiesis; ARCH Age related Clonal Hematopoiesis; ARCH Age-related Clonal Hematopoiesis; Clonal Hematopoiesis, Age-related; Hematopoiesis, Age-related Clonal
 
Monarch Initiative: MONDO:0100544

Definition

The gradual, clonal expansion of hematopoietic stem and progenitor cells carrying specific, disruptive, and recurrent genetic variants, in individuals without clear diagnosis of hematological malignancies. It is associated with an increased risk of developing hematologic cancers. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAge-related clonal hematopoiesis

Professional guidelines

PubMed

Sun Y, Zhu G, Zhong H
Eur J Haematol 2024 Jun;112(6):870-878. Epub 2024 Feb 11 doi: 10.1111/ejh.14187. PMID: 38342613

Recent clinical studies

Etiology

Evans MA, Walsh K
Physiol Rev 2023 Jan 1;103(1):649-716. Epub 2022 Sep 1 doi: 10.1152/physrev.00004.2022. PMID: 36049115Free PMC Article
Jung C, Evans MA, Walsh K
Curr Opin Cardiol 2020 May;35(3):219-225. doi: 10.1097/HCO.0000000000000726. PMID: 32073406Free PMC Article
Evans MA, Sano S, Walsh K
Annu Rev Pathol 2020 Jan 24;15:419-438. Epub 2019 Nov 5 doi: 10.1146/annurev-pathmechdis-012419-032544. PMID: 31689371Free PMC Article
Shlush LI
Blood 2018 Feb 1;131(5):496-504. Epub 2017 Nov 15 doi: 10.1182/blood-2017-07-746453. PMID: 29141946
Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman PV, Mar BG, Lindsley RC, Mermel CH, Burtt N, Chavez A, Higgins JM, Moltchanov V, Kuo FC, Kluk MJ, Henderson B, Kinnunen L, Koistinen HA, Ladenvall C, Getz G, Correa A, Banahan BF, Gabriel S, Kathiresan S, Stringham HM, McCarthy MI, Boehnke M, Tuomilehto J, Haiman C, Groop L, Atzmon G, Wilson JG, Neuberg D, Altshuler D, Ebert BL
N Engl J Med 2014 Dec 25;371(26):2488-98. Epub 2014 Nov 26 doi: 10.1056/NEJMoa1408617. PMID: 25426837Free PMC Article

Diagnosis

Ogawa S
Blood 2019 Mar 7;133(10):1049-1059. Epub 2019 Jan 22 doi: 10.1182/blood-2018-10-844621. PMID: 30670442Free PMC Article
Mufti GJ, Marsh JCW
Hematol Oncol Clin North Am 2018 Aug;32(4):595-607. Epub 2018 Jun 5 doi: 10.1016/j.hoc.2018.03.002. PMID: 30047413
Busque L, Buscarlet M, Mollica L, Levine RL
Stem Cells 2018 Sep;36(9):1287-1294. Epub 2018 Jun 8 doi: 10.1002/stem.2845. PMID: 29883022Free PMC Article
Jongen-Lavrencic M, Grob T, Hanekamp D, Kavelaars FG, Al Hinai A, Zeilemaker A, Erpelinck-Verschueren CAJ, Gradowska PL, Meijer R, Cloos J, Biemond BJ, Graux C, van Marwijk Kooy M, Manz MG, Pabst T, Passweg JR, Havelange V, Ossenkoppele GJ, Sanders MA, Schuurhuis GJ, Löwenberg B, Valk PJM
N Engl J Med 2018 Mar 29;378(13):1189-1199. doi: 10.1056/NEJMoa1716863. PMID: 29601269
Shlush LI
Blood 2018 Feb 1;131(5):496-504. Epub 2017 Nov 15 doi: 10.1182/blood-2017-07-746453. PMID: 29141946

Therapy

Dawoud AAZ, Gilbert RD, Tapper WJ, Cross NCP
Leukemia 2022 Feb;36(2):507-515. Epub 2021 Aug 19 doi: 10.1038/s41375-021-01382-3. PMID: 34413458Free PMC Article
Dharan NJ, Yeh P, Bloch M, Yeung MM, Baker D, Guinto J, Roth N, Ftouni S, Ognenovska K, Smith D, Hoy JF, Woolley I, Pell C, Templeton DJ, Fraser N, Rose N, Hutchinson J, Petoumenos K, Dawson SJ, Polizzotto MN, Dawson MA; ARCHIVE Study Group
Nat Med 2021 Jun;27(6):1006-1011. Epub 2021 Jun 7 doi: 10.1038/s41591-021-01357-y. PMID: 34099923
Nawas MT, Schetelig J, Damm F, Levine RL, Perales MA, Giralt SA, VanDenBrink MR, Arcila ME, Zehir A, Papaemmanuil E, Klussmeier A, Schmidt AH, Maiwald S, Bolton KL, Tamari R
Blood Rev 2021 Mar;46:100744. Epub 2020 Aug 24 doi: 10.1016/j.blre.2020.100744. PMID: 32896435Free PMC Article
Zuckerman T, Rowe JM
Curr Opin Hematol 2019 Mar;26(2):51-57. doi: 10.1097/MOH.0000000000000480. PMID: 30585895
Spira A, Yurgelun MB, Alexandrov L, Rao A, Bejar R, Polyak K, Giannakis M, Shilatifard A, Finn OJ, Dhodapkar M, Kay NE, Braggio E, Vilar E, Mazzilli SA, Rebbeck TR, Garber JE, Velculescu VE, Disis ML, Wallace DC, Lippman SM
Cancer Res 2017 Apr 1;77(7):1510-1541. doi: 10.1158/0008-5472.CAN-16-2346. PMID: 28373404Free PMC Article

Prognosis

Ye B, Sheng Y, Zhang M, Hu Y, Huang H
Cancer Lett 2022 Jul 10;538:215691. Epub 2022 Apr 23 doi: 10.1016/j.canlet.2022.215691. PMID: 35469959
Evans MA, Sano S, Walsh K
Annu Rev Pathol 2020 Jan 24;15:419-438. Epub 2019 Nov 5 doi: 10.1146/annurev-pathmechdis-012419-032544. PMID: 31689371Free PMC Article
Ogawa S
Blood 2019 Mar 7;133(10):1049-1059. Epub 2019 Jan 22 doi: 10.1182/blood-2018-10-844621. PMID: 30670442Free PMC Article
Mufti GJ, McLornan DP, van de Loosdrecht AA, Germing U, Hasserjian RP
Leukemia 2018 Aug;32(8):1679-1696. Epub 2018 Jun 26 doi: 10.1038/s41375-018-0173-2. PMID: 29946191
Jongen-Lavrencic M, Grob T, Hanekamp D, Kavelaars FG, Al Hinai A, Zeilemaker A, Erpelinck-Verschueren CAJ, Gradowska PL, Meijer R, Cloos J, Biemond BJ, Graux C, van Marwijk Kooy M, Manz MG, Pabst T, Passweg JR, Havelange V, Ossenkoppele GJ, Sanders MA, Schuurhuis GJ, Löwenberg B, Valk PJM
N Engl J Med 2018 Mar 29;378(13):1189-1199. doi: 10.1056/NEJMoa1716863. PMID: 29601269

Clinical prediction guides

Ye B, Sheng Y, Zhang M, Hu Y, Huang H
Cancer Lett 2022 Jul 10;538:215691. Epub 2022 Apr 23 doi: 10.1016/j.canlet.2022.215691. PMID: 35469959
Dharan NJ, Yeh P, Bloch M, Yeung MM, Baker D, Guinto J, Roth N, Ftouni S, Ognenovska K, Smith D, Hoy JF, Woolley I, Pell C, Templeton DJ, Fraser N, Rose N, Hutchinson J, Petoumenos K, Dawson SJ, Polizzotto MN, Dawson MA; ARCHIVE Study Group
Nat Med 2021 Jun;27(6):1006-1011. Epub 2021 Jun 7 doi: 10.1038/s41591-021-01357-y. PMID: 34099923
Evans MA, Sano S, Walsh K
Annu Rev Pathol 2020 Jan 24;15:419-438. Epub 2019 Nov 5 doi: 10.1146/annurev-pathmechdis-012419-032544. PMID: 31689371Free PMC Article
Jongen-Lavrencic M, Grob T, Hanekamp D, Kavelaars FG, Al Hinai A, Zeilemaker A, Erpelinck-Verschueren CAJ, Gradowska PL, Meijer R, Cloos J, Biemond BJ, Graux C, van Marwijk Kooy M, Manz MG, Pabst T, Passweg JR, Havelange V, Ossenkoppele GJ, Sanders MA, Schuurhuis GJ, Löwenberg B, Valk PJM
N Engl J Med 2018 Mar 29;378(13):1189-1199. doi: 10.1056/NEJMoa1716863. PMID: 29601269
Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman PV, Mar BG, Lindsley RC, Mermel CH, Burtt N, Chavez A, Higgins JM, Moltchanov V, Kuo FC, Kluk MJ, Henderson B, Kinnunen L, Koistinen HA, Ladenvall C, Getz G, Correa A, Banahan BF, Gabriel S, Kathiresan S, Stringham HM, McCarthy MI, Boehnke M, Tuomilehto J, Haiman C, Groop L, Atzmon G, Wilson JG, Neuberg D, Altshuler D, Ebert BL
N Engl J Med 2014 Dec 25;371(26):2488-98. Epub 2014 Nov 26 doi: 10.1056/NEJMoa1408617. PMID: 25426837Free PMC Article

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