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Unresectable Digestive System Neuroendocrine Carcinoma

MedGen UID:
1670620
•Concept ID:
C4744460
•
Neoplastic Process
Synonym: Unresectable Gastrointestinal System Neuroendocrine Carcinoma

Definition

A neuroendocrine carcinoma that arises from any part of the digestive system and is not amenable to surgical resection. [from NCI]

Professional guidelines

PubMed

Radioembolization in the treatment of unresectable liver tumors: experience across a range of primary cancers.
Coldwell D, Sangro B, Salem R, Wasan H, Kennedy A
Am J Clin Oncol 2012 Apr;35(2):167-77. doi: 10.1097/COC.0b013e3181f47923. PMID: 21127414
Role of liver transplantation in the treatment of unresectable liver cancer.
Pichlmayr R, Weimann A, Oldhafer KJ, Schlitt HJ, Klempnauer J, Bornscheuer A, Chavan A, Schmoll E, Lang H, Tusch G
World J Surg 1995 Nov-Dec;19(6):807-13. doi: 10.1007/BF00299775. PMID: 8553670

Recent clinical studies

Therapy

Updates and Expert Opinions on Liver Transplantation for Gastrointestinal Malignancies.
Shannon AH, Ruff SM, Schenk AD, Washburn K, Pawlik TM
Medicina (Kaunas) 2023 Jul 13;59(7) doi: 10.3390/medicina59071290. PMID: 37512101Free PMC Article
Effectiveness of Etoposide and Cisplatin vs Irinotecan and Cisplatin Therapy for Patients With Advanced Neuroendocrine Carcinoma of the Digestive System: The TOPIC-NEC Phase 3 Randomized Clinical Trial.
Morizane C, Machida N, Honma Y, Okusaka T, Boku N, Kato K, Nomura S, Hiraoka N, Sekine S, Taniguchi H, Okano N, Yamaguchi K, Sato T, Ikeda M, Mizuno N, Ozaka M, Kataoka T, Ueno M, Kitagawa Y, Terashima M, Furuse J; Japan Clinical Oncology Group (JCOG)
JAMA Oncol 2022 Oct 1;8(10):1447-1455. doi: 10.1001/jamaoncol.2022.3395. PMID: 35980649Free PMC Article
Brain metastasis from gallbladder neuroendocrine carcinoma.
Sasaki H, Goto T, Hirao M, Fujimoto Y
BMJ Case Rep 2020 Nov 30;13(11) doi: 10.1136/bcr-2020-238114. PMID: 33257386Free PMC Article
Liver transplantation for malignancies.
Eghtesad B, Aucejo F
J Gastrointest Cancer 2014 Sep;45(3):353-62. doi: 10.1007/s12029-014-9590-2. PMID: 24604263
Radioembolization in the treatment of unresectable liver tumors: experience across a range of primary cancers.
Coldwell D, Sangro B, Salem R, Wasan H, Kennedy A
Am J Clin Oncol 2012 Apr;35(2):167-77. doi: 10.1097/COC.0b013e3181f47923. PMID: 21127414

Prognosis

Brain metastasis from gallbladder neuroendocrine carcinoma.
Sasaki H, Goto T, Hirao M, Fujimoto Y
BMJ Case Rep 2020 Nov 30;13(11) doi: 10.1136/bcr-2020-238114. PMID: 33257386Free PMC Article
Biliary tract large cell neuroendocrine carcinoma: current evidence.
Raiker R, Chauhan A, Hasanein H, Burkeen G, Horn M, Veedu J, Vela C, Arnold S, Kolesar J, Anthony L, Evers BM, Cavnar M
Orphanet J Rare Dis 2019 Nov 21;14(1):266. doi: 10.1186/s13023-019-1230-2. PMID: 31752927Free PMC Article
Multicenter retrospective analysis of systemic chemotherapy for advanced neuroendocrine carcinoma of the digestive system.
Yamaguchi T, Machida N, Morizane C, Kasuga A, Takahashi H, Sudo K, Nishina T, Tobimatsu K, Ishido K, Furuse J, Boku N, Okusaka T
Cancer Sci 2014 Sep;105(9):1176-81. Epub 2014 Sep 6 doi: 10.1111/cas.12473. PMID: 24975505Free PMC Article
Interventional endoscopy, neoadjuvant therapy and the gastroenterologist.
Snady H
Hematol Oncol Clin North Am 2002 Feb;16(1):53-79. doi: 10.1016/s0889-8588(01)00010-7. PMID: 12063829
Tumor diagnosis in the adult liver transplant candidate.
Mahfouz A, Vogl T, Hamm B
Eur Radiol 1999;9(5):841-52. doi: 10.1007/s003300050754. PMID: 10369978

Clinical prediction guides

The potential of somatostatin receptor 2 as a novel therapeutic target in salivary gland malignant tumors.
Meirovitz A, Shouchane-Blum K, Maly A, Bersudski E, Hirshoren N, Abrams R, Popovtzer A, Orevi M, Weinberger J
J Cancer Res Clin Oncol 2021 May;147(5):1335-1340. Epub 2021 Feb 17 doi: 10.1007/s00432-021-03538-1. PMID: 33598797
Liver transplantation for non-hepatocellular carcinoma malignancy: Indications, limitations, and analysis of the current literature.
Grossman EJ, Millis JM
Liver Transpl 2010 Aug;16(8):930-42. doi: 10.1002/lt.22106. PMID: 20677284
Tumor diagnosis in the adult liver transplant candidate.
Mahfouz A, Vogl T, Hamm B
Eur Radiol 1999;9(5):841-52. doi: 10.1007/s003300050754. PMID: 10369978

Supplemental Content

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