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Recurrent Chordoma

MedGen UID:
1670910
•Concept ID:
C4744483
•
Neoplastic Process

Definition

The reemergence of chordoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Chordoma

Professional guidelines

PubMed

Best practices for the management of local-regional recurrent chordoma: a position paper by the Chordoma Global Consensus Group.
Stacchiotti S, Gronchi A, Fossati P, Akiyama T, Alapetite C, Baumann M, Blay JY, Bolle S, Boriani S, Bruzzi P, Capanna R, Caraceni A, Casadei R, Colia V, Debus J, Delaney T, Desai A, Dileo P, Dijkstra S, Doglietto F, Flanagan A, Froelich S, Gardner PA, Gelderblom H, Gokaslan ZL, Haas R, Heery C, Hindi N, Hohenberger P, Hornicek F, Imai R, Jeys L, Jones RL, Kasper B, Kawai A, Krengli M, Leithner A, Logowska I, Martin Broto J, Mazzatenta D, Morosi C, Nicolai P, Norum OJ, Patel S, Penel N, Picci P, Pilotti S, Radaelli S, Ricchini F, Rutkowski P, Scheipl S, Sen C, Tamborini E, Thornton KA, Timmermann B, Torri V, Tunn PU, Uhl M, Yamada Y, Weber DC, Vanel D, Varga PP, Vleggeert-Lankamp CLA, Casali PG, Sommer J
Ann Oncol 2017 Jun 1;28(6):1230-1242. doi: 10.1093/annonc/mdx054. PMID: 28184416Free PMC Article
Management of Locally Recurrent Chordoma of the Mobile Spine and Sacrum: A Systematic Review.
Ailon T, Torabi R, Fisher CG, Rhines LD, Clarke MJ, Bettegowda C, Boriani S, Yamada YJ, Kawahara N, Varga PP, Shin JH, Saghal A, Gokaslan ZL
Spine (Phila Pa 1976) 2016 Oct 15;41 Suppl 20(Suppl 20):S193-S198. doi: 10.1097/BRS.0000000000001812. PMID: 27753782Free PMC Article
Multidisciplinary management of recurrent chordomas.
Yamada Y, Gounder M, Laufer I
Curr Treat Options Oncol 2013 Sep;14(3):442-53. doi: 10.1007/s11864-013-0247-3. PMID: 23860859

Recent clinical studies

Etiology

Activity of pemetrexed in pre-clinical chordoma models and humans.
Kesari S, Wang F, Juarez T, Ashili S, Patro CPK, Carrillo J, Nguyen M, Truong J, Levy J, Sommer J, Freed DM, Xiu J, Takasumi Y, Bouffet E, Gill JM
Sci Rep 2023 May 5;13(1):7317. doi: 10.1038/s41598-023-34404-4. PMID: 37147496Free PMC Article
Characteristics and functional outcomes of chordoma patients admitted for inpatient rehabilitation.
Knowlton SE, Zafonte R, O'Connor KC, Schwab J, Hornicek F
Disabil Rehabil 2018 Sep;40(19):2275-2280. Epub 2017 Jun 7 doi: 10.1080/09638288.2017.1334233. PMID: 28589739
Best practices for the management of local-regional recurrent chordoma: a position paper by the Chordoma Global Consensus Group.
Stacchiotti S, Gronchi A, Fossati P, Akiyama T, Alapetite C, Baumann M, Blay JY, Bolle S, Boriani S, Bruzzi P, Capanna R, Caraceni A, Casadei R, Colia V, Debus J, Delaney T, Desai A, Dileo P, Dijkstra S, Doglietto F, Flanagan A, Froelich S, Gardner PA, Gelderblom H, Gokaslan ZL, Haas R, Heery C, Hindi N, Hohenberger P, Hornicek F, Imai R, Jeys L, Jones RL, Kasper B, Kawai A, Krengli M, Leithner A, Logowska I, Martin Broto J, Mazzatenta D, Morosi C, Nicolai P, Norum OJ, Patel S, Penel N, Picci P, Pilotti S, Radaelli S, Ricchini F, Rutkowski P, Scheipl S, Sen C, Tamborini E, Thornton KA, Timmermann B, Torri V, Tunn PU, Uhl M, Yamada Y, Weber DC, Vanel D, Varga PP, Vleggeert-Lankamp CLA, Casali PG, Sommer J
Ann Oncol 2017 Jun 1;28(6):1230-1242. doi: 10.1093/annonc/mdx054. PMID: 28184416Free PMC Article
Management of Locally Recurrent Chordoma of the Mobile Spine and Sacrum: A Systematic Review.
Ailon T, Torabi R, Fisher CG, Rhines LD, Clarke MJ, Bettegowda C, Boriani S, Yamada YJ, Kawahara N, Varga PP, Shin JH, Saghal A, Gokaslan ZL
Spine (Phila Pa 1976) 2016 Oct 15;41 Suppl 20(Suppl 20):S193-S198. doi: 10.1097/BRS.0000000000001812. PMID: 27753782Free PMC Article
Cryoablation of recurrent sacrococcygeal tumors.
Kurup AN, Woodrum DA, Morris JM, Atwell TD, Schmit GD, Welch TJ, Yaszemski MJ, Callstrom MR
J Vasc Interv Radiol 2012 Aug;23(8):1070-5. doi: 10.1016/j.jvir.2012.05.043. PMID: 22840806

Diagnosis

Immune Checkpoint Inhibitors Have Clinical Activity in Patients With Recurrent Chordoma.
Bishop AJ, Amini B, Lin H, Raza SM, Patel S, Grosshans DR, Ghia A, Farooqi A, Guadagnolo BA, Mitra D, Akdemir KC, Lazar AJ, Wang WL, Alvarez-Breckenridge C, Bird J, Rhines LD, Somaiah N, Conley AP
J Immunother 2022 Oct 1;45(8):374-378. Epub 2022 Aug 4 doi: 10.1097/CJI.0000000000000431. PMID: 35943386Free PMC Article
Results following surgical resection of recurrent chordoma of the spine: experience in a single institution.
Chanplakorn P, Lertudomphonwanit T, Homcharoen W, Suwanpramote P, Laohacharoensombat W
World J Surg Oncol 2020 Aug 27;18(1):228. doi: 10.1186/s12957-020-02005-4. PMID: 32854731Free PMC Article
Characteristics and functional outcomes of chordoma patients admitted for inpatient rehabilitation.
Knowlton SE, Zafonte R, O'Connor KC, Schwab J, Hornicek F
Disabil Rehabil 2018 Sep;40(19):2275-2280. Epub 2017 Jun 7 doi: 10.1080/09638288.2017.1334233. PMID: 28589739
Difficulty distinguishing benign notochordal cell tumor from chordoma further suggests a link between them.
Kreshak J, Larousserie F, Picci P, Boriani S, Mirra J, Merlino B, Brunocilla E, Vanel D
Cancer Imaging 2014 Apr 22;14(1):4. doi: 10.1186/1470-7330-14-4. PMID: 25609192Free PMC Article
Establishment and characterization of a novel chordoma cell line: CH22.
Liu X, Nielsen GP, Rosenberg AE, Waterman PR, Yang W, Choy E, Sassi S, Yang S, Harmon DC, Yang C, Schwab JH, Kobayashi E, Mankin HJ, Xavier R, Weissleder R, Duan Z, Hornicek FJ
J Orthop Res 2012 Oct;30(10):1666-73. Epub 2012 Apr 13 doi: 10.1002/jor.22113. PMID: 22504929

Therapy

Activity of pemetrexed in pre-clinical chordoma models and humans.
Kesari S, Wang F, Juarez T, Ashili S, Patro CPK, Carrillo J, Nguyen M, Truong J, Levy J, Sommer J, Freed DM, Xiu J, Takasumi Y, Bouffet E, Gill JM
Sci Rep 2023 May 5;13(1):7317. doi: 10.1038/s41598-023-34404-4. PMID: 37147496Free PMC Article
Outcomes, Prognostic Factors and Salvage Treatment for Recurrent Chordoma After Pencil Beam Scanning Proton Therapy at the Paul Scherrer Institute.
Beer J, Kountouri M, Kole AJ, Murray FR, Leiser D, Kliebsch U, Combescure C, Pica A, Bachtiary B, Bolsi A, Lomax AJ, Walser M, Weber DC
Clin Oncol (R Coll Radiol) 2020 Aug;32(8):537-544. Epub 2020 Mar 26 doi: 10.1016/j.clon.2020.03.002. PMID: 32222414
Safety and Local Control of Radiation Therapy for Chordoma of the Spine and Sacrum: A Systematic Review.
Pennicooke B, Laufer I, Sahgal A, Varga PP, Gokaslan ZL, Bilsky MH, Yamada YJ
Spine (Phila Pa 1976) 2016 Oct 15;41 Suppl 20(Suppl 20):S186-S192. doi: 10.1097/BRS.0000000000001831. PMID: 27509195Free PMC Article
Proton therapy for reirradiation of progressive or recurrent chordoma.
McDonald MW, Linton OR, Shah MV
Int J Radiat Oncol Biol Phys 2013 Dec 1;87(5):1107-14. doi: 10.1016/j.ijrobp.2013.09.038. PMID: 24267972
Cryoablation of recurrent sacrococcygeal tumors.
Kurup AN, Woodrum DA, Morris JM, Atwell TD, Schmit GD, Welch TJ, Yaszemski MJ, Callstrom MR
J Vasc Interv Radiol 2012 Aug;23(8):1070-5. doi: 10.1016/j.jvir.2012.05.043. PMID: 22840806

Prognosis

Activity of pemetrexed in pre-clinical chordoma models and humans.
Kesari S, Wang F, Juarez T, Ashili S, Patro CPK, Carrillo J, Nguyen M, Truong J, Levy J, Sommer J, Freed DM, Xiu J, Takasumi Y, Bouffet E, Gill JM
Sci Rep 2023 May 5;13(1):7317. doi: 10.1038/s41598-023-34404-4. PMID: 37147496Free PMC Article
Loss of SMARCB1 promotes autophagy and facilitates tumour progression in chordoma by transcriptionally activating ATG5.
Li M, Shen Y, Xiong Y, Wang S, Li C, Bai J, Zhang Y
Cell Prolif 2021 Dec;54(12):e13136. Epub 2021 Oct 20 doi: 10.1111/cpr.13136. PMID: 34668612Free PMC Article
Results following surgical resection of recurrent chordoma of the spine: experience in a single institution.
Chanplakorn P, Lertudomphonwanit T, Homcharoen W, Suwanpramote P, Laohacharoensombat W
World J Surg Oncol 2020 Aug 27;18(1):228. doi: 10.1186/s12957-020-02005-4. PMID: 32854731Free PMC Article
Outcomes, Prognostic Factors and Salvage Treatment for Recurrent Chordoma After Pencil Beam Scanning Proton Therapy at the Paul Scherrer Institute.
Beer J, Kountouri M, Kole AJ, Murray FR, Leiser D, Kliebsch U, Combescure C, Pica A, Bachtiary B, Bolsi A, Lomax AJ, Walser M, Weber DC
Clin Oncol (R Coll Radiol) 2020 Aug;32(8):537-544. Epub 2020 Mar 26 doi: 10.1016/j.clon.2020.03.002. PMID: 32222414
MTNR1B loss promotes chordoma recurrence by abrogating melatonin-mediated β-catenin signaling repression.
Liu L, Wang T, Yang X, Xu C, Liao Z, Wang X, Su D, Li Y, Zhou H, Qiu X, Chen Y, Huang D, Lian C, Su P
J Pineal Res 2019 Sep;67(2):e12588. Epub 2019 Jun 28 doi: 10.1111/jpi.12588. PMID: 31140197

Clinical prediction guides

Activity of pemetrexed in pre-clinical chordoma models and humans.
Kesari S, Wang F, Juarez T, Ashili S, Patro CPK, Carrillo J, Nguyen M, Truong J, Levy J, Sommer J, Freed DM, Xiu J, Takasumi Y, Bouffet E, Gill JM
Sci Rep 2023 May 5;13(1):7317. doi: 10.1038/s41598-023-34404-4. PMID: 37147496Free PMC Article
Immune Checkpoint Inhibitors Have Clinical Activity in Patients With Recurrent Chordoma.
Bishop AJ, Amini B, Lin H, Raza SM, Patel S, Grosshans DR, Ghia A, Farooqi A, Guadagnolo BA, Mitra D, Akdemir KC, Lazar AJ, Wang WL, Alvarez-Breckenridge C, Bird J, Rhines LD, Somaiah N, Conley AP
J Immunother 2022 Oct 1;45(8):374-378. Epub 2022 Aug 4 doi: 10.1097/CJI.0000000000000431. PMID: 35943386Free PMC Article
MTNR1B loss promotes chordoma recurrence by abrogating melatonin-mediated β-catenin signaling repression.
Liu L, Wang T, Yang X, Xu C, Liao Z, Wang X, Su D, Li Y, Zhou H, Qiu X, Chen Y, Huang D, Lian C, Su P
J Pineal Res 2019 Sep;67(2):e12588. Epub 2019 Jun 28 doi: 10.1111/jpi.12588. PMID: 31140197
Characteristics and functional outcomes of chordoma patients admitted for inpatient rehabilitation.
Knowlton SE, Zafonte R, O'Connor KC, Schwab J, Hornicek F
Disabil Rehabil 2018 Sep;40(19):2275-2280. Epub 2017 Jun 7 doi: 10.1080/09638288.2017.1334233. PMID: 28589739
Cryoablation of recurrent sacrococcygeal tumors.
Kurup AN, Woodrum DA, Morris JM, Atwell TD, Schmit GD, Welch TJ, Yaszemski MJ, Callstrom MR
J Vasc Interv Radiol 2012 Aug;23(8):1070-5. doi: 10.1016/j.jvir.2012.05.043. PMID: 22840806

Recent systematic reviews

Management of Locally Recurrent Chordoma of the Mobile Spine and Sacrum: A Systematic Review.
Ailon T, Torabi R, Fisher CG, Rhines LD, Clarke MJ, Bettegowda C, Boriani S, Yamada YJ, Kawahara N, Varga PP, Shin JH, Saghal A, Gokaslan ZL
Spine (Phila Pa 1976) 2016 Oct 15;41 Suppl 20(Suppl 20):S193-S198. doi: 10.1097/BRS.0000000000001812. PMID: 27753782Free PMC Article
Safety and Local Control of Radiation Therapy for Chordoma of the Spine and Sacrum: A Systematic Review.
Pennicooke B, Laufer I, Sahgal A, Varga PP, Gokaslan ZL, Bilsky MH, Yamada YJ
Spine (Phila Pa 1976) 2016 Oct 15;41 Suppl 20(Suppl 20):S186-S192. doi: 10.1097/BRS.0000000000001831. PMID: 27509195Free PMC Article

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