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Metastatic Lip and Oral Cavity Carcinoma

MedGen UID:
1670926
•Concept ID:
C4744556
•
Neoplastic Process

Definition

A carcinoma that arises from the lip and/or oral cavity and has metastasized to another anatomic site. [from NCI]

Professional guidelines

PubMed

Lower lip basal cell and squamous cell carcinomas: a reappraisal of the similarities and differences in clinical presentation and management.
Hwang JR, Khachemoune A
Arch Dermatol Res 2023 Mar;315(2):117-125. Epub 2022 Mar 21 doi: 10.1007/s00403-022-02345-z. PMID: 35312855
Cheilitis glandularis: clinico-histopathological diagnostic criteria.
Reiter S, Vered M, Yarom N, Goldsmith C, Gorsky M
Oral Dis 2011 Apr;17(3):335-9. Epub 2010 Oct 28 doi: 10.1111/j.1601-0825.2010.01762.x. PMID: 21029266
Occult primary tumors. The management of isolated submandibular lymph node metastases.
Strasnick B, Moore DM, Abemayor E, Juillard G, Fu YS
Arch Otolaryngol Head Neck Surg 1990 Feb;116(2):173-6. doi: 10.1001/archotol.1990.01870020049013. PMID: 2297408

Recent clinical studies

Etiology

Lower lip basal cell and squamous cell carcinomas: a reappraisal of the similarities and differences in clinical presentation and management.
Hwang JR, Khachemoune A
Arch Dermatol Res 2023 Mar;315(2):117-125. Epub 2022 Mar 21 doi: 10.1007/s00403-022-02345-z. PMID: 35312855
Squamous Cell Carcinoma of the Lip-A Review of Squamous Cell Carcinogenesis of the Mucosal and Cutaneous Junction.
Bota JP, Lyons AB, Carroll BT
Dermatol Surg 2017 Apr;43(4):494-506. doi: 10.1097/DSS.0000000000001020. PMID: 28157733
Cystic cervical metastases: incidence and diagnosis using fine needle aspiration biopsy.
Sheahan P, O'leary G, Lee G, Fitzgibbon J
Otolaryngol Head Neck Surg 2002 Oct;127(4):294-8. doi: 10.1067/mhn.2002.128600. PMID: 12402008
Distant metastases from lip and oral cavity cancer.
Betka J
ORL J Otorhinolaryngol Relat Spec 2001 Jul-Aug;63(4):217-21. doi: 10.1159/000055744. PMID: 11408816
Primary adenoid squamous cell carcinoma of the upper lip associated with a locoregional metastasis: a case report and review of the literature.
Blackburn TK, Macpherson D, Conroy B
J Oral Maxillofac Surg 1999 May;57(5):612-6. doi: 10.1016/s0278-2391(99)90086-1. PMID: 10319839

Diagnosis

Head and Neck Cancer Incidence in the United States Before and During the COVID-19 Pandemic.
Semprini J, Pagedar NA, Boakye EA, Osazuwa-Peters N
JAMA Otolaryngol Head Neck Surg 2024 Mar 1;150(3):193-200. doi: 10.1001/jamaoto.2023.4322. PMID: 38206603Free PMC Article
Lower lip basal cell and squamous cell carcinomas: a reappraisal of the similarities and differences in clinical presentation and management.
Hwang JR, Khachemoune A
Arch Dermatol Res 2023 Mar;315(2):117-125. Epub 2022 Mar 21 doi: 10.1007/s00403-022-02345-z. PMID: 35312855
Paraneoplastic vitelliform maculopathy secondary to squamous cell carcinoma of the lip.
Ouederni M, Nefaa F, Chakroun H, Maamouri R, Cheour M
J Fr Ophtalmol 2022 Feb;45(2):255-258. Epub 2021 Dec 27 doi: 10.1016/j.jfo.2021.08.027. PMID: 34969547
Adenoid cystic carcinoma of the labium oris with rare metastasis to the pleural cavity.
Mosalem O, Alsara A, Abu Rous F, Hrinczenko B
BMJ Case Rep 2021 Jan 7;14(1) doi: 10.1136/bcr-2020-237622. PMID: 33414116Free PMC Article
Distant metastases from lip and oral cavity cancer.
Betka J
ORL J Otorhinolaryngol Relat Spec 2001 Jul-Aug;63(4):217-21. doi: 10.1159/000055744. PMID: 11408816

Therapy

Adenoid cystic carcinoma of the labium oris with rare metastasis to the pleural cavity.
Mosalem O, Alsara A, Abu Rous F, Hrinczenko B
BMJ Case Rep 2021 Jan 7;14(1) doi: 10.1136/bcr-2020-237622. PMID: 33414116Free PMC Article
Mucosa Does Not Matter: Successful Secondary Intention Healing of the Lip and Vermilion Border in Mohs Surgery Patients.
Brahe C, Wu S, Miladi A
Dermatol Surg 2021 May 1;47(5):692-694. doi: 10.1097/DSS.0000000000002335. PMID: 32028481
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Classifying pain in transoral endoscopic thyroidectomy.
Zhang D, Caruso E, Sun H, Anuwong A, Tufano R, Materazzi G, Dionigi G, Kim HY
J Endocrinol Invest 2019 Nov;42(11):1345-1351. Epub 2019 Jun 11 doi: 10.1007/s40618-019-01071-0. PMID: 31187465
High-dose-rate brachytherapy using molds for lip and oral cavity tumors.
Unetsubo T, Matsuzaki H, Takemoto M, Katsui K, Hara M, Katayama N, Waki T, Kanazawa S, Asaumi J
Radiat Oncol 2015 Apr 8;10:81. doi: 10.1186/s13014-015-0390-z. PMID: 25888772Free PMC Article

Prognosis

Head and Neck Cancer Incidence in the United States Before and During the COVID-19 Pandemic.
Semprini J, Pagedar NA, Boakye EA, Osazuwa-Peters N
JAMA Otolaryngol Head Neck Surg 2024 Mar 1;150(3):193-200. doi: 10.1001/jamaoto.2023.4322. PMID: 38206603Free PMC Article
Squamous Cell Carcinoma of the Lip-A Review of Squamous Cell Carcinogenesis of the Mucosal and Cutaneous Junction.
Bota JP, Lyons AB, Carroll BT
Dermatol Surg 2017 Apr;43(4):494-506. doi: 10.1097/DSS.0000000000001020. PMID: 28157733
Cystic cervical metastases: incidence and diagnosis using fine needle aspiration biopsy.
Sheahan P, O'leary G, Lee G, Fitzgibbon J
Otolaryngol Head Neck Surg 2002 Oct;127(4):294-8. doi: 10.1067/mhn.2002.128600. PMID: 12402008
Distant metastases from lip and oral cavity cancer.
Betka J
ORL J Otorhinolaryngol Relat Spec 2001 Jul-Aug;63(4):217-21. doi: 10.1159/000055744. PMID: 11408816
Primary adenoid squamous cell carcinoma of the upper lip associated with a locoregional metastasis: a case report and review of the literature.
Blackburn TK, Macpherson D, Conroy B
J Oral Maxillofac Surg 1999 May;57(5):612-6. doi: 10.1016/s0278-2391(99)90086-1. PMID: 10319839

Clinical prediction guides

Head and Neck Cancer Incidence in the United States Before and During the COVID-19 Pandemic.
Semprini J, Pagedar NA, Boakye EA, Osazuwa-Peters N
JAMA Otolaryngol Head Neck Surg 2024 Mar 1;150(3):193-200. doi: 10.1001/jamaoto.2023.4322. PMID: 38206603Free PMC Article
Resuming Oral Feeding in Patients With Oral Squamous Cell Carcinoma With Free Anterolateral Thigh Flap Reconstruction.
Chiang TY, Huang CH, Kuan CH, Horng SY, Hsieh JH, Wu YF, Chuang SY, Yu YH, Ho CC, Cheng NC, Tai HC
Ann Plast Surg 2021 Feb 1;86(2S Suppl 1):S108-S112. doi: 10.1097/SAP.0000000000002652. PMID: 33438960
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions.
Macey R, Walsh T, Brocklehurst P, Kerr AR, Liu JL, Lingen MW, Ogden GR, Warnakulasuriya S, Scully C
Cochrane Database Syst Rev 2015 May 29;2015(5):CD010276. doi: 10.1002/14651858.CD010276.pub2. PMID: 26021841Free PMC Article
Some observations on the deposition of metastatic carcinoma within cervical lymph nodes.
TOKER C
Cancer 1963 Mar;16:364-74. doi: 10.1002/1097-0142(196303)16:3<364::aid-cncr2820160311>3.0.co;2-k. PMID: 13985306

Recent systematic reviews

Cribriform adenocarcinoma of the tongue and minor salivary glands: a systematic review of an uncommon clinicopathological entity.
De Luca P, Tassone D, de Campora L, Simone M, Marra P, Colacurcio V, Scarpa A, Costarelli L, Camaioni A
Eur Arch Otorhinolaryngol 2022 Jun;279(6):2719-2725. Epub 2021 Oct 23 doi: 10.1007/s00405-021-07140-6. PMID: 34687340
Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions.
Walsh T, Macey R, Kerr AR, Lingen MW, Ogden GR, Warnakulasuriya S
Cochrane Database Syst Rev 2021 Jul 20;7(7):CD010276. doi: 10.1002/14651858.CD010276.pub3. PMID: 34282854Free PMC Article
Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions.
Macey R, Walsh T, Brocklehurst P, Kerr AR, Liu JL, Lingen MW, Ogden GR, Warnakulasuriya S, Scully C
Cochrane Database Syst Rev 2015 May 29;2015(5):CD010276. doi: 10.1002/14651858.CD010276.pub2. PMID: 26021841Free PMC Article

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