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Metastatic Lip and Oral Cavity Carcinoma

MedGen UID:
1670926
•Concept ID:
C4744556
•
Neoplastic Process

Definition

A carcinoma that arises from the lip and/or oral cavity and has metastasized to another anatomic site. [from NCI]

Professional guidelines

PubMed

Lower lip basal cell and squamous cell carcinomas: a reappraisal of the similarities and differences in clinical presentation and management.
Hwang JR, Khachemoune A
Arch Dermatol Res 2023 Mar;315(2):117-125. Epub 2022 Mar 21 doi: 10.1007/s00403-022-02345-z. PMID: 35312855
Cheilitis glandularis: clinico-histopathological diagnostic criteria.
Reiter S, Vered M, Yarom N, Goldsmith C, Gorsky M
Oral Dis 2011 Apr;17(3):335-9. Epub 2010 Oct 28 doi: 10.1111/j.1601-0825.2010.01762.x. PMID: 21029266
The role of neoadjuvant and adjuvant chemotherapy regimens consisting of different combinations of drugs in the treatment of advanced oral cancer.
Basu S, Khanra M, Dash B, Majumdar J, Biswas J, Chaudhuri P
Med Oncol 1999 Sep;16(3):199-203. doi: 10.1007/BF02906132. PMID: 10523800

Recent clinical studies

Etiology

Classifying pain in transoral endoscopic thyroidectomy.
Zhang D, Caruso E, Sun H, Anuwong A, Tufano R, Materazzi G, Dionigi G, Kim HY
J Endocrinol Invest 2019 Nov;42(11):1345-1351. Epub 2019 Jun 11 doi: 10.1007/s40618-019-01071-0. PMID: 31187465
Squamous Cell Carcinoma of the Lip-A Review of Squamous Cell Carcinogenesis of the Mucosal and Cutaneous Junction.
Bota JP, Lyons AB, Carroll BT
Dermatol Surg 2017 Apr;43(4):494-506. doi: 10.1097/DSS.0000000000001020. PMID: 28157733
Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions.
Macey R, Walsh T, Brocklehurst P, Kerr AR, Liu JL, Lingen MW, Ogden GR, Warnakulasuriya S, Scully C
Cochrane Database Syst Rev 2015 May 29;2015(5):CD010276. doi: 10.1002/14651858.CD010276.pub2. PMID: 26021841Free PMC Article
Distant metastases from lip and oral cavity cancer.
Betka J
ORL J Otorhinolaryngol Relat Spec 2001 Jul-Aug;63(4):217-21. doi: 10.1159/000055744. PMID: 11408816
Carcinoma of the lip.
Heller KS, Shah JP
Am J Surg 1979 Oct;138(4):600-3. doi: 10.1016/0002-9610(79)90427-6. PMID: 484790

Diagnosis

Squamous Cell Carcinoma of the Lip-A Review of Squamous Cell Carcinogenesis of the Mucosal and Cutaneous Junction.
Bota JP, Lyons AB, Carroll BT
Dermatol Surg 2017 Apr;43(4):494-506. doi: 10.1097/DSS.0000000000001020. PMID: 28157733
Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions.
Macey R, Walsh T, Brocklehurst P, Kerr AR, Liu JL, Lingen MW, Ogden GR, Warnakulasuriya S, Scully C
Cochrane Database Syst Rev 2015 May 29;2015(5):CD010276. doi: 10.1002/14651858.CD010276.pub2. PMID: 26021841Free PMC Article
Lip squamous cell carcinoma in a Brazilian population: epidemiological study and clinicopathological associations.
Souza RL, Fonseca-Fonseca T, Oliveira-Santos CC, Corrêa GT, Santos FB, Cardoso CM, Sant' Ana-Haikal D, Guimarães AL, Batista-De Paula AM
Med Oral Patol Oral Cir Bucal 2011 Sep 1;16(6):e757-62. doi: 10.4317/medoral.16954. PMID: 21196879
Living with oral cancer: epidemiology with particular reference to prevalence and life-style changes that influence survival.
Warnakulasuriya S
Oral Oncol 2010 Jun;46(6):407-10. Epub 2010 Apr 18 doi: 10.1016/j.oraloncology.2010.02.015. PMID: 20403722
Distant metastases from lip and oral cavity cancer.
Betka J
ORL J Otorhinolaryngol Relat Spec 2001 Jul-Aug;63(4):217-21. doi: 10.1159/000055744. PMID: 11408816

Therapy

Safety and Efficacy of Pembrolizumab With Chemoradiotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma: A Phase IB Study.
Powell SF, Gold KA, Gitau MM, Sumey CJ, Lohr MM, McGraw SC, Nowak RK, Jensen AW, Blanchard MJ, Fischer CD, Bykowski J, Ellison CA, Black LJ, Thompson PA, Callejas-Valera JL, Lee JH, Cohen EEW, Spanos WC
J Clin Oncol 2020 Jul 20;38(21):2427-2437. Epub 2020 Jun 1 doi: 10.1200/JCO.19.03156. PMID: 32479189Free PMC Article
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Classifying pain in transoral endoscopic thyroidectomy.
Zhang D, Caruso E, Sun H, Anuwong A, Tufano R, Materazzi G, Dionigi G, Kim HY
J Endocrinol Invest 2019 Nov;42(11):1345-1351. Epub 2019 Jun 11 doi: 10.1007/s40618-019-01071-0. PMID: 31187465
High-dose-rate brachytherapy using molds for lip and oral cavity tumors.
Unetsubo T, Matsuzaki H, Takemoto M, Katsui K, Hara M, Katayama N, Waki T, Kanazawa S, Asaumi J
Radiat Oncol 2015 Apr 8;10:81. doi: 10.1186/s13014-015-0390-z. PMID: 25888772Free PMC Article
Treatment of squamous cell carcinoma of the lip using Foscan-mediated photodynamic therapy.
Kübler AC, de Carpentier J, Hopper C, Leonard AG, Putnam G
Int J Oral Maxillofac Surg 2001 Dec;30(6):504-9. doi: 10.1054/ijom.2001.0160. PMID: 11829232

Prognosis

Classifying pain in transoral endoscopic thyroidectomy.
Zhang D, Caruso E, Sun H, Anuwong A, Tufano R, Materazzi G, Dionigi G, Kim HY
J Endocrinol Invest 2019 Nov;42(11):1345-1351. Epub 2019 Jun 11 doi: 10.1007/s40618-019-01071-0. PMID: 31187465
Squamous Cell Carcinoma of the Lip-A Review of Squamous Cell Carcinogenesis of the Mucosal and Cutaneous Junction.
Bota JP, Lyons AB, Carroll BT
Dermatol Surg 2017 Apr;43(4):494-506. doi: 10.1097/DSS.0000000000001020. PMID: 28157733
Distant metastases from lip and oral cavity cancer.
Betka J
ORL J Otorhinolaryngol Relat Spec 2001 Jul-Aug;63(4):217-21. doi: 10.1159/000055744. PMID: 11408816
Prognostic significance of DNA ploidy in oral squamous cell carcinomas. A retrospective flow and image cytometric study with comparison of DNA ploidy in excisional biopsy specimens and resection specimens, primary, tumors, and lymph node metastases.
Baretton G, Li X, Stoll C, Fischer-Brandies E, Schmidt M, Löhrs U
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995 Jan;79(1):68-76. doi: 10.1016/s1079-2104(05)80077-0. PMID: 7614165
Carcinoma of the lip.
Heller KS, Shah JP
Am J Surg 1979 Oct;138(4):600-3. doi: 10.1016/0002-9610(79)90427-6. PMID: 484790

Clinical prediction guides

Resuming Oral Feeding in Patients With Oral Squamous Cell Carcinoma With Free Anterolateral Thigh Flap Reconstruction.
Chiang TY, Huang CH, Kuan CH, Horng SY, Hsieh JH, Wu YF, Chuang SY, Yu YH, Ho CC, Cheng NC, Tai HC
Ann Plast Surg 2021 Feb 1;86(2S Suppl 1):S108-S112. doi: 10.1097/SAP.0000000000002652. PMID: 33438960
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Classifying pain in transoral endoscopic thyroidectomy.
Zhang D, Caruso E, Sun H, Anuwong A, Tufano R, Materazzi G, Dionigi G, Kim HY
J Endocrinol Invest 2019 Nov;42(11):1345-1351. Epub 2019 Jun 11 doi: 10.1007/s40618-019-01071-0. PMID: 31187465
Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions.
Macey R, Walsh T, Brocklehurst P, Kerr AR, Liu JL, Lingen MW, Ogden GR, Warnakulasuriya S, Scully C
Cochrane Database Syst Rev 2015 May 29;2015(5):CD010276. doi: 10.1002/14651858.CD010276.pub2. PMID: 26021841Free PMC Article
Lip squamous cell carcinoma in a Brazilian population: epidemiological study and clinicopathological associations.
Souza RL, Fonseca-Fonseca T, Oliveira-Santos CC, Corrêa GT, Santos FB, Cardoso CM, Sant' Ana-Haikal D, Guimarães AL, Batista-De Paula AM
Med Oral Patol Oral Cir Bucal 2011 Sep 1;16(6):e757-62. doi: 10.4317/medoral.16954. PMID: 21196879

Recent systematic reviews

Cribriform adenocarcinoma of the tongue and minor salivary glands: a systematic review of an uncommon clinicopathological entity.
De Luca P, Tassone D, de Campora L, Simone M, Marra P, Colacurcio V, Scarpa A, Costarelli L, Camaioni A
Eur Arch Otorhinolaryngol 2022 Jun;279(6):2719-2725. Epub 2021 Oct 23 doi: 10.1007/s00405-021-07140-6. PMID: 34687340
Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions.
Walsh T, Macey R, Kerr AR, Lingen MW, Ogden GR, Warnakulasuriya S
Cochrane Database Syst Rev 2021 Jul 20;7(7):CD010276. doi: 10.1002/14651858.CD010276.pub3. PMID: 34282854Free PMC Article
Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions.
Macey R, Walsh T, Brocklehurst P, Kerr AR, Liu JL, Lingen MW, Ogden GR, Warnakulasuriya S, Scully C
Cochrane Database Syst Rev 2015 May 29;2015(5):CD010276. doi: 10.1002/14651858.CD010276.pub2. PMID: 26021841Free PMC Article

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