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Increased level of carnosine in blood

MedGen UID:
1671072
•Concept ID:
C4732914
•
Finding
Synonyms: High blood carnosine levels; Increased blood carnosine concenrtation
 
HPO: HP:0500161

Definition

An increased amount of carnosine in the blood. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased level of carnosine in blood

Professional guidelines

PubMed

Plasma Metabonomics in Insulin-Resistant Hypogonadic Patients Induced by Testosterone Treatment.
Zolla L, Grande G, Milardi D
Int J Mol Sci 2022 Jul 14;23(14) doi: 10.3390/ijms23147754. PMID: 35887101Free PMC Article
Management of the virulent influenza virus infection by oral formulation of nonhydrolized carnosine and isopeptide of carnosine attenuating proinflammatory cytokine-induced nitric oxide production.
Babizhayev MA, Deyev AI
Am J Ther 2012 Jan;19(1):e25-47. doi: 10.1097/MJT.0b013e3181dcf589. PMID: 20841992
Vegetarianism, female gender and increasing age, but not CNDP1 genotype, are associated with reduced muscle carnosine levels in humans.
Everaert I, Mooyaart A, Baguet A, Zutinic A, Baelde H, Achten E, Taes Y, De Heer E, Derave W
Amino Acids 2011 Apr;40(4):1221-9. Epub 2010 Sep 24 doi: 10.1007/s00726-010-0749-2. PMID: 20865290

Recent clinical studies

Etiology

Serum levels of carnosine may be associated with the duration of MDD episodes.
Ali-Sisto T, Tolmunen T, Kraav SL, Mäntyselkä P, Valkonen-Korhonen M, Honkalampi K, Ruusunen A, Velagapudi V, Lehto SM
J Affect Disord 2023 Jan 1;320:647-655. Epub 2022 Oct 5 doi: 10.1016/j.jad.2022.09.092. PMID: 36208690
The ergogenic effect of acute carnosine and anserine supplementation: dosing, timing, and underlying mechanism.
de Jager S, Blancquaert L, Van der Stede T, Lievens E, De Baere S, Croubels S, Gilardoni E, Regazzoni LG, Aldini G, Bourgois JG, Derave W
J Int Soc Sports Nutr 2022;19(1):70-91. Epub 2022 Mar 26 doi: 10.1080/15502783.2022.2053300. PMID: 35599917Free PMC Article
Food-Related Carbonyl Stress in Cardiometabolic and Cancer Risk Linked to Unhealthy Modern Diet.
Iacobini C, Vitale M, Haxhi J, Pesce C, Pugliese G, Menini S
Nutrients 2022 Mar 3;14(5) doi: 10.3390/nu14051061. PMID: 35268036Free PMC Article
β-Alanine supplementation increased physical performance and improved executive function following endurance exercise in middle aged individuals.
Furst T, Massaro A, Miller C, Williams BT, LaMacchia ZM, Horvath PJ
J Int Soc Sports Nutr 2018 Jul 11;15(1):32. doi: 10.1186/s12970-018-0238-7. PMID: 29996843Free PMC Article
Effects of Histidine and β-alanine Supplementation on Human Muscle Carnosine Storage.
Blancquaert L, Everaert I, Missinne M, Baguet A, Stegen S, Volkaert A, Petrovic M, Vervaet C, Achten E, DE Maeyer M, DE Henauw S, Derave W
Med Sci Sports Exerc 2017 Mar;49(3):602-609. doi: 10.1249/MSS.0000000000001213. PMID: 28106620

Diagnosis

Plasma Free Amino Acid Profile in HIV-Positive Cases.
Binici I, Alp HH, Karsen H, Koyuncu I, Gonel A, Çelik H, Karahocagil MK
Curr HIV Res 2022;20(3):228-235. doi: 10.2174/1570162X20666220428103250. PMID: 36111751
Plasma Metabonomics in Insulin-Resistant Hypogonadic Patients Induced by Testosterone Treatment.
Zolla L, Grande G, Milardi D
Int J Mol Sci 2022 Jul 14;23(14) doi: 10.3390/ijms23147754. PMID: 35887101Free PMC Article
Metabolic patterns in insulin-sensitive male hypogonadism.
Fanelli G, Gevi F, Belardo A, Zolla L
Cell Death Dis 2018 Apr 22;9(6):653. doi: 10.1038/s41419-018-0588-8. PMID: 29844353Free PMC Article
Faecal and Serum Metabolomics in Paediatric Inflammatory Bowel Disease.
Kolho KL, Pessia A, Jaakkola T, de Vos WM, Velagapudi V
J Crohns Colitis 2017 Mar 1;11(3):321-334. doi: 10.1093/ecco-jcc/jjw158. PMID: 27609529
Effects of carnosine supplementation on glucose metabolism: Pilot clinical trial.
de Courten B, Jakubova M, de Courten MP, Kukurova IJ, Vallova S, Krumpolec P, Valkovic L, Kurdiova T, Garzon D, Barbaresi S, Teede HJ, Derave W, Krssak M, Aldini G, Ukropec J, Ukropcova B
Obesity (Silver Spring) 2016 May;24(5):1027-34. Epub 2016 Apr 4 doi: 10.1002/oby.21434. PMID: 27040154

Therapy

The ergogenic effect of acute carnosine and anserine supplementation: dosing, timing, and underlying mechanism.
de Jager S, Blancquaert L, Van der Stede T, Lievens E, De Baere S, Croubels S, Gilardoni E, Regazzoni LG, Aldini G, Bourgois JG, Derave W
J Int Soc Sports Nutr 2022;19(1):70-91. Epub 2022 Mar 26 doi: 10.1080/15502783.2022.2053300. PMID: 35599917Free PMC Article
Food-Related Carbonyl Stress in Cardiometabolic and Cancer Risk Linked to Unhealthy Modern Diet.
Iacobini C, Vitale M, Haxhi J, Pesce C, Pugliese G, Menini S
Nutrients 2022 Mar 3;14(5) doi: 10.3390/nu14051061. PMID: 35268036Free PMC Article
Benefits and Adverse Effects of Histidine Supplementation.
Thalacker-Mercer AE, Gheller ME
J Nutr 2020 Oct 1;150(Suppl 1):2588S-2592S. doi: 10.1093/jn/nxaa229. PMID: 33000165
β-Alanine supplementation increased physical performance and improved executive function following endurance exercise in middle aged individuals.
Furst T, Massaro A, Miller C, Williams BT, LaMacchia ZM, Horvath PJ
J Int Soc Sports Nutr 2018 Jul 11;15(1):32. doi: 10.1186/s12970-018-0238-7. PMID: 29996843Free PMC Article
Effects of Histidine and β-alanine Supplementation on Human Muscle Carnosine Storage.
Blancquaert L, Everaert I, Missinne M, Baguet A, Stegen S, Volkaert A, Petrovic M, Vervaet C, Achten E, DE Maeyer M, DE Henauw S, Derave W
Med Sci Sports Exerc 2017 Mar;49(3):602-609. doi: 10.1249/MSS.0000000000001213. PMID: 28106620

Prognosis

Food-Related Carbonyl Stress in Cardiometabolic and Cancer Risk Linked to Unhealthy Modern Diet.
Iacobini C, Vitale M, Haxhi J, Pesce C, Pugliese G, Menini S
Nutrients 2022 Mar 3;14(5) doi: 10.3390/nu14051061. PMID: 35268036Free PMC Article
The free amino acid profiles and metabolic biomarkers of predicting the chemotherapeutic response in advanced sarcoma patients.
Jia B, Wang W, Lin S, Shi L, Li Y, Gu Y, Gao F, Qin Y
Clin Transl Oncol 2020 Dec;22(12):2213-2221. Epub 2020 Sep 18 doi: 10.1007/s12094-020-02494-5. PMID: 32948983
Association Between Serum β-Alanine and Risk of Dementia.
Hata J, Ohara T, Katakura Y, Shimizu K, Yamashita S, Yoshida D, Honda T, Hirakawa Y, Shibata M, Sakata S, Kitazono T, Kuhara S, Ninomiya T
Am J Epidemiol 2019 Sep 1;188(9):1637-1645. doi: 10.1093/aje/kwz116. PMID: 31127276
Effects of beta-alanine supplementation on muscle function during recovery from resistance exercise in young adults.
Roveratti MC, Jacinto JL, Oliveira DB, da Silva RA, Andraus RAC, de Oliveira EP, Ribeiro AS, Aguiar AF
Amino Acids 2019 Apr;51(4):589-597. Epub 2019 Jan 9 doi: 10.1007/s00726-018-02686-y. PMID: 30627787
Zinc deficiency anemia and effects of zinc therapy in maintenance hemodialysis patients.
Fukushima T, Horike H, Fujiki S, Kitada S, Sasaki T, Kashihara N
Ther Apher Dial 2009 Jun;13(3):213-9. doi: 10.1111/j.1744-9987.2009.00656.x. PMID: 19527468

Clinical prediction guides

Serum levels of carnosine may be associated with the duration of MDD episodes.
Ali-Sisto T, Tolmunen T, Kraav SL, Mäntyselkä P, Valkonen-Korhonen M, Honkalampi K, Ruusunen A, Velagapudi V, Lehto SM
J Affect Disord 2023 Jan 1;320:647-655. Epub 2022 Oct 5 doi: 10.1016/j.jad.2022.09.092. PMID: 36208690
Pivotal role of carnosine in the modulation of brain cells activity: Multimodal mechanism of action and therapeutic potential in neurodegenerative disorders.
Caruso G, Caraci F, Jolivet RB
Prog Neurobiol 2019 Apr;175:35-53. Epub 2018 Dec 26 doi: 10.1016/j.pneurobio.2018.12.004. PMID: 30593839
Metabolic patterns in insulin-sensitive male hypogonadism.
Fanelli G, Gevi F, Belardo A, Zolla L
Cell Death Dis 2018 Apr 22;9(6):653. doi: 10.1038/s41419-018-0588-8. PMID: 29844353Free PMC Article
Anserine and carnosine supplementation in the elderly: Effects on cognitive functioning and physical capacity.
Szcześniak D, Budzeń S, Kopeć W, Rymaszewska J
Arch Gerontol Geriatr 2014 Sep-Oct;59(2):485-90. Epub 2014 May 2 doi: 10.1016/j.archger.2014.04.008. PMID: 24880197
Management of the virulent influenza virus infection by oral formulation of nonhydrolized carnosine and isopeptide of carnosine attenuating proinflammatory cytokine-induced nitric oxide production.
Babizhayev MA, Deyev AI
Am J Ther 2012 Jan;19(1):e25-47. doi: 10.1097/MJT.0b013e3181dcf589. PMID: 20841992

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