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Increased circulating carnosine concentration

MedGen UID:
1671072
•Concept ID:
C4732914
•
Finding
Synonyms: High blood carnosine levels; Increased blood carnosine concentration; Increased level of carnosine in blood
 
HPO: HP:0500161

Definition

Concentration of carnosine in the blood circulation above normal limits. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating carnosine concentration

Professional guidelines

PubMed

A Systematic Risk Assessment and Meta-Analysis on the Use of Oral β-Alanine Supplementation.
Dolan E, Swinton PA, Painelli VS, Stephens Hemingway B, Mazzolani B, Infante Smaira F, Saunders B, Artioli GG, Gualano B
Adv Nutr 2019 May 1;10(3):452-463. doi: 10.1093/advances/nmy115. PMID: 30980076Free PMC Article
Vegetarianism, female gender and increasing age, but not CNDP1 genotype, are associated with reduced muscle carnosine levels in humans.
Everaert I, Mooyaart A, Baguet A, Zutinic A, Baelde H, Achten E, Taes Y, De Heer E, Derave W
Amino Acids 2011 Apr;40(4):1221-9. Epub 2010 Sep 24 doi: 10.1007/s00726-010-0749-2. PMID: 20865290
Telomere length is a biomarker of cumulative oxidative stress, biologic age, and an independent predictor of survival and therapeutic treatment requirement associated with smoking behavior.
Babizhayev MA, Savel'yeva EL, Moskvina SN, Yegorov YE
Am J Ther 2011 Nov;18(6):e209-26. doi: 10.1097/MJT.0b013e3181cf8ebb. PMID: 20228673

Recent clinical studies

Etiology

A Systematic Risk Assessment and Meta-Analysis on the Use of Oral β-Alanine Supplementation.
Dolan E, Swinton PA, Painelli VS, Stephens Hemingway B, Mazzolani B, Infante Smaira F, Saunders B, Artioli GG, Gualano B
Adv Nutr 2019 May 1;10(3):452-463. doi: 10.1093/advances/nmy115. PMID: 30980076Free PMC Article
Vegetarianism, female gender and increasing age, but not CNDP1 genotype, are associated with reduced muscle carnosine levels in humans.
Everaert I, Mooyaart A, Baguet A, Zutinic A, Baelde H, Achten E, Taes Y, De Heer E, Derave W
Amino Acids 2011 Apr;40(4):1221-9. Epub 2010 Sep 24 doi: 10.1007/s00726-010-0749-2. PMID: 20865290
Telomere length is a biomarker of cumulative oxidative stress, biologic age, and an independent predictor of survival and therapeutic treatment requirement associated with smoking behavior.
Babizhayev MA, Savel'yeva EL, Moskvina SN, Yegorov YE
Am J Ther 2011 Nov;18(6):e209-26. doi: 10.1097/MJT.0b013e3181cf8ebb. PMID: 20228673
Importance of luminal and mucosal zinc in the mechanism of experimental gastric ulcer healing.
Opoka W, Adamek D, Plonka M, Reczynski W, Bas B, Drozdowicz D, Jagielski P, Sliwowski Z, Adamski P, Brzozowski T
J Physiol Pharmacol 2010 Oct;61(5):581-91. PMID: 21081802
Antithrombin activity is inhibited by acrolein and homocysteine thiolactone: Protection by cysteine.
Gugliucci A
Life Sci 2008 Feb 13;82(7-8):413-8. doi: 10.1016/j.lfs.2007.11.023. PMID: 18206177

Therapy

Benefits and Adverse Effects of Histidine Supplementation.
Thalacker-Mercer AE, Gheller ME
J Nutr 2020 Oct 1;150(Suppl 1):2588S-2592S. doi: 10.1093/jn/nxaa229. PMID: 33000165
Insulin does not stimulate β-alanine transport into human skeletal muscle.
Gonçalves LS, Kratz C, Santos L, Carvalho VH, Sales LP, Nemezio K, Longobardi I, Riani LA, Lima MMO, Saito T, Fernandes AL, Rodrigues J, James RM, Sale C, Gualano B, Geloneze B, de Medeiros MHG, Artioli GG
Am J Physiol Cell Physiol 2020 Apr 1;318(4):C777-C786. Epub 2020 Feb 26 doi: 10.1152/ajpcell.00550.2019. PMID: 32101455
A Systematic Risk Assessment and Meta-Analysis on the Use of Oral β-Alanine Supplementation.
Dolan E, Swinton PA, Painelli VS, Stephens Hemingway B, Mazzolani B, Infante Smaira F, Saunders B, Artioli GG, Gualano B
Adv Nutr 2019 May 1;10(3):452-463. doi: 10.1093/advances/nmy115. PMID: 30980076Free PMC Article
Telomere length is a biomarker of cumulative oxidative stress, biologic age, and an independent predictor of survival and therapeutic treatment requirement associated with smoking behavior.
Babizhayev MA, Savel'yeva EL, Moskvina SN, Yegorov YE
Am J Ther 2011 Nov;18(6):e209-26. doi: 10.1097/MJT.0b013e3181cf8ebb. PMID: 20228673
Oxidants, antioxidants and alcohol: implications for skeletal and cardiac muscle.
Preedy VR, Patel VB, Reilly ME, Richardson PJ, Falkous G, Mantle D
Front Biosci 1999 Aug 1;4:e58-66. doi: 10.2741/A480. PMID: 10430553

Prognosis

Telomere length is a biomarker of cumulative oxidative stress, biologic age, and an independent predictor of survival and therapeutic treatment requirement associated with smoking behavior.
Babizhayev MA, Savel'yeva EL, Moskvina SN, Yegorov YE
Am J Ther 2011 Nov;18(6):e209-26. doi: 10.1097/MJT.0b013e3181cf8ebb. PMID: 20228673

Clinical prediction guides

Effects of High-Dose, Short-Duration β-Alanine Supplementation on Cognitive Function, Mood, and Circulating Brain-Derived Neurotropic Factor (BDNF) in Recreationally-Active Males Before Simulated Military Operational Stress.
Varanoske AN, Wells AJ, Boffey D, Harat I, Frosti CL, Kozlowski GJ, Gepner Y, Hoffman JR
J Diet Suppl 2021;18(2):147-168. Epub 2020 Mar 6 doi: 10.1080/19390211.2020.1733730. PMID: 32138563
Telomere length is a biomarker of cumulative oxidative stress, biologic age, and an independent predictor of survival and therapeutic treatment requirement associated with smoking behavior.
Babizhayev MA, Savel'yeva EL, Moskvina SN, Yegorov YE
Am J Ther 2011 Nov;18(6):e209-26. doi: 10.1097/MJT.0b013e3181cf8ebb. PMID: 20228673
Oxidants, antioxidants and alcohol: implications for skeletal and cardiac muscle.
Preedy VR, Patel VB, Reilly ME, Richardson PJ, Falkous G, Mantle D
Front Biosci 1999 Aug 1;4:e58-66. doi: 10.2741/A480. PMID: 10430553

Recent systematic reviews

A Systematic Risk Assessment and Meta-Analysis on the Use of Oral β-Alanine Supplementation.
Dolan E, Swinton PA, Painelli VS, Stephens Hemingway B, Mazzolani B, Infante Smaira F, Saunders B, Artioli GG, Gualano B
Adv Nutr 2019 May 1;10(3):452-463. doi: 10.1093/advances/nmy115. PMID: 30980076Free PMC Article

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