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Reduced blood 5-methyltetrahydrofolate level

MedGen UID:
1671096
Concept ID:
C4732855
Finding
Synonym: Reduced serum methylfolate Level
 
HPO: HP:0410217

Definition

A decreased concentration of 5-methyltetrahydrofolate in the blood. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced blood 5-methyltetrahydrofolate level

Professional guidelines

PubMed

Coppola A, D'Angelo A, Fermo I, Mazzola G, Di Minno MN, Cajani A, Sala A, Folco G, Tremoli E, Di Minno G
Br J Haematol 2005 Oct;131(1):100-8. doi: 10.1111/j.1365-2141.2005.05732.x. PMID: 16173969
Spotila LD, Jacques PF, Berger PB, Ballman KV, Ellison RC, Rozen R
Am J Epidemiol 2003 Nov 1;158(9):871-7. doi: 10.1093/aje/kwg234. PMID: 14585765
Wilcken B, Turner B
Arch Dis Child 1973 Jan;48(1):58-62. doi: 10.1136/adc.48.1.58. PMID: 4685596Free PMC Article

Recent clinical studies

Etiology

Vukotic R, Di Donato R, Roncarati G, Simoni P, Renzulli M, Gitto S, Schepis F, Villa E, Berzigotti A, Bosch J, Andreone P
J Hepatol 2023 Oct;79(4):977-988. Epub 2023 Jul 22 doi: 10.1016/j.jhep.2023.06.017. PMID: 37482222
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Kubo Y, Fukuoka H, Kawabata T, Shoji K, Mori C, Sakurai K, Nishikawa M, Ohkubo T, Oshida K, Yanagisawa N, Yamashiro Y
Nutrients 2020 Jun 1;12(6) doi: 10.3390/nu12061633. PMID: 32492914Free PMC Article
Clément A, Menezo Y, Cohen M, Cornet D, Clément P
J Gynecol Obstet Hum Reprod 2020 Jan;49(1):101622. Epub 2019 Aug 22 doi: 10.1016/j.jogoh.2019.08.005. PMID: 31446167
Obeid R, Holzgreve W, Pietrzik K
J Perinat Med 2013 Sep 1;41(5):469-83. doi: 10.1515/jpm-2012-0256. PMID: 23482308

Diagnosis

Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Shoffner J, Trommer B, Thurm A, Farmer C, Langley WA 3rd, Soskey L, Rodriguez AN, D'Souza P, Spence SJ, Hyland K, Swedo SE
Neurology 2016 Jun 14;86(24):2258-63. Epub 2016 May 13 doi: 10.1212/WNL.0000000000002766. PMID: 27178705Free PMC Article
Stoffregen CC, Odin EA, Carlsson GU, Kurlberg GK, Björkqvist HG, Tångefjord MT, Gustavsson BG
Anticancer Drugs 2016 Jun;27(5):439-46. doi: 10.1097/CAD.0000000000000345. PMID: 26825869Free PMC Article
Ambrosino P, Lupoli R, Di Minno A, Nardo A, Marrone E, Lupoli V, Scaravilli A, Mitidieri E, Tufano A, Di Minno MN
Nutr Res 2015 Jun;35(6):489-95. Epub 2015 Feb 26 doi: 10.1016/j.nutres.2015.02.006. PMID: 25841618
Watkins D, Rosenblatt DS
Am J Med Genet 1989 Nov;34(3):427-34. doi: 10.1002/ajmg.1320340320. PMID: 2688421

Therapy

Vukotic R, Di Donato R, Roncarati G, Simoni P, Renzulli M, Gitto S, Schepis F, Villa E, Berzigotti A, Bosch J, Andreone P
J Hepatol 2023 Oct;79(4):977-988. Epub 2023 Jul 22 doi: 10.1016/j.jhep.2023.06.017. PMID: 37482222
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Clément A, Menezo Y, Cohen M, Cornet D, Clément P
J Gynecol Obstet Hum Reprod 2020 Jan;49(1):101622. Epub 2019 Aug 22 doi: 10.1016/j.jogoh.2019.08.005. PMID: 31446167
Andras A, Stansby G, Hansrani M
Cochrane Database Syst Rev 2013 Jul 19;2013(7):CD003285. doi: 10.1002/14651858.CD003285.pub2. PMID: 23881650Free PMC Article
Obeid R, Holzgreve W, Pietrzik K
J Perinat Med 2013 Sep 1;41(5):469-83. doi: 10.1515/jpm-2012-0256. PMID: 23482308

Prognosis

Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Oosterom N, de Jonge R, Smith DEC, Pieters R, Tissing WJE, Fiocco M, van Zelst BD, van den Heuvel-Eibrink MM, Heil SG
PLoS One 2019;14(9):e0221591. Epub 2019 Sep 17 doi: 10.1371/journal.pone.0221591. PMID: 31527879Free PMC Article
Shoffner J, Trommer B, Thurm A, Farmer C, Langley WA 3rd, Soskey L, Rodriguez AN, D'Souza P, Spence SJ, Hyland K, Swedo SE
Neurology 2016 Jun 14;86(24):2258-63. Epub 2016 May 13 doi: 10.1212/WNL.0000000000002766. PMID: 27178705Free PMC Article
Ng X, Boyd L, Dufficy L, Naumovski N, Blades B, Travers C, Lewis P, Sturm J, Yates Z, Townley-Jones M, Roach P, Veysey M, Lucock M
J Nutrigenet Nutrigenomics 2009;2(1):1-8. Epub 2008 Oct 8 doi: 10.1159/000160079. PMID: 19776634
Coppola A, D'Angelo A, Fermo I, Mazzola G, Di Minno MN, Cajani A, Sala A, Folco G, Tremoli E, Di Minno G
Br J Haematol 2005 Oct;131(1):100-8. doi: 10.1111/j.1365-2141.2005.05732.x. PMID: 16173969

Clinical prediction guides

Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Sicińska E, Brzozowska A, Roszkowski W, Finglas PM
Int J Food Sci Nutr 2018 Feb;69(1):64-73. Epub 2017 May 2 doi: 10.1080/09637486.2017.1320536. PMID: 28460586
Shoffner J, Trommer B, Thurm A, Farmer C, Langley WA 3rd, Soskey L, Rodriguez AN, D'Souza P, Spence SJ, Hyland K, Swedo SE
Neurology 2016 Jun 14;86(24):2258-63. Epub 2016 May 13 doi: 10.1212/WNL.0000000000002766. PMID: 27178705Free PMC Article
Zappacosta B, Mastroiacovo P, Persichilli S, Pounis G, Ruggeri S, Minucci A, Carnovale E, Andria G, Ricci R, Scala I, Genovese O, Turrini A, Mistura L, Giardina B, Iacoviello L
Nutrients 2013 May 8;5(5):1531-43. doi: 10.3390/nu5051531. PMID: 23698160Free PMC Article
Valik D, Radina M, Sterba J, Vojtesek B
Pharmacogenomics 2004 Dec;5(8):1151-62. doi: 10.1517/14622416.5.8.1151. PMID: 15584881

Recent systematic reviews

Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Andras A, Stansby G, Hansrani M
Cochrane Database Syst Rev 2013 Jul 19;2013(7):CD003285. doi: 10.1002/14651858.CD003285.pub2. PMID: 23881650Free PMC Article

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