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Vascular Hemorrhagic Disorder

MedGen UID:
167269
•Concept ID:
C0851563
•
Disease or Syndrome

Definition

A hemorrhagic disorder that is caused by pathologic changes in the vasculature. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVascular Hemorrhagic Disorder

Professional guidelines

PubMed

Coagulopathy and sepsis: Pathophysiology, clinical manifestations and treatment.
Giustozzi M, Ehrlinder H, Bongiovanni D, Borovac JA, Guerreiro RA, Gąsecka A, Papakonstantinou PE, Parker WAE
Blood Rev 2021 Nov;50:100864. Epub 2021 Jun 25 doi: 10.1016/j.blre.2021.100864. PMID: 34217531
Post-stroke Movement Disorders: Clinical Spectrum, Pathogenesis, and Management.
Tater P, Pandey S
Neurol India 2021 Mar-Apr;69(2):272-283. doi: 10.4103/0028-3886.314574. PMID: 33904435
Disseminated intravascular coagulation: epidemiology, biomarkers, and management.
Adelborg K, Larsen JB, Hvas AM
Br J Haematol 2021 Mar;192(5):803-818. Epub 2021 Feb 8 doi: 10.1111/bjh.17172. PMID: 33555051

Recent clinical studies

Etiology

Hereditary hemorrhagic telangiectasia (HHT): a practical guide to management.
Hammill AM, Wusik K, Kasthuri RS
Hematology Am Soc Hematol Educ Program 2021 Dec 10;2021(1):469-477. doi: 10.1182/hematology.2021000281. PMID: 34889398Free PMC Article
Vascular pathologies in chronic kidney disease: pathophysiological mechanisms and novel therapeutic approaches.
Düsing P, Zietzer A, Goody PR, Hosen MR, Kurts C, Nickenig G, Jansen F
J Mol Med (Berl) 2021 Mar;99(3):335-348. Epub 2021 Jan 22 doi: 10.1007/s00109-021-02037-7. PMID: 33481059Free PMC Article
Cerebral Cavernous Malformations, Developmental Venous Anomaly, and Its Coexistence: A Review.
Idiculla PS, Gurala D, Philipose J, Rajdev K, Patibandla P
Eur Neurol 2020;83(4):360-368. Epub 2020 Jul 30 doi: 10.1159/000508748. PMID: 32731220
Pseudoxanthoma elasticum.
Germain DP
Orphanet J Rare Dis 2017 May 10;12(1):85. doi: 10.1186/s13023-017-0639-8. PMID: 28486967Free PMC Article
Ehlers-Danlos syndrome--a historical review.
Parapia LA, Jackson C
Br J Haematol 2008 Apr;141(1):32-5. doi: 10.1111/j.1365-2141.2008.06994.x. PMID: 18324963

Diagnosis

Hereditary hemorrhagic telangiectasia (HHT): a practical guide to management.
Hammill AM, Wusik K, Kasthuri RS
Hematology Am Soc Hematol Educ Program 2021 Dec 10;2021(1):469-477. doi: 10.1182/hematology.2021000281. PMID: 34889398Free PMC Article
A diagnostic approach to mild bleeding disorders.
Boender J, Kruip MJ, Leebeek FW
J Thromb Haemost 2016 Aug;14(8):1507-16. Epub 2016 Jun 27 doi: 10.1111/jth.13368. PMID: 27208505
Ehlers-Danlos syndrome--a historical review.
Parapia LA, Jackson C
Br J Haematol 2008 Apr;141(1):32-5. doi: 10.1111/j.1365-2141.2008.06994.x. PMID: 18324963
Single-organ vasculitis.
Hernández-Rodríguez J, Molloy ES, Hoffman GS
Curr Opin Rheumatol 2008 Jan;20(1):40-6. doi: 10.1097/BOR.0b013e3282f176a0. PMID: 18281856
Cutaneous pseudovasculitis.
Carlson JA, Chen KR
Am J Dermatopathol 2007 Feb;29(1):44-55. doi: 10.1097/01.dad.0000245195.35106.3c. PMID: 17284961

Therapy

Valoctocogene Roxaparvovec Gene Therapy for Hemophilia A.
Ozelo MC, Mahlangu J, Pasi KJ, Giermasz A, Leavitt AD, Laffan M, Symington E, Quon DV, Wang JD, Peerlinck K, Pipe SW, Madan B, Key NS, Pierce GF, O'Mahony B, Kaczmarek R, Henshaw J, Lawal A, Jayaram K, Huang M, Yang X, Wong WY, Kim B; GENEr8-1 Trial Group
N Engl J Med 2022 Mar 17;386(11):1013-1025. doi: 10.1056/NEJMoa2113708. PMID: 35294811
Disseminated intravascular coagulation: epidemiology, biomarkers, and management.
Adelborg K, Larsen JB, Hvas AM
Br J Haematol 2021 Mar;192(5):803-818. Epub 2021 Feb 8 doi: 10.1111/bjh.17172. PMID: 33555051
Vascular pathologies in chronic kidney disease: pathophysiological mechanisms and novel therapeutic approaches.
Düsing P, Zietzer A, Goody PR, Hosen MR, Kurts C, Nickenig G, Jansen F
J Mol Med (Berl) 2021 Mar;99(3):335-348. Epub 2021 Jan 22 doi: 10.1007/s00109-021-02037-7. PMID: 33481059Free PMC Article
von Willebrand factor regulation of blood vessel formation.
Randi AM, Smith KE, Castaman G
Blood 2018 Jul 12;132(2):132-140. Epub 2018 Jun 4 doi: 10.1182/blood-2018-01-769018. PMID: 29866817Free PMC Article
Essential thrombocythemia.
Finazzi G, Harrison C
Semin Hematol 2005 Oct;42(4):230-8. doi: 10.1053/j.seminhematol.2005.05.022. PMID: 16210036

Prognosis

Hereditary hemorrhagic telangiectasia (HHT): a practical guide to management.
Hammill AM, Wusik K, Kasthuri RS
Hematology Am Soc Hematol Educ Program 2021 Dec 10;2021(1):469-477. doi: 10.1182/hematology.2021000281. PMID: 34889398Free PMC Article
Vascular pathologies in chronic kidney disease: pathophysiological mechanisms and novel therapeutic approaches.
Düsing P, Zietzer A, Goody PR, Hosen MR, Kurts C, Nickenig G, Jansen F
J Mol Med (Berl) 2021 Mar;99(3):335-348. Epub 2021 Jan 22 doi: 10.1007/s00109-021-02037-7. PMID: 33481059Free PMC Article
Cryoglobulinemia (review).
Takada S, Shimizu T, Hadano Y, Matsumoto K, Kataoka Y, Arima Y, Inoue T, Sorano S
Mol Med Rep 2012 Jul;6(1):3-8. Epub 2012 Apr 6 doi: 10.3892/mmr.2012.861. PMID: 22484457
Single-organ vasculitis.
Hernández-Rodríguez J, Molloy ES, Hoffman GS
Curr Opin Rheumatol 2008 Jan;20(1):40-6. doi: 10.1097/BOR.0b013e3282f176a0. PMID: 18281856
Essential thrombocythemia.
Finazzi G, Harrison C
Semin Hematol 2005 Oct;42(4):230-8. doi: 10.1053/j.seminhematol.2005.05.022. PMID: 16210036

Clinical prediction guides

An international, multicenter study of intravenous bevacizumab for bleeding in hereditary hemorrhagic telangiectasia: the InHIBIT-Bleed study.
Al-Samkari H, Kasthuri RS, Parambil JG, Albitar HA, Almodallal YA, Vázquez C, Serra MM, Dupuis-Girod S, Wilsen CB, McWilliams JP, Fountain EH, Gossage JR, Weiss CR, Latif MA, Issachar A, Mei-Zahav M, Meek ME, Conrad M, Rodriguez-Lopez J, Kuter DJ, Iyer VN
Haematologica 2021 Aug 1;106(8):2161-2169. doi: 10.3324/haematol.2020.261859. PMID: 32675221Free PMC Article
How we manage haemostasis during sepsis.
Scully M, Levi M
Br J Haematol 2019 Apr;185(2):209-218. Epub 2019 Mar 3 doi: 10.1111/bjh.15821. PMID: 30828800
The definition, diagnosis and management of mild hemophilia A: communication from the SSC of the ISTH.
Makris M, Oldenburg J, Mauser-Bunschoten EP, Peerlinck K, Castaman G, Fijnvandraat K; subcommittee on Factor VIII, Factor IX and Rare Bleeding Disorders
J Thromb Haemost 2018 Dec;16(12):2530-2533. Epub 2018 Nov 15 doi: 10.1111/jth.14315. PMID: 30430726
A diagnostic approach to mild bleeding disorders.
Boender J, Kruip MJ, Leebeek FW
J Thromb Haemost 2016 Aug;14(8):1507-16. Epub 2016 Jun 27 doi: 10.1111/jth.13368. PMID: 27208505
Single-organ vasculitis.
Hernández-Rodríguez J, Molloy ES, Hoffman GS
Curr Opin Rheumatol 2008 Jan;20(1):40-6. doi: 10.1097/BOR.0b013e3282f176a0. PMID: 18281856

Recent systematic reviews

Outcomes in Patients With Poststroke Seizures: A Systematic Review and Meta-Analysis.
Misra S, Kasner SE, Dawson J, Tanaka T, Zhao Y, Zaveri HP, Eldem E, Vazquez J, Silva LS, Mohidat S, Hickman LB, Khan EI, Funaro MC, Nicolo JP, Mazumder R, Yasuda CL, Sunnerhagen KS, Ihara M, Ross JS, Liebeskind DS, Kwan P, Quinn TJ, Engel J Jr, Mishra NK
JAMA Neurol 2023 Nov 1;80(11):1155-1165. doi: 10.1001/jamaneurol.2023.3240. PMID: 37721736Free PMC Article
Hypertensive primary intraventricular hemorrhage: a systematic review.
Robles LA, Volovici V
Neurosurg Rev 2022 Jun;45(3):2013-2026. Epub 2022 Feb 20 doi: 10.1007/s10143-022-01758-8. PMID: 35184233
Myocardial infarction, stroke and cardiovascular mortality among migraine patients: a systematic review and meta-analysis.
Ng CYH, Tan BYQ, Teo YN, Teo YH, Syn NLX, Leow AST, Ho JSY, Chan MY, Wong RCC, Chai P, Chan ACY, Sharma VK, Yeo LLL, Sia CH, Ong JJY
J Neurol 2022 May;269(5):2346-2358. Epub 2022 Jan 8 doi: 10.1007/s00415-021-10930-x. PMID: 34997286
The Role of TEG and ROTEM in Damage Control Resuscitation.
Brill JB, Brenner M, Duchesne J, Roberts D, Ferrada P, Horer T, Kauvar D, Khan M, Kirkpatrick A, Ordonez C, Perreira B, Priouzram A, Cotton BA
Shock 2021 Dec 1;56(1S):52-61. doi: 10.1097/SHK.0000000000001686. PMID: 33769424Free PMC Article
Vascular phenotypes in nonvascular subtypes of the Ehlers-Danlos syndrome: a systematic review.
D'hondt S, Van Damme T, Malfait F
Genet Med 2018 Jun;20(6):562-573. Epub 2017 Oct 5 doi: 10.1038/gim.2017.138. PMID: 28981071Free PMC Article

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