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Kidney Neuroendocrine Neoplasm

MedGen UID:
1672808
•Concept ID:
C4763823
•
Neoplastic Process

Definition

An epithelial neoplasm with neuroendocrine differentiation that arises from the kidney. It includes neuroendocrine tumor, small cell neuroendocrine carcinoma, large cell neuroendocrine carcinoma, and paraganglioma. [from NCI]

Professional guidelines

PubMed

Clinical practice guidelines for the diagnosis and surveillance of BAP1 tumour predisposition syndrome.
Lalloo F, Kulkarni A, Chau C, Nielsen M, Sheaff M, Steele J, van Doorn R, Wadt K, Hamill M, Torr B, Tischkowitz M; Delphi respondents, Hanson H
Eur J Hum Genet 2023 Nov;31(11):1261-1269. Epub 2023 Aug 22 doi: 10.1038/s41431-023-01448-z. PMID: 37607989Free PMC Article
Management of toxicities of immune checkpoint inhibitors.
Spain L, Diem S, Larkin J
Cancer Treat Rev 2016 Mar;44:51-60. Epub 2016 Feb 6 doi: 10.1016/j.ctrv.2016.02.001. PMID: 26874776
Multiple Endocrine Neoplasia: Genetics and Clinical Management.
Norton JA, Krampitz G, Jensen RT
Surg Oncol Clin N Am 2015 Oct;24(4):795-832. Epub 2015 Jul 27 doi: 10.1016/j.soc.2015.06.008. PMID: 26363542Free PMC Article

Recent clinical studies

Etiology

Cancer statistics, 2023.
Siegel RL, Miller KD, Wagle NS, Jemal A
CA Cancer J Clin 2023 Jan;73(1):17-48. doi: 10.3322/caac.21763. PMID: 36633525
The 2022 revision of the World Health Organization classification of tumors of the urinary system and male genital organs: advances and challenges.
Mohanty SK, Lobo A, Cheng L
Hum Pathol 2023 Jun;136:123-143. Epub 2022 Sep 6 doi: 10.1016/j.humpath.2022.08.006. PMID: 36084769
Pyroptosis relates to tumor microenvironment remodeling and prognosis: A pan-cancer perspective.
Khan M, Ai M, Du K, Song J, Wang B, Lin J, Ren A, Chen C, Huang Z, Qiu W, Zhang J, Tian Y, Yuan Y
Front Immunol 2022;13:1062225. Epub 2022 Dec 20 doi: 10.3389/fimmu.2022.1062225. PMID: 36605187Free PMC Article
Belzutifan for Renal Cell Carcinoma in von Hippel-Lindau Disease.
Jonasch E, Donskov F, Iliopoulos O, Rathmell WK, Narayan VK, Maughan BL, Oudard S, Else T, Maranchie JK, Welsh SJ, Thamake S, Park EK, Perini RF, Linehan WM, Srinivasan R; MK-6482-004 Investigators
N Engl J Med 2021 Nov 25;385(22):2036-2046. doi: 10.1056/NEJMoa2103425. PMID: 34818478Free PMC Article
Chronic Immune-Related Adverse Events Following Adjuvant Anti-PD-1 Therapy for High-risk Resected Melanoma.
Patrinely JR Jr, Johnson R, Lawless AR, Bhave P, Sawyers A, Dimitrova M, Yeoh HL, Palmeri M, Ye F, Fan R, Davis EJ, Rapisuwon S, Long GV, Haydon A, Osman I, Mehnert JM, Carlino MS, Sullivan RJ, Menzies AM, Johnson DB
JAMA Oncol 2021 May 1;7(5):744-748. doi: 10.1001/jamaoncol.2021.0051. PMID: 33764387Free PMC Article

Diagnosis

Radiopharmaceuticals used for diagnosis and therapy of NETs.
Papachristou M
Hell J Nucl Med 2023 May-Aug;26 Suppl:19-20. PMID: 37658556
Everolimus in the treatment of neuroendocrine tumors: efficacy, side-effects, resistance, and factors affecting its place in the treatment sequence.
Lee L, Ito T, Jensen RT
Expert Opin Pharmacother 2018 Jun;19(8):909-928. Epub 2018 May 24 doi: 10.1080/14656566.2018.1476492. PMID: 29757017Free PMC Article
Advances in the diagnosis and treatment of pancreatic neuroendocrine neoplasms in Japan.
Ito T, Hijioka S, Masui T, Kasajima A, Nakamoto Y, Kobayashi N, Komoto I, Hijioka M, Lee L, Igarashi H, Jensen RT, Imamura M
J Gastroenterol 2017 Jan;52(1):9-18. Epub 2016 Aug 18 doi: 10.1007/s00535-016-1250-9. PMID: 27539256
Secondary Hypertension in Pregnancy.
Malha L, August P
Curr Hypertens Rep 2015 Jul;17(7):53. doi: 10.1007/s11906-015-0563-z. PMID: 26068655
Amphicrine tumor.
Mándoky L
Pathol Oncol Res 1999;5(3):239-44. doi: 10.1053/paor.1999.0211. PMID: 10491026

Therapy

Immune Checkpoint Inhibitor Therapy in Neuroendocrine Tumors.
Gubbi S, Vijayvergia N, Yu JQ, Klubo-Gwiezdzinska J, Koch CA
Horm Metab Res 2022 Dec;54(12):795-812. Epub 2022 Jul 25 doi: 10.1055/a-1908-7790. PMID: 35878617Free PMC Article
Long-Term Outcomes With Nivolumab Plus Ipilimumab or Nivolumab Alone Versus Ipilimumab in Patients With Advanced Melanoma.
Wolchok JD, Chiarion-Sileni V, Gonzalez R, Grob JJ, Rutkowski P, Lao CD, Cowey CL, Schadendorf D, Wagstaff J, Dummer R, Ferrucci PF, Smylie M, Butler MO, Hill A, Márquez-Rodas I, Haanen JBAG, Guidoboni M, Maio M, Schöffski P, Carlino MS, Lebbé C, McArthur G, Ascierto PA, Daniels GA, Long GV, Bas T, Ritchings C, Larkin J, Hodi FS
J Clin Oncol 2022 Jan 10;40(2):127-137. Epub 2021 Nov 24 doi: 10.1200/JCO.21.02229. PMID: 34818112Free PMC Article
Belzutifan for Renal Cell Carcinoma in von Hippel-Lindau Disease.
Jonasch E, Donskov F, Iliopoulos O, Rathmell WK, Narayan VK, Maughan BL, Oudard S, Else T, Maranchie JK, Welsh SJ, Thamake S, Park EK, Perini RF, Linehan WM, Srinivasan R; MK-6482-004 Investigators
N Engl J Med 2021 Nov 25;385(22):2036-2046. doi: 10.1056/NEJMoa2103425. PMID: 34818478Free PMC Article
Immune Checkpoint Inhibitor Toxicities.
Marin-Acevedo JA, Chirila RM, Dronca RS
Mayo Clin Proc 2019 Jul;94(7):1321-1329. doi: 10.1016/j.mayocp.2019.03.012. PMID: 31272574
Everolimus in the treatment of neuroendocrine tumors: efficacy, side-effects, resistance, and factors affecting its place in the treatment sequence.
Lee L, Ito T, Jensen RT
Expert Opin Pharmacother 2018 Jun;19(8):909-928. Epub 2018 May 24 doi: 10.1080/14656566.2018.1476492. PMID: 29757017Free PMC Article

Prognosis

Cancer statistics, 2024.
Siegel RL, Giaquinto AN, Jemal A
CA Cancer J Clin 2024 Jan-Feb;74(1):12-49. Epub 2024 Jan 17 doi: 10.3322/caac.21820. PMID: 38230766
Cancer statistics, 2023.
Siegel RL, Miller KD, Wagle NS, Jemal A
CA Cancer J Clin 2023 Jan;73(1):17-48. doi: 10.3322/caac.21763. PMID: 36633525
Annual report to the nation on the status of cancer, part 1: National cancer statistics.
Cronin KA, Scott S, Firth AU, Sung H, Henley SJ, Sherman RL, Siegel RL, Anderson RN, Kohler BA, Benard VB, Negoita S, Wiggins C, Cance WG, Jemal A
Cancer 2022 Dec 15;128(24):4251-4284. Epub 2022 Oct 27 doi: 10.1002/cncr.34479. PMID: 36301149Free PMC Article
Belzutifan for Renal Cell Carcinoma in von Hippel-Lindau Disease.
Jonasch E, Donskov F, Iliopoulos O, Rathmell WK, Narayan VK, Maughan BL, Oudard S, Else T, Maranchie JK, Welsh SJ, Thamake S, Park EK, Perini RF, Linehan WM, Srinivasan R; MK-6482-004 Investigators
N Engl J Med 2021 Nov 25;385(22):2036-2046. doi: 10.1056/NEJMoa2103425. PMID: 34818478Free PMC Article
Chronic Immune-Related Adverse Events Following Adjuvant Anti-PD-1 Therapy for High-risk Resected Melanoma.
Patrinely JR Jr, Johnson R, Lawless AR, Bhave P, Sawyers A, Dimitrova M, Yeoh HL, Palmeri M, Ye F, Fan R, Davis EJ, Rapisuwon S, Long GV, Haydon A, Osman I, Mehnert JM, Carlino MS, Sullivan RJ, Menzies AM, Johnson DB
JAMA Oncol 2021 May 1;7(5):744-748. doi: 10.1001/jamaoncol.2021.0051. PMID: 33764387Free PMC Article

Clinical prediction guides

Hypoxia-Inducible Factor 2 Alpha (HIF2α) Inhibitors: Targeting Genetically Driven Tumor Hypoxia.
Toledo RA, Jimenez C, Armaiz-Pena G, Arenillas C, Capdevila J, Dahia PLM
Endocr Rev 2023 Mar 4;44(2):312-322. doi: 10.1210/endrev/bnac025. PMID: 36301191Free PMC Article
Pyroptosis relates to tumor microenvironment remodeling and prognosis: A pan-cancer perspective.
Khan M, Ai M, Du K, Song J, Wang B, Lin J, Ren A, Chen C, Huang Z, Qiu W, Zhang J, Tian Y, Yuan Y
Front Immunol 2022;13:1062225. Epub 2022 Dec 20 doi: 10.3389/fimmu.2022.1062225. PMID: 36605187Free PMC Article
Belzutifan for Renal Cell Carcinoma in von Hippel-Lindau Disease.
Jonasch E, Donskov F, Iliopoulos O, Rathmell WK, Narayan VK, Maughan BL, Oudard S, Else T, Maranchie JK, Welsh SJ, Thamake S, Park EK, Perini RF, Linehan WM, Srinivasan R; MK-6482-004 Investigators
N Engl J Med 2021 Nov 25;385(22):2036-2046. doi: 10.1056/NEJMoa2103425. PMID: 34818478Free PMC Article
Programmed death ligand-1 (PD-L1) as a predictive marker for immunotherapy in solid tumours: a guide to immunohistochemistry implementation and interpretation.
Paver EC, Cooper WA, Colebatch AJ, Ferguson PM, Hill SK, Lum T, Shin JS, O'Toole S, Anderson L, Scolyer RA, Gupta R
Pathology 2021 Feb;53(2):141-156. Epub 2020 Dec 30 doi: 10.1016/j.pathol.2020.10.007. PMID: 33388161
Evaluation of Outcomes Following Surgery for Locally Advanced Pancreatic Neuroendocrine Tumors.
Titan AL, Norton JA, Fisher AT, Foster DS, Harris EJ, Worhunsky DJ, Worth PJ, Dua MM, Visser BC, Poultsides GA, Longaker MT, Jensen RT
JAMA Netw Open 2020 Nov 2;3(11):e2024318. doi: 10.1001/jamanetworkopen.2020.24318. PMID: 33146734Free PMC Article

Recent systematic reviews

Impact of concomitant medications on the efficacy of immune checkpoint inhibitors: an umbrella review.
Li H, Zhang L, Yang F, Zhao R, Li X, Li H
Front Immunol 2023;14:1218386. Epub 2023 Sep 29 doi: 10.3389/fimmu.2023.1218386. PMID: 37841249Free PMC Article
Association of soft drinks and 100% fruit juice consumption with risk of cancer: a systematic review and dose-response meta-analysis of prospective cohort studies.
Pan B, Lai H, Ma N, Li D, Deng X, Wang X, Zhang Q, Yang Q, Wang Q, Zhu H, Li M, Cao X, Tian J, Ge L, Yang K
Int J Behav Nutr Phys Act 2023 May 15;20(1):58. doi: 10.1186/s12966-023-01459-5. PMID: 37189146Free PMC Article
Metastases to the nail unit and distal phalanx: a systematic review.
Curtis KL, Lipner SR
Arch Dermatol Res 2023 Apr;315(3):347-358. Epub 2022 Oct 19 doi: 10.1007/s00403-022-02411-6. PMID: 36260150
Isolated ACTH deficiency induced by cancer immunotherapy: a systematic review.
Iglesias P, Sánchez JC, Díez JJ
Pituitary 2021 Aug;24(4):630-643. Epub 2021 Mar 24 doi: 10.1007/s11102-021-01141-8. PMID: 33761049
Understanding pathologic variants of renal cell carcinoma: distilling therapeutic opportunities from biologic complexity.
Shuch B, Amin A, Armstrong AJ, Eble JN, Ficarra V, Lopez-Beltran A, Martignoni G, Rini BI, Kutikov A
Eur Urol 2015 Jan;67(1):85-97. Epub 2014 May 21 doi: 10.1016/j.eururo.2014.04.029. PMID: 24857407

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