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Recurrent Polymorphic Post-Transplant Lymphoproliferative Disorder

MedGen UID:
1672883
•Concept ID:
C4763647
•
Neoplastic Process
Synonym: Relapsed Polymorphic Post-Transplant Lymphoproliferative Disorder

Definition

The reemergence of polymorphic post-transplant lymphoproliferative disorder after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Polymorphic Post-Transplant Lymphoproliferative Disorder

Professional guidelines

PubMed

Diagnostic and management roles of FDG PET/CT imaging in post-transplant lympho-proliferation in pediatric heart transplantation.
Brown AK, Carapellucci J, Oshrine B, Gomez A, Meoded A, Asante-Korang A
Clin Transplant 2023 Sep;37(9):e15015. Epub 2023 May 26 doi: 10.1111/ctr.15015. PMID: 37237443
Course of renal allograft function after diagnosis and treatment of post-transplant lymphoproliferative disorders in pediatric kidney transplant recipients.
Zierhut H, Kanzelmeyer N, Buescher A, Höcker B, Mauz-Körholz C, Tönshoff B, Metzler M, Pohl M, Pape L, Maecker-Kolhoff B
Pediatr Transplant 2021 Sep;25(6):e14042. Epub 2021 May 22 doi: 10.1111/petr.14042. PMID: 34021949

Recent clinical studies

Etiology

Diagnostic and management roles of FDG PET/CT imaging in post-transplant lympho-proliferation in pediatric heart transplantation.
Brown AK, Carapellucci J, Oshrine B, Gomez A, Meoded A, Asante-Korang A
Clin Transplant 2023 Sep;37(9):e15015. Epub 2023 May 26 doi: 10.1111/ctr.15015. PMID: 37237443
Course of renal allograft function after diagnosis and treatment of post-transplant lymphoproliferative disorders in pediatric kidney transplant recipients.
Zierhut H, Kanzelmeyer N, Buescher A, Höcker B, Mauz-Körholz C, Tönshoff B, Metzler M, Pohl M, Pape L, Maecker-Kolhoff B
Pediatr Transplant 2021 Sep;25(6):e14042. Epub 2021 May 22 doi: 10.1111/petr.14042. PMID: 34021949
Iatrogenic immunodeficiency-associated lymphoproliferative disorder in a child with B-cell acute lymphoblastic leukemia.
Shahid S, Rossi C, Vyas P, Bollard C, Dave H
Pediatr Hematol Oncol 2019 Aug;36(5):309-316. Epub 2019 Jul 17 doi: 10.1080/08880018.2019.1637982. PMID: 31314679
Post-transplant lymphoproliferative disorders after live donor renal transplantation.
Jain M, Badwal S, Pandey R, Srivastava A, Sharma RK, Gupta RK
Clin Transplant 2005 Oct;19(5):668-73. doi: 10.1111/j.1399-0012.2005.00406.x. PMID: 16146560
The diverse pathology of post-transplant lymphoproliferative disorders: the importance of a standardized approach.
Nalesnik MA
Transpl Infect Dis 2001 Jun;3(2):88-96. doi: 10.1034/j.1399-3062.2001.003002088.x. PMID: 11395974

Diagnosis

Diagnostic and management roles of FDG PET/CT imaging in post-transplant lympho-proliferation in pediatric heart transplantation.
Brown AK, Carapellucci J, Oshrine B, Gomez A, Meoded A, Asante-Korang A
Clin Transplant 2023 Sep;37(9):e15015. Epub 2023 May 26 doi: 10.1111/ctr.15015. PMID: 37237443
Course of renal allograft function after diagnosis and treatment of post-transplant lymphoproliferative disorders in pediatric kidney transplant recipients.
Zierhut H, Kanzelmeyer N, Buescher A, Höcker B, Mauz-Körholz C, Tönshoff B, Metzler M, Pohl M, Pape L, Maecker-Kolhoff B
Pediatr Transplant 2021 Sep;25(6):e14042. Epub 2021 May 22 doi: 10.1111/petr.14042. PMID: 34021949
Post-transplant primary cutaneous peripheral T-cell lymphoma not otherwise specified in a pediatric patient.
Cardwell LA, Majerowski J, Chiu YE, Harrington AM, Sokumbi O
J Cutan Pathol 2021 May;48(5):706-712. Epub 2021 Mar 9 doi: 10.1111/cup.13967. PMID: 33476057
Post-transplant lymphoproliferative disorders after live donor renal transplantation.
Jain M, Badwal S, Pandey R, Srivastava A, Sharma RK, Gupta RK
Clin Transplant 2005 Oct;19(5):668-73. doi: 10.1111/j.1399-0012.2005.00406.x. PMID: 16146560
The diverse pathology of post-transplant lymphoproliferative disorders: the importance of a standardized approach.
Nalesnik MA
Transpl Infect Dis 2001 Jun;3(2):88-96. doi: 10.1034/j.1399-3062.2001.003002088.x. PMID: 11395974

Therapy

Diagnostic and management roles of FDG PET/CT imaging in post-transplant lympho-proliferation in pediatric heart transplantation.
Brown AK, Carapellucci J, Oshrine B, Gomez A, Meoded A, Asante-Korang A
Clin Transplant 2023 Sep;37(9):e15015. Epub 2023 May 26 doi: 10.1111/ctr.15015. PMID: 37237443
Course of renal allograft function after diagnosis and treatment of post-transplant lymphoproliferative disorders in pediatric kidney transplant recipients.
Zierhut H, Kanzelmeyer N, Buescher A, Höcker B, Mauz-Körholz C, Tönshoff B, Metzler M, Pohl M, Pape L, Maecker-Kolhoff B
Pediatr Transplant 2021 Sep;25(6):e14042. Epub 2021 May 22 doi: 10.1111/petr.14042. PMID: 34021949
Post-transplant primary cutaneous peripheral T-cell lymphoma not otherwise specified in a pediatric patient.
Cardwell LA, Majerowski J, Chiu YE, Harrington AM, Sokumbi O
J Cutan Pathol 2021 May;48(5):706-712. Epub 2021 Mar 9 doi: 10.1111/cup.13967. PMID: 33476057
Trisomy 3, a sole recurrent cytogenetic abnormality in pediatric polymorphic post-transplant lymphoproliferative disorder (PTLD).
Shestakova A, Grove N, Said J, Song S, Quintero-Rivera F
Cancer Genet 2020 Oct;248-249:39-48. Epub 2020 Oct 2 doi: 10.1016/j.cancergen.2020.09.006. PMID: 33065430
The diverse pathology of post-transplant lymphoproliferative disorders: the importance of a standardized approach.
Nalesnik MA
Transpl Infect Dis 2001 Jun;3(2):88-96. doi: 10.1034/j.1399-3062.2001.003002088.x. PMID: 11395974

Prognosis

Course of renal allograft function after diagnosis and treatment of post-transplant lymphoproliferative disorders in pediatric kidney transplant recipients.
Zierhut H, Kanzelmeyer N, Buescher A, Höcker B, Mauz-Körholz C, Tönshoff B, Metzler M, Pohl M, Pape L, Maecker-Kolhoff B
Pediatr Transplant 2021 Sep;25(6):e14042. Epub 2021 May 22 doi: 10.1111/petr.14042. PMID: 34021949
Trisomy 3, a sole recurrent cytogenetic abnormality in pediatric polymorphic post-transplant lymphoproliferative disorder (PTLD).
Shestakova A, Grove N, Said J, Song S, Quintero-Rivera F
Cancer Genet 2020 Oct;248-249:39-48. Epub 2020 Oct 2 doi: 10.1016/j.cancergen.2020.09.006. PMID: 33065430
Three different histological subtypes of Epstein-Barr virus-negative post-transplant lymphoproliferative disorder in a patient with hepatitis C infection.
Kobayashi M, Asano N, Fukushima M, Honda T
Int J Hematol 2014 Sep;100(3):307-11. Epub 2014 May 31 doi: 10.1007/s12185-014-1599-6. PMID: 24879033
Post-transplant lymphoproliferative disorders after live donor renal transplantation.
Jain M, Badwal S, Pandey R, Srivastava A, Sharma RK, Gupta RK
Clin Transplant 2005 Oct;19(5):668-73. doi: 10.1111/j.1399-0012.2005.00406.x. PMID: 16146560
The diverse pathology of post-transplant lymphoproliferative disorders: the importance of a standardized approach.
Nalesnik MA
Transpl Infect Dis 2001 Jun;3(2):88-96. doi: 10.1034/j.1399-3062.2001.003002088.x. PMID: 11395974

Clinical prediction guides

Chimerism analysis in peripheral blood using indel quantitative real-time PCR is a useful tool to predict post-transplant relapse in acute leukemia.
Jacque N, Nguyen S, Golmard JL, Uzunov M, Garnier A, Leblond V, Vernant JP, Bories D, Dhédin N
Bone Marrow Transplant 2015 Feb;50(2):259-65. Epub 2014 Nov 10 doi: 10.1038/bmt.2014.254. PMID: 25387089
Three different histological subtypes of Epstein-Barr virus-negative post-transplant lymphoproliferative disorder in a patient with hepatitis C infection.
Kobayashi M, Asano N, Fukushima M, Honda T
Int J Hematol 2014 Sep;100(3):307-11. Epub 2014 May 31 doi: 10.1007/s12185-014-1599-6. PMID: 24879033
Single nucleotide polymorphism-arrays provide new insights in the pathogenesis of post-transplant diffuse large B-cell lymphoma.
Rinaldi A, Capello D, Scandurra M, Greiner TC, Chan WC, Bhagat G, Rossi D, Morra E, Paulli M, Rambaldi A, Rancoita PM, Inghirami G, Ponzoni M, Moreno SM, Piris MA, Mian M, Chigrinova E, Zucca E, Favera RD, Gaidano G, Kwee I, Bertoni F
Br J Haematol 2010 May;149(4):569-77. Epub 2010 Mar 3 doi: 10.1111/j.1365-2141.2010.08125.x. PMID: 20230398
Genetic and phenotypic analysis of B-cell post-transplant lymphoproliferative disorders provides insights into disease biology.
Vakiani E, Basso K, Klein U, Mansukhani MM, Narayan G, Smith PM, Murty VV, Dalla-Favera R, Pasqualucci L, Bhagat G
Hematol Oncol 2008 Dec;26(4):199-211. doi: 10.1002/hon.859. PMID: 18457340
Post-transplant lymphoproliferative disorders after live donor renal transplantation.
Jain M, Badwal S, Pandey R, Srivastava A, Sharma RK, Gupta RK
Clin Transplant 2005 Oct;19(5):668-73. doi: 10.1111/j.1399-0012.2005.00406.x. PMID: 16146560

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