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Recurrent Primary Effusion Lymphoma

MedGen UID:
1673067
•Concept ID:
C4763783
•
Neoplastic Process
Synonym: Recurrent HHV8-Positive Primary Effusion Lymphoma

Definition

The reemergence of primary effusion lymphoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Primary Effusion Lymphoma

Professional guidelines

PubMed

High-dose Therapy and Autologous Hematopoietic Cell Transplantation as Consolidation Treatment for Primary Effusion Lymphoma.
Mirza AS, Dholaria BR, Hussaini M, Mushtaq S, Horna P, Ravindran A, Kumar A, Ayala E, Kharfan-Dabaja MA, Bello C, Chavez JC, Sokol L
Clin Lymphoma Myeloma Leuk 2019 Sep;19(9):e513-e520. Epub 2019 Mar 29 doi: 10.1016/j.clml.2019.03.021. PMID: 31253594
Primary cardiac lymphoma: diagnosis, treatment and outcome in a modern series.
Carras S, Berger F, Chalabreysse L, Callet-Bauchut E, Cordier JF, Salles G, Girard N
Hematol Oncol 2017 Dec;35(4):510-519. Epub 2016 May 3 doi: 10.1002/hon.2301. PMID: 27140394
Iodized talc pleurodesis for the treatment of pleural effusions.
Webb WR, Ozmen V, Moulder PV, Shabahang B, Breaux J
J Thorac Cardiovasc Surg 1992 May;103(5):881-5; discussion 885-6. PMID: 1569770

Recent clinical studies

Etiology

Pembrolizumab in paediatric patients with advanced melanoma or a PD-L1-positive, advanced, relapsed, or refractory solid tumour or lymphoma (KEYNOTE-051): interim analysis of an open-label, single-arm, phase 1-2 trial.
Geoerger B, Kang HJ, Yalon-Oren M, Marshall LV, Vezina C, Pappo A, Laetsch TW, Petrilli AS, Ebinger M, Toporski J, Glade-Bender J, Nicholls W, Fox E, DuBois SG, Macy ME, Cohn SL, Pathiraja K, Diede SJ, Ebbinghaus S, Pinto N
Lancet Oncol 2020 Jan;21(1):121-133. Epub 2019 Dec 4 doi: 10.1016/S1470-2045(19)30671-0. PMID: 31812554
High-dose Therapy and Autologous Hematopoietic Cell Transplantation as Consolidation Treatment for Primary Effusion Lymphoma.
Mirza AS, Dholaria BR, Hussaini M, Mushtaq S, Horna P, Ravindran A, Kumar A, Ayala E, Kharfan-Dabaja MA, Bello C, Chavez JC, Sokol L
Clin Lymphoma Myeloma Leuk 2019 Sep;19(9):e513-e520. Epub 2019 Mar 29 doi: 10.1016/j.clml.2019.03.021. PMID: 31253594
Primary cardiac lymphoma: diagnosis, treatment and outcome in a modern series.
Carras S, Berger F, Chalabreysse L, Callet-Bauchut E, Cordier JF, Salles G, Girard N
Hematol Oncol 2017 Dec;35(4):510-519. Epub 2016 May 3 doi: 10.1002/hon.2301. PMID: 27140394
Vogt-Koyanagi-Harada disease.
Damico FM, Kiss S, Young LH
Semin Ophthalmol 2005 Jul-Sep;20(3):183-90. doi: 10.1080/08820530500232126. PMID: 16282153
Body cavity lymphoma.
Ascoli V, Lo-Coco F
Curr Opin Pulm Med 2002 Jul;8(4):317-22. doi: 10.1097/00063198-200207000-00013. PMID: 12055396

Diagnosis

Mechanisms of Sensitivity and Resistance of Primary Effusion Lymphoma to Dimethyl Fumarate (DMF).
Gonnella R, Zarrella R, Santarelli R, Germano CA, Gilardini Montani MS, Cirone M
Int J Mol Sci 2022 Jun 17;23(12) doi: 10.3390/ijms23126773. PMID: 35743211Free PMC Article
Lymphoproliferative Disorders of the Lung.
Borie R, Wislez M, Antoine M, Cadranel J
Respiration 2017;94(2):157-175. Epub 2017 Jun 14 doi: 10.1159/000477740. PMID: 28609772
Primary cardiac lymphoma: diagnosis, treatment and outcome in a modern series.
Carras S, Berger F, Chalabreysse L, Callet-Bauchut E, Cordier JF, Salles G, Girard N
Hematol Oncol 2017 Dec;35(4):510-519. Epub 2016 May 3 doi: 10.1002/hon.2301. PMID: 27140394
Vogt-Koyanagi-Harada disease.
Damico FM, Kiss S, Young LH
Semin Ophthalmol 2005 Jul-Sep;20(3):183-90. doi: 10.1080/08820530500232126. PMID: 16282153
Body cavity lymphoma.
Ascoli V, Lo-Coco F
Curr Opin Pulm Med 2002 Jul;8(4):317-22. doi: 10.1097/00063198-200207000-00013. PMID: 12055396

Therapy

Mechanisms of Sensitivity and Resistance of Primary Effusion Lymphoma to Dimethyl Fumarate (DMF).
Gonnella R, Zarrella R, Santarelli R, Germano CA, Gilardini Montani MS, Cirone M
Int J Mol Sci 2022 Jun 17;23(12) doi: 10.3390/ijms23126773. PMID: 35743211Free PMC Article
Pembrolizumab in paediatric patients with advanced melanoma or a PD-L1-positive, advanced, relapsed, or refractory solid tumour or lymphoma (KEYNOTE-051): interim analysis of an open-label, single-arm, phase 1-2 trial.
Geoerger B, Kang HJ, Yalon-Oren M, Marshall LV, Vezina C, Pappo A, Laetsch TW, Petrilli AS, Ebinger M, Toporski J, Glade-Bender J, Nicholls W, Fox E, DuBois SG, Macy ME, Cohn SL, Pathiraja K, Diede SJ, Ebbinghaus S, Pinto N
Lancet Oncol 2020 Jan;21(1):121-133. Epub 2019 Dec 4 doi: 10.1016/S1470-2045(19)30671-0. PMID: 31812554
High-dose Therapy and Autologous Hematopoietic Cell Transplantation as Consolidation Treatment for Primary Effusion Lymphoma.
Mirza AS, Dholaria BR, Hussaini M, Mushtaq S, Horna P, Ravindran A, Kumar A, Ayala E, Kharfan-Dabaja MA, Bello C, Chavez JC, Sokol L
Clin Lymphoma Myeloma Leuk 2019 Sep;19(9):e513-e520. Epub 2019 Mar 29 doi: 10.1016/j.clml.2019.03.021. PMID: 31253594
Primary mediastinal large B-cell lymphoma.
Martelli M, Ferreri AJ, Johnson P
Crit Rev Oncol Hematol 2008 Dec;68(3):256-63. Epub 2008 Sep 7 doi: 10.1016/j.critrevonc.2008.07.020. PMID: 18774728
Vogt-Koyanagi-Harada disease.
Damico FM, Kiss S, Young LH
Semin Ophthalmol 2005 Jul-Sep;20(3):183-90. doi: 10.1080/08820530500232126. PMID: 16282153

Prognosis

Pembrolizumab in paediatric patients with advanced melanoma or a PD-L1-positive, advanced, relapsed, or refractory solid tumour or lymphoma (KEYNOTE-051): interim analysis of an open-label, single-arm, phase 1-2 trial.
Geoerger B, Kang HJ, Yalon-Oren M, Marshall LV, Vezina C, Pappo A, Laetsch TW, Petrilli AS, Ebinger M, Toporski J, Glade-Bender J, Nicholls W, Fox E, DuBois SG, Macy ME, Cohn SL, Pathiraja K, Diede SJ, Ebbinghaus S, Pinto N
Lancet Oncol 2020 Jan;21(1):121-133. Epub 2019 Dec 4 doi: 10.1016/S1470-2045(19)30671-0. PMID: 31812554
High-dose Therapy and Autologous Hematopoietic Cell Transplantation as Consolidation Treatment for Primary Effusion Lymphoma.
Mirza AS, Dholaria BR, Hussaini M, Mushtaq S, Horna P, Ravindran A, Kumar A, Ayala E, Kharfan-Dabaja MA, Bello C, Chavez JC, Sokol L
Clin Lymphoma Myeloma Leuk 2019 Sep;19(9):e513-e520. Epub 2019 Mar 29 doi: 10.1016/j.clml.2019.03.021. PMID: 31253594
Lymphoproliferative Disorders of the Lung.
Borie R, Wislez M, Antoine M, Cadranel J
Respiration 2017;94(2):157-175. Epub 2017 Jun 14 doi: 10.1159/000477740. PMID: 28609772
Primary cardiac lymphoma: diagnosis, treatment and outcome in a modern series.
Carras S, Berger F, Chalabreysse L, Callet-Bauchut E, Cordier JF, Salles G, Girard N
Hematol Oncol 2017 Dec;35(4):510-519. Epub 2016 May 3 doi: 10.1002/hon.2301. PMID: 27140394
Vogt-Koyanagi-Harada disease.
Damico FM, Kiss S, Young LH
Semin Ophthalmol 2005 Jul-Sep;20(3):183-90. doi: 10.1080/08820530500232126. PMID: 16282153

Clinical prediction guides

Mechanisms of Sensitivity and Resistance of Primary Effusion Lymphoma to Dimethyl Fumarate (DMF).
Gonnella R, Zarrella R, Santarelli R, Germano CA, Gilardini Montani MS, Cirone M
Int J Mol Sci 2022 Jun 17;23(12) doi: 10.3390/ijms23126773. PMID: 35743211Free PMC Article
Cytologic manifestations of Hodgkin lymphoma in serous effusions.
AbdullGaffar B, Raman L
Diagn Cytopathol 2022 Sep;50(9):E255-E263. Epub 2022 May 17 doi: 10.1002/dc.24976. PMID: 35581946
Pembrolizumab in paediatric patients with advanced melanoma or a PD-L1-positive, advanced, relapsed, or refractory solid tumour or lymphoma (KEYNOTE-051): interim analysis of an open-label, single-arm, phase 1-2 trial.
Geoerger B, Kang HJ, Yalon-Oren M, Marshall LV, Vezina C, Pappo A, Laetsch TW, Petrilli AS, Ebinger M, Toporski J, Glade-Bender J, Nicholls W, Fox E, DuBois SG, Macy ME, Cohn SL, Pathiraja K, Diede SJ, Ebbinghaus S, Pinto N
Lancet Oncol 2020 Jan;21(1):121-133. Epub 2019 Dec 4 doi: 10.1016/S1470-2045(19)30671-0. PMID: 31812554
Primary mediastinal large B-cell lymphoma.
Martelli M, Ferreri AJ, Johnson P
Crit Rev Oncol Hematol 2008 Dec;68(3):256-63. Epub 2008 Sep 7 doi: 10.1016/j.critrevonc.2008.07.020. PMID: 18774728
A clinical, molecular and cytogenetic study of 12 cases of human herpesvirus 8 associated primary effusion lymphoma in HIV-infected patients.
Boulanger E, Agbalika F, Maarek O, Daniel MT, Grollet L, Molina JM, Sigaux F, Oksenhendler E
Hematol J 2001;2(3):172-9. doi: 10.1038/sj.thj.6200096. PMID: 11920242

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