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Smooth Muscle Metaplasia

MedGen UID:
1673699
•Concept ID:
C4763821
•
Finding

Definition

A morphologic finding indicating the transformation of non-smooth muscle cells to smooth muscle cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmooth Muscle Metaplasia

Professional guidelines

PubMed

Ovarian endometriomas in adolescents often represent active angiogenic disease requiring early diagnosis and careful management.
Benagiano G, Bianchi P, Brosens I
Minerva Ginecol 2017 Feb;69(1):100-107. Epub 2016 May 13 doi: 10.23736/S0026-4784.16.03919-8. PMID: 27176460
Robotic management of endometriosis: where do we stand?
Zanotti KM, Abdelbadee AY
Minerva Ginecol 2015 Jun;67(3):257-72. Epub 2015 Feb 20 PMID: 25697976

Recent clinical studies

Etiology

Rectovaginal endometriosis with nodular smooth muscle metaplasia diagnosed via transrectal ultrasound-guided fine-needle aspiration cytology: An underused minimally invasive diagnostic technique?
Molina M, Moreno GA, Singh R, Hunt B, Giorgadze TA
Diagn Cytopathol 2023 Oct;51(10):E273-E278. Epub 2023 Jun 15 doi: 10.1002/dc.25183. PMID: 37318678
Histological and Immunohistochemical Characterization of the Similarity and Difference Between Ovarian Endometriomas and Deep Infiltrating Endometriosis.
Liu X, Zhang Q, Guo SW
Reprod Sci 2018 Mar;25(3):329-340. Epub 2017 Jul 18 doi: 10.1177/1933719117718275. PMID: 28718381
Cellular mesenchymal tumors of the uterus: a review emphasizing recent observations.
Oliva E
Int J Gynecol Pathol 2014 Jul;33(4):374-84. doi: 10.1097/PGP.0000000000000141. PMID: 24901397
Smooth muscle metaplasia and innervation in interstitium of endometriotic lesions related to pain.
Odagiri K, Konno R, Fujiwara H, Netsu S, Yang C, Suzuki M
Fertil Steril 2009 Nov;92(5):1525-31. Epub 2008 Oct 18 doi: 10.1016/j.fertnstert.2008.08.101. PMID: 18930216
Expression of estrogen and progesterone receptors in smooth muscle metaplasia of rectovaginal endometriosis.
Kitano T, Matsumoto T, Takeuchi H, Kikuchi I, Itoga T, Sasahara N, Kinoshita K
Int J Gynecol Pathol 2007 Apr;26(2):124-9. doi: 10.1097/01.pgp.0000235067.16054.dd. PMID: 17413977

Diagnosis

Cracking the enigma of adenomyosis: an update on its pathogenesis and pathophysiology.
Guo SW
Reproduction 2022 Nov 1;164(5):R101-R121. Epub 2022 Oct 10 doi: 10.1530/REP-22-0224. PMID: 36099328
The Uterine Plexiform Lesions Revisited.
Karpathiou G, Papoudou-Bai A, Clemenson A, Chauleur C, Peoc'h M
Am J Clin Pathol 2020 Jul 7;154(2):178-189. doi: 10.1093/ajcp/aqaa054. PMID: 32459343
Cellular mesenchymal tumors of the uterus: a review emphasizing recent observations.
Oliva E
Int J Gynecol Pathol 2014 Jul;33(4):374-84. doi: 10.1097/PGP.0000000000000141. PMID: 24901397
Smooth muscle metaplasia and innervation in interstitium of endometriotic lesions related to pain.
Odagiri K, Konno R, Fujiwara H, Netsu S, Yang C, Suzuki M
Fertil Steril 2009 Nov;92(5):1525-31. Epub 2008 Oct 18 doi: 10.1016/j.fertnstert.2008.08.101. PMID: 18930216
Fibrosis and smooth muscle metaplasia in rectovaginal endometriosis.
Itoga T, Matsumoto T, Takeuchi H, Yamasaki S, Sasahara N, Hoshi T, Kinoshita K
Pathol Int 2003 Jun;53(6):371-5. doi: 10.1046/j.1440-1827.2003.01483.x. PMID: 12787311

Therapy

Sensory nerve-derived neuropeptides accelerate the development and fibrogenesis of endometriosis.
Liu X, Yan D, Guo SW
Hum Reprod 2019 Mar 1;34(3):452-468. doi: 10.1093/humrep/dey392. PMID: 30689856
The establishment of a mouse model of deep endometriosis.
Yan D, Liu X, Guo SW
Hum Reprod 2019 Feb 1;34(2):235-247. doi: 10.1093/humrep/dey361. PMID: 30561644
Robotic management of endometriosis: where do we stand?
Zanotti KM, Abdelbadee AY
Minerva Ginecol 2015 Jun;67(3):257-72. Epub 2015 Feb 20 PMID: 25697976
Morphological variations of scar-related and spontaneous endometriosis of the skin and superficial soft tissue: a study of 71 cases with emphasis on atypical features and types of müllerian differentiations.
Kazakov DV, Ondic O, Zamecnik M, Shelekhova KV, Mukensnabl P, Hes O, Dvorak V, Michal M
J Am Acad Dermatol 2007 Jul;57(1):134-46. doi: 10.1016/j.jaad.2006.11.036. PMID: 17572279
A comparative study of ovarian and pelvic wall-infiltrating endometriosis.
Khare VK, Martin DC, Eltorky M
J Am Assoc Gynecol Laparosc 1996 Feb;3(2):235-9. doi: 10.1016/s1074-3804(96)80006-5. PMID: 9050632

Prognosis

Update on selected renal cell tumors with clear cell features. With emphasis on multilocular cystic clear cell renal cell carcinoma.
Montironi R, Mazzucchelli R, Scarpelli M, Lopez-Beltran A, Cheng L
Histol Histopathol 2013 Dec;28(12):1555-66. Epub 2013 Jul 30 doi: 10.14670/HH-28.1555. PMID: 23893851
Difficulties in assessing the depth of myometrial invasion in endometrial carcinoma.
Ali A, Black D, Soslow RA
Int J Gynecol Pathol 2007 Apr;26(2):115-23. doi: 10.1097/01.pgp.0000233165.56385.0b. PMID: 17413976

Clinical prediction guides

Nodular smooth muscle metaplasia in multiple peritoneal endometriosis.
Kim HS, Yoon G, Ha SY, Song SY
Int J Clin Exp Pathol 2015;8(3):3370-3. Epub 2015 Mar 1 PMID: 26045871Free PMC Article
Cellular mesenchymal tumors of the uterus: a review emphasizing recent observations.
Oliva E
Int J Gynecol Pathol 2014 Jul;33(4):374-84. doi: 10.1097/PGP.0000000000000141. PMID: 24901397
High frequency of JAZF1-JJAZ1 gene fusion in endometrial stromal tumors with smooth muscle differentiation by interphase FISH detection.
Oliva E, de Leval L, Soslow RA, Herens C
Am J Surg Pathol 2007 Aug;31(8):1277-84. doi: 10.1097/PAS.0b013e318031f012. PMID: 17667554
Fibrosis and smooth muscle metaplasia in rectovaginal endometriosis.
Itoga T, Matsumoto T, Takeuchi H, Yamasaki S, Sasahara N, Hoshi T, Kinoshita K
Pathol Int 2003 Jun;53(6):371-5. doi: 10.1046/j.1440-1827.2003.01483.x. PMID: 12787311
Smooth muscle metaplasia in ovarian endometriosis.
Fukunaga M
Histopathology 2000 Apr;36(4):348-52. doi: 10.1046/j.1365-2559.2000.00845.x. PMID: 10759949

Recent systematic reviews

The Uterine Plexiform Lesions Revisited.
Karpathiou G, Papoudou-Bai A, Clemenson A, Chauleur C, Peoc'h M
Am J Clin Pathol 2020 Jul 7;154(2):178-189. doi: 10.1093/ajcp/aqaa054. PMID: 32459343

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