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Unresectable Renal Pelvis Urothelial Carcinoma

MedGen UID:
1674126
•Concept ID:
C4764280
•
Neoplastic Process

Definition

A renal pelvis urothelial carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Renal Pelvis Urothelial Carcinoma

Recent clinical studies

Etiology

Difference of oncological efficacy between two immune checkpoint inhibitors following first-line platinum-based chemotherapy in patients with unresectable, metastatic, advanced urothelial carcinoma: a multicenter real-world Japanese cohort.
Miyake M, Nishimura N, Oda Y, Miyamoto T, Iida K, Inoue K, Tachibana A, Yoshikawa T, Sakamoto K, Ohnishi M, Maesaka F, Takamatsu N, Mieda K, Ohmori C, Matsubara T, Tomizawa M, Shimizu T, Ohnishi K, Hori S, Morizawa Y, Gotoh D, Nakai Y, Torimoto K, Tanaka N, Fujimoto K; Nara Urological Research and Treatment Group
Int J Clin Oncol 2024 Sep;29(9):1311-1325. Epub 2024 Jun 18 doi: 10.1007/s10147-024-02573-5. PMID: 38888683
Enfortumab vedotin following platinum-based chemotherapy and immune checkpoint inhibitors for advanced urothelial carcinoma: response, survival and safety analysis from a multicentre real-world Japanese cohort.
Miyake M, Nishimura N, Oda Y, Miyamoto T, Ohmori C, Takamatsu N, Itami Y, Tachibana A, Matsumoto Y, Kiba K, Tomioka A, Yamamoto H, Okajima E, Masaomi K, Sakamoto K, Tomizawa M, Shimizu T, Ohnishi K, Hori S, Morizawa Y, Gotoh D, Nakai Y, Torimoto K, Tanaka N, Fujimoto K; Nara Urological Research and Treatment Group
Jpn J Clin Oncol 2024 Mar 9;54(3):329-338. doi: 10.1093/jjco/hyad170. PMID: 38061911
Immune checkpoint inhibition in upper tract urothelial carcinoma.
Califano G, Ouzaid I, Verze P, Hermieu JF, Mirone V, Xylinas E
World J Urol 2021 May;39(5):1357-1367. Epub 2020 Oct 31 doi: 10.1007/s00345-020-03502-7. PMID: 33128595
Newer developments in the therapeutics of the transitional cell carcinoma of renal pelvis.
Dasanu CA, Ong-Bacay A, Codreanu I
J Oncol Pharm Pract 2012 Mar;18(1):97-103. Epub 2011 Jan 19 doi: 10.1177/1078155210394695. PMID: 21248173
Transitional cell carcinoma of the renal pelvis or ureter: patterns of failure.
Cozad SC, Smalley SR, Austenfeld M, Noble M, Jennings S, Raymond R
Urology 1995 Dec;46(6):796-800. doi: 10.1016/S0090-4295(99)80346-X. PMID: 7502418

Diagnosis

Difference of oncological efficacy between two immune checkpoint inhibitors following first-line platinum-based chemotherapy in patients with unresectable, metastatic, advanced urothelial carcinoma: a multicenter real-world Japanese cohort.
Miyake M, Nishimura N, Oda Y, Miyamoto T, Iida K, Inoue K, Tachibana A, Yoshikawa T, Sakamoto K, Ohnishi M, Maesaka F, Takamatsu N, Mieda K, Ohmori C, Matsubara T, Tomizawa M, Shimizu T, Ohnishi K, Hori S, Morizawa Y, Gotoh D, Nakai Y, Torimoto K, Tanaka N, Fujimoto K; Nara Urological Research and Treatment Group
Int J Clin Oncol 2024 Sep;29(9):1311-1325. Epub 2024 Jun 18 doi: 10.1007/s10147-024-02573-5. PMID: 38888683
Enfortumab vedotin following platinum-based chemotherapy and immune checkpoint inhibitors for advanced urothelial carcinoma: response, survival and safety analysis from a multicentre real-world Japanese cohort.
Miyake M, Nishimura N, Oda Y, Miyamoto T, Ohmori C, Takamatsu N, Itami Y, Tachibana A, Matsumoto Y, Kiba K, Tomioka A, Yamamoto H, Okajima E, Masaomi K, Sakamoto K, Tomizawa M, Shimizu T, Ohnishi K, Hori S, Morizawa Y, Gotoh D, Nakai Y, Torimoto K, Tanaka N, Fujimoto K; Nara Urological Research and Treatment Group
Jpn J Clin Oncol 2024 Mar 9;54(3):329-338. doi: 10.1093/jjco/hyad170. PMID: 38061911
Switch-maintenance avelumab immunotherapy following first-line chemotherapy for patients with advanced, unresectable or metastatic urothelial carcinoma: the first Japanese real-world evidence from a multicenter study.
Miyake M, Shimizu T, Oda Y, Tachibana A, Ohmori C, Itami Y, Kiba K, Tomioka A, Yamamoto H, Ohnishi K, Nishimura N, Hori S, Morizawa Y, Gotoh D, Nakai Y, Torimoto K, Fujii T, Tanaka N, Fujimoto K
Jpn J Clin Oncol 2023 Mar 7;53(3):253-262. doi: 10.1093/jjco/hyac186. PMID: 36484294
Phase I combination study of the PARP inhibitor veliparib plus carboplatin and gemcitabine in patients with advanced ovarian cancer and other solid malignancies.
Gray HJ, Bell-McGuinn K, Fleming GF, Cristea M, Xiong H, Sullivan D, Luo Y, McKee MD, Munasinghe W, Martin LP
Gynecol Oncol 2018 Mar;148(3):507-514. Epub 2018 Jan 17 doi: 10.1016/j.ygyno.2017.12.029. PMID: 29352572
A phase II trial of sequential chemotherapy with docetaxel and methotrexate followed by gemcitabine and cisplatin for metastatic urothelial cancer.
Artz A, Stadler WM, Vogelzang NJ, Zimmerman T, Ryan C
Am J Clin Oncol 2005 Apr;28(2):109-13. doi: 10.1097/01.coc.0000142591.62299.8f. PMID: 15803001

Therapy

Difference of oncological efficacy between two immune checkpoint inhibitors following first-line platinum-based chemotherapy in patients with unresectable, metastatic, advanced urothelial carcinoma: a multicenter real-world Japanese cohort.
Miyake M, Nishimura N, Oda Y, Miyamoto T, Iida K, Inoue K, Tachibana A, Yoshikawa T, Sakamoto K, Ohnishi M, Maesaka F, Takamatsu N, Mieda K, Ohmori C, Matsubara T, Tomizawa M, Shimizu T, Ohnishi K, Hori S, Morizawa Y, Gotoh D, Nakai Y, Torimoto K, Tanaka N, Fujimoto K; Nara Urological Research and Treatment Group
Int J Clin Oncol 2024 Sep;29(9):1311-1325. Epub 2024 Jun 18 doi: 10.1007/s10147-024-02573-5. PMID: 38888683
Enfortumab vedotin following platinum-based chemotherapy and immune checkpoint inhibitors for advanced urothelial carcinoma: response, survival and safety analysis from a multicentre real-world Japanese cohort.
Miyake M, Nishimura N, Oda Y, Miyamoto T, Ohmori C, Takamatsu N, Itami Y, Tachibana A, Matsumoto Y, Kiba K, Tomioka A, Yamamoto H, Okajima E, Masaomi K, Sakamoto K, Tomizawa M, Shimizu T, Ohnishi K, Hori S, Morizawa Y, Gotoh D, Nakai Y, Torimoto K, Tanaka N, Fujimoto K; Nara Urological Research and Treatment Group
Jpn J Clin Oncol 2024 Mar 9;54(3):329-338. doi: 10.1093/jjco/hyad170. PMID: 38061911
Tailored immunotherapy approach with nivolumab with or without ipilimumab in patients with advanced transitional cell carcinoma after platinum-based chemotherapy (TITAN-TCC): a multicentre, single-arm, phase 2 trial.
Grimm MO, Grün CB, Niegisch G, Pichler M, Roghmann F, Schmitz-Dräger B, Baretton G, Schmitz M, Bolenz C, Foller S, Leucht K, Schumacher U, Schostak M, Meran J, Loidl W, Zengerling F
Lancet Oncol 2023 Apr;24(4):347-359. Epub 2023 Feb 28 doi: 10.1016/S1470-2045(23)00053-0. PMID: 36868252
Immune checkpoint inhibition in upper tract urothelial carcinoma.
Califano G, Ouzaid I, Verze P, Hermieu JF, Mirone V, Xylinas E
World J Urol 2021 May;39(5):1357-1367. Epub 2020 Oct 31 doi: 10.1007/s00345-020-03502-7. PMID: 33128595
Newer developments in the therapeutics of the transitional cell carcinoma of renal pelvis.
Dasanu CA, Ong-Bacay A, Codreanu I
J Oncol Pharm Pract 2012 Mar;18(1):97-103. Epub 2011 Jan 19 doi: 10.1177/1078155210394695. PMID: 21248173

Prognosis

The high incidence of vascular thromboembolic events in patients with metastatic or unresectable urothelial cancer treated with platinum chemotherapy agents.
Tully CM, Apolo AB, Zabor EC, Regazzi AM, Ostrovnaya I, Furberg HF, Rosenberg JE, Bajorin DF
Cancer 2016 Mar 1;122(5):712-21. Epub 2015 Nov 30 doi: 10.1002/cncr.29801. PMID: 26618338Free PMC Article
Long-term results with M-VAC for advanced urothelial cancer: high relapse rate and low survival in patients with a complete response.
Igawa M, Urakami S, Shiina H, Ishibe T, Kadena H, Usui T
Br J Urol 1995 Sep;76(3):321-4. doi: 10.1111/j.1464-410x.1995.tb07708.x. PMID: 7551840
Transitional cell carcinoma of the renal pelvis or ureter: patterns of failure.
Cozad SC, Smalley SR, Austenfeld M, Noble M, Jennings S, Raymond R
Urology 1995 Dec;46(6):796-800. doi: 10.1016/S0090-4295(99)80346-X. PMID: 7502418

Clinical prediction guides

Enfortumab vedotin following platinum-based chemotherapy and immune checkpoint inhibitors for advanced urothelial carcinoma: response, survival and safety analysis from a multicentre real-world Japanese cohort.
Miyake M, Nishimura N, Oda Y, Miyamoto T, Ohmori C, Takamatsu N, Itami Y, Tachibana A, Matsumoto Y, Kiba K, Tomioka A, Yamamoto H, Okajima E, Masaomi K, Sakamoto K, Tomizawa M, Shimizu T, Ohnishi K, Hori S, Morizawa Y, Gotoh D, Nakai Y, Torimoto K, Tanaka N, Fujimoto K; Nara Urological Research and Treatment Group
Jpn J Clin Oncol 2024 Mar 9;54(3):329-338. doi: 10.1093/jjco/hyad170. PMID: 38061911
Tailored immunotherapy approach with nivolumab with or without ipilimumab in patients with advanced transitional cell carcinoma after platinum-based chemotherapy (TITAN-TCC): a multicentre, single-arm, phase 2 trial.
Grimm MO, Grün CB, Niegisch G, Pichler M, Roghmann F, Schmitz-Dräger B, Baretton G, Schmitz M, Bolenz C, Foller S, Leucht K, Schumacher U, Schostak M, Meran J, Loidl W, Zengerling F
Lancet Oncol 2023 Apr;24(4):347-359. Epub 2023 Feb 28 doi: 10.1016/S1470-2045(23)00053-0. PMID: 36868252
Phase I combination study of the PARP inhibitor veliparib plus carboplatin and gemcitabine in patients with advanced ovarian cancer and other solid malignancies.
Gray HJ, Bell-McGuinn K, Fleming GF, Cristea M, Xiong H, Sullivan D, Luo Y, McKee MD, Munasinghe W, Martin LP
Gynecol Oncol 2018 Mar;148(3):507-514. Epub 2018 Jan 17 doi: 10.1016/j.ygyno.2017.12.029. PMID: 29352572
A phase II trial of sequential chemotherapy with docetaxel and methotrexate followed by gemcitabine and cisplatin for metastatic urothelial cancer.
Artz A, Stadler WM, Vogelzang NJ, Zimmerman T, Ryan C
Am J Clin Oncol 2005 Apr;28(2):109-13. doi: 10.1097/01.coc.0000142591.62299.8f. PMID: 15803001

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