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Cirrhosis of the Liver Secondary to Hepatitis C

MedGen UID:
1674707
•Concept ID:
C4763867
•
Disease or Syndrome

Definition

Cirrhosis of the liver that develops as a sequelae of a hepatitis c infection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCirrhosis of the Liver Secondary to Hepatitis C

Professional guidelines

PubMed

The role of fibrosis index FIB-4 in predicting liver fibrosis stage and clinical prognosis: A diagnostic or screening tool?
Xu XL, Jiang LS, Wu CS, Pan LY, Lou ZQ, Peng CT, Dong Y, Ruan B
J Formos Med Assoc 2022 Feb;121(2):454-466. Epub 2021 Jul 26 doi: 10.1016/j.jfma.2021.07.013. PMID: 34325952
Diagnosis and management of secondary causes of steatohepatitis.
Liebe R, Esposito I, Bock HH, Vom Dahl S, Stindt J, Baumann U, Luedde T, Keitel V
J Hepatol 2021 Jun;74(6):1455-1471. Epub 2021 Feb 10 doi: 10.1016/j.jhep.2021.01.045. PMID: 33577920
Liver transplantation beyond or downstaging within the Milan criteria for hepatocellular carcinoma.
Rudnick SR, Russo MW
Expert Rev Gastroenterol Hepatol 2018 Mar;12(3):265-275. Epub 2017 Dec 28 doi: 10.1080/17474124.2018.1417035. PMID: 29231769

Recent clinical studies

Etiology

Preliminary evidence of safety and tolerability of atezolizumab plus bevacizumab in patients with hepatocellular carcinoma and Child-Pugh A and B cirrhosis: A real-world study.
D'Alessio A, Fulgenzi CAM, Nishida N, Schönlein M, von Felden J, Schulze K, Wege H, Gaillard VE, Saeed A, Wietharn B, Hildebrand H, Wu L, Ang C, Marron TU, Weinmann A, Galle PR, Bettinger D, Bengsch B, Vogel A, Balcar L, Scheiner B, Lee PC, Huang YH, Amara S, Muzaffar M, Naqash AR, Cammarota A, Personeni N, Pressiani T, Sharma R, Pinter M, Cortellini A, Kudo M, Rimassa L, Pinato DJ
Hepatology 2022 Oct;76(4):1000-1012. Epub 2022 Apr 8 doi: 10.1002/hep.32468. PMID: 35313048Free PMC Article
BMS-986263 in patients with advanced hepatic fibrosis: 36-week results from a randomized, placebo-controlled phase 2 trial.
Lawitz EJ, Shevell DE, Tirucherai GS, Du S, Chen W, Kavita U, Coste A, Poordad F, Karsdal M, Nielsen M, Goodman Z, Charles ED
Hepatology 2022 Apr;75(4):912-923. Epub 2021 Dec 13 doi: 10.1002/hep.32181. PMID: 34605045Free PMC Article
The role of fibrosis index FIB-4 in predicting liver fibrosis stage and clinical prognosis: A diagnostic or screening tool?
Xu XL, Jiang LS, Wu CS, Pan LY, Lou ZQ, Peng CT, Dong Y, Ruan B
J Formos Med Assoc 2022 Feb;121(2):454-466. Epub 2021 Jul 26 doi: 10.1016/j.jfma.2021.07.013. PMID: 34325952
Artificial intelligence for hepatitis evaluation.
Liu W, Liu X, Peng M, Chen GQ, Liu PH, Cui XW, Jiang F, Dietrich CF
World J Gastroenterol 2021 Sep 14;27(34):5715-5726. doi: 10.3748/wjg.v27.i34.5715. PMID: 34629796Free PMC Article
Outcomes of immunosuppression minimization and withdrawal early after liver transplantation.
Shaked A, DesMarais MR, Kopetskie H, Feng S, Punch JD, Levitsky J, Reyes J, Klintmalm GB, Demetris AJ, Burrell BE, Priore A, Bridges ND, Sayre PH
Am J Transplant 2019 May;19(5):1397-1409. Epub 2018 Dec 31 doi: 10.1111/ajt.15205. PMID: 30506630Free PMC Article

Diagnosis

The role of fibrosis index FIB-4 in predicting liver fibrosis stage and clinical prognosis: A diagnostic or screening tool?
Xu XL, Jiang LS, Wu CS, Pan LY, Lou ZQ, Peng CT, Dong Y, Ruan B
J Formos Med Assoc 2022 Feb;121(2):454-466. Epub 2021 Jul 26 doi: 10.1016/j.jfma.2021.07.013. PMID: 34325952
Artificial intelligence for hepatitis evaluation.
Liu W, Liu X, Peng M, Chen GQ, Liu PH, Cui XW, Jiang F, Dietrich CF
World J Gastroenterol 2021 Sep 14;27(34):5715-5726. doi: 10.3748/wjg.v27.i34.5715. PMID: 34629796Free PMC Article
Diagnosis and management of secondary causes of steatohepatitis.
Liebe R, Esposito I, Bock HH, Vom Dahl S, Stindt J, Baumann U, Luedde T, Keitel V
J Hepatol 2021 Jun;74(6):1455-1471. Epub 2021 Feb 10 doi: 10.1016/j.jhep.2021.01.045. PMID: 33577920
Hepatocellular carcinoma from the view of gastroenterologist/hepatologist.
Petr U, Petr H
Klin Onkol 2020 Fall;33(Supplementum 3):34-44. doi: 10.14735/amko20203S34. PMID: 33213164
Outcomes of immunosuppression minimization and withdrawal early after liver transplantation.
Shaked A, DesMarais MR, Kopetskie H, Feng S, Punch JD, Levitsky J, Reyes J, Klintmalm GB, Demetris AJ, Burrell BE, Priore A, Bridges ND, Sayre PH
Am J Transplant 2019 May;19(5):1397-1409. Epub 2018 Dec 31 doi: 10.1111/ajt.15205. PMID: 30506630Free PMC Article

Therapy

Nonselective beta blockers, hepatic decompensation, and mortality in cirrhosis: A national cohort study.
Serper M, Kaplan DE, Taddei TH, Tapper EB, Cohen JB, Mahmud N
Hepatology 2023 Feb 1;77(2):489-500. Epub 2022 Oct 17 doi: 10.1002/hep.32737. PMID: 35984731Free PMC Article
Preliminary evidence of safety and tolerability of atezolizumab plus bevacizumab in patients with hepatocellular carcinoma and Child-Pugh A and B cirrhosis: A real-world study.
D'Alessio A, Fulgenzi CAM, Nishida N, Schönlein M, von Felden J, Schulze K, Wege H, Gaillard VE, Saeed A, Wietharn B, Hildebrand H, Wu L, Ang C, Marron TU, Weinmann A, Galle PR, Bettinger D, Bengsch B, Vogel A, Balcar L, Scheiner B, Lee PC, Huang YH, Amara S, Muzaffar M, Naqash AR, Cammarota A, Personeni N, Pressiani T, Sharma R, Pinter M, Cortellini A, Kudo M, Rimassa L, Pinato DJ
Hepatology 2022 Oct;76(4):1000-1012. Epub 2022 Apr 8 doi: 10.1002/hep.32468. PMID: 35313048Free PMC Article
BMS-986263 in patients with advanced hepatic fibrosis: 36-week results from a randomized, placebo-controlled phase 2 trial.
Lawitz EJ, Shevell DE, Tirucherai GS, Du S, Chen W, Kavita U, Coste A, Poordad F, Karsdal M, Nielsen M, Goodman Z, Charles ED
Hepatology 2022 Apr;75(4):912-923. Epub 2021 Dec 13 doi: 10.1002/hep.32181. PMID: 34605045Free PMC Article
Outcomes of immunosuppression minimization and withdrawal early after liver transplantation.
Shaked A, DesMarais MR, Kopetskie H, Feng S, Punch JD, Levitsky J, Reyes J, Klintmalm GB, Demetris AJ, Burrell BE, Priore A, Bridges ND, Sayre PH
Am J Transplant 2019 May;19(5):1397-1409. Epub 2018 Dec 31 doi: 10.1111/ajt.15205. PMID: 30506630Free PMC Article
Hepatitis C.
Burra P
Semin Liver Dis 2009 Feb;29(1):53-65. Epub 2009 Feb 23 doi: 10.1055/s-0029-1192055. PMID: 19235659

Prognosis

The role of fibrosis index FIB-4 in predicting liver fibrosis stage and clinical prognosis: A diagnostic or screening tool?
Xu XL, Jiang LS, Wu CS, Pan LY, Lou ZQ, Peng CT, Dong Y, Ruan B
J Formos Med Assoc 2022 Feb;121(2):454-466. Epub 2021 Jul 26 doi: 10.1016/j.jfma.2021.07.013. PMID: 34325952
Artificial intelligence for hepatitis evaluation.
Liu W, Liu X, Peng M, Chen GQ, Liu PH, Cui XW, Jiang F, Dietrich CF
World J Gastroenterol 2021 Sep 14;27(34):5715-5726. doi: 10.3748/wjg.v27.i34.5715. PMID: 34629796Free PMC Article
Outcomes of immunosuppression minimization and withdrawal early after liver transplantation.
Shaked A, DesMarais MR, Kopetskie H, Feng S, Punch JD, Levitsky J, Reyes J, Klintmalm GB, Demetris AJ, Burrell BE, Priore A, Bridges ND, Sayre PH
Am J Transplant 2019 May;19(5):1397-1409. Epub 2018 Dec 31 doi: 10.1111/ajt.15205. PMID: 30506630Free PMC Article
Viral hepatitis and liver transplantation: pathogenesis, prevention and therapy of recurrent disease.
Gambato M, Lens S, Fernández-Carrillo C, Alfaro I, Forns X
Dig Dis 2014;32(5):538-44. Epub 2014 Jul 14 doi: 10.1159/000360831. PMID: 25034286
Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis.
Mazzaferro V, Regalia E, Doci R, Andreola S, Pulvirenti A, Bozzetti F, Montalto F, Ammatuna M, Morabito A, Gennari L
N Engl J Med 1996 Mar 14;334(11):693-9. doi: 10.1056/NEJM199603143341104. PMID: 8594428

Clinical prediction guides

BMS-986263 in patients with advanced hepatic fibrosis: 36-week results from a randomized, placebo-controlled phase 2 trial.
Lawitz EJ, Shevell DE, Tirucherai GS, Du S, Chen W, Kavita U, Coste A, Poordad F, Karsdal M, Nielsen M, Goodman Z, Charles ED
Hepatology 2022 Apr;75(4):912-923. Epub 2021 Dec 13 doi: 10.1002/hep.32181. PMID: 34605045Free PMC Article
The role of fibrosis index FIB-4 in predicting liver fibrosis stage and clinical prognosis: A diagnostic or screening tool?
Xu XL, Jiang LS, Wu CS, Pan LY, Lou ZQ, Peng CT, Dong Y, Ruan B
J Formos Med Assoc 2022 Feb;121(2):454-466. Epub 2021 Jul 26 doi: 10.1016/j.jfma.2021.07.013. PMID: 34325952
Artificial intelligence for hepatitis evaluation.
Liu W, Liu X, Peng M, Chen GQ, Liu PH, Cui XW, Jiang F, Dietrich CF
World J Gastroenterol 2021 Sep 14;27(34):5715-5726. doi: 10.3748/wjg.v27.i34.5715. PMID: 34629796Free PMC Article
Pleiotropic effects of statins in the diseases of the liver.
Janicko M, Drazilova S, Pella D, Fedacko J, Jarcuska P
World J Gastroenterol 2016 Jul 21;22(27):6201-13. doi: 10.3748/wjg.v22.i27.6201. PMID: 27468210Free PMC Article
Hepatitis C in the pediatric population: transmission, natural history, treatment and liver transplantation.
Khaderi S, Shepherd R, Goss JA, Leung DH
World J Gastroenterol 2014 Aug 28;20(32):11281-6. doi: 10.3748/wjg.v20.i32.11281. PMID: 25170212Free PMC Article

Recent systematic reviews

Hepatitis B reactivation in hepatitis B and C coinfected patients treated with antiviral agents: A systematic review and meta-analysis.
Chen G, Wang C, Chen J, Ji D, Wang Y, Wu V, Karlberg J, Lau G
Hepatology 2017 Jul;66(1):13-26. Epub 2017 May 27 doi: 10.1002/hep.29109. PMID: 28195337
Antiviral prophylaxis for the prevention of chronic hepatitis C virus in patients undergoing liver transplantation.
Gurusamy KS, Tsochatzis E, Toon CD, Davidson BR, Burroughs AK
Cochrane Database Syst Rev 2013 Dec 2;2013(12):CD006573. doi: 10.1002/14651858.CD006573.pub3. PMID: 24297303Free PMC Article
Interferon for interferon nonresponding and relapsing patients with chronic hepatitis C.
Koretz RL, Pleguezuelo M, Arvaniti V, Barrera Baena P, Ciria R, Gurusamy KS, Davidson BR, Burroughs AK
Cochrane Database Syst Rev 2013 Jan 31;2013(1):CD003617. doi: 10.1002/14651858.CD003617.pub2. PMID: 23440791Free PMC Article
Pegylated-interferon and ribavirin in liver transplant candidates and recipients with HCV cirrhosis: systematic review and meta-analysis of prospective controlled studies.
Xirouchakis E, Triantos C, Manousou P, Sigalas A, Calvaruso V, Corbani A, Leandro G, Patch D, Burroughs A
J Viral Hepat 2008 Oct;15(10):699-709. Epub 2008 Jul 28 doi: 10.1111/j.1365-2893.2008.01019.x. PMID: 18673428
Bicyclol for chronic hepatitis C.
Yang XY, Zhuo Q, Wu TX, Liu GJ
Cochrane Database Syst Rev 2007 Jan 24;(1):CD004994. doi: 10.1002/14651858.CD004994.pub2. PMID: 17253534

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