U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Refractory Lymphoproliferative Disorder

MedGen UID:
1675052
•Concept ID:
C4763790
•
Disease or Syndrome

Definition

Lymphoproliferative disorder that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Lymphoproliferative Disorder

Professional guidelines

PubMed

Waldenström macroglobulinemia: 2021 update on diagnosis, risk stratification, and management.
Gertz MA
Am J Hematol 2021 Feb 1;96(2):258-269. doi: 10.1002/ajh.26082. PMID: 33368476
Multiple myeloma: 2020 update on diagnosis, risk-stratification and management.
Rajkumar SV
Am J Hematol 2020 May;95(5):548-567. doi: 10.1002/ajh.25791. PMID: 32212178
Chronic lymphocytic leukemia: 2020 update on diagnosis, risk stratification and treatment.
Hallek M
Am J Hematol 2019 Nov;94(11):1266-1287. Epub 2019 Oct 4 doi: 10.1002/ajh.25595. PMID: 31364186

Recent clinical studies

Etiology

Extramedullary disease in multiple myeloma: a systematic literature review.
Bladé J, Beksac M, Caers J, Jurczyszyn A, von Lilienfeld-Toal M, Moreau P, Rasche L, Rosiñol L, Usmani SZ, Zamagni E, Richardson P
Blood Cancer J 2022 Mar 21;12(3):45. doi: 10.1038/s41408-022-00643-3. PMID: 35314675Free PMC Article
CLL update 2022: A continuing evolution in care.
Kay NE, Hampel PJ, Van Dyke DL, Parikh SA
Blood Rev 2022 Jul;54:100930. Epub 2022 Jan 26 doi: 10.1016/j.blre.2022.100930. PMID: 35151528
Recent Advances in Managing Acute Lymphoblastic Leukemia.
DeAngelo DJ, Jabbour E, Advani A
Am Soc Clin Oncol Educ Book 2020 May;40:330-342. doi: 10.1200/EDBK_280175. PMID: 32421447
Acute lymphoblastic leukaemia.
Malard F, Mohty M
Lancet 2020 Apr 4;395(10230):1146-1162. doi: 10.1016/S0140-6736(19)33018-1. PMID: 32247396
Transformed follicular lymphoma.
Fischer T, Zing NPC, Chiattone CS, Federico M, Luminari S
Ann Hematol 2018 Jan;97(1):17-29. Epub 2017 Oct 18 doi: 10.1007/s00277-017-3151-2. PMID: 29043381

Diagnosis

Sarcoidosis.
Brito-Zerón P, Pérez-Álvarez R, Ramos-Casals M
Med Clin (Barc) 2022 Aug 26;159(4):195-204. Epub 2022 Jun 6 doi: 10.1016/j.medcli.2022.03.009. PMID: 35680449
Recent Advances in Diagnosis and Therapy of Angioimmunoblastic T Cell Lymphoma.
Mohammed Saleh MF, Kotb A, Abdallah GEM, Muhsen IN, El Fakih R, Aljurf M
Curr Oncol 2021 Dec 20;28(6):5480-5498. doi: 10.3390/curroncol28060456. PMID: 34940095Free PMC Article
Acute lymphoblastic leukaemia.
Malard F, Mohty M
Lancet 2020 Apr 4;395(10230):1146-1162. doi: 10.1016/S0140-6736(19)33018-1. PMID: 32247396
Primary CNS Lymphoma.
Grommes C, DeAngelis LM
J Clin Oncol 2017 Jul 20;35(21):2410-2418. Epub 2017 Jun 22 doi: 10.1200/JCO.2017.72.7602. PMID: 28640701Free PMC Article
Sarcoidosis.
Valeyre D, Prasse A, Nunes H, Uzunhan Y, Brillet PY, Müller-Quernheim J
Lancet 2014 Mar 29;383(9923):1155-67. Epub 2013 Oct 1 doi: 10.1016/S0140-6736(13)60680-7. PMID: 24090799

Therapy

Chronic lymphocytic leukemia: 2022 update on diagnostic and therapeutic procedures.
Hallek M, Al-Sawaf O
Am J Hematol 2021 Dec 1;96(12):1679-1705. doi: 10.1002/ajh.26367. PMID: 34625994
Immunotherapy in pediatric acute lymphoblastic leukemia.
Inaba H, Pui CH
Cancer Metastasis Rev 2019 Dec;38(4):595-610. doi: 10.1007/s10555-019-09834-0. PMID: 31811553Free PMC Article
Management of relapsed and refractory multiple myeloma: novel agents, antibodies, immunotherapies and beyond.
Chim CS, Kumar SK, Orlowski RZ, Cook G, Richardson PG, Gertz MA, Giralt S, Mateos MV, Leleu X, Anderson KC
Leukemia 2018 Feb;32(2):252-262. Epub 2017 Nov 16 doi: 10.1038/leu.2017.329. PMID: 29257139Free PMC Article
Primary CNS Lymphoma.
Grommes C, DeAngelis LM
J Clin Oncol 2017 Jul 20;35(21):2410-2418. Epub 2017 Jun 22 doi: 10.1200/JCO.2017.72.7602. PMID: 28640701Free PMC Article
Bortezomib for the treatment of multiple myeloma.
Scott K, Hayden PJ, Will A, Wheatley K, Coyne I
Cochrane Database Syst Rev 2016 Apr 20;4(4):CD010816. doi: 10.1002/14651858.CD010816.pub2. PMID: 27096326Free PMC Article

Prognosis

Enteropathy-Associated T cell Lymphoma.
Al Somali Z, Hamadani M, Kharfan-Dabaja M, Sureda A, El Fakih R, Aljurf M
Curr Hematol Malig Rep 2021 Apr;16(2):140-147. Epub 2021 May 19 doi: 10.1007/s11899-021-00634-4. PMID: 34009525
Effect of Blinatumomab vs Chemotherapy on Event-Free Survival Among Children With High-risk First-Relapse B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial.
Locatelli F, Zugmaier G, Rizzari C, Morris JD, Gruhn B, Klingebiel T, Parasole R, Linderkamp C, Flotho C, Petit A, Micalizzi C, Mergen N, Mohammad A, Kormany WN, Eckert C, Möricke A, Sartor M, Hrusak O, Peters C, Saha V, Vinti L, von Stackelberg A
JAMA 2021 Mar 2;325(9):843-854. doi: 10.1001/jama.2021.0987. PMID: 33651091Free PMC Article
Hodgkin lymphoma.
Connors JM, Cozen W, Steidl C, Carbone A, Hoppe RT, Flechtner HH, Bartlett NL
Nat Rev Dis Primers 2020 Jul 23;6(1):61. doi: 10.1038/s41572-020-0189-6. PMID: 32703953
Tafasitamab plus lenalidomide in relapsed or refractory diffuse large B-cell lymphoma (L-MIND): a multicentre, prospective, single-arm, phase 2 study.
Salles G, Duell J, González Barca E, Tournilhac O, Jurczak W, Liberati AM, Nagy Z, Obr A, Gaidano G, André M, Kalakonda N, Dreyling M, Weirather J, Dirnberger-Hertweck M, Ambarkhane S, Fingerle-Rowson G, Maddocks K
Lancet Oncol 2020 Jul;21(7):978-988. Epub 2020 Jun 5 doi: 10.1016/S1470-2045(20)30225-4. PMID: 32511983
Management of relapsed/refractory DLBCL.
Sarkozy C, Sehn LH
Best Pract Res Clin Haematol 2018 Sep;31(3):209-216. Epub 2018 Jul 23 doi: 10.1016/j.beha.2018.07.014. PMID: 30213390

Clinical prediction guides

Hodgkin lymphoma.
Connors JM, Cozen W, Steidl C, Carbone A, Hoppe RT, Flechtner HH, Bartlett NL
Nat Rev Dis Primers 2020 Jul 23;6(1):61. doi: 10.1038/s41572-020-0189-6. PMID: 32703953
The Changing Landscape of Autoimmune Hemolytic Anemia.
Barcellini W, Fattizzo B
Front Immunol 2020;11:946. Epub 2020 Jun 3 doi: 10.3389/fimmu.2020.00946. PMID: 32655543Free PMC Article
Update on mantle cell lymphoma.
Maddocks K
Blood 2018 Oct 18;132(16):1647-1656. Epub 2018 Aug 28 doi: 10.1182/blood-2018-03-791392. PMID: 30154113
Pulmonary sarcoidosis.
Spagnolo P, Rossi G, Trisolini R, Sverzellati N, Baughman RP, Wells AU
Lancet Respir Med 2018 May;6(5):389-402. Epub 2018 Apr 3 doi: 10.1016/S2213-2600(18)30064-X. PMID: 29625772
Advances in adult acute lymphoblastic leukemia therapy.
Aldoss I, Stein AS
Leuk Lymphoma 2018 May;59(5):1033-1050. Epub 2017 Jul 26 doi: 10.1080/10428194.2017.1354372. PMID: 28745565

Recent systematic reviews

Relapsed and refractory multiple myeloma: A systematic review and network meta-analysis of the efficacy of novel therapies.
Minakata D, Fujiwara SI, Yokoyama D, Noguchi A, Aoe S, Oyama T, Koyama S, Murahashi R, Nakashima H, Hyodo K, Ikeda T, Kawaguchi SI, Toda Y, Ito S, Nagayama T, Mashima K, Umino K, Morita K, Ashizawa M, Yamamoto C, Hatano K, Sato K, Ohmine K, Kanda Y
Br J Haematol 2023 Mar;200(6):694-703. Epub 2023 Jan 20 doi: 10.1111/bjh.18654. PMID: 36661264
CAR-T cell therapy for patients with hematological malignancies. A systematic review.
Pasqui DM, Latorraca CDOC, Pacheco RL, Riera R
Eur J Haematol 2022 Dec;109(6):601-618. Epub 2022 Sep 18 doi: 10.1111/ejh.13851. PMID: 36018500
Extramedullary disease in multiple myeloma: a systematic literature review.
Bladé J, Beksac M, Caers J, Jurczyszyn A, von Lilienfeld-Toal M, Moreau P, Rasche L, Rosiñol L, Usmani SZ, Zamagni E, Richardson P
Blood Cancer J 2022 Mar 21;12(3):45. doi: 10.1038/s41408-022-00643-3. PMID: 35314675Free PMC Article
Burkitt and Burkitt-Like Lymphomas: a Systematic Review.
Saleh K, Michot JM, Camara-Clayette V, Vassetsky Y, Ribrag V
Curr Oncol Rep 2020 Mar 6;22(4):33. doi: 10.1007/s11912-020-0898-8. PMID: 32144513
Bortezomib for the treatment of multiple myeloma.
Scott K, Hayden PJ, Will A, Wheatley K, Coyne I
Cochrane Database Syst Rev 2016 Apr 20;4(4):CD010816. doi: 10.1002/14651858.CD010816.pub2. PMID: 27096326Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...