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JAK2 Gene Rearrangement

MedGen UID:
1675259
•Concept ID:
C4763711
•
Cell or Molecular Dysfunction
Synonyms: JAK-2 Gene Rearrangement; JAK2 Rearrangement; Janus Kinase 2 Gene Rearrangement; JTK10 Gene Rearrangement

Definition

A molecular abnormality indicating rearrangement of the JAK2 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVJAK2 Gene Rearrangement

Professional guidelines

PubMed

Clinicopathologic characteristics, genetic features, and treatment options for acute lymphoblastic leukemia with JAK2 rearrangement-A 10-case study and literature review.
Zhang L, Shah B, Zhang Y, Tashkandi H, Xiao W, Fernandez-Pol S, Vergara-Lluri M, Hussaini M, Song J, Lancet J, Moscinski L, Yun S, Lu CM, Medeiros LJ, Tang G
Hum Pathol 2023 Jun;136:1-15. Epub 2023 Mar 22 doi: 10.1016/j.humpath.2023.03.002. PMID: 36958463
World Health Organization-defined eosinophilic disorders: 2022 update on diagnosis, risk stratification, and management.
Shomali W, Gotlib J
Am J Hematol 2022 Jan 1;97(1):129-148. Epub 2021 Oct 8 doi: 10.1002/ajh.26352. PMID: 34533850
Molecular genetic tests for JAK2V617F, Exon12_JAK2 and MPLW515K/L are highly informative in the evaluation of patients suspected to have BCR-ABL1-negative myeloproliferative neoplasms.
dos Santos MT, Mitne-Neto M, Miyashiro K, Chauffaille Mde L, Rizzatti EG
J Clin Pathol 2014 Feb;67(2):176-8. Epub 2013 Aug 28 doi: 10.1136/jclinpath-2013-201822. PMID: 23986553Free PMC Article

Recent clinical studies

Diagnosis

VITREORETINAL INVOLVEMENT BY INDOLENT T-CELL LYMPHOPROLIFERATIVE DISORDER OF THE GASTROINTESTINAL TRACT DIAGNOSED BY FLUORESCENCE IN SITU HYBRIDIZATION.
Salman AR, Ferenchak K, Olsen TW, Smith WM, Ketterling RP, McPhail ED, Salomao DR, Dalvin LA
Retin Cases Brief Rep 2023 Sep 1;17(5):572-576. doi: 10.1097/ICB.0000000000001263. PMID: 37490925

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