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Iodine deficiency

MedGen UID:
1675459
•Concept ID:
C4759669
•
Disease or Syndrome
Synonym: Iodine Deficiency
SNOMED CT: Iodine deficiency (238121000)

Definition

A deficiency of iodine in the diet. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIodine deficiency

Professional guidelines

PubMed

Assessment and treatment of thyroid disorders in pregnancy and the postpartum period.
Lee SY, Pearce EN
Nat Rev Endocrinol 2022 Mar;18(3):158-171. Epub 2022 Jan 4 doi: 10.1038/s41574-021-00604-z. PMID: 34983968Free PMC Article
Evaluation and management of the child with hypothyroidism.
Leung AKC, Leung AAC
World J Pediatr 2019 Apr;15(2):124-134. Epub 2019 Feb 8 doi: 10.1007/s12519-019-00230-w. PMID: 30734891
Etiopathology, clinical features, and treatment of diffuse and multinodular nontoxic goiters.
Knobel M
J Endocrinol Invest 2016 Apr;39(4):357-73. Epub 2015 Sep 21 doi: 10.1007/s40618-015-0391-7. PMID: 26392367

Recent clinical studies

Etiology

Iodine and Iodine Deficiency: A Comprehensive Review of a Re-Emerging Issue.
Hatch-McChesney A, Lieberman HR
Nutrients 2022 Aug 24;14(17) doi: 10.3390/nu14173474. PMID: 36079737Free PMC Article
Assessment and treatment of thyroid disorders in pregnancy and the postpartum period.
Lee SY, Pearce EN
Nat Rev Endocrinol 2022 Mar;18(3):158-171. Epub 2022 Jan 4 doi: 10.1038/s41574-021-00604-z. PMID: 34983968Free PMC Article
Iodine deficiency and thyroid disorders.
Zimmermann MB, Boelaert K
Lancet Diabetes Endocrinol 2015 Apr;3(4):286-95. Epub 2015 Jan 13 doi: 10.1016/S2213-8587(14)70225-6. PMID: 25591468
Iodine deficiency.
Zimmermann MB
Endocr Rev 2009 Jun;30(4):376-408. Epub 2009 May 21 doi: 10.1210/er.2009-0011. PMID: 19460960
Iodine-deficiency disorders.
Zimmermann MB, Jooste PL, Pandav CS
Lancet 2008 Oct 4;372(9645):1251-62. doi: 10.1016/S0140-6736(08)61005-3. PMID: 18676011

Diagnosis

MECHANISMS IN ENDOCRINOLOGY: The pathophysiology of transient congenital hypothyroidism.
Peters C, Schoenmakers N
Eur J Endocrinol 2022 Jun 20;187(2):R1-R16. doi: 10.1530/EJE-21-1278. PMID: 35588090Free PMC Article
Assessment and treatment of thyroid disorders in pregnancy and the postpartum period.
Lee SY, Pearce EN
Nat Rev Endocrinol 2022 Mar;18(3):158-171. Epub 2022 Jan 4 doi: 10.1038/s41574-021-00604-z. PMID: 34983968Free PMC Article
Current Evaluation of Thyroid Nodules.
Holt EH
Med Clin North Am 2021 Nov;105(6):1017-1031. doi: 10.1016/j.mcna.2021.06.006. PMID: 34688412
Congenital Hypothyroidism.
Wassner AJ
Clin Perinatol 2018 Mar;45(1):1-18. doi: 10.1016/j.clp.2017.10.004. PMID: 29405999
Epidemiology of thyroid nodules.
Dean DS, Gharib H
Best Pract Res Clin Endocrinol Metab 2008 Dec;22(6):901-11. doi: 10.1016/j.beem.2008.09.019. PMID: 19041821

Therapy

Iodine Deficiency and Supplementation in Pregnancy.
Chittimoju SB, Pearce EN
Clin Obstet Gynecol 2019 Jun;62(2):330-338. doi: 10.1097/GRF.0000000000000428. PMID: 30829881
Evidence-based interventions for improvement of maternal and child nutrition: what can be done and at what cost?
Bhutta ZA, Das JK, Rizvi A, Gaffey MF, Walker N, Horton S, Webb P, Lartey A, Black RE; Lancet Nutrition Interventions Review Group, the Maternal and Child Nutrition Study Group
Lancet 2013 Aug 3;382(9890):452-477. Epub 2013 Jun 6 doi: 10.1016/S0140-6736(13)60996-4. PMID: 23746776
Role of iodine, selenium and other micronutrients in thyroid function and disorders.
Triggiani V, Tafaro E, Giagulli VA, Sabbà C, Resta F, Licchelli B, Guastamacchia E
Endocr Metab Immune Disord Drug Targets 2009 Sep;9(3):277-94. Epub 2009 Sep 1 doi: 10.2174/187153009789044392. PMID: 19594417
Iodine deficiency.
Zimmermann MB
Endocr Rev 2009 Jun;30(4):376-408. Epub 2009 May 21 doi: 10.1210/er.2009-0011. PMID: 19460960
Iodine-deficiency disorders.
Zimmermann MB, Jooste PL, Pandav CS
Lancet 2008 Oct 4;372(9645):1251-62. doi: 10.1016/S0140-6736(08)61005-3. PMID: 18676011

Prognosis

MECHANISMS IN ENDOCRINOLOGY: The pathophysiology of transient congenital hypothyroidism.
Peters C, Schoenmakers N
Eur J Endocrinol 2022 Jun 20;187(2):R1-R16. doi: 10.1530/EJE-21-1278. PMID: 35588090Free PMC Article
Consequences of Severe Iodine Deficiency in Pregnancy: Evidence in Humans.
Toloza FJK, Motahari H, Maraka S
Front Endocrinol (Lausanne) 2020;11:409. Epub 2020 Jun 19 doi: 10.3389/fendo.2020.00409. PMID: 32636808Free PMC Article
Congenital Hypothyroidism.
Wassner AJ
Clin Perinatol 2018 Mar;45(1):1-18. doi: 10.1016/j.clp.2017.10.004. PMID: 29405999
The epidemiology of thyroid disease.
Vanderpump MP
Br Med Bull 2011;99:39-51. doi: 10.1093/bmb/ldr030. PMID: 21893493
Maternal and child undernutrition: global and regional exposures and health consequences.
Black RE, Allen LH, Bhutta ZA, Caulfield LE, de Onis M, Ezzati M, Mathers C, Rivera J; Maternal and Child Undernutrition Study Group
Lancet 2008 Jan 19;371(9608):243-60. doi: 10.1016/S0140-6736(07)61690-0. PMID: 18207566

Clinical prediction guides

MECHANISMS IN ENDOCRINOLOGY: The pathophysiology of transient congenital hypothyroidism.
Peters C, Schoenmakers N
Eur J Endocrinol 2022 Jun 20;187(2):R1-R16. doi: 10.1530/EJE-21-1278. PMID: 35588090Free PMC Article
Iodoprophylaxis and thyroid autoimmunity: an update.
Teti C, Panciroli M, Nazzari E, Pesce G, Mariotti S, Olivieri A, Bagnasco M
Immunol Res 2021 Apr;69(2):129-138. Epub 2021 Apr 29 doi: 10.1007/s12026-021-09192-6. PMID: 33914231Free PMC Article
Iodine status and supplementation before, during, and after pregnancy.
Rodriguez-Diaz E, Pearce EN
Best Pract Res Clin Endocrinol Metab 2020 Jul;34(4):101430. Epub 2020 Jun 19 doi: 10.1016/j.beem.2020.101430. PMID: 32792134
Soils and geomedicine.
Steinnes E
Environ Geochem Health 2009 Oct;31(5):523-35. doi: 10.1007/s10653-009-9257-2. PMID: 19350398
Epidemiology of thyroid nodules.
Dean DS, Gharib H
Best Pract Res Clin Endocrinol Metab 2008 Dec;22(6):901-11. doi: 10.1016/j.beem.2008.09.019. PMID: 19041821

Recent systematic reviews

Systematic review and meta-analysis of iodine nutrition in modern vegan and vegetarian diets.
Eveleigh ER, Coneyworth L, Welham SJM
Br J Nutr 2023 Nov 14;130(9):1580-1594. Epub 2023 Mar 13 doi: 10.1017/S000711452300051X. PMID: 36912094Free PMC Article
The effect of sodium restriction on iodine prophylaxis: a review.
Nista F, Bagnasco M, Gatto F, Albertelli M, Vera L, Boschetti M, Musso N, Ferone D
J Endocrinol Invest 2022 Jun;45(6):1121-1138. Epub 2022 Jan 25 doi: 10.1007/s40618-022-01749-y. PMID: 35079975
Micronutrient's deficiency in India: a systematic review and meta-analysis.
Venkatesh U, Sharma A, Ananthan VA, Subbiah P, Durga R; CSIR Summer Research training team
J Nutr Sci 2021;10:e110. Epub 2021 Dec 21 doi: 10.1017/jns.2021.102. PMID: 35059191Free PMC Article
Implications of iodine deficiency by gestational trimester: a systematic review.
Candido AC, Azevedo FM, Machamba AAL, Pinto CA, Lopes SO, de Souza Macedo M, Ribeiro SAV, Priore SE, do Carmo Castro Franceschini S
Arch Endocrinol Metab 2021 May 18;64(5):507-513. doi: 10.20945/2359-3997000000289. PMID: 34033289Free PMC Article
Iodine deficiency status in the WHO Eastern Mediterranean Region: a systematic review.
Mohammadi M, Azizi F, Hedayati M
Environ Geochem Health 2018 Feb;40(1):87-97. Epub 2017 Feb 21 doi: 10.1007/s10653-017-9911-z. PMID: 28224254

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