U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Refractory Spindle Cell Sarcoma

MedGen UID:
1676240
•Concept ID:
C4764230
•
Neoplastic Process

Definition

Spindle cell sarcoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Spindle Cell Sarcoma

Professional guidelines

PubMed

Advances in the Management of Pediatric Sarcomas.
Hernandez Tejada FN, Zamudio A, Marques-Piubelli ML, Cuglievan B, Harrison D
Curr Oncol Rep 2020 Nov 16;23(1):3. doi: 10.1007/s11912-020-00995-8. PMID: 33196879
The treatment of renal hyperparathyroidism.
Almquist M, Isaksson E, Clyne N
Endocr Relat Cancer 2020 Jan;27(1):R21-R34. doi: 10.1530/ERC-19-0284. PMID: 31693488
Anti-viral treatment and cancer control.
Shih WL, Fang CT, Chen PJ
Recent Results Cancer Res 2014;193:269-90. doi: 10.1007/978-3-642-38965-8_14. PMID: 24008303

Recent clinical studies

Therapy

A Phase I/II Trial of Nivolumab plus Ipilimumab in Children and Young Adults with Relapsed/Refractory Solid Tumors: A Children's Oncology Group Study ADVL1412.
Davis KL, Fox E, Isikwei E, Reid JM, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Clin Cancer Res 2022 Dec 1;28(23):5088-5097. doi: 10.1158/1078-0432.CCR-22-2164. PMID: 36190525Free PMC Article
Randomized Phase II Trial of Vincristine-Irinotecan With or Without Temozolomide, in Children and Adults With Relapsed or Refractory Rhabdomyosarcoma: A European Paediatric Soft Tissue Sarcoma Study Group and Innovative Therapies for Children With Cancer Trial.
Defachelles AS, Bogart E, Casanova M, Merks JHM, Bisogno G, Calareso G, Gallego Melcon S, Gatz SA, Le Deley MC, McHugh K, Probst A, Rocourt N, van Rijn RR, Wheatley K, Minard-Colin V, Chisholm JC
J Clin Oncol 2021 Sep 20;39(27):2979-2990. Epub 2021 Aug 3 doi: 10.1200/JCO.21.00124. PMID: 34343032
Naxitamab: First Approval.
Markham A
Drugs 2021 Feb;81(2):291-296. doi: 10.1007/s40265-021-01467-4. PMID: 33616889
Human Epidermal Growth Factor Receptor 2 (HER2) -Specific Chimeric Antigen Receptor-Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma.
Ahmed N, Brawley VS, Hegde M, Robertson C, Ghazi A, Gerken C, Liu E, Dakhova O, Ashoori A, Corder A, Gray T, Wu MF, Liu H, Hicks J, Rainusso N, Dotti G, Mei Z, Grilley B, Gee A, Rooney CM, Brenner MK, Heslop HE, Wels WS, Wang LL, Anderson P, Gottschalk S
J Clin Oncol 2015 May 20;33(15):1688-96. Epub 2015 Mar 23 doi: 10.1200/JCO.2014.58.0225. PMID: 25800760Free PMC Article
Ewing's sarcoma.
Karosas AO
Am J Health Syst Pharm 2010 Oct 1;67(19):1599-605. doi: 10.2146/ajhp090526. PMID: 20852160

Prognosis

Alternative RNA splicing defects in pediatric cancers: new insights in tumorigenesis and potential therapeutic vulnerabilities.
Venkataramany AS, Schieffer KM, Lee K, Cottrell CE, Wang PY, Mardis ER, Cripe TP, Chandler DS
Ann Oncol 2022 Jun;33(6):578-592. Epub 2022 Mar 23 doi: 10.1016/j.annonc.2022.03.011. PMID: 35339647
Progress Update in Pediatric Renal Tumors.
Jain J, Sutton KS, Hong AL
Curr Oncol Rep 2021 Feb 16;23(3):33. doi: 10.1007/s11912-021-01016-y. PMID: 33591402
SMARCB1/INI1-deficient tumors of adulthood.
Parker NA, Al-Obaidi A, Deutsch JM
F1000Res 2020;9:662. Epub 2020 Jun 30 doi: 10.12688/f1000research.24808.2. PMID: 33796273Free PMC Article
Single-cell RNA sequencing reveals the tumor microenvironment and facilitates strategic choices to circumvent treatment failure in a chemorefractory bladder cancer patient.
Lee HW, Chung W, Lee HO, Jeong DE, Jo A, Lim JE, Hong JH, Nam DH, Jeong BC, Park SH, Joo KM, Park WY
Genome Med 2020 May 27;12(1):47. doi: 10.1186/s13073-020-00741-6. PMID: 32460812Free PMC Article
Ewing's sarcoma.
Karosas AO
Am J Health Syst Pharm 2010 Oct 1;67(19):1599-605. doi: 10.2146/ajhp090526. PMID: 20852160

Clinical prediction guides

Tazemetostat for tumors harboring SMARCB1/SMARCA4 or EZH2 alterations: results from NCI-COG pediatric MATCH APEC1621C.
Chi SN, Yi JS, Williams PM, Roy-Chowdhuri S, Patton DR, Coffey BD, Reid JM, Piao J, Saguilig L, Alonzo TA, Berg SL, Ramirez NC, Jaju A, Mhlanga JC, Fox E, Hawkins DS, Mooney MM, Takebe N, Tricoli JV, Janeway KA, Seibel NL, Parsons DW
J Natl Cancer Inst 2023 Nov 8;115(11):1355-1363. doi: 10.1093/jnci/djad085. PMID: 37228094Free PMC Article
A Phase I/II Trial of Nivolumab plus Ipilimumab in Children and Young Adults with Relapsed/Refractory Solid Tumors: A Children's Oncology Group Study ADVL1412.
Davis KL, Fox E, Isikwei E, Reid JM, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Clin Cancer Res 2022 Dec 1;28(23):5088-5097. doi: 10.1158/1078-0432.CCR-22-2164. PMID: 36190525Free PMC Article
Alternative RNA splicing defects in pediatric cancers: new insights in tumorigenesis and potential therapeutic vulnerabilities.
Venkataramany AS, Schieffer KM, Lee K, Cottrell CE, Wang PY, Mardis ER, Cripe TP, Chandler DS
Ann Oncol 2022 Jun;33(6):578-592. Epub 2022 Mar 23 doi: 10.1016/j.annonc.2022.03.011. PMID: 35339647
Nivolumab in children and young adults with relapsed or refractory solid tumours or lymphoma (ADVL1412): a multicentre, open-label, single-arm, phase 1-2 trial.
Davis KL, Fox E, Merchant MS, Reid JM, Kudgus RA, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Lancet Oncol 2020 Apr;21(4):541-550. Epub 2020 Mar 17 doi: 10.1016/S1470-2045(20)30023-1. PMID: 32192573Free PMC Article
Tazemetostat, an EZH2 inhibitor, in relapsed or refractory B-cell non-Hodgkin lymphoma and advanced solid tumours: a first-in-human, open-label, phase 1 study.
Italiano A, Soria JC, Toulmonde M, Michot JM, Lucchesi C, Varga A, Coindre JM, Blakemore SJ, Clawson A, Suttle B, McDonald AA, Woodruff M, Ribich S, Hedrick E, Keilhack H, Thomson B, Owa T, Copeland RA, Ho PTC, Ribrag V
Lancet Oncol 2018 May;19(5):649-659. Epub 2018 Apr 9 doi: 10.1016/S1470-2045(18)30145-1. PMID: 29650362

Recent systematic reviews

The efficacy of gemcitabine and docetaxel chemotherapy for the treatment of relapsed and refractory osteosarcoma: A systematic review and pre-clinical study.
Low K, Foulkes P, Hills F, Roberts HC, Stordal B
Cancer Med 2024 Sep;13(18):e70248. doi: 10.1002/cam4.70248. PMID: 39315544Free PMC Article
A systematic review of combined surgery and brachytherapy approaches for children and young people with relapsed and refractory rhabdomyosarcoma (Local-REFoRMS).
Ballantyne E, Evans C, Shepherd L, Fulbright H, Wakeling S, Phillips B, Morgan JE
Pediatr Blood Cancer 2024 Jun;71(6):e30952. Epub 2024 Apr 2 doi: 10.1002/pbc.30952. PMID: 38566349
High-dose chemotherapy for Ewing sarcoma and Rhabdomyosarcoma: A systematic review by the Australia and New Zealand sarcoma association clinical practice guidelines working party.
Ramamurthy A, Connolly EA, Mar J, Lewin J, Bhadri VA, Phillips MB, Winstanley M, Orme LM, Grimison P, Connor J, Lazarakis S, Hong AM, Omer N, Cayrol J
Cancer Treat Rev 2024 Mar;124:102694. Epub 2024 Feb 2 doi: 10.1016/j.ctrv.2024.102694. PMID: 38325070
A systematic review of early phase studies for children and young people with relapsed and refractory rhabdomyosarcoma: The REFoRMS-SR project.
Evans C, Shepherd L, Bryan G, Fulbright H, Crowther S, Wakeling S, Stewart A, Stewart C, Chisholm J, Gibson F, Phillips B, Morgan JE
Int J Cancer 2024 Apr 1;154(7):1235-1260. Epub 2023 Dec 10 doi: 10.1002/ijc.34808. PMID: 38071594
Systematic review of phase-I/II trials enrolling refractory and recurrent Ewing sarcoma: Actual knowledge and future directions to optimize the research.
Felix A, Berlanga P, Toulmonde M, Landman-Parker J, Dumont S, Vassal G, Le Deley MC, Gaspar N
Cancer Med 2021 Mar;10(5):1589-1604. Epub 2021 Jan 15 doi: 10.1002/cam4.3712. PMID: 33452711Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...