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Cirrhosis of the Liver Secondary to Hepatitis B

MedGen UID:
1676576
•Concept ID:
C4763866
•
Disease or Syndrome

Definition

Cirrhosis of the liver that develops as a sequelae of a hepatitis b infection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCirrhosis of the Liver Secondary to Hepatitis B

Professional guidelines

PubMed

Reasons to consider early treatment in chronic hepatitis B patients.
Koffas A, Petersen J, Kennedy PT
Antiviral Res 2020 May;177:104783. Epub 2020 Mar 23 doi: 10.1016/j.antiviral.2020.104783. PMID: 32217150
Prevention of Hepatitis B Virus Infection in the United States: Recommendations of the Advisory Committee on Immunization Practices.
Schillie S, Vellozzi C, Reingold A, Harris A, Haber P, Ward JW, Nelson NP
MMWR Recomm Rep 2018 Jan 12;67(1):1-31. doi: 10.15585/mmwr.rr6701a1. PMID: 29939980Free PMC Article
Hepatitis B Reactivation Associated With Immune Suppressive and Biological Modifier Therapies: Current Concepts, Management Strategies, and Future Directions.
Loomba R, Liang TJ
Gastroenterology 2017 May;152(6):1297-1309. Epub 2017 Feb 20 doi: 10.1053/j.gastro.2017.02.009. PMID: 28219691Free PMC Article

Recent clinical studies

Etiology

Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy.
Singal AG, Kanwal F, Llovet JM
Nat Rev Clin Oncol 2023 Dec;20(12):864-884. Epub 2023 Oct 26 doi: 10.1038/s41571-023-00825-3. PMID: 37884736
A Phase 3, Randomized Trial of Bulevirtide in Chronic Hepatitis D.
Wedemeyer H, Aleman S, Brunetto MR, Blank A, Andreone P, Bogomolov P, Chulanov V, Mamonova N, Geyvandova N, Morozov V, Sagalova O, Stepanova T, Berger A, Manuilov D, Suri V, An Q, Da B, Flaherty J, Osinusi A, Liu Y, Merle U, Schulze Zur Wiesch J, Zeuzem S, Ciesek S, Cornberg M, Lampertico P; MYR 301 Study Group
N Engl J Med 2023 Jul 6;389(1):22-32. Epub 2023 Jun 22 doi: 10.1056/NEJMoa2213429. PMID: 37345876
Preliminary evidence of safety and tolerability of atezolizumab plus bevacizumab in patients with hepatocellular carcinoma and Child-Pugh A and B cirrhosis: A real-world study.
D'Alessio A, Fulgenzi CAM, Nishida N, Schönlein M, von Felden J, Schulze K, Wege H, Gaillard VE, Saeed A, Wietharn B, Hildebrand H, Wu L, Ang C, Marron TU, Weinmann A, Galle PR, Bettinger D, Bengsch B, Vogel A, Balcar L, Scheiner B, Lee PC, Huang YH, Amara S, Muzaffar M, Naqash AR, Cammarota A, Personeni N, Pressiani T, Sharma R, Pinter M, Cortellini A, Kudo M, Rimassa L, Pinato DJ
Hepatology 2022 Oct;76(4):1000-1012. Epub 2022 Apr 8 doi: 10.1002/hep.32468. PMID: 35313048Free PMC Article
Hepatitis B Reactivation Associated With Immune Suppressive and Biological Modifier Therapies: Current Concepts, Management Strategies, and Future Directions.
Loomba R, Liang TJ
Gastroenterology 2017 May;152(6):1297-1309. Epub 2017 Feb 20 doi: 10.1053/j.gastro.2017.02.009. PMID: 28219691Free PMC Article
Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis.
Mazzaferro V, Regalia E, Doci R, Andreola S, Pulvirenti A, Bozzetti F, Montalto F, Ammatuna M, Morabito A, Gennari L
N Engl J Med 1996 Mar 14;334(11):693-9. doi: 10.1056/NEJM199603143341104. PMID: 8594428

Diagnosis

Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy.
Singal AG, Kanwal F, Llovet JM
Nat Rev Clin Oncol 2023 Dec;20(12):864-884. Epub 2023 Oct 26 doi: 10.1038/s41571-023-00825-3. PMID: 37884736
Early Diagnosis and Prevention of Infections in Cirrhosis.
Kulkarni AV, Premkumar M, Arab JP, Kumar K, Sharma M, Reddy ND, Padaki NR, Reddy RK
Semin Liver Dis 2022 Aug;42(3):293-312. Epub 2022 Jun 7 doi: 10.1055/a-1869-7607. PMID: 35672014
Liver Transplantation in Hepatitis B/Hepatitis D (Delta) Virus Coinfected Recipients.
Martini S, Tandoi F, Romagnoli R, Rizzetto M
Transplantation 2022 Oct 1;106(10):1935-1939. Epub 2022 Apr 11 doi: 10.1097/TP.0000000000004138. PMID: 35404869
Artificial intelligence for hepatitis evaluation.
Liu W, Liu X, Peng M, Chen GQ, Liu PH, Cui XW, Jiang F, Dietrich CF
World J Gastroenterol 2021 Sep 14;27(34):5715-5726. doi: 10.3748/wjg.v27.i34.5715. PMID: 34629796Free PMC Article
Hepatocellular carcinoma from the view of gastroenterologist/hepatologist.
Petr U, Petr H
Klin Onkol 2020 Fall;33(Supplementum 3):34-44. doi: 10.14735/amko20203S34. PMID: 33213164

Therapy

A Phase 3, Randomized Trial of Bulevirtide in Chronic Hepatitis D.
Wedemeyer H, Aleman S, Brunetto MR, Blank A, Andreone P, Bogomolov P, Chulanov V, Mamonova N, Geyvandova N, Morozov V, Sagalova O, Stepanova T, Berger A, Manuilov D, Suri V, An Q, Da B, Flaherty J, Osinusi A, Liu Y, Merle U, Schulze Zur Wiesch J, Zeuzem S, Ciesek S, Cornberg M, Lampertico P; MYR 301 Study Group
N Engl J Med 2023 Jul 6;389(1):22-32. Epub 2023 Jun 22 doi: 10.1056/NEJMoa2213429. PMID: 37345876
Entecavir plus Biejia-Ruangan compound reduces the risk of hepatocellular carcinoma in Chinese patients with chronic hepatitis B.
Ji D, Chen Y, Bi J, Shang Q, Liu H, Wang JB, Tan L, Wang J, Chen Y, Li Q, Long Q, Song L, Jiang L, Xiao G, Yu Z, Chen L, Wang X, Chen D, Li Z, Dong Z, Yang Y
J Hepatol 2022 Dec;77(6):1515-1524. Epub 2022 Aug 18 doi: 10.1016/j.jhep.2022.07.018. PMID: 35985545
Preliminary evidence of safety and tolerability of atezolizumab plus bevacizumab in patients with hepatocellular carcinoma and Child-Pugh A and B cirrhosis: A real-world study.
D'Alessio A, Fulgenzi CAM, Nishida N, Schönlein M, von Felden J, Schulze K, Wege H, Gaillard VE, Saeed A, Wietharn B, Hildebrand H, Wu L, Ang C, Marron TU, Weinmann A, Galle PR, Bettinger D, Bengsch B, Vogel A, Balcar L, Scheiner B, Lee PC, Huang YH, Amara S, Muzaffar M, Naqash AR, Cammarota A, Personeni N, Pressiani T, Sharma R, Pinter M, Cortellini A, Kudo M, Rimassa L, Pinato DJ
Hepatology 2022 Oct;76(4):1000-1012. Epub 2022 Apr 8 doi: 10.1002/hep.32468. PMID: 35313048Free PMC Article
Prevention of Hepatitis B Virus Infection in the United States: Recommendations of the Advisory Committee on Immunization Practices.
Schillie S, Vellozzi C, Reingold A, Harris A, Haber P, Ward JW, Nelson NP
MMWR Recomm Rep 2018 Jan 12;67(1):1-31. doi: 10.15585/mmwr.rr6701a1. PMID: 29939980Free PMC Article
Hepatitis B Reactivation Associated With Immune Suppressive and Biological Modifier Therapies: Current Concepts, Management Strategies, and Future Directions.
Loomba R, Liang TJ
Gastroenterology 2017 May;152(6):1297-1309. Epub 2017 Feb 20 doi: 10.1053/j.gastro.2017.02.009. PMID: 28219691Free PMC Article

Prognosis

Liver Transplantation in Hepatitis B/Hepatitis D (Delta) Virus Coinfected Recipients.
Martini S, Tandoi F, Romagnoli R, Rizzetto M
Transplantation 2022 Oct 1;106(10):1935-1939. Epub 2022 Apr 11 doi: 10.1097/TP.0000000000004138. PMID: 35404869
Hepatitis B Before and After Hepatocellular Carcinoma.
Harputluoglu M, Carr BI
J Gastrointest Cancer 2021 Dec;52(4):1206-1210. Epub 2021 Nov 11 doi: 10.1007/s12029-021-00745-4. PMID: 34762265
Artificial intelligence for hepatitis evaluation.
Liu W, Liu X, Peng M, Chen GQ, Liu PH, Cui XW, Jiang F, Dietrich CF
World J Gastroenterol 2021 Sep 14;27(34):5715-5726. doi: 10.3748/wjg.v27.i34.5715. PMID: 34629796Free PMC Article
Review article: the prevention of hepatitis B-related hepatocellular carcinoma.
Lin CL, Kao JH
Aliment Pharmacol Ther 2018 Jul;48(1):5-14. Epub 2018 May 3 doi: 10.1111/apt.14683. PMID: 29722445
Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis.
Mazzaferro V, Regalia E, Doci R, Andreola S, Pulvirenti A, Bozzetti F, Montalto F, Ammatuna M, Morabito A, Gennari L
N Engl J Med 1996 Mar 14;334(11):693-9. doi: 10.1056/NEJM199603143341104. PMID: 8594428

Clinical prediction guides

The current and future burden of hepatitis B in Switzerland: a modelling study.
Negro F, Müllhaupt B, Semela D, Blach S, Bruggmann P, De Gottardi A, Dufour JF, Fraga M, Galante A, Razavi H, Vieira Barbosa J, Razavi-Shearer D
Swiss Med Wkly 2023 Jun 5;153:40086. doi: 10.57187/smw.2023.40086. PMID: 37410921
Entecavir plus Biejia-Ruangan compound reduces the risk of hepatocellular carcinoma in Chinese patients with chronic hepatitis B.
Ji D, Chen Y, Bi J, Shang Q, Liu H, Wang JB, Tan L, Wang J, Chen Y, Li Q, Long Q, Song L, Jiang L, Xiao G, Yu Z, Chen L, Wang X, Chen D, Li Z, Dong Z, Yang Y
J Hepatol 2022 Dec;77(6):1515-1524. Epub 2022 Aug 18 doi: 10.1016/j.jhep.2022.07.018. PMID: 35985545
Safety, tolerability and antiviral activity of the antisense oligonucleotide bepirovirsen in patients with chronic hepatitis B: a phase 2 randomized controlled trial.
Yuen MF, Heo J, Jang JW, Yoon JH, Kweon YO, Park SJ, Tami Y, You S, Yates P, Tao Y, Cremer J, Campbell F, Elston R, Theodore D, Paff M, Bennett CF, Kwoh TJ
Nat Med 2021 Oct;27(10):1725-1734. Epub 2021 Oct 12 doi: 10.1038/s41591-021-01513-4. PMID: 34642494Free PMC Article
Artificial intelligence for hepatitis evaluation.
Liu W, Liu X, Peng M, Chen GQ, Liu PH, Cui XW, Jiang F, Dietrich CF
World J Gastroenterol 2021 Sep 14;27(34):5715-5726. doi: 10.3748/wjg.v27.i34.5715. PMID: 34629796Free PMC Article
Pleiotropic effects of statins in the diseases of the liver.
Janicko M, Drazilova S, Pella D, Fedacko J, Jarcuska P
World J Gastroenterol 2016 Jul 21;22(27):6201-13. doi: 10.3748/wjg.v22.i27.6201. PMID: 27468210Free PMC Article

Recent systematic reviews

Compound Biejia-Ruangan tablet as an adjunctive therapy to entecavir for chronic hepatitis B complicated with hepatic fibrosis: A systematic review and meta-analysis of randomized controlled trials.
Xu YH, Xue C
Medicine (Baltimore) 2022 Aug 12;101(32):e30020. doi: 10.1097/MD.0000000000030020. PMID: 35960113Free PMC Article
Acupuncture for chronic hepatitis B.
Kong Z, Liang N, Yang GL, Zhang Z, Liu Y, Yang Y, Liu YX, Wang QG, Zhang F, Zhang HY, Nikolova D, Jakobsen JC, Gluud C, Liu JP
Cochrane Database Syst Rev 2019 Aug 22;8(8):CD013107. doi: 10.1002/14651858.CD013107.pub2. PMID: 31436846Free PMC Article
Hepatitis B reactivation in hepatitis B and C coinfected patients treated with antiviral agents: A systematic review and meta-analysis.
Chen G, Wang C, Chen J, Ji D, Wang Y, Wu V, Karlberg J, Lau G
Hepatology 2017 Jul;66(1):13-26. Epub 2017 May 27 doi: 10.1002/hep.29109. PMID: 28195337
Systematic review with meta-analysis: the proportion of chronic hepatitis B patients with normal alanine transaminase ≤ 40 IU/L and significant hepatic fibrosis.
Chao DT, Lim JK, Ayoub WS, Nguyen LH, Nguyen MH
Aliment Pharmacol Ther 2014 Feb;39(4):349-58. Epub 2014 Jan 6 doi: 10.1111/apt.12590. PMID: 24387289
Bicyclol for chronic hepatitis B.
Wu T, Roger H, Xie L, Liu G, Hao B
Cochrane Database Syst Rev 2006 Oct 18;(4):CD004480. doi: 10.1002/14651858.CD004480.pub2. PMID: 17054206

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