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Cirrhosis of the Liver Secondary to Hepatitis B

MedGen UID:
1676576
•Concept ID:
C4763866
•
Disease or Syndrome

Definition

Cirrhosis of the liver that develops as a sequelae of a hepatitis b infection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCirrhosis of the Liver Secondary to Hepatitis B

Professional guidelines

PubMed

The role of fibrosis index FIB-4 in predicting liver fibrosis stage and clinical prognosis: A diagnostic or screening tool?
Xu XL, Jiang LS, Wu CS, Pan LY, Lou ZQ, Peng CT, Dong Y, Ruan B
J Formos Med Assoc 2022 Feb;121(2):454-466. Epub 2021 Jul 26 doi: 10.1016/j.jfma.2021.07.013. PMID: 34325952
Prevention of Hepatitis B Virus Infection in the United States: Recommendations of the Advisory Committee on Immunization Practices.
Schillie S, Vellozzi C, Reingold A, Harris A, Haber P, Ward JW, Nelson NP
MMWR Recomm Rep 2018 Jan 12;67(1):1-31. doi: 10.15585/mmwr.rr6701a1. PMID: 29939980Free PMC Article
Hepatitis B Reactivation Associated With Immune Suppressive and Biological Modifier Therapies: Current Concepts, Management Strategies, and Future Directions.
Loomba R, Liang TJ
Gastroenterology 2017 May;152(6):1297-1309. Epub 2017 Feb 20 doi: 10.1053/j.gastro.2017.02.009. PMID: 28219691Free PMC Article

Recent clinical studies

Etiology

Early Diagnosis and Prevention of Infections in Cirrhosis.
Kulkarni AV, Premkumar M, Arab JP, Kumar K, Sharma M, Reddy ND, Padaki NR, Reddy RK
Semin Liver Dis 2022 Aug;42(3):293-312. Epub 2022 Jun 7 doi: 10.1055/a-1869-7607. PMID: 35672014
Preliminary evidence of safety and tolerability of atezolizumab plus bevacizumab in patients with hepatocellular carcinoma and Child-Pugh A and B cirrhosis: A real-world study.
D'Alessio A, Fulgenzi CAM, Nishida N, Schönlein M, von Felden J, Schulze K, Wege H, Gaillard VE, Saeed A, Wietharn B, Hildebrand H, Wu L, Ang C, Marron TU, Weinmann A, Galle PR, Bettinger D, Bengsch B, Vogel A, Balcar L, Scheiner B, Lee PC, Huang YH, Amara S, Muzaffar M, Naqash AR, Cammarota A, Personeni N, Pressiani T, Sharma R, Pinter M, Cortellini A, Kudo M, Rimassa L, Pinato DJ
Hepatology 2022 Oct;76(4):1000-1012. Epub 2022 Apr 8 doi: 10.1002/hep.32468. PMID: 35313048Free PMC Article
Safety, tolerability and antiviral activity of the antisense oligonucleotide bepirovirsen in patients with chronic hepatitis B: a phase 2 randomized controlled trial.
Yuen MF, Heo J, Jang JW, Yoon JH, Kweon YO, Park SJ, Tami Y, You S, Yates P, Tao Y, Cremer J, Campbell F, Elston R, Theodore D, Paff M, Bennett CF, Kwoh TJ
Nat Med 2021 Oct;27(10):1725-1734. Epub 2021 Oct 12 doi: 10.1038/s41591-021-01513-4. PMID: 34642494Free PMC Article
Artificial intelligence for hepatitis evaluation.
Liu W, Liu X, Peng M, Chen GQ, Liu PH, Cui XW, Jiang F, Dietrich CF
World J Gastroenterol 2021 Sep 14;27(34):5715-5726. doi: 10.3748/wjg.v27.i34.5715. PMID: 34629796Free PMC Article
Hepatitis B Reactivation Associated With Immune Suppressive and Biological Modifier Therapies: Current Concepts, Management Strategies, and Future Directions.
Loomba R, Liang TJ
Gastroenterology 2017 May;152(6):1297-1309. Epub 2017 Feb 20 doi: 10.1053/j.gastro.2017.02.009. PMID: 28219691Free PMC Article

Diagnosis

Early Diagnosis and Prevention of Infections in Cirrhosis.
Kulkarni AV, Premkumar M, Arab JP, Kumar K, Sharma M, Reddy ND, Padaki NR, Reddy RK
Semin Liver Dis 2022 Aug;42(3):293-312. Epub 2022 Jun 7 doi: 10.1055/a-1869-7607. PMID: 35672014
Liver Transplantation in Hepatitis B/Hepatitis D (Delta) Virus Coinfected Recipients.
Martini S, Tandoi F, Romagnoli R, Rizzetto M
Transplantation 2022 Oct 1;106(10):1935-1939. Epub 2022 Apr 11 doi: 10.1097/TP.0000000000004138. PMID: 35404869
The role of fibrosis index FIB-4 in predicting liver fibrosis stage and clinical prognosis: A diagnostic or screening tool?
Xu XL, Jiang LS, Wu CS, Pan LY, Lou ZQ, Peng CT, Dong Y, Ruan B
J Formos Med Assoc 2022 Feb;121(2):454-466. Epub 2021 Jul 26 doi: 10.1016/j.jfma.2021.07.013. PMID: 34325952
Artificial intelligence for hepatitis evaluation.
Liu W, Liu X, Peng M, Chen GQ, Liu PH, Cui XW, Jiang F, Dietrich CF
World J Gastroenterol 2021 Sep 14;27(34):5715-5726. doi: 10.3748/wjg.v27.i34.5715. PMID: 34629796Free PMC Article
Pharyngeal metastasis following living-donor liver transplantation for hepatocellular carcinoma: a case report and literature review.
Tohyama T, Sakamoto K, Tamura K, Nakamura T, Watanabe J, Wakisaka H, Takada Y
World J Surg Oncol 2020 May 28;18(1):109. doi: 10.1186/s12957-020-01873-0. PMID: 32466780Free PMC Article

Therapy

Early Diagnosis and Prevention of Infections in Cirrhosis.
Kulkarni AV, Premkumar M, Arab JP, Kumar K, Sharma M, Reddy ND, Padaki NR, Reddy RK
Semin Liver Dis 2022 Aug;42(3):293-312. Epub 2022 Jun 7 doi: 10.1055/a-1869-7607. PMID: 35672014
Preliminary evidence of safety and tolerability of atezolizumab plus bevacizumab in patients with hepatocellular carcinoma and Child-Pugh A and B cirrhosis: A real-world study.
D'Alessio A, Fulgenzi CAM, Nishida N, Schönlein M, von Felden J, Schulze K, Wege H, Gaillard VE, Saeed A, Wietharn B, Hildebrand H, Wu L, Ang C, Marron TU, Weinmann A, Galle PR, Bettinger D, Bengsch B, Vogel A, Balcar L, Scheiner B, Lee PC, Huang YH, Amara S, Muzaffar M, Naqash AR, Cammarota A, Personeni N, Pressiani T, Sharma R, Pinter M, Cortellini A, Kudo M, Rimassa L, Pinato DJ
Hepatology 2022 Oct;76(4):1000-1012. Epub 2022 Apr 8 doi: 10.1002/hep.32468. PMID: 35313048Free PMC Article
Hepatitis B Before and After Hepatocellular Carcinoma.
Harputluoglu M, Carr BI
J Gastrointest Cancer 2021 Dec;52(4):1206-1210. Epub 2021 Nov 11 doi: 10.1007/s12029-021-00745-4. PMID: 34762265
Safety, tolerability and antiviral activity of the antisense oligonucleotide bepirovirsen in patients with chronic hepatitis B: a phase 2 randomized controlled trial.
Yuen MF, Heo J, Jang JW, Yoon JH, Kweon YO, Park SJ, Tami Y, You S, Yates P, Tao Y, Cremer J, Campbell F, Elston R, Theodore D, Paff M, Bennett CF, Kwoh TJ
Nat Med 2021 Oct;27(10):1725-1734. Epub 2021 Oct 12 doi: 10.1038/s41591-021-01513-4. PMID: 34642494Free PMC Article
Hepatitis B Reactivation Associated With Immune Suppressive and Biological Modifier Therapies: Current Concepts, Management Strategies, and Future Directions.
Loomba R, Liang TJ
Gastroenterology 2017 May;152(6):1297-1309. Epub 2017 Feb 20 doi: 10.1053/j.gastro.2017.02.009. PMID: 28219691Free PMC Article

Prognosis

Effect of a 12-week home-based exercise training program on aerobic capacity, muscle mass, liver and spleen stiffness, and quality of life in cirrhotic patients: a randomized controlled clinical trial.
Sirisunhirun P, Bandidniyamanon W, Jrerattakon Y, Muangsomboon K, Pramyothin P, Nimanong S, Tanwandee T, Charatcharoenwitthaya P, Chainuvati S, Chotiyaputta W
BMC Gastroenterol 2022 Feb 14;22(1):66. doi: 10.1186/s12876-022-02147-7. PMID: 35164698Free PMC Article
The role of fibrosis index FIB-4 in predicting liver fibrosis stage and clinical prognosis: A diagnostic or screening tool?
Xu XL, Jiang LS, Wu CS, Pan LY, Lou ZQ, Peng CT, Dong Y, Ruan B
J Formos Med Assoc 2022 Feb;121(2):454-466. Epub 2021 Jul 26 doi: 10.1016/j.jfma.2021.07.013. PMID: 34325952
Hepatitis B Before and After Hepatocellular Carcinoma.
Harputluoglu M, Carr BI
J Gastrointest Cancer 2021 Dec;52(4):1206-1210. Epub 2021 Nov 11 doi: 10.1007/s12029-021-00745-4. PMID: 34762265
Artificial intelligence for hepatitis evaluation.
Liu W, Liu X, Peng M, Chen GQ, Liu PH, Cui XW, Jiang F, Dietrich CF
World J Gastroenterol 2021 Sep 14;27(34):5715-5726. doi: 10.3748/wjg.v27.i34.5715. PMID: 34629796Free PMC Article
Pharyngeal metastasis following living-donor liver transplantation for hepatocellular carcinoma: a case report and literature review.
Tohyama T, Sakamoto K, Tamura K, Nakamura T, Watanabe J, Wakisaka H, Takada Y
World J Surg Oncol 2020 May 28;18(1):109. doi: 10.1186/s12957-020-01873-0. PMID: 32466780Free PMC Article

Clinical prediction guides

Entecavir plus Biejia-Ruangan compound reduces the risk of hepatocellular carcinoma in Chinese patients with chronic hepatitis B.
Ji D, Chen Y, Bi J, Shang Q, Liu H, Wang JB, Tan L, Wang J, Chen Y, Li Q, Long Q, Song L, Jiang L, Xiao G, Yu Z, Chen L, Wang X, Chen D, Li Z, Dong Z, Yang Y
J Hepatol 2022 Dec;77(6):1515-1524. Epub 2022 Aug 18 doi: 10.1016/j.jhep.2022.07.018. PMID: 35985545
Effect of a 12-week home-based exercise training program on aerobic capacity, muscle mass, liver and spleen stiffness, and quality of life in cirrhotic patients: a randomized controlled clinical trial.
Sirisunhirun P, Bandidniyamanon W, Jrerattakon Y, Muangsomboon K, Pramyothin P, Nimanong S, Tanwandee T, Charatcharoenwitthaya P, Chainuvati S, Chotiyaputta W
BMC Gastroenterol 2022 Feb 14;22(1):66. doi: 10.1186/s12876-022-02147-7. PMID: 35164698Free PMC Article
The role of fibrosis index FIB-4 in predicting liver fibrosis stage and clinical prognosis: A diagnostic or screening tool?
Xu XL, Jiang LS, Wu CS, Pan LY, Lou ZQ, Peng CT, Dong Y, Ruan B
J Formos Med Assoc 2022 Feb;121(2):454-466. Epub 2021 Jul 26 doi: 10.1016/j.jfma.2021.07.013. PMID: 34325952
Safety, tolerability and antiviral activity of the antisense oligonucleotide bepirovirsen in patients with chronic hepatitis B: a phase 2 randomized controlled trial.
Yuen MF, Heo J, Jang JW, Yoon JH, Kweon YO, Park SJ, Tami Y, You S, Yates P, Tao Y, Cremer J, Campbell F, Elston R, Theodore D, Paff M, Bennett CF, Kwoh TJ
Nat Med 2021 Oct;27(10):1725-1734. Epub 2021 Oct 12 doi: 10.1038/s41591-021-01513-4. PMID: 34642494Free PMC Article
Artificial intelligence for hepatitis evaluation.
Liu W, Liu X, Peng M, Chen GQ, Liu PH, Cui XW, Jiang F, Dietrich CF
World J Gastroenterol 2021 Sep 14;27(34):5715-5726. doi: 10.3748/wjg.v27.i34.5715. PMID: 34629796Free PMC Article

Recent systematic reviews

Compound Biejia-Ruangan tablet as an adjunctive therapy to entecavir for chronic hepatitis B complicated with hepatic fibrosis: A systematic review and meta-analysis of randomized controlled trials.
Xu YH, Xue C
Medicine (Baltimore) 2022 Aug 12;101(32):e30020. doi: 10.1097/MD.0000000000030020. PMID: 35960113Free PMC Article
Differential Effectiveness of Tenofovir and Entecavir for Prophylaxis of Hepatocellular Carcinoma in Chronic Hepatitis B Patients Depending on Coexisting Cirrhosis and Prior Exposure to Antiviral Therapy: A Systematic Review and Meta-analysis.
Jeong S, Cho Y, Park SM, Kim W
J Clin Gastroenterol 2021 Oct 1;55(9):e77-e86. doi: 10.1097/MCG.0000000000001548. PMID: 33883516
Hepatitis B reactivation in hepatitis B and C coinfected patients treated with antiviral agents: A systematic review and meta-analysis.
Chen G, Wang C, Chen J, Ji D, Wang Y, Wu V, Karlberg J, Lau G
Hepatology 2017 Jul;66(1):13-26. Epub 2017 May 27 doi: 10.1002/hep.29109. PMID: 28195337
Systematic review with meta-analysis: the proportion of chronic hepatitis B patients with normal alanine transaminase ≤ 40 IU/L and significant hepatic fibrosis.
Chao DT, Lim JK, Ayoub WS, Nguyen LH, Nguyen MH
Aliment Pharmacol Ther 2014 Feb;39(4):349-58. Epub 2014 Jan 6 doi: 10.1111/apt.12590. PMID: 24387289
Bicyclol for chronic hepatitis B.
Wu T, Roger H, Xie L, Liu G, Hao B
Cochrane Database Syst Rev 2006 Oct 18;(4):CD004480. doi: 10.1002/14651858.CD004480.pub2. PMID: 17054206

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